期刊
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
卷 63, 期 2, 页码 73-79出版社
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2013.769250
关键词
2-acrylamido-2-methyl-1-propane sulfonic acid; AMPS; chloramphenicol; drug delivery; superabsorbency; TEA; triethylamine
资金
- EU FP7 IRSES [PIRSES-GA-2009-247599]
- Dongguan Municipal Science & Technology Planning Project of China [201110810100327]
Novel copolymeric gels of poly(AMPS-TEA-co-AAm) with superabsorbency in both water and alcohols were synthesized by neutralizing 2-acrylamido-2-methyl-1-propane sulfonic acid (AMPS) with triethylamine (TEA) followed by copolymerizing the resulted salt with acrylamide (AAm) in aqueous solutions using N, N'-methylenebisacrylamide (MBAm) as a crosslinker, and ammonium persulfate (APS) as an initiator. By swelling the xerogel of poly(AMPS-TEA-co-AAm) in the drug solution followed by removing the solvent to give drug-polymer conjugate, the incorporation of a model drug, chloramphenicol, into the gels was investigated by using water and alcohols as solvent, respectively. The in vitro drug release profile of the drug-polymer conjugate was investigated in PBS. The results showed that poly(AMPS-TEA-co-AAm) gels exhibited superabsorbency in both water and a series of alcohols; and the alcohol-facilitated uploading of chloramphenicol into the gels was much greater than that achieved in water. The poly(AMPS-TEA-co-AAm) gels exhibited a similar drug release profile with conventional hydrogels; and only part of the drug uptaken by the gels was released as a result of poor aqueous solubility of chloramphenicol.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据