Article
Clinical Neurology
Linda Steinholtz, Johan Reutfors, Lena Brandt, Pia Nordanskog, Elin Thornblom, Jonas Persson, Robert Boden
Summary: Response rates to electroconvulsive therapy in depression may be lower in patients with concurrent personality or anxiety disorders, but the majority of patients still respond positively. The impact of comorbidity decreases with higher age and severity of depressive episode; subjective ratings of memory impairment do not differ between patients with and without comorbidity.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Neurosciences
Dan Dong, Xiaofeng Liu, Lijiang Ma, Yu Lei Hao, Li Zhang, Meiying Song, Zhonggao Xu, Hua Zhao
Summary: The prevalence of depression in diabetes mellitus (DM) patients is high, and the new type of oral hypoglycemic drugs called sodium-glucose co-transporter 2 (SGLT2) inhibitors have shown potential in alleviating depressive symptoms. This study focused on the involvement of the lateral habenula (LHb) in the antidepressant effects of the SGLT2 inhibitor dapagliflozin. The results suggest that dapagliflozin directly acts on the LHb to alleviate depressive-like behavior in DM-induced depression.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Clinical Neurology
Dan Liu, Roger S. McIntyre, Ruonan Li, Ming Yang, Yu Xue, Bing Cao
Summary: This study revealed overlapping genes between MDD and T2DM, related to the innate immune system, tau protein formation, and cellular aging. The results suggest a shared genetic and pathophysiological connection between the commonly comorbid conditions of MDD and T2DM.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Psychiatry
Daniel Braun, Jens Schlossmann, Ekkehard Haen
Summary: In patients with various psychiatric diseases, elevated serum concentrations of ADMA were found, suggesting its involvement in the pathophysiology of these disorders.
PSYCHIATRY RESEARCH
(2021)
Article
Clinical Neurology
Eduardo Duarte-Silva, Michel Gomes de Melo, Michael Maes, Adriano Jose Maia Chaves Filho, Danielle Macedo, Christina Alves Peixoto
Summary: Type 2 Diabetes Mellitus and Major Depressive Disorder share common neuroimmune mechanisms, such as neurodegeneration and neuroinflammation. Understanding and addressing depressive symptoms in diabetic patients is crucial for fully addressing the pathophysiology and treatment of T2DM.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Endocrinology & Metabolism
Mu-Hong Chen, Shih-Jen Tsai, Ya-Mei Bai, Kai-Lin Huang, Tung-Ping Su, Tzeng-Ji Chen, Ju-Wei Hsu
Summary: This study found that patients with type 1 diabetes mellitus (T1DM) have an increased risk of major psychiatric disorders such as schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorder (ASD), and attention-deficit hyperactivity disorder (ADHD). These findings highlight the importance of closely monitoring the mental health of individuals with T1DM and conducting further research to elucidate the underlying mechanisms of comorbidities between T1DM and major psychiatric disorders.
DIABETES & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Weiyao Yin, Martina Persson, Sven Sandin
Summary: This study examined the risk of type 1 diabetes mellitus (T1DM) in the offspring of parents with a psychiatric history at the birth of the child. The findings suggested a higher risk of T1DM in children of mothers with psychiatric disorders at delivery, but not in children of fathers with psychiatric disorders or those diagnosed after delivery. The association disappeared after adjusting for T1DM in parents, but remained significant in female offspring. Maternal eating disorder and obsessive-compulsive disorder were independently associated with offspring T1DM.
