Article
Immunology
Long Mu, Zhibin Han, Shengkun Yu, Aowen Wang, Dongjiang Chen, Sijia Kong, Yifei Gu, Lin Xu, Axiang Liu, Ruohan Sun, Yu Long
Summary: ASB3 is aberrantly expressed in various tumors, particularly in GBM, and is significantly correlated with patient prognosis, TMB, MSI, and immune cell infiltration. In GBM, ASB3 expression is negatively associated with Tregs, cancer-associated fibroblasts, and oncogenetic signaling pathways. Overexpression of ASB3 reduces the proportion of Tregs in TILs.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Mohammad Khoonkari, Dong Liang, Marleen Kamperman, Frank A. E. Kruyt, Patrick van Rijn
Summary: The biology and physics of glioblastoma are not completely understood, leading to limited effectiveness of current clinical therapy. Mechanical stress plays an important role in the development and malignancy of cancer, including glioblastoma. Alterations in the extracellular matrix (ECM) of the brain and the resulting stiffening of the ECM affect signaling activity and contribute to the aggressive behavior of glioblastoma cells. Mechanosensing signaling pathways, such as Hippo/YAP, CD44, and actin skeleton signaling, play a role in remodeling the cytoskeleton and influencing cellular properties. Hydrogels are used to mimic the stiffening of the brain ECM in vitro. Understanding these processes could potentially lead to new therapeutic approaches for glioblastoma.
Article
Oncology
Amin Izadpanah, Fatemeh Daneshimehr, Kurtis Willingham, Zahra Barabadi, Stephen E. Braun, Aaron Dumont, Ricardo Mostany, Bysani Chandrasekar, Eckhard U. Alt, Reza Izadpanah
Summary: TRAF3IP2 has been identified as a critical regulator of angiogenesis in glioblastoma multiforme (GBM), and targeting TRAF3IP2 could significantly reduce vascularization and inhibit the expression of growth factors, providing a potential therapeutic option for GBM.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Seungjo Park, Alexandra D. Avera, Yonghyun Kim
Summary: This study developed a simple, matrix-free, and in vivo-like GBM organoids (GBOs) model. Compared to traditional tumorsphere cultures, GBOs exhibited high stemness and strong cell-to-cell interactions, and showed spatial heterogeneity. The model can recapitulate the features of GBM tumor microenvironment and serve as an improved GBM in vitro model.
BIOTECHNOLOGY AND BIOENGINEERING
(2022)
Review
Oncology
David Bakhshinyan, Neil Savage, Sabra Khalid Salim, Chitra Venugopal, Sheila K. Singh
Summary: Studies have found that neural stem cells (NSCs) and glioblastoma stem cells (GSCs) in the adult brain overlap in function, but differences in gene expression, transcriptional programs, and external environmental cues influence their divergent behavior.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Shohei Iyoshi, Masato Yoshihara, Kae Nakamura, Mai Sugiyama, Yoshihiro Koya, Kazuhisa Kitami, Kaname Uno, Kazumasa Mogi, Sho Tano, Hiroyuki Tomita, Keiji Kajiwara, Masayasu Taki, Shigehiro Yamaguchi, Akihiro Nawa, Hiroaki Kajiyama
Summary: The study demonstrated that OvCa cells induce dedifferentiation of peritoneal adipocytes, resulting in the generation of O-ADFs with pro-tumoral characteristics. Inhibition of Wnt signaling pathway blocked the dedifferentiation effect of malignant ascites on adipocytes.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Editorial Material
Oncology
Lucas Leite Cunha, Guilherme Augusto Barcelos Domingues, Elaine Cristina Morari, Fernando Augusto Soares, Jose Vassallo, Laura Sterian Ward
Summary: The study indicates that the immune microenvironment may be correlated with the differentiation status of thyroid cancer. IL-6 positivity is associated with infiltration in malignant tumors. This concept could assist in determining patients who require more attention.
