Targeting the insulin-like growth factor receptor and Src signaling network for the treatment of non-small cell lung cancer
出版年份 2015 全文链接
标题
Targeting the insulin-like growth factor receptor and Src signaling network for the treatment of non-small cell lung cancer
作者
关键词
Insulin-like growth factor receptor, Src, Linsitinib, Lung cancer
出版物
Molecular Cancer
Volume 14, Issue 1, Pages -
出版商
Springer Nature
发表日期
2015-06-04
DOI
10.1186/s12943-015-0392-3
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Transcriptional and posttranslational regulation of insulin-like growth factor binding protein-3 by Akt3
- (2014) Quanri Jin et al. CARCINOGENESIS
- Acquired resistance to TKIs in solid tumours: learning from lung cancer
- (2014) D. Ross Camidge et al. Nature Reviews Clinical Oncology
- Cancer statistics, 2013
- (2013) Rebecca Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Combating Resistance to Anti-IGFR Antibody by Targeting the Integrin β 3-Src Pathway
- (2013) Dong Hoon Shin et al. JNCI-Journal of the National Cancer Institute
- ERK Phosphorylation Is Predictive of Resistance to IGF-1R Inhibition in Small Cell Lung Cancer
- (2013) R. L. Zinn et al. MOLECULAR CANCER THERAPEUTICS
- Phase II study of figitumumab in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck: clinical activity and molecular response (GORTEC 2008-02)
- (2012) S. Schmitz et al. ANNALS OF ONCOLOGY
- Epidermal growth factor receptor and K-Ras mutations and resistance of lung cancer to insulin-like growth factor 1 receptor tyrosine kinase inhibitors
- (2012) Woo-Young Kim et al. CANCER
- NIH Image to ImageJ: 25 years of image analysis
- (2012) Caroline A Schneider et al. NATURE METHODS
- Global cancer statistics
- (2011) Ahmedin Jemal et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Prognostic impact of insulin receptor expression on survival of patients with nonsmall cell lung cancer
- (2011) Jin-Soo Kim et al. CANCER
- The role of the insulin-like growth factor signaling pathway in non-small cell lung cancer and other solid tumors
- (2011) Giorgio V. Scagliotti et al. CANCER TREATMENT REVIEWS
- Dasatinib: An Anti-Tumour Agent via Src Inhibition
- (2011) Antonio Gnoni et al. CURRENT DRUG TARGETS
- Randomized Phase II Study of Erlotinib in Combination With Placebo or R1507, a Monoclonal Antibody to Insulin-Like Growth Factor-1 Receptor, for Advanced-Stage Non–Small-Cell Lung Cancer
- (2011) Suresh S. Ramalingam et al. JOURNAL OF CLINICAL ONCOLOGY
- Evasion Mechanisms to Igf1r Inhibition in Rhabdomyosarcoma
- (2011) J. Abraham et al. MOLECULAR CANCER THERAPEUTICS
- Epithelial-Mesenchymal Transition Predicts Sensitivity to the Dual IGF-1R/IR Inhibitor OSI-906 in Hepatocellular Carcinoma Cell Lines
- (2011) H. Zhao et al. MOLECULAR CANCER THERAPEUTICS
- Akt/mTOR Counteract the Antitumor Activities of Cixutumumab, an Anti-Insulin-like Growth Factor I Receptor Monoclonal Antibody
- (2011) D. H. Shin et al. MOLECULAR CANCER THERAPEUTICS
- Targeting Src family kinases in anti-cancer therapies: turning promise into triumph
- (2011) Siyuan Zhang et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Dual Targeting of the Insulin-Like Growth Factor and Collateral Pathways in Cancer: Combating Drug Resistance
- (2011) Joseph A. Ludwig et al. Cancers
- Development of an Integrated Genomic Classifier for a Novel Agent in Colorectal Cancer: Approach to Individualized Therapy in Early Development
- (2010) T. M. Pitts et al. CLINICAL CANCER RESEARCH
- Novel dual Src/Abl inhibitors for hematologic and solid malignancies
- (2010) Silvia Schenone et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Randomized, Phase II Study of the Insulin-Like Growth Factor-1 Receptor Inhibitor IMC-A12, With or Without Cetuximab, in Patients With Cetuximab- or Panitumumab-Refractory Metastatic Colorectal Cancer
- (2010) Diane Lauren Reidy et al. JOURNAL OF CLINICAL ONCOLOGY
- Small Is Beautiful: Insulin-Like Growth Factors and Their Role in Growth, Development, and Cancer
- (2010) Robert G. Maki JOURNAL OF CLINICAL ONCOLOGY
- The Insulin-Like Growth Factor Pathway in Lung Cancer
- (2010) Rafal Dziadziuszko et al. Journal of Thoracic Oncology
- Compensatory Insulin Receptor (IR) Activation on Inhibition of Insulin-Like Growth Factor-1 Receptor (IGF-1R): Rationale for Cotargeting IGF-1R and IR in Cancer
- (2010) E. Buck et al. MOLECULAR CANCER THERAPEUTICS
- Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy
- (2010) D. B. Ulanet et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- High coexpression of both insulin-like growth factor receptor-1 (IGFR-1) and epidermal growth factor receptor (EGFR) is associated with shorter disease-free survival in resected non-small-cell lung cancer patients
- (2009) V. Ludovini et al. ANNALS OF ONCOLOGY
- Elevated Epithelial Insulin-like Growth Factor Expression Is a Risk Factor for Lung Cancer Development
- (2009) W.-Y. Kim et al. CANCER RESEARCH
- Resistance to Targeted Therapies: Refining Anticancer Therapy in the Era of Molecular Oncology
- (2009) L. M. Ellis et al. CLINICAL CANCER RESEARCH
- Tyrosine Kinase Inhibitors – A Review on Pharmacology, Metabolism and Side Effects
- (2009) Jorg Hartmann et al. CURRENT DRUG METABOLISM
- Clinical Development of Inhibitors of the Insulin-like Growth Factor Receptor in Oncology
- (2009) Antonio Gualberto et al. CURRENT DRUG TARGETS
- Targeted therapies for non-small cell lung cancer
- (2009) Wolfram C.M. Dempke et al. LUNG CANCER
- Src kinases as therapeutic targets for cancer
- (2009) Lori C. Kim et al. Nature Reviews Clinical Oncology
- Src as a potential therapeutic target in non-small-cell lung cancer
- (2008) G. Giaccone et al. ANNALS OF ONCOLOGY
- Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations
- (2008) J LOPICCOLO et al. DRUG RESISTANCE UPDATES
- The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
- (2008) C.-H. Yun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Proteomic Analysis for the Assessment of Different Lots of Fetal Bovine Serum as a Raw Material for Cell Culture. Part IV. Application of Proteomics to the Manufacture of Biological Drugs
- (2006) Xiaoyang Zheng et al. BIOTECHNOLOGY PROGRESS
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