DIABETES & METABOLISM
(2023)
Article
Clinical Neurology
Qian Zhao, Bingbing Fu, Nan Lyu, Xiangdong Xu, Guangbiao Huang, Yunlong Tan, Xiufeng Xu, Xuehua Zhang, Xueyi Wang, Zhiqiang Wang, Keqing Li, ZhenYu Hu, Hengfen Li, Hongbo He, Shuang Li, Jingyuan Zhao, Ruifeng He, Hua Guo, Yi Li, Lehua Li, Chuang Yang, Shaohong Zou, Bo Wei, Wenqiang Wang, Ce Chen, Zheng Lu, Shunqiang He, Qian Wang, Jinghua Zhao, Xiaoyue Pan, Zhenyu Pan, Junqing Li, Gang Wang
Summary: This study compared the efficacy and safety of Desvenlafaxine and duloxetine in treating patients with MDD. The results showed that Desvenlafaxine was non-inferior to duloxetine in efficacy and had a lower incidence of adverse events.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Qingxia Yang, Qiaowen Xing, Qingfang Yang, Yaguo Gong
Summary: Schizophrenia, bipolar disorder, and major depressive disorder are the most common psychiatric disorders. Diagnosing these disorders is difficult due to overlaps in genetic epidemiology and molecular genetics. This study used transcriptomic data to identify key genes and construct a classification model for differentiating these disorders. The model showed potential for improving the diagnoses of these psychiatric disorders.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Wei-Syun Hu, Cheng-Li Lin
Summary: Research shows that patients with type 2 diabetes mellitus who use SGLT2 inhibitors have a lower risk of developing psychiatric disorders compared to those who do not use this medication.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Gabriela Carrillo-Balam, Yu-Mei Li, Omar Silverman-Retana
Summary: The study investigated the potential sex differences in the association between diabetes and depressive symptoms and whether sex mediates the effect of diabetes on depressive symptoms. The results showed a positive interaction between diabetes and sex, increasing the odds of having depressive symptoms.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2023)
Article
Endocrinology & Metabolism
Mei-Hsin Su, Ying-Hsiu Shih, Yen-Feng Lin, Pei-Chun Chen, Chia-Yen Chen, Po-Chang Hsiao, Yi-Jiun Pan, Yu-Li Liu, Shih-Jen Tsai, Po-Hsiu Kuo, Chi-Shin Wu, Yen-Tsung Huang, Shi-Heng Wang
Summary: This study investigates the familial aggregation and shared genetic loading between common psychiatric disorders (such as schizophrenia, major depressive disorder, and bipolar disorder) and type 2 diabetes. The results suggest a familial association between type 2 diabetes and the psychiatric disorders studied, as well as a shared genetic etiology between major depressive disorder and type 2 diabetes.
Article
Medicine, General & Internal
Santosh Wakode, Sandip Hulke, Naina S. Wakode, Tanusha Pathak, Ragini Shrivastava, Avinash Thakare, Varun Malhotra
Summary: This study explored the association between cognitive impairment and rating scales for major depression. The results showed that cognitive impairment, as objectively recorded using event-related potentials (P300), was not significantly associated with HAM-D and MADRS scores.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Clinical Neurology
Saba Hoobehfekr, Hossein Sanjari Moghaddam, Mohammadreza Shalbafan, Maryam Ghazizadeh Hashemi, Mohammad Mehdi Pirmoradi, Amirhossein Sakenian, Amirhossein Poopak, Shayan Kashefinejad, Masoomeh Yarahmadi, Shahin Akhondzadeh
Summary: Combination therapy of tipepidine with citalopram can effectively improve symptoms of patients with major depressive disorder in a shorter period of treatment, with higher rates of remission and response. There was no significant difference between the two groups in baseline parameters or frequency of side-effects. Further studies with larger sample sizes and longer follow-up treatment are needed to confirm these findings.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Mubashir Hassan, Aqsa Amir, Saba Shahzadi, Andrzej Kloczkowski
Summary: MicroRNAs play a significant role in depression, affecting associated proteins and signaling pathways. They have the potential to be used as biomarkers and therapy targets for treating depression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Psychiatry
Joshua D. Rosenblat, M. Ishrat Husain, Yena Lee, Roger S. McIntyre, Rodrigo B. Mansur, David Castle, Hilary Offman, Sagar Parikh, Benicio N. Frey, Ayal Schaffer, Kyle T. Greenwaym, Nicolas Garel, Serge Beaulieu, Sidney H. Kennedy, Raymond W. Lam, Roumen Milev, Arun Ravindran, Valerie Tourjman, Michael Van Ameringen, Lakshmi N. Yatham, Valerie Taylor
Summary: There is currently only low-level evidence to support the efficacy and safety of psychedelics for major depressive disorder.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Review
Clinical Neurology
Muhammad Youshay Jawad, Shakila Meshkat, Aniqa Tabassum, Andrea Mckenzie, Joshua D. Di Vincenzo, Ziji Guo, Nabiha Batool Musavi, Lee Phan, Felicia Ceban, Angela T. H. Kwan, Ranuk Ramachandra, Gia Han Le, Rodrigo B. Mansur, Joshua D. Rosenblat, Roger Ho, Taeho Greg Rhee, Roger S. McIntyre
Summary: Nonalcoholic fatty liver disease (NAFLD) is associated with psychiatric disorders, in particular mood disorders, due to various reasons such as dysregulation of the hypothalamic-pituitary-adrenal axis, metabolic syndrome, and chronic perceived stress. The clinical manifestations and treatment strategies of mood disorders can increase the susceptibility of patients to develop NAFLD. Regular screenings for NAFLD are recommended in patients with mood disorders exhibiting signs of increased risk to ensure better diagnosis and holistic care for both conditions.
