Article
Medicine, General & Internal
Claudio Barbiellini Amidei, Aurore Fayosse, Julien Dumurgier, Marcos D. Machado-Fragua, Adam G. Tabak, Thomas van Sloten, Mika Kivimaki, Aline Dugravot, Severine Sabia, Archana Singh-Manoux
Summary: Younger age at onset of type 2 diabetes is significantly associated with a higher risk of subsequent dementia, indicating a graded association between age at onset of type 2 diabetes and dementia.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Genetics & Heredity
Emil M. Pedersen, Esben Agerbo, Oleguer Plana-Ripoll, Jakob Grove, Julie W. Dreier, Katherine L. Musliner, Marie Baekvad-Hansen, Georgios Athanasiadis, Andrew Schork, Jonas Bybjerg-Grauholm, David M. Hougaard, Thomas Werge, Merete Nordentoft, Ole Mors, Soren Dalsgaard, Jakob Christensen, Anders D. Borglum, Preben B. Mortensen, John J. McGrath, Florian Prive, Bjarni J. Vilhjalmsson
Summary: Genome-wide association studies (GWASs) have greatly advanced human genetics research by identifying disease-related genes and drug targets. However, the current methods used in GWASs do not take into account factors such as age of onset, sex, and family history. The proposed LT-FH++ method, which considers these factors, shows significant power gains over existing methods and has identified numerous significant genetic associations.
AMERICAN JOURNAL OF HUMAN GENETICS
(2022)
Article
Psychiatry
Mariachiara Buonocore, Marta Bosia, Francesca Martini, Margherita Bechi, Marco Spangaro, Giulia Agostoni, Olympia Diddi, Federica Cocchi, Federica Cuoco, Roberto Cavallaro
Summary: Sex and age of onset are crucial factors influencing cognition in schizophrenia. Females have higher age and age of onset, while males perform better in executive functions. Late-onset patients have better verbal memory performance, while early-onset patients have lower IQ. There is an interaction effect between sex and age at onset, with early-onset being associated with worse global cognition only in male patients.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Jiaxin Li, Deyang Li, Junru Guo, Dongmei Wang, Xiangyang Zhang
Summary: Patients with early-onset schizophrenia have more severe negative symptoms and cognitive deficits. Oxidative stress is believed to be involved in cognitive impairment in schizophrenia. Total antioxidant capacity (TAOC) is an important indicator of oxidative stress. However, the relationship between age of onset, TAOC, and cognitive performance in schizophrenia has not been explored.
Article
Clinical Neurology
Gonzalo Forno, Jose Contador, Agnes Perez-Millan, Nuria Guillen, Neus Falgas, Jordi Sarto, Adria Tort-Merino, Magdalena Castellvi, Beatriz Bosch, Guadalupe Fernandez-Villullas, Mircea Balasa, Anna Antonell, Roser Sala-Llonch, Raquel Sanchez-Valle, Michael Hornberger, Albert Llado
Summary: This study assessed how the APOE genotype differentially affects cortical and subcortical memory structures in biomarker-confirmed early-onset (EOAD) and late-onset (LOAD) Alzheimer's disease patients. The results showed that the APOE genotype has a significant effect on grey matter volume, with LOAD APOE4 genotype mostly associated with cortical and temporal atrophy, while EOAD APOE4 genotype might have a more specific effect on subcortical structures (mammillary body). Therefore, the APOE genotype needs to be taken into account when classifying patients by age at onset.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Marco Solmi, Joaquim Radua, Miriam Olivola, Enrico Croce, Livia Soardo, Gonzalo Salazar de Pablo, Jae Il Shin, James B. Kirkbride, Peter Jones, Jae Han Kim, Jong Yeob Kim, Andre F. Carvalho, Mary V. Seeman, Christoph U. Correll, Paolo Fusar-Poli
Summary: This study emphasizes the importance of promoting good mental health, prevention, and early intervention before the onset of mental disorders. It found that different types of mental disorders have different age at onset characteristics, providing valuable guidance for the timing of interventions for specific mental disorders.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Yi Yin, Shuangshuang Li, Jinghui Tong, Junchao Huang, Baopeng Tian, Song Chen, Yimin Cui, Shuping Tan, Zhiren Wang, Fude Yang, Yongsheng Tong, L. Elliot Hong, Yunlong Tan
Summary: This study aimed to compare pre-treatment neurocognitive profiles among individuals with early-onset schizophrenia (EOS), typical-onset schizophrenia (TOS), and late-onset schizophrenia (LOS). The results showed that TOS patients had lower scores in verbal learning compared to LOS patients, while there were no differences in other cognitive domains. The association between age of onset and verbal memory showed a U-shaped curve.
