期刊
MOLECULAR BIOSYSTEMS
卷 11, 期 10, 页码 2680-2698出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5mb00310e
关键词
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资金
- European Research Council [IR-DC (616434)]
- Spanish Ministry of Economy and Competitiveness [BFU2011-26206]
- Spanish Ministry of Economy and Competitiveness (Centro de Excelencia Severo Ochoa) [SEV-2012-0208]
- AXA Research Fund
- FP7 project 4DCellFate [277899]
- Agencia de Gestio d'Ajuts Universitaris i de Recerca (AGAUR)
- EMBL-CRG Systems Biology Program
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1355462] Funding Source: National Science Foundation
Technological advances now enable routine measurement of mRNA and protein abundances, and estimates of their rates of synthesis and degradation that inform on their values and the degree of change in response to stimuli. Importantly, more and more data on time-series experiments are emerging, e.g. of cells responding to stress, enabling first insights into a new dimension of gene expression regulation - its dynamics and how it allows for very different response signals across genes. This review discusses recently published methods and datasets, their impact on what we now know about the relationships between concentrations and synthesis rates of mRNAs and proteins in yeast and mammalian cells, their evolution, and new hypotheses on translation regulatory mechanisms generated by approaches that involve ribosome footprinting.
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