Article
Neurosciences
Muhammad Youshay Jawad, Joshua D. Di Vincenzo, Sebastian Badulescu, Kayla M. Teopiz, Aniqa Tabassum, Felicia Ceban, Andrea Mckenzie, Shakila Meshkat, Joshua D. Rosenblat, Roger C. Ho, Roger S. McIntyre
Summary: Ketamine has emerged as a novel and effective antidepressant, with the potential to improve various domains of depressive symptomatology. While its effectiveness in reducing depression severity is well-studied, more research is needed to explore its effects on cognition, anhedonia, suicidality, and psychosocial functionality. Findings suggest that ketamine is most effective in reducing suicidality but further studies are required to assess its effectiveness in other domains.
Article
Neurosciences
Elysha Ringin, David W. Dunstan, Roger S. McIntyre, Michael Berk, Neville Owen, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Type 2 diabetes is more prevalent in bipolar disorder and is linked to cognitive deficits. This study explored the interaction between type 2 diabetes, bipolar disorder, and cognition, as well as the effect of age on cognitive performance in bipolar disorder with type 2 diabetes. The results showed that type 2 diabetes was associated with a negative impact on visuospatial memory in bipolar disorder. Processing speed and prospective memory were also negatively affected by type 2 diabetes, regardless of bipolar disorder diagnosis. Cognitive deficits were evident in bipolar disorder patients with type 2 diabetes compared to those without, and their cognitive performance remained stable or improved as they aged. In contrast, bipolar disorder patients without type 2 diabetes showed worse cognitive performance as they aged, but the age-related trajectory was similar to the psychiatrically healthy comparison group. The study suggests that comorbid type 2 diabetes may contribute to cognitive dysfunction in bipolar disorder, and bipolar disorder patients with type 2 diabetes may experience premature deterioration of cognitive functioning.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Giovanni Martinotti, Bernardo Dell'Osso, Giorgio Di Lorenzo, Giuseppe Maina, Alessandro Bertolino, Massimo Clerici, Stefano Barlati, Gianluca Rosso, Marco Di Nicola, Matteo Marcatili, Giacomo d'Andrea, Clara Cavallotto, Stefania Chiappini, Sergio De Filippis, Giuseppe Nicolo, Pasquale De Fazio, Ileana Andriola, Raffaella Zanardi, Domenica Nucifora, Stefania Di Mauro, Roberta Bassetti, Mauro Pettorruso, Roger S. McIntyre, Stefano L. Sensi, Massimo di Giannantonio, Antonio Vita
Summary: This study aimed to compare the efficacy of esketamine in treating unipolar and bipolar treatment-resistant depression (TRD) and provide preliminary evidence of its effectiveness in bipolar TRD (B-TRD). The results showed that esketamine significantly reduced depressive symptoms in B-TRD patients compared to TRD patients, and it had a better anxiolytic action in B-TRD patients. The low risk of side effects confirmed the safety of this treatment.
Review
Clinical Neurology
Elena Koning, Alexandra McDonald, Alexander Bambokian, Fabiano A. Gomes, Jacob Vorstman, Michael Berk, Jennifer Fabe, Roger S. McIntyre, Roumen Milev, Rodrigo B. Mansur, Elisa Brietzke
Summary: Bipolar disorder (BD) is a chronic mental disorder characterized by depressive and manic episodes, circadian rhythm disruption, and changes in energetic metabolism. Metabolic jet lag is considered a core component of BD pathophysiology, associated with irregular eating rhythms and circadian desynchronization of energetic metabolism.