COGNITIVE NEURODYNAMICS
(2023)
Article
Neurosciences
Nora Penzel, Linda A. Antonucci, Linda T. Betz, Rachele Sanfelici, Johanna Weiske, Oliver Pogarell, Paul Cumming, Boris B. Quednow, Oliver Howes, Peter Falkai, Rachel Upthegrove, Alessandro Bertolino, Stefan Borgwardt, Paolo Brambilla, Rebekka Lencer, Eva Meisenzahl, Marlene Rosen, Theresa Haidl, Lana Kambeitz-Ilankovic, Stephan Ruhrmann, Raimo R. K. Salokangas, Christos Pantelis, Stephen J. Wood, Nikolaos Koutsouleris, Joseph Kambeitz
Summary: Studies have shown that early initiation of cannabis is associated with more severe positive symptoms of psychosis, and changes in gray matter volume can affect the risk of psychosis. These findings are consistent with previous investigations in healthy cannabis users.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Xue Tian, Shuohua Chen, Yingting Zuo, Yijun Zhang, Xiaoli Zhang, Qin Xu, Yanxia Luo, Shouling Wu, Anxin Wang
Summary: This study revealed that diabetes and insulin resistance, as well as hypertension, metabolic syndrome, overweight or obesity, dyslipidemia, and smoking, appeared to be the strongest risk factors for premature cardiovascular disease onset. Most risk factors showed attenuated relative rates with increasing age at onset.
Article
Clinical Neurology
Denis S. Smirnov, David P. Salmon, Douglas Galasko, Vanessa S. Goodwill, Lawrence A. Hansen, Yu Zhao, Steven D. Edland, Gabriel C. Leger, Guerry M. Peavy, Diane M. Jacobs, Robert Rissman, Donald P. Pizzo, Annie Hiniker
Summary: Patients with early-onset sporadic Alzheimer's disease (AD) are more likely to exhibit atypical clinical and cognitive features compared to those with late onset. Late-onset AD patients have fewer non-memory complaints, psychiatric symptoms, and functional impairments. Moreover, they have lower NFT density and less cognitive impairment in executive function and visuospatial abilities.
Article
Clinical Neurology
Pilar M. Ferraro, Corrado Cabona, Giuseppe Meo, Claudia Rolla-Bigliani, Lucio Castellan, Matteo Pardini, Matilde Inglese, Claudia Caponnetto, Luca Roccatagliata
Summary: Research suggests that ALS patients with older age at symptom onset have greater cortical thinning in frontotemporal regions, which is predictive of shorter survival. These findings could help uncover the neurobiological mechanisms linking older age at symptom onset to worse prognosis in ALS.
