Article
Biochemistry & Molecular Biology
Kyuheum Jeon, Jaemin Eom, Byungkuk Min, Jung Sun Park, Yong-Kook Kang
Summary: This study demonstrates that the histone H3 lysine 9-specific methyltransferase SETDB1 transcriptionally controls the expression of C19MC miRNA genes in a coordinated manner. It specifically binds to and modifies the upstream promoter locus of C19MC with H3K9 trimethylation, acting as a repressor. The findings suggest that SETDB1 and H3K9 methylation are responsible for the coordinated regulation of miRNA genes in the C19MC cluster.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Ganji Purnachandra Nagaraju, Begum Dariya, Prameswari Kasa, Sujatha Peela, Sujatha Peela Bassel F. El-Rayes
Summary: HCC is the most common primary malignancy of the liver, with a high fatality rate. Genetic and epigenetic aberrations are commonly observed in HCC, including chromatin remodeling, histone alterations, DNA methylation, and ncRNA expression. In-depth understanding of the epigenetics of HCC is critical for developing rational clinical strategies, improving overall survival, and predicting therapeutic outcomes.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Oncology
Ewa Wolinska, Maciej Skrzypczak
Summary: Hepatocellular carcinoma (HCC) is a life-threatening disease with unsatisfactory treatment outcomes. Epigenetic studies have revealed modified methylation patterns in HCC, dysfunction of enzymes engaged in DNA methylation process, aberrant function of non-coding RNAs, and histone modifications affecting gene expression.
Article
Medicine, Research & Experimental
Mengke Chen, Yi Fang, Meinong Liang, Ning Zhang, Xinyue Zhang, Lixia Xu, Xuxin Ren, Qingfeng Zhang, Yufeng Zhou, Sui Peng, Jun Yu, Judeng Zeng, Xiaoxing Li
Summary: This study found that the level of DNA methylation is positively associated with the activation of mTOR signaling in hepatocellular carcinoma (HCC) tissues and cell lines. HCC patients with higher DNA methylation levels and enhanced mTOR signaling activation have a worse prognosis. Activation of mTOR signaling increases the expression and activity of DNMT1, promoting DNA methylation. Combined inhibition of mTOR and DNMT1 has a more effective tumor suppressive function in HCC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Krzysztof Kozniewski, Michal Wasowski, Marta Izabela Jonas, Wojciech Lisik, Maurycy Jonas, Artur Binda, Pawel Jaworski, Wieslaw Tarnowski, Bartlomiej Noszczyk, Monika Puzianowska-Kuznicka, Alina Kurylowicz
Summary: Obesity-related downregulation of ER mRNA levels in adipose tissue might be associated with miRNA interference.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Siyu Fu, Jose D. Debes, Andre Boonstra
Summary: Hepatocellular carcinoma (HCC) is a common primary liver malignancy with poor prognosis. Epigenetic modification, specifically DNA methylation, plays a significant role in HCC development by impacting cell differentiation, proliferation, and function. Methylated DNA markers have shown promise as specific biomarkers for early-stage HCC detection, offering higher sensitivity and specificity compared to current surveillance methods. However, the immediate application of these biomarkers is limited by various factors. This review provides a detailed rationale for using methylation biomarkers in HCC detection and summarizes recent studies on methylated DNA markers, emphasizing the importance of the underlying cause of liver disease in cancer mechanisms.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Cell Biology
Rongfeng Shi, Hui Zhao, Suming Zhao, Hongxin Yuan
Summary: This study comprehensively integrated the transcriptome profiling of DNA methylation regulators in hepatocellular carcinoma, identifying three distinct DNA methylation regulator-related molecular subtypes and constructing a prognostic and immunotherapeutic relevant gene signature. These findings contribute to the advancement of individualized immunotherapy for hepatocellular carcinoma.
