Article
Biotechnology & Applied Microbiology
Na Qi, Shangqian Zhang, Xiantai Zhou, Wenjuan Duan, Duan Gao, Jianfang Feng, Aimin Li
Summary: The study demonstrated the significant advantages of RGD-Lf-LP in cellular uptake and tumor spheroid penetration, with both in vitro and in vivo experiments confirming its strong targeting effects for brain orthotopic gliomas. The dual modification of RGD and Lf is a promising combination for brain targeting delivery.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Chemistry, Medicinal
Ahmed M. Fatouh, Ahmed H. Elshafeey, Ahmed Abdelbary
Summary: The study successfully enhanced the delivery of ledipasvir to hepatocytes and prolonged its retention within the liver by synthesizing galactosylated chitosan and coating it on liposomes. The coated liposomes exhibited a small particle size, high entrapment efficiency, and significantly improved uptake of ledipasvir into targeted hepatocytes. Pharmacokinetic analysis revealed increased liver concentration and prolonged half-life and residence time compared to oral dispersal of ledipasvir.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Instruments & Instrumentation
Antonella Barone, Anna Maria Zimbo, Nicola d'Avanzo, Anna Maria Tolomeo, Stefano Ruga, Antonio Cardamone, Christian Celia, Mariangela Scalise, Daniele Torella, Massimo La Deda, Enrico Iaccino, Donatella Paolino
Summary: Nanomedicine and extracellular vesicles are powerful tools for enhancing anticancer therapies. This study aims to create a hybrid nanosystem by combining M1 macrophage-derived extracellular vesicles (EVs-M1) with thermoresponsive liposomes, in order to develop a drug delivery system that can utilize the tumor-targeting capability of immune cells and the thermoresponsiveness of synthetic nanovesicles.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Mohamadreza Amin, Mercedeh Mansourian, Peter C. Burgers, Bahareh Amin, Mahmoud Reza Jaafari, Timo L. M. ten Hagen
Summary: Modification with polyethylene glycol (PEGylation) and the use of rigid phospholipids improve the pharmacokinetics of chemotherapeutics and reduce side-effects. However, cellular delivery and tumor heterogeneity are the main obstacles against tumor targeting. This study designed liposomes decorated with two ligands for enhanced cellular delivery and targeting of tumor vasculature and tumor cells.
Article
Pharmacology & Pharmacy
Maryam Ebrahimi Nik, Mahmoud Reza Jaafari, Mohammad Mashreghi, Sara Nikoofal-Sahlabadi, Mohamadreza Amin, Hamid Reza Sadeghnia, Mehrdad Iranshahi, Jamshid Gholizadeh Navashenaq, Bizhan Malaekeh-Nikouei
Summary: The study developed new liposomal formulations to enhance the anti-cancer therapeutic application of Galbanic acid, and demonstrated that RGD peptide decoration could improve targeted delivery to tumor vasculature. The results showed that the targeted liposomes could enhance receptor-mediated endocytosis both in vitro and in vivo, leading to increased accumulation in colon tumors.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Mohamed M. Badran, Nadia N. Alouny, Basmah N. Aldosari, Ahlam M. Alhusaini, Amal El Sayeh Abou El Ela
Summary: The study developed a sustained-release transdermal GLP film using chitosan-coated deformable liposomes (DLs) to overcome the challenges associated with oral administration of the drug. The DLs showed improved drug transdermal delivery compared to conventional liposomes (CL), with high stability and deformability. The in vitro release study confirmed sustained release of GLP, and coating with CS further enhanced the sustained release. The transdermal films demonstrated promising pharmacokinetic profiles and higher hypoglycemic effect compared to oral GLP, indicating the potential of systemic action through local topical delivery.
Article
Biochemistry & Molecular Biology
Zhiyang Li, Jiaqi Lu, Baolan Tang, Yuesen Shi, Li Hai, Li Guo, Yong Wu
Summary: Liposomes decorated with multi-branched RGD ligand show promise in the treatment of glioma, as they have enhanced targeting ability for the blood-brain barrier and glioma cells.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Grzegorz Zurek, Magdalena Przybylo, Wojciech Witkiewicz, Marek Langner
Summary: Due to the changing environment and modified lifestyles, many people are deficient in vitamins and minerals. Supplementation is a viable approach to maintain health and well-being. For highly hydrophobic compound cholecalciferol, the formulation plays a crucial role in its supplementation efficiency. A method based on short time absorption data and mathematical modeling was proposed to evaluate the pharmacokinetics of cholecalciferol, comparing the liposomal and oily formulations of vitamin D-3. The liposomal formulation showed higher effectiveness in increasing calcidiol concentration in serum, with a four times bigger AUC value compared to the oily formulation.
Article
Nanoscience & Nanotechnology
Hongfei Xu, Hongyu Ji, Zerong Li, Wenmei Qiao, Chenghao Wang, Jingling Tang
Summary: The study developed IM-loaded liposomes for pulmonary delivery to treat PAH, showing potential applications and promising outcomes. The IM-LPs demonstrated nanosized ranges and sustained release of IM, indicating potential for therapeutic use in pulmonary delivery.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yoonyoung Kim, Yu Seok Youn, Kyung Taek Oh, Dongin Kim, Eun Seong Lee
Summary: The strategy of transient hole formation on liposomes allows safe encapsulation of high-molecular weight antibodies, leading to enhanced release and biological effects in vivo.
Review
Medicine, Research & Experimental
Behjat Sheikholeslami, Nga Wing Lam, Kamal Dua, Mehra Haghi
Summary: This article reviews the unique properties of liposomes as an advanced drug delivery system and their fate in vivo. The impact of the physicochemical properties of liposomes on their pharmacokinetics is discussed, as well as the different mechanisms of liposomal uptake by cells.
Review
Biochemistry & Molecular Biology
Fatemeh Ebrahimi, Seyed Jalal Hosseinimehr
Summary: Homomultimeric radioligands have the potential to detect overexpressed receptors on cancer cells and are used in peptide and monoclonal antibody-based molecular imaging and therapy. They offer a reliable method for preparing biologically-based targeting with different affinities and pharmacokinetic characteristics.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Jordi Llop, Twan Lammers
Summary: Nanoparticles with surface-modified esterase-cleavable radionuclide anchors can reduce retention in liver and spleen, leading to enhanced accumulation and imaging contrast in tumors. These advances have potential applications in early cancer detection, diagnosis, and radionuclide therapy.
Article
Biochemistry & Molecular Biology
Jiaxin Shen, Yanping Wu, Teng Wei, Yangzheng He, Xiaoru Liu, Zeyuan Deng, Jing Li
Summary: Phospholipids are crucial for the growth and neurodevelopment of infants. Human milk phospholipid analogs (HMPAs) show better digestion and absorption characteristics compared to soybean phospholipids (SPLs), which are commonly used in infant formulas.
Article
Instruments & Instrumentation
Yanzhi Song, Zhennan She, Zhenjun Huang, Shuo Wang, Xinrong Liu, Qi Zhang, Jing Sun, Donghua Di, Yihui Deng
Summary: Treatment with SA-ODA-modified Pix liposomes showed favorable antitumor effects by targeting TAMs. Different types of SA decorations on liposomes were explored, with PEGylated formulations showing increased blood circulation time and tumor accumulation. However, the antitumor activity of SA-modified liposomes was not directly correlated with circulation time or tumor accumulation in S180-bearing mice.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)