Article
Psychology, Clinical
Birgitte Fagerlund, Christos Pantelis, Jens Richardt Mollegaard Jepsen, Jayachandra Mitta Raghava, Egill Rostrup, Marie Bjerregaard Thomas, Mette Odegaard Nielsen, Kirsten Bojesen, Karsten Gjessing Jensen, Marie Stentebjerg-Decara, Dea Gowers Klauber, Ditte Ruda, Bjorn H. Ebdrup, Kasper Jessen, Anne Sigvard, Karen Tangmose, Pia Jeppesen, Christoph U. Correll, Anders Fink-Jensen, Anne Katrine Pagsberg, Birte Yding Glenthoj
Summary: The study found that there are different impacts of age on cognition among patients with early and late onset schizophrenia, particularly in verbal memory and digit sequencing. This suggests a potential interaction between neurodevelopmental maturation timing and cognitive functioning in schizophrenia.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Clinical Neurology
Chunyu Li, Junyu Lin, Qirui Jiang, Tianmi Yang, Yi Xiao, Jingxuan Huang, Yanbing Hou, Qianqian Wei, Yiyuan Cui, Shichan Wang, Xiaoting Zheng, Ruwei Ou, Kuncheng Liu, Xueping Chen, Wei Song, Bi Zhao, Huifang Shang
Summary: This study identified a novel genetic variant rs2046243 (CTIF) that was significantly associated with earlier age at onset of amyotrophic lateral sclerosis (ALS). Functional exploration revealed that this variant was associated with increased expression of CTIF in multiple tissues, including the brain. Additionally, higher education level was found to be associated with later age at onset of ALS.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Christiane Kehrer, Saskia Elgun, Christa Raabe, Judith Bohringer, Stefanie Beck-Wodl, Andrea Bevot, Nadja Kaiser, Ludger Schols, Ingeborg Krageloh-Mann, Samuel Groeschel
Summary: This study compared disease progression in different onset forms of metachromatic leukodystrophy (MLD) and found that the type of first symptoms predicts the rate of disease progression, providing important insights for counseling and therapy.
Article
Multidisciplinary Sciences
Lars Lau Raket, Daniel Oudin Astrom, Jenny M. Norlin, Klas Kellerborg, Pablo Martinez-Martin, Per Odin
Summary: This study investigates the interactions between PD progression and aging, and finds that advanced age may be associated with more severe PD symptoms and accelerated progression. Additionally, higher age is also related to worse trajectories of quality of life.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Weiyang Shi, Lingzhong Fan, Haiyan Wang, Bing Liu, Wen Li, Jin Li, Luqi Cheng, Congying Chu, Ming Song, Jing Sui, Na Luo, Yue Cui, Zhenwei Dong, Yuheng Lu, Yawei Ma, Liang Ma, Kaixin Li, Jun Chen, Yunchun Chen, Hua Guo, Peng Li, Lin Lu, Luxian Lv, Ping Wan, Huaning Wang, Huiling Wang, Hao Yan, Jun Yan, Yongfeng Yang, Hongxing Zhang, Dai Zhang, Tianzi Jiang
Summary: By utilizing a large-scale multisite SCZ dataset, this study identified and validated two neuroanatomical subtypes of schizophrenia with individual-level abnormal patterns. The study revealed the heterogeneity in neuroanatomical patterns among SCZ patients with different clinical symptoms and identified potential underlying biological factors.
Article
Psychiatry
Yaoyao Sun, Yuyanan Zhang, Zhe Lu, Hao Yan, Liangkun Guo, Yundan Liao, Tianlan Lu, Lifang Wang, Jun Li, Wenqiang Li, Yongfeng Yang, Hao Yu, Luxian Lv, Dai Zhang, Wenjian Bi, Weihua Yue
Summary: This study aimed to evaluate the changes in schizophrenia symptoms under different antipsychotic treatments by analyzing data from a multicenter clinical trial. The results identified central and bridge symptoms in the networks that changed over time. Acute antipsychotic treatment altered the network structure, and responsive patients showed lower global strength after treatment compared to resistant patients. The central and bridge symptoms remained prominent across different antipsychotics.