Article
Biochemistry & Molecular Biology
Fernanda Wisnieski, Jaqueline Cruz Geraldis, Leonardo Caires Santos, Mariana Ferreira Leal, Danielle Queiroz Calcagno, Carolina Oliveira Gigek, Elizabeth Suchi Chen, Ana Carolina Anauate, Ricardo Artigiani, Samia Demachki, Paulo Pimentel Assumpcao, Laercio Gomes Lourenco, Carlos Haruo Arasaki, Julie Krainer, Stephan Pabinger, Rommel Rodriguez Burbano, Marilia Arruda Cardoso Smith
Summary: In this study, the research group identified a list of 83 genes potentially modulated by DNA methylation in GC cell lines, with LRRC37A2 playing a role in undifferentiated and poorly differentiated tumors. The study showed that reduced LRRC37A2 mRNA levels and increased LRRC37A2 exon methylation are associated with GC progression, emphasizing the potential utility of gene-related stratification for epigenetic therapy in GC patients.
Review
Hematology
Elisa Danese, Martina Montagnana, Matteo Gelati, Giuseppe Lippi
Summary: Epigenetics is now seen as fundamental in developmental biology, with evidence suggesting its key role in primary and secondary hemostasis. Epigenetic alterations, like DNA methylation and histone modifications, may impact platelet functions, drug responsiveness, and protein production relevant to blood clotting and fibrinolysis. Understanding these mechanisms could lead to new therapeutic targets and tests for assessing bleeding or thrombosis risk.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2021)
Review
Allergy
Sunita Sharma, Ivana Yang, David A. Schwartz
Summary: This review examines the relationship between asthma and three key epigenetic processes: DNA methylation, modification of histone tails, and noncoding RNAs. Epigenetic marks play an important role in the pathogenesis of asthma and can serve as therapeutic targets and biomarkers. There are future directions for studying immune regulation in asthma and investigating epigenetics in allergic airway disease.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Katerina-Marina Pilala, Maria-Alexandra Papadimitriou, Konstantina Panoutsopoulou, Petros Barbarigos, Panagiotis Levis, Georgios Kotronopoulos, Konstantinos Stravodimos, Andreas Scorilas, Margaritis Avgeris
Summary: Bladder cancer (BlCa) is characterized by heterogeneous molecular landscape and lacks personalized treatment. In this study, we investigated the epigenetic regulation of the miR-143/145 cluster in BlCa. We found that the methylation of MIR145 core promoter was associated with disease progression and poor survival in BlCa patients. Combining MIR145 core promoter methylation with established disease markers improved risk stratification and prediction of treatment outcome. Our findings highlight the importance of personalized risk stratification and management in BlCa.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Oncology
Ling-Yan Cai, Shi-Jie Chen, Sen-Hao Xiao, Qin-Juan Sun, Chen-Hong Ding, Bai-Nan Zheng, Xin-Yan Zhu, Shu-Qing Liu, Feng Yang, Ya-Xi Yang, Bing Zhou, Cheng Luo, Xin Zhang, Wei-Fen Xie
Summary: This study demonstrates p300/CBP as a critical epigenetic regulator of glycolysis-related metabolic enzymes in HCC and identifies the p300/CBP inhibitor B029-2 as a potential therapeutic strategy in this disease.
Review
Oncology
Chenbin Liu, Han Wu, Yinqi Mao, Wei Chen, Shuying Chen
Summary: Exosomal microRNAs play a crucial role in hepatocellular carcinoma, holding significant value in the early diagnosis and treatment of this disease.
