期刊
MOLECULAR BIOSYSTEMS
卷 11, 期 6, 页码 1507-1514出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4mb00716f
关键词
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资金
- MIUR: FIRB, FAR [RBRN07BMCT_11]
- i-MODE-CKD (FP7-PEOPLE-ITN)
- EuroKUP COST Action [BM1104]
Recent advancements in Matrix Assisted Laser Desorption/Ionisation (MALDI) Mass Spectrometry Imaging (MSI) technology have enabled the analysis of formalin-fixed paraffin-embedded (FFPE) tissue samples, unlocking a wealth of new proteomic information and facilitating the possibility of performing studies with higher statistical power as well as multi-centric collaborations within the field of proteomics research. However, current methods used to analyse these specimens are often time-consuming and they need to be modified when applied to human tissues of different origin. Here we present a reproducible and time-effective method that could address these aforementioned issues and widen the applicability of this technology to a number of challenging tissue types. Additionally, tissue molecular images show high spatial resolution and a strong correlation with the morphological features, enabling the identification of tissue morphology using statistically derived visualisation, without any prior knowledge.
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