CANCER CELL INTERNATIONAL
(2021)
Article
Engineering, Biomedical
Shuhan Liu, Ji Liu, Haisong Li, Kuirong Mao, Haorui Wang, Xiandi Meng, Jialiang Wang, Chenxi Wu, Hongmei Chen, Xin Wang, Xiuxiu Cong, Yue Hou, Ye Wang, Ming Wang, Yong-Guang Yang, Tianmeng Sun
Summary: This study develops a novel cationic lipid nanoparticle (LNP) that efficiently delivers siRNA across the blood-brain barrier (BBB) and targets the tumor microenvironment in the brain of mice for immunotherapy of glioblastoma multiforme (GBM). The LNP is effective in delivering siRNA against CD47 and PD-L1 into the cranial GBM in mice, resulting in downregulation of target gene expression and activation of antitumor immunity.
Review
Medicine, Research & Experimental
Hector Mayani, Antonieta Chavez-Gonzalez, Karla Vazquez-Santillan, Jorge Contreras, Monica L. Guzman
Summary: This review article summarizes the biology of cancer stem cells (CSCs) and their significance in tumor development. CSCs are not only capable of initiating tumor growth, but also drive tumor progression and metastasis, exhibit resistance to cancer drugs, and are responsible for cancer relapse. Therefore, CSCs are attractive targets for the development of more effective oncologic treatments.
ARCHIVES OF MEDICAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Xiaoxuan Xu, Zhiqi Zhang, Jiawei Du, Yonger Xue, Xin Chen, Jianqiong Zhang, Xue Yang, Di Chang, Jinbing Xie, Shenghong Ju
Summary: This study describes nanovesicles with a macrophage-mimicking membrane that co-deliver CXCL10 and aPD-L1 to enhance the effect of immunotherapy for glioblastoma multiforme.
ADVANCED MATERIALS
(2023)
Article
Neurosciences
Jiaxin Li, Fredrik Ek, Roger Olsson, Mattias Belting, Johan Bengzon
Summary: This study identified CD105(+) cells as a potential subset of glioma stem-like cells (GSCs) that play a crucial role in tumor growth and treatment resistance. CD105(+) cells exhibited stem-like characteristics and differentiated into osteocytes and adipocytes. They also produced immunosuppressive and protumorigenic cytokines. Targeting CD105(+) cells could reshape the tumor microenvironment and block glioblastoma progression.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Ying Shi, Jian Jiang, Yingzhe Cui, Yaodong Chen, Tianxiu Dong, Hongda An, Pengfei Liu
Summary: MSH6 is a critical molecule in GBM, exerting a positive impact on the tumor microenvironment and metastasis, potentially promoting metastasis through inducing hypoxic TME, and serving as a promising therapeutic target.
DNA AND CELL BIOLOGY
(2021)
Review
Cell Biology
Aaron Galindo-Vega, Vilma Maldonado-Lagunas, Irma B. Mitre-Aguilar, Jorge Melendez-Zajgla
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy due to a complex tumor microenvironment and the presence of cancer stem cells, which contribute to therapy resistance and tumor relapse. Understanding and targeting the tumor microenvironment and cancer stem cells may be crucial for effective PDAC therapies. This review summarizes recent advances in the role of tumor microenvironment in pancreatic neoplastic progression.
Review
Oncology
Moloud Sooreshjani, Shashwat Tripathi, Corey Dussold, Hinda Najem, John de Groot, Rimas V. Lukas, Amy B. Heimberger
Summary: Glioblastoma, a highly infiltrative tumor, often recurs despite multi-modal treatment. Novel strategies incorporating cytokines as potential therapeutic options, including virotherapy, systemic cytokine therapy, and cellular and gene therapy, are being explored to improve treatment outcomes in glioblastoma patients.
Review
Biochemistry & Molecular Biology
Yansui Mai, Jiyan Su, Chuan Yang, Chenglai Xia, Liwu Fu
Summary: Cancer stem-like cells, with their remarkable capabilities, are crucial in tumor progression and metastasis. Targeting CSC biomarkers, stemness-associated pathways, tumor microenvironment, and immunoevasion can improve cancer treatment outcomes.