Article
Clinical Neurology
Michael Cronquist Christensen, Michael Adair, Henrik Loft, Roger S. McIntyre
Summary: This study aimed to establish the clinically relevant response threshold for the Motivation and Energy Inventory (MEI), a scale used to assess the impact of mental, social, and physical energy on daily functioning in patients with major depressive disorder (MDD). The results showed that the minimal clinically important difference (MCID) for the MEI total score is 15 points.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Taeho Greg Rhee, Emily S. Gillissie, Andrew A. Nierenberg, Roger S. McIntyre
Summary: This study aimed to investigate the associations between current and remitted bipolar disorder and health-related quality of life. The results showed that both current BD and BD in remission were associated with lower mental HRQOL, but these associations were no longer significant when accounting for behavioral co-morbidities. Therefore, it is important to treat both the disorder and the co-morbidities to improve HRQOL in these patients.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Clinical Neurology
Shakila Meshkat, Roger C. Ho, Bing Cao, Kayla M. Teopiz, Joshua D. Rosenblat, Taeho Greg Rhee, Joshua D. Di Vincenzo, Felicia Ceban, Muhammad Youshay Jawad, Roger S. McIntyre
Summary: Ketamine, a NMDA receptor antagonist, has rapid acting antidepressant effect with high efficacy. However, not all patients respond to ketamine and some may even experience symptom deterioration. The discovery of repeatable and mechanistically relevant biomarkers is needed for treatment response prediction.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Emily S. Gillissie, Gia Han Le, Taeho Greg Rhee, Bing Cao, Joshua D. Rosenblat, Rodrigo B. Mansur, Roger C. Ho, Roger S. McIntyre
Summary: This meta-analysis examined the relationship between anhedonia and suicidality, and found a significant and moderate correlation between the two, especially in psychiatric populations. The results suggest that anhedonia may be a core risk factor for suicidal ideation and behaviors.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Clinical Neurology
Trisha Suppes, Suresh Durgam, Susan G. Kozauer, Richard Chen, Hassan D. Lakkis, Robert E. Davis, Andrew Satlin, Kimberly E. Vanover, Sharon Mates, Roger S. McIntyre, Mauricio Tohen
Summary: This study evaluated the efficacy and safety of Lumateperone as adjunctive therapy to lithium or valproate for patients with bipolar depression. The results showed that adjunctive Lumateperone 42mg significantly improved depression symptoms in patients with bipolar I or bipolar II disorder. The treatment was well tolerated with minimal side effects.
Article
Psychiatry
Wenyan Li, Wenjian Lai, Lan Guo, Wanxin Wang, Xiuwen Li, Liwan Zhu, Jingman Shi, Kayla M. Teopiz, Roger S. McIntyre, Ciyong Lu
Summary: This study found that childhood maltreatment is a major risk factor for adolescent depression. It also revealed that self-esteem and internalizing problems mediate the relationship between childhood maltreatment and depressive symptoms, while externalizing problems play an independent mediating role. Furthermore, sex differences need to be considered in prevention and intervention strategies.
Article
Medicine, General & Internal
Roger S. McIntyre, Lisa Bloudek, Jack Y. Timmons, Patrick Gillard, Amanda Harrington
Summary: This study assessed the cost-effectiveness of the Rapid Mood Screener (RMS) in identifying bipolar I disorder in patients with major depressive disorder. The results demonstrated that screening with the RMS can lead to cost savings and reduce misdiagnosis in patients with depressive symptoms.
CURRENT MEDICAL RESEARCH AND OPINION
(2023)
Article
Psychiatry
Kevork Danayan, Noah Chisamore, Nelson B. Rodrigues, Joshua D. Di Vincenzo, Shakila Meshkat, Zoe Doyle, Rodrigo Mansur, Lee Phan, Farhan Fancy, Edmond Chau, Aniqa Tabassum, Kevin Kratiuk, Anil Arekapudi, Kayla M. Teopiz, Roger S. McIntyre, Joshua D. Rosenblat
Summary: Borderline personality disorder (BPD) is often comorbid with mood disorders, particularly treatment-resistant depression (TRD), and this comorbidity is associated with poor response to antidepressants. This study aimed to evaluate the effectiveness of intravenous ketamine in a TRD population with comorbid BPD. The results showed that patients with TRD and comorbid BPD receiving ketamine experienced significant improvement in symptoms of depression, borderline personality, suicidality, and anxiety, with no significant difference between the BPD-positive and BPD-negative groups.
PSYCHIATRY RESEARCH
(2023)
Article
Psychiatry
Elysha Ringin, David W. Dunstan, Roger S. McIntyre, Neville Owen, Michael Berk, Susan L. Rossell, Mats Hallgren, Tamsyn E. Van Rheenen
Summary: This study examined the impact of physical activity and sedentary behavior on cognitive function in individuals with bipolar disorder. The results showed a negative association between physical activity and passive sedentary behavior with cognitive function, and a positive association between mentally-active sedentary behavior and cognitive function. These associations were stronger in individuals with bipolar disorder.
MENTAL HEALTH AND PHYSICAL ACTIVITY
(2023)