Estimating the Ages of Selection Signals from Different Epochs in Human History

The utility of ancient human DNA for improving allele age estimates, with implications for demographic models and tests of natural selection

(2015) Aaron J. Sams et al.   JOURNAL OF HUMAN EVOLUTION

Genome-wide patterns of selection in 230 ancient Eurasians

(2015) Iain Mathieson et al.   NATURE

Massive migration from the steppe was a source for Indo-European languages in Europe

(2015) Wolfgang Haak et al.   NATURE

Population genomics of Bronze Age Eurasia

(2015) Morten E. Allentoft et al.   NATURE

Genome-Wide Association Study Identifies Variants Associated With Autoimmune Hepatitis Type 1

(2014) Ynto S. de Boer et al.   GASTROENTEROLOGY

Ancient human genomes suggest three ancestral populations for present-day Europeans

(2014) Iosif Lazaridis et al.   NATURE

Genomic Diversity and Admixture Differs for Stone-Age Scandinavian Foragers and Farmers

(2014) P. Skoglund et al.   SCIENCE

Detecting Natural Selection in Genomic Data

(2013) Joseph J. Vitti et al.   Annual Review of Genetics

Identifying Recent Adaptations in Large-Scale Genomic Data

(2013) Sharon R. Grossman et al.   CELL

Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans

(2013) Mingfeng Zhang et al.   HUMAN MOLECULAR GENETICS

Seeing is believing

(2013) Luc G Berthiaume   Nature Chemical Biology

The Timing of Pigmentation Lightening in Europeans

(2012) Sandra Beleza et al.   MOLECULAR BIOLOGY AND EVOLUTION

Insights into hominid evolution from the gorilla genome sequence

(2012) Aylwyn Scally et al.   NATURE

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Testing for the association of the KIAA1109/Tenr/IL2/IL21 gene region with rheumatoid arthritis in a European family-based study

(2012) Vitor Teixeira et al.   ARTHRITIS RESEARCH & THERAPY

abc: an R package for approximate Bayesian computation (ABC)

(2012) Katalin Csilléry et al.   Methods in Ecology and Evolution

Distinguishing between Selective Sweeps from Standing Variation and from a De Novo Mutation

(2012) Benjamin M. Peter et al.   PLoS Genetics

Stature and robusticity during the agricultural transition: Evidence from the bioarchaeological record

(2011) Amanda Mummert et al.   Economics & Human Biology

Incomplete lineage sorting patterns among human, chimpanzee, and orangutan suggest recent orangutan speciation and widespread selection

(2011) A. Hobolth et al.   GENOME RESEARCH

The earliest evidence for anatomically modern humans in northwestern Europe

(2011) Tom Higham et al.   NATURE

Early dispersal of modern humans in Europe and implications for Neanderthal behaviour

(2011) Stefano Benazzi et al.   NATURE

The earliest modern humans in Europe

(2011) Paul Mellars   NATURE

Inference of human population history from individual whole-genome sequences

(2011) Heng Li et al.   NATURE

A linear complexity phasing method for thousands of genomes

(2011) Olivier Delaneau et al.   NATURE METHODS

Inter-ethnic differences in lymphocyte sensitivity to glucocorticoids reflect variation in transcriptional response

(2011) J C Maranville et al.   PHARMACOGENOMICS JOURNAL

Performance of Microarray and Liquid Based Capture Methods for Target Enrichment for Massively Parallel Sequencing and SNP Discovery

(2011) Anna Kiialainen et al.   PLoS One

Comparison of Three Targeted Enrichment Strategies on the SOLiD Sequencing Platform

(2011) Dale J. Hedges et al.   PLoS One

Genotype Imputation with Thousands of Genomes

(2011) Bryan Howie et al.   G3-Genes Genomes Genetics

Genome-Wide Association Study SNPs in the Human Genome Diversity Project Populations: Does Selection Affect Unlinked SNPs with Shared Trait Associations?