Article
Oncology
Anne Steins, Remy Klaassen, Igor Jacobs, Matthias C. Schabel, Monique G. J. T. B. van Lier, Eva A. Ebbing, Stefanie J. Hectors, Sander W. Tas, Chrissta X. Maracle, Cornelis J. A. Punt, Maria Siebes, Jacques J. G. H. M. Bergman, Jan Paul Medema, Johanna W. Wilmink, Ron A. A. Mathot, Gustav J. Strijkers, Maarten F. Bijlsma, Hanneke W. M. van Laarhoven
MOLECULAR ONCOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Prashanthi Ramesh, Jan Paul Medema
Article
Biochemistry & Molecular Biology
Anne Steins, Madelaine G. van Mackelenbergh, Amber P. van der Zalm, Remy Klaassen, Bryan Serrels, Sandrine G. Goris, Hemant M. Kocher, Cynthia Waasdorp, Joan H. de Jong, Cansu Tekin, Marc G. Besselink, Olivier R. Busch, Marc J. van de Vijver, Joanne Verheij, Frederike Dijk, Geertjan van Tienhoven, Johanna W. Wilmink, Jan Paul Medema, Hanneke W. M. van Laarhoven, Maarten F. Bijlsma
Article
Chemistry, Multidisciplinary
Naroa Serna, Patricia Alamo, Prashanthi Ramesh, Daria Vinokurova, Laura Sanchez-Garcia, Ugutz Unzueta, Alberto Gallardo, Maria Virtudes Cespedes, Esther Vazquez, Antonio Villaverde, Ramon Mangues, Jan Paul Medema
JOURNAL OF CONTROLLED RELEASE
(2020)
Article
Biochemistry & Molecular Biology
Maureen Spit, Nicola Fenderico, Ingrid Jordens, Tomasz Radaszkiewicz, Rik G. H. Lindeboom, Jeroen M. Bugter, Alba Cristobal, Lars Ootes, Max van Osch, Eline Janssen, Kim E. Boonekamp, Katerina Hanakova, David Potesil, Zbynek Zdrahal, Sylvia F. Boj, Jan Paul Medema, Vitezslav Bryja, Bon-Kyoung Koo, Michiel Vermeulen, Madelon M. Maurice
Review
Oncology
Joyce Y. Buikhuisen, Arezo Torang, Jan Paul Medema
Article
Oncology
I. van den Berg, S. van de Weerd, J. M. L. Roodhart, G. R. Vink, R. R. J. Coebergh van den Braak, C. R. Jimenez, S. G. Elias, D. van Vliet, M. Koelink, E. Hong, W. M. U. van Grevenstein, M. G. H. van Oijen, R. G. H. Beets-Tan, J. H. J. M. van Krieken, J. N. M. IJzermans, J. P. Medema, M. Koopman
Article
Oncology
R. R. J. Coebergh van den Braak, S. ten Hoorn, A. M. Sieuwerts, J. B. Tuynman, M. Smid, S. M. Wilting, J. W. M. Martens, C. J. A. Punt, J. A. Foekens, J. P. Medema, J. N. M. IJzermans, L. Vermeulen
Article
Multidisciplinary Sciences
Wouter Laurentius Smit, Claudia Nanette Spaan, Ruben Johannes de Boer, Prashanthi Ramesh, Tania Martins Garcia, Bartolomeus Joannes Meijer, Jacqueline Ludovicus Maria Vermeulen, Marco Lezzerini, Alyson Winfried MacInnes, Jan Koster, Jan Paul Medema, Gijs Robert van den Brink, Vanesa Muncan, Jarom Heijmans
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Gastroenterology & Hepatology
Laura Rosa Mangiapane, Annalisa Nicotra, Alice Turdo, Miriam Gaggianesi, Paola Bianca, Simone Di Franco, Davide Stefano Sardina, Veronica Veschi, Michele Signore, Sven Beyes, Luca Fagnocchi, Micol Eleonora Fiori, Maria Rita Bongiorno, Melania Lo Iacono, Irene Pillitteri, Gloria Ganduscio, Gaspare Gulotta, Jan Paul Medema, Alessio Zippo, Matilde Todaro, Ruggero De Maria, Giorgio Stassi
Summary: In colorectal cancer stem cells, high HER2 expression levels are associated with activation of the PI3K/AKT pathway. The targeting of HER2 in combination with PI3K and MEK inhibitors induces CR-CSC death and regression of tumor xenografts, including those with specific mutations. Triple targeting of PI3K, HER2, and MEK is necessary to overcome resistance to anti-EGFR therapies.