SCHIZOPHRENIA BULLETIN
(2023)
Review
Engineering, Mechanical
Chao Fu, Jean-Jacques Sinou, Weidong Zhu, Kuan Lu, Yongfeng Yang
Summary: This paper presents a comprehensive review on uncertainty handling and analysis in rotor systems. It covers the identification and classification of uncertainties, popular uncertainty analysis methods, dynamic characteristics of rotor systems under uncertainties, reliability analysis, optimizations, and vibration control. It provides useful guidelines for designers and researchers in efficiently handling uncertainty and conducting robust dynamic analysis for rotor systems, as well as insightful prospects for future research directions.
MECHANICAL SYSTEMS AND SIGNAL PROCESSING
(2023)
Article
Engineering, Mechanical
Xiantao Zhang, Yongfeng Yang, Hui Ma, Mingming Shi, Ping Wang
Summary: This paper proposes a novel diagnosis indicator for rotor systems with rub-impact fault. The indicator takes into account the force, velocity, and phase information in a time interval and is developed based on the vibration power flow theory. The results of theoretical analysis and experiments show that the proposed indicator can accurately detect the severity of rub-impact faults.
MECHANICAL SYSTEMS AND SIGNAL PROCESSING
(2023)
Article
Engineering, Biomedical
Ziru Sang, Zhonghua Kuang, Xiaohui Wang, Ning Ren, San Wu, Ming Niu, Longhan Cong, Zheng Liu, Zhanli Hu, Tao Sun, Dong Liang, Xin Liu, Hairong Zheng, Ye Li, Yongfeng Yang
Summary: This study evaluated the mutual interference between the SIAT aPET and the 3 T uMR 790 MRI scanner. The results showed that the mutual interference between the two scanners was acceptable, and simultaneous PET/MRI imaging of small animals can be performed.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Genetics & Heredity
Xinglun Dang, Meng Song, Luxian Lv, Yongfeng Yang, Xiong-Jian Luo
Summary: In this study, a Mendelian randomization approach was used to integrate plasma proteomics and GWASs data of schizophrenia, bipolar disorder, and depression. The primate-specific immune-related protein BTN3A3 was found to be significantly associated with all three psychiatric disorders. Furthermore, several other immune-related proteins were also found to be significantly associated with psychiatric disorders. This study provides direct evidence connecting the genetic risk of psychiatric disorders to the immune system.
Article
Psychiatry
Zhaonian Chen, Xiaojing Li, Xiangzheng Cui, Luwen Zhang, Qing Liu, Yanli Lu, Xiujuan Wang, Han Shi, Minli Ding, Yongfeng Yang, Wenqiang Li, Luxian Lv
Summary: This study investigates the association between CTNND2 gene and schizophrenia (SZ). Through case-control analysis, three SNPs (rs16901943, rs7733427, rs2168878) were found to be associated with SZ, and rs10058868 and rs2168878 were linked to symptoms of depression and excitement in SZ patients.
INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE
(2023)
Article
Acoustics
Xiantao Zhang, Yongfeng Yang, Ruize Gao, Feng Ming, Ping Wang
Summary: Early crack faults bring challenges to fault detection process due to external disturbances in the whole rotor system. To address this issue, the harmonic balance-energy power flow analysis (HB-EPFA) is used to investigate rotor systems with transverse cracks. A novel indicator, Time-averaged power flow, is proposed for crack fault evaluation. The study also reveals the influence of crack depth on power flow values and identifies a zone of abrupt energy change for crack position detection.
JOURNAL OF SOUND AND VIBRATION
(2023)
Article
Acoustics
Anbo Ming, Wei Zhang, Chao Fu, Yongfeng Yang, Fulei Chu, Yajuan Liu
Summary: An optimal wavelet filtering method is developed using genetic algorithm to extract weak repetitive transients buried in heavy noise and disturbed by outliers. The capability of L-kurtosis for characterizing the impulsiveness and cyclostationary of repetitive transients is studied numerically. The proposed method is validated through simulations and experiments, showing its superior performance compared to other commonly used indexes-based optimal wavelet filtering methods.