(2011) Amanda M. Casto et al.   PLoS Genetics

Meta-Analysis of Genome-Wide Association Studies in Celiac Disease and Rheumatoid Arthritis Identifies Fourteen Non-HLA Shared Loci

(2011) Alexandra Zhernakova et al.   PLoS Genetics

Adaptations to Climate-Mediated Selective Pressures in Humans

(2011) Angela M. Hancock et al.   PLoS Genetics

Evolutionary Adaptations to Dietary Changes

(2010) F. Luca et al.   Annual Review of Nutrition

Confirmation of an association between rs6822844 at theIl2-Il21region and multiple autoimmune diseases: Evidence of a general susceptibility locus

(2010) Amit K. Maiti et al.   ARTHRITIS AND RHEUMATISM

Experiences with array-based sequence capture; toward clinical applications

(2010) Rowida Almomani et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis

(2010) A Alcina et al.   GENES AND IMMUNITY

Population differentiation as a test for selective sweeps

(2010) H. Chen et al.   GENOME RESEARCH

Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease

(2010) Dermot P.B. McGovern et al.   HUMAN MOLECULAR GENETICS

Genome-wide association study in alopecia areata implicates both innate and adaptive immunity

(2010) Lynn Petukhova et al.   NATURE

Multiple common variants for celiac disease influencing immune gene expression

(2010) Patrick C A Dubois et al.   NATURE GENETICS

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

(2010) Eli A Stahl et al.   NATURE GENETICS

A Composite of Multiple Signals Distinguishes Causal Variants in Regions of Positive Selection

(2010) S. R. Grossman et al.   SCIENCE

Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude

(2010) X. Yi et al.   SCIENCE

Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance

(2010) Jade E Hollis-Moffatt et al.   ARTHRITIS RESEARCH & THERAPY

The Changing Disease-Scape in the Third Epidemiological Transition

(2010) Kristin Harper et al.   International Journal of Environmental Research and Public Health

Digital Quantification of Human Eye Color Highlights Genetic Association of Three New Loci

(2010) Fan Liu et al.   PLoS Genetics

Web-Based, Participant-Driven Studies Yield Novel Genetic Associations for Common Traits

(2010) Nicholas Eriksson et al.   PLoS Genetics

Novel Association of the Interleukin 2–Interleukin 21 Region With Inflammatory Bowel Disease

(2009) Ana Márquez et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Interactions BetweenHERC2,OCA2andMC1RMay Influence Human Pigmentation Phenotype

(2009) Wojciech Branicki et al.   ANNALS OF HUMAN GENETICS

Confirmation ofSTAT4,IL2/IL21, andCTLA4polymorphisms in rheumatoid arthritis

(2009) Nina A. Daha et al.   ARTHRITIS AND RHEUMATISM

Association of the autoimmunity locus 4q27 with juvenile idiopathic arthritis

(2009) H. M. Albers et al.   ARTHRITIS AND RHEUMATISM

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

Efficient Approximate Bayesian Computation Coupled With Markov Chain Monte Carlo Without Likelihood

(2009) Daniel Wegmann et al.   GENETICS

Signals of recent positive selection in a worldwide sample of human populations

(2009) J. K. Pickrell et al.   GENOME RESEARCH

Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis

(2009) E A M Festen et al.   GUT

Group differences in proneness to inflammation

(2009) Renee Pennington et al.   INFECTION GENETICS AND EVOLUTION

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

From evolutionary genetics to human immunology: how selection shapes host defence genes

(2009) Luis B. Barreiro et al.   NATURE REVIEWS GENETICS

Reduced Neutrophil Count in People of African Descent Is Due To a Regulatory Variant in the Duffy Antigen Receptor for Chemokines Gene

(2009) David Reich et al.   PLoS Genetics

The Role of Geography in Human Adaptation

(2009) Graham Coop et al.   PLoS Genetics

Three Genome-wide Association Studies and a Linkage Analysis Identify HERC2 as a Human Iris Color Gene

(2008) Manfred Kayser et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Ethnic Differences in C-Reactive Protein Concentrations

(2008) A. Kelley-Hedgepeth et al.   CLINICAL CHEMISTRY

Association study of IL2/IL21 and FcgRIIa: significant association with the IL2/IL21 region in Scandinavian coeliac disease families

(2008) S Adamovic et al.   GENES AND IMMUNITY

A Bayesian method for jointly estimating allele age and selection intensity

(2008) MONTGOMERY SLATKIN   Genetics Research

Analysis of Cultured Human Melanocytes Based on Polymorphisms within the SLC45A2/MATP, SLC24A5/NCKX5, and OCA2/P Loci

(2008) Anthony L. Cook et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Newly identified genetic risk variants for celiac disease related to the immune response

(2008) Karen A Hunt et al.   NATURE GENETICS

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS

A Genome-Wide Association Study of Psoriasis and Psoriatic Arthritis Identifies New Disease Loci

(2008) Ying Liu et al.   PLoS Genetics

A Genome-Wide Association Study Identifies Novel Alleles Associated with Hair Color and Skin Pigmentation

(2008) Jiali Han et al.   PLoS Genetics

Adaptation from standing genetic variation

(2007) R BARRETT et al.   TRENDS IN ECOLOGY & EVOLUTION