Article
Multidisciplinary Sciences
K. A. Pickering, K. Gilroy, J. W. Cassidy, S. K. Fey, A. K. Najumudeen, L. B. Zeiger, D. F. Vincent, D. M. Gay, J. Johansson, R. P. Fordham, B. Miller, W. Clark, A. Hedley, E. B. Unal, C. Kiel, E. McGhee, L. M. Machesky, C. Nixon, A. E. Johnsson, M. Bain, D. Strathdee, S. R. van Hoof, J. P. Medema, K. Anderson, S. M. Brachmann, V. M. Stucke, A. Malliri, M. Drysdale, M. Turner, L. Serrano, K. Myant, A. D. Campbell, O. J. Sansom
Summary: Indirect targeting of RAC1 via RAC-GEFs can effectively suppress hyperproliferation and tumorigenesis in the murine intestine without affecting normal intestinal homeostasis. Combined targeting of three RAC-GEFs can effectively inhibit RAC1 activity and delay intestinal tumorigenesis.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Joyce Y. Buikhuisen, Patricia M. Gomez Barila, Arezo Torang, Danielle Dekker, Joan H. de Jong, Kate Cameron, Sara Vitale, Giorgio Stassi, Sander R. van Hooff, Mauro A. A. Castro, Louis Vermeulen, Jan Paul Medema
Summary: The study identified that the protein AKT3 is highly expressed in CMS4 colorectal cancer subtype, promoting cancer cell growth by inhibiting the cell cycle regulator p27(KIP1). Inhibitors targeting AKT3 significantly reduced the growth of CMS4 categorized cancer cell lines. High AKT3 expression may serve as a marker for poor prognosis in colorectal cancer patients and could potentially guide the selection of patients who could benefit from AKT3-targeted therapy.
Article
Oncology
I van den Berg, S. van de Weerd, D. van Klaveren, R. R. J. Coebergh van den Braak, J. H. J. M. van Krieken, M. Koopman, J. M. L. Roodhart, J. P. Medema, J. N. M. IJzermans
Summary: This study revealed significant variation in guideline adherence to adjuvant chemotherapy among stage III colon cancer patients, with poor documentation on reasons for non-adherence. Patients who received adjuvant chemotherapy had longer recurrence free survival (RFS), and high T- and N-stage were associated with poorer RFS. Risk groups were identified with distinct prognosis and treatment effect, emphasizing the importance of adherence to guidelines for improved patient outcomes.
Article
Biochemistry & Molecular Biology
Le Zhang, Prashanthi Ramesh, Maxime Steinmetz, Jan Paul Medema
Summary: The study found that colorectal cancer cells have different responses to BH3 mimetics, which can be predicted by their consensus molecular subtype and KRAS/BRAF mutations. Most colorectal cancer cell lines are sensitive to combined MCL-1 and BCL-XL targeting in the nanomolar range.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Economics
Gabrielle Jongeneel, Marjolein J. E. Greuter, Felice N. van Erning, Miriam Koopman, Jan P. Medema, Raju Kandimalla, Ajay Goel, Luis Bujanda, Gerrit A. Meijer, Remond J. A. Fijneman, Martijn G. H. van Oijen, Jan Ijzermans, Cornelis J. A. Punt, Geraldine R. Vink, Veerle M. H. Coupe
EUROPEAN JOURNAL OF HEALTH ECONOMICS
(2020)