Article
Biochemistry & Molecular Biology
Yang Han, Jieyi Pan, Na Liang, Xianfeng Gong, Shaoping Sun
Summary: The study synthesized an amphiphilic conjugate based on mPEG and cholesterol-modified chitosan with hydrazone bonds, which was used to prepare PTX-loaded micelles. These micelles exhibited promising therapeutic efficacy of PTX and reduced side effects, indicating potential as pH-sensitive nanocarriers for drug delivery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Polymer Science
Nour M. AlSawaftah, Nahid S. Awad, William G. Pitt, Ghaleb A. Husseini
Summary: Stimuli-responsive nanoparticles have shown promising potential in overcoming the limitations of conventional chemotherapy. pH-sensitive nanoparticles, in particular, have proven to be highly efficient in delivering drugs to tumors compared to conventional nanoparticles. This review summarizes the different strategies used to develop pH-sensitive nanoparticles for cancer therapy.
Article
Biochemistry & Molecular Biology
Panpan Song, Nannan Song, Li Li, Minghao Wu, Zhongxia Lu, Xia Zhao
Summary: A pH/reduction-sensitive carboxymethyl chitosan nanogel modified by targeting peptide angiopep-2 loaded with doxorubicin shows promising potential for targeted chemotherapy of glioblastoma. The targeted nanogel exhibited good stability, biocompatibility, and enhanced BBB penetration and tumor targeting ability, leading to higher drug uptake and stronger antitumor activity compared to nontargeted nanogels. This innovative nanogel platform with pH/reduction dual-stimuli response may hold great significance for GBM-targeted therapy.
Article
Polymer Science
Kadambari Bairagi, Jiang Tian Liu, Anna Thinphang-nga, Jung Kwon Oh
Summary: Stimuli-responsive degradable amphiphilic block copolymers (SRD-ABPs) have been extensively investigated for the construction of smart nanoassemblies with controlled release of encapsulated molecules. A new approach using conjugated benzoic imine chemistry was developed to achieve dual acidic pH/light responses with a single labile linkage. The synthesized SRD-ABP self-assembled into stable nanoassemblies which degraded upon dual responses to acidic pH and UV/visible light. This work demonstrates the versatility of the new approach for designing advanced nanoassemblies for intracellular drug delivery.
Article
Materials Science, Multidisciplinary
Fariha Chowdhury, Sakiba Ahmed, Muntasir Rahman, Md Alomgir Ahmed, Md Delower Hossain, Hasan Mahmud Reza, Sung Young Park, Shazid Md Sharker
Summary: Natural or synthetic polymeric films have gained interest in biomedical research due to their biocompatibility. A nanocomposite film using the chitosan-tannic acid (CT) crosslinking process has been developed, showing antibacterial activity and pH-responsive drug release both in vitro and in vivo.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Fatima Fernandez-Alvarez, Gracia Garcia-Garcia, Jose L. Arias
Summary: The study successfully constructed a maghemite/PLGA/chitosan nanostructure with good stability, magnetism, and drug release behavior, showing significant anti-lung adenocarcinoma effect of cisplatin loading on the matrix.
Review
Chemistry, Multidisciplinary
Xiao Dong, Rajeev K. Brahma, Chao Fang, Shao Q. Yao
Summary: This review summarizes the application of self-assembled prodrugs in cancer drug development. Self-assembled prodrugs can improve the physicochemical properties of drugs and achieve controlled release at tumor sites, thus showing potential for clinical applications.
Article
Chemistry, Applied
Ariel C. de Oliveira, Glayce R. F. de Lima, Rosecler S. Klein, Paulo R. Souza, Bruno H. Vilsinski, Francielle P. Garcia, Celso V. Nakamura, Alessandro F. Martins
Summary: Thermo- and pH-sensitive hydrogels based on chitosan and gellan gum were developed for efficient curcumin delivery. The hydrogel structure containing 40-80% chitosan exhibited significant release of curcumin in simulated intestinal fluid.