JOURNAL OF VIBRATION AND CONTROL
(2023)
Article
Multidisciplinary Sciences
Liang Yang, Junfeng Shen, Chunhua Liu, Zhonghua Kuang, Yong Tang, Zhengjiang Qian, Min Guan, Yongfeng Yang, Yang Zhan, Nan Li, Xiang Li
Summary: Nicotine has been found to improve age-related symptoms by activating NAD(+) metabolic pathways.
NATURE COMMUNICATIONS
(2023)
Article
Computer Science, Information Systems
Minghan Fu, Meiyun Wang, Yaping Wu, Na Zhang, Yongfeng Yang, Haining Wang, Yun Zhou, Yue Shang, Fang-Xiang Wu, Hairong Zheng, Dong Liang, Zhanli Hu
Summary: A novel two-branch network architecture called SW-GCN is proposed to improve PET image quality. The network utilizes Swin Transformer units and graph convolution operation to handle different types of input information flow and enables better processing of long-range contextual information. Experimental results demonstrate that the proposed approach outperforms state-of-the-art methods in both quantitative and qualitative evaluations.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)
Article
Green & Sustainable Science & Technology
Xinsheng Zhu, Yongfeng Yang, Jun Yuan, Ziru Niu
Summary: An evaluation of the ecological status of 63 wetlands of international importance in China was carried out using monitoring data and analysis, revealing that the ecological status of these wetlands is generally good but can be adversely affected by human activities and alien species invasion. There needs to be a focus on improving protection and management mechanisms to enhance the ecological status of these wetlands.
Article
Chemistry, Multidisciplinary
Yu Li, Yankang Zhang, Ting Zhang, Xiaodan Ping, Dongmei Wang, Yanru Chen, Jian Yu, Caizhi Liu, Ziqi Liu, Yuhan Zheng, Yongfeng Yang, Chengchao Ruan, Dali Li, Zhenyu Du, Jiqiu Wang, Lingyan Xu, Xinran Ma
Summary: This study investigates the impact of m(6)A modification on beige fat biology. The results show that glycolytic genes undergo m(6)A modification and transcriptional activation upon beige adipocytes activation. Deficiency of Mettl3 in mature beige adipocytes leads to suppressed glycolytic capability, reduced thermogenesis, and impaired preadipocytes proliferation through lactate production. Additionally, Mettl3 and m(6)A reader Igf2bp2 control mRNA stability of key glycolytic genes in beige adipocytes.
Article
Medicine, General & Internal
Liang-Kun Guo, Yi Su, Yu-Ya-Nan Zhang, Hao Yu, Zhe Lu, Wen-Qiang Li, Yong-Feng Yang, Xiao Xiao, Hao Yan, Tian-Lan Lu, Jun Li, Yun-Dan Liao, Zhe-Wei Kang, Li-Fang Wang, Yue Li, Ming Li, Bing Liu, Hai-Liang Huang, Lu-Xian Lv, Yin Yao, Yun-Long Tan, Gerome Breen, Ian Everall, Hong-Xing Wang, Zhuo Huang, Dai Zhang, Wei-Hua Yue
Summary: This study developed a prediction model based on the genetic-epigenetic interaction associated with treatment response in schizophrenia patients. The model showed positive benefits in predicting treatment response to antipsychotic drugs, providing a promising approach for precision medicine.
MILITARY MEDICAL RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Haiyan Wang, Yaping Wu, Zhenxing Huang, Zhicheng Li, Na Zhang, Fangfang Fu, Nan Meng, Haining Wang, Yun Zhou, Yongfeng Yang, Xin Liu, Dong Liang, Hairong Zheng, Greta S. P. Mok, Meiyun Wang, Zhanli Hu
Summary: Our proposed deep learning method can synthesize highly correlated and consistent dynamic parametric images obtained from static lung PET. The image quality of the synthesized images was evaluated qualitatively and quantitatively, and statistical analysis of correlation and consistency was performed on the synthetic images.
EUROPEAN RADIOLOGY
(2023)