CANCER CELL INTERNATIONAL
(2021)
Article
Immunology
Qi Chen, Hao Li, Yusi Liu, Min Zhao
Summary: This study comprehensively analyzed the epigenetic regulation in rheumatoid arthritis (RA) using differential analysis and cross-analysis. The results identified differentially methylated sites, differentially expressed genes, and differentially expressed miRNAs associated with RA. A comprehensive epigenetic regulatory network was constructed, and core regulatory genes were identified. This study provides a new direction for future research on the epigenetic mechanisms of RA.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
I. Gilyazova, E. Ivanova, G. Gilyazova, I. Sultanov, A. Izmailov, R. Safiullin, V. Pavlov, E. Khusnutdinova
Summary: The study identified differential methylation levels of microRNA genes in clear cell renal cell carcinoma tissue, as well as abnormal expression of certain microRNA genes in the tumors. Further research is needed to determine the functional significance of these changes.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Oncology
Hui-Ying Xue, Yong Liu, Jia-Zhi Liao, Ju-Sheng Lin, Bin Li, Wei-Gang Yuan, Robert J. Lee, Lei Li, Chuan-Rui Xu, Xing-Xing He
Article
Nanoscience & Nanotechnology
Pengxuan Zhao, Shuangping Wu, Yao Cheng, Jia You, Yan Chen, Minsi Li, Chuanchuan He, Xiaojuan Zhang, Tan Yang, Yao Lu, Robert J. Lee, Xingxing He, Guangya Xiang
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2017)
Review
Oncology
Lian Liu, Jia-Zhi Liao, Xing-Xing He, Pei-Yuan Li
Article
Medicine, Research & Experimental
Yin-Ping Fan, Jia-Zhi Liao, Ya-Qi Lu, De-An Tian, Feng Ye, Peng-Xuan Zhao, Guang-Ya Xiang, Wang-Xian Tang, Xing-Xing He
MOLECULAR THERAPY-NUCLEIC ACIDS
(2017)
Article
Medicine, Research & Experimental
Juan-Feng Zhao, Qiu Zhao, Hui Hu, Jia-Zhi Liao, Ju-Sheng Lin, Chao Xia, Ying Chang, Jing Liu, An-Yuan Guo, Xing-Xing He
MOLECULAR THERAPY-NUCLEIC ACIDS
(2018)
Article
Medicine, Research & Experimental
Fei Xu, Jing-Jun Yan, Yun Gan, Ying Chang, Hong-Ling Wang, Xing-Xing He, Qiu Zhao
MOLECULAR THERAPY-NUCLEIC ACIDS
(2019)
Article
Biotechnology & Applied Microbiology
Lian Liu, Jia-Qi Sheng, Mu-Ru Wang, Yun Gan, Xiao-Li Wu, Jia-Zhi Liao, De-An Tian, Xing-Xing He, Pei-Yuan Li
BIOMED RESEARCH INTERNATIONAL
(2019)
Review
Oncology
Xiang-Yuan Luo, Kong-Ming Wu, Xing-Xing He
Summary: Hepatocellular carcinoma is a deadly health burden worldwide, but recent years have seen significant breakthroughs in new drug development. The FDA has approved multiple drugs for HCC treatment, with over 1000 ongoing clinical trials globally, indicating a vibrant atmosphere in the HCC drug research field.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Xiangyuan Luo, Mengdie Cao, Fan Gao, Xingxing He
Summary: YTHDF1 is overexpressed in HCC and associated with HCC grade. It promotes the growth of HCC cells by activating the PI3K/AKT/mTOR signaling pathway and inducing epithelial-mesenchymal transition (EMT) to enhance migration and invasion.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2021)
Editorial Material
Oncology
Xing-Xing He, Da-Wei Ye
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Yuan Yuan, Fan Gao, Ying Chang, Qiu Zhao, Xingxing He
Summary: High-frequency mutations in tumor genomes can be utilized to develop tumor vaccines. With advancements in genomics, intelligent algorithms and tumor immunology, it is now possible to target genetic alterations in tumor cells and select vaccine targets efficiently. The application of mRNA in tumor vaccines was initially limited, but the development of mRNA vaccines against SARS-COV-2 has allowed for rapid and cost-effective preparation of tumor mRNA vaccines with good stability and efficiency. This review systematically summarizes the classification and characteristics of tumor antigens, methods for screening neoantigens, vaccine preparation strategies, clinical trial advances, and the main challenges in mRNA tumor vaccine development.
BIOMARKER RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Mengdie Cao, Xiangyuan Luo, Kongming Wu, Xingxing He
Summary: Lysosomes play a crucial role in regulating cellular and organismal homeostasis, with dysfunction associated with the development of various diseases. Understanding the biological functions of lysosomes in different aspects can help elucidate the pathogenesis and treatment strategies of related diseases. Current targeting strategies and corresponding drugs in clinical trials provide direction for further research in targeting lysosomes in human disease.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Review
Oncology
Yun Gan, Feng Yee, Xing-Xing He
Review
Medicine, Research & Experimental
Qian Wu, Hua Qin, Qiu Zhao, Xing-Xing He
BIOMEDICAL REPORTS
(2015)