REACTIVE & FUNCTIONAL POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
T. S. Anirudhan, V. Manjusha, V. Chithra Sekhar
Summary: The study prepared a nano cellulose-based drug delivery system for effective delivery of curcumin, showing high drug loading capacity and maximum drug release at specific pH levels. In vitro studies demonstrated cytotoxicity towards cancer cells, and further investigations suggest its potential application for targeted delivery and controlled release of CUR in cancer treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Biomedical
Katayon Hemmati, Navid Ahmadi Nasab, Saeed Hesaraki, Nader Nezafati
Summary: Nanotechnology has potential applications in cancer treatment, with high-performance HA nanoparticles coated by chitosan showing promise in enhancing the efficiency and bioavailability of curcumin. Experimental results suggest that these nano-drugs may serve as a new method for treating cancer.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2021)
Article
Chemistry, Multidisciplinary
Won Jung Kim, Eu Hyun Lee, Yong-Jin Kwon, Sang-Kyu Ye, Kyu Oh Kim
Summary: An amphipathic PAA-POSS@DOX drug delivery system that is sensitive to pH changes in the cancer microenvironment has been developed using a nanoparticle based on inorganic polyhedral oligomeric silsesquioxane (POSS). This system has high loading efficiency and can quickly release the drug to the target area, as confirmed by cell death in the MDA-MB-231 breast cancer line.
Article
Medicine, Research & Experimental
Carolina Henriques Cavalcante, Renata Salgado Fernandes, Juliana de Oliveira Silva, Caroline Mari Ramos Oda, Elaine Amaral Leite, Geovanni Dantas Cassali, Ives Charlie-Silva, Bianca Helena Ventura Fernandes, Lucas Antonio Miranda Ferreira, Andre Luis Branco de Barros
Summary: The developed pH-sensitive micelles encapsulating DOX showed promising results with small diameter, high stability, low toxicity, and significantly better inhibition of tumor growth compared to other forms of DOX.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Madhappan Santhamoorthy, Vanaraj Ramkumar, Kokila Thirupathi, Lalitha Gnanasekaran, Vanitha Karuppannan, Thi Tuong Vy Phan, Seong-Cheol Kim
Summary: In this study, L-lysine modified mesoporous silica nanoparticles (MS@Lys NPs) were synthesized for the delivery of the anticancer drug curcumin (Cur) to cancer cells. The functionalization of L-lysine groups onto the mesopore channel surfaces of MS@GPTS NPs was achieved through a ring-opening reaction. The structural properties of MS@Lys NPs were examined using various instrumental techniques. The drug loading and pH-responsive drug delivery behavior of MS@Lys NPs were investigated using curcumin as a model drug, and their cytocompatibility and cell uptake behavior were evaluated using MDA-MB-231 cells. The results suggest that MS@Lys NPs have potential for pH-responsive drug delivery in cancer therapy.
Article
Nanoscience & Nanotechnology
Mengru Cai, Boran Ni, Xueling Hu, Kaixin Wang, Dongge Yin, Gongsen Chen, Tingting Fu, Rongyue Zhu, Xiaoxv Dong, Changhai Qu, Xingbin Yin
Summary: This study successfully prepared MOFs-based nanoparticles as a drug delivery platform with fluorescence imaging capability. The nanoparticles showed potential for tumor microenvironment-responsive drug release and exhibited high antitumor activity in vitro experiments.
JOURNAL OF SCIENCE-ADVANCED MATERIALS AND DEVICES
(2022)
Article
Multidisciplinary Sciences
Dharmar Manimaran, Namasivayam Elangovan, Panagal Mani, Kumaran Subramanian, Daoud Ali, Saud Alarifi, Chella Perumal Palanisamy, Hongxia Zhang, Kowsalya Rangasamy, Vasan Palanisamy, Renuka Mani, Kavitha Govarthanan, Wilson Aruni, Rajeshkumar Shanmugam, Guru Prasad Srinivasan, Aruncahllam Kalirajan
Summary: Recent breakthroughs in nanoparticle-based therapeutic delivery methods have revolutionized cancer therapy by enhancing penetration capability and disease management. In this study, isolongifolene-loaded chitosan nanoparticles were successfully synthesized and characterized. The nanoparticles demonstrated excellent hemocompatibility, plasma stability, and sustained drug release, suggesting their potential as adjuvants in combating multi-drug resistance in solid tumors.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)