Article
Biotechnology & Applied Microbiology
Hitendra S. Mahajan, Vikram D. Jadhao, Sachin M. Chandankar
Summary: This study explores the use of Pullulan and PF-127 as gel-forming materials for intranasal delivery of sildenafil citrate (SLC). The addition of Pullulan lowers the gelation temperature and enhances mucoadhesive force and drug permeation. Histological investigation confirms the safety of the formulation for nasal mucosa.
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
(2022)
Article
Chemistry, Multidisciplinary
Ying Huang, Jialun Wang, Chunyan Yue, Ran Wang, Qiyuan Guo, Tingyu Wang, Daojuan Wang, Hong Dong, Yiqiao Hu, Gaojian Tao, Xihan Li
Summary: An in situ assembled trapping gel (PF-SA-GAD) has been developed to sweep glutamate and free Ca2+ from spinal cord injuries, promoting functional repair. This gel effectively reduces secondary neuron injury, inflammation, and restores motor function in rat models of SCI.
Article
Pharmacology & Pharmacy
Essam M. Eissa, Mohammed H. Elkomy, Hussein M. Eid, Adel A. Ali, Mohammed A. S. Abourehab, Amal M. Alsubaiyel, Ibrahim A. Naguib, Izzeddin Alsalahat, Amira H. Hassan
Summary: This study successfully prepared cubosomes for granisetron delivery to the brain through the intranasal route, demonstrating sustained release characteristics, increased ex vivo permeability, and improved physical stability.
Article
Pharmacology & Pharmacy
Dhaval J. Kamothi, Vinay Kant, Babu L. Jangir, Vinay G. Joshi, Munish Ahuja, Vinod Kumar
Summary: This study demonstrated the effectiveness of encapsulated bilirubin nanoparticles in promoting wound healing, as compared to native bulk bilirubin. The nanoparticles, formed using Pluronic F-127, showed promising results in accelerating wound closure, reducing inflammation, and promoting tissue regeneration. These findings highlight the potential of encapsulated bilirubin nanoparticles as a novel biomaterial for wound healing in the future.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Physical
Michal Piotrowski, Piotr Maras, Radoslaw Wach, Slawomir Kadlubowski, Marek Kozicki
Summary: This study aims to optimize the solution-to-gel transition temperature of the Fricke-XO-Pluronic F-127 dosimeter and has achieved some success by adding NaCl salt. It is effective against different types of radiation and exhibits tissue equivalence.
Article
Engineering, Biomedical
Anyang Wang, Lina Dong, Zhongwei Guo, Wei Sun, Shengli Mi
Summary: In this study, a novel thermoresponsive gel was developed for sustained drug delivery in the treatment of bacterial keratitis. The gel exhibited improved antibacterial ability and low cytotoxicity to human corneal cells.
BIOMEDICAL MATERIALS
(2022)
Article
Chemistry, Physical
Jina Youn, Joo Hee Choi, Sumi Lee, Seong Won Lee, Byung Kwan Moon, Jeong Eun Song, Gilson Khang
Summary: An injectable thermosensitive hydrogel was developed for drug and cellular delivery, combining pluronic F-127 and silk fibroin. The addition of silk fibroin to pluronic F-127 improved mechanical strength, decreased degradation rate, and enhanced the release of hydrophobic drugs. The composite showed promising potential as a cell and drug delivery system for tissue engineering and regenerative medicine.
Article
Polymer Science
Abdulsalam Abuelsamen, Shahrom Mahmud, Noor Haida Mohd Kaus, Omar F. Farhat, Sabah M. Mohammad, Fouad Saleih R. Al-Suede, Amin Malik Shah Abdul Majid
Summary: Zinc oxide nanoparticles coated with Pluronic F-127 showed enhanced stability and reduced cytotoxicity towards normal healthy human endothelial cells. The modification significantly improved the biocompatibility of ZnO NPs, suggesting their promising potential for various biomedical applications.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2021)
Article
Environmental Sciences
Adnan Yildiz, Omer Faruk Yesilbas, Mehmet Salih Nas, Mehmet Harbi Calimli, Ramazan Bayat, Fatih Sen
Summary: In this study, TiO2-F127f-/MWCNT nanocatalysts were prepared and used for the degradation of methylene blue (MB) under ultrasonic conditions. The morphological and chemical properties of TiO2-F127/MWCNT nanocatalysts were characterized using TEM, SEM, and XRD analyses. The optimal parameters for MB degradation were determined through various experimental conditions. The results showed that TiO2-F127/f-MWCNT nanocatalysts had a homogenous structure and a particle size of 12.23 nm, while TiO2-F127/MWCNT nanocatalysts had a crystalline particle size of 13.31 nm. The COD removal efficiency reached a maximum of 92% under the optimum conditions.
ENVIRONMENTAL RESEARCH
(2023)
Article
Chemistry, Physical
Brenely Gonzalez-Penguelly, Grethell Georgina Perez-Sanchez, Dulce Yolotzin Medina-Velazquez, Paulina Martinez-Falcon, Angel de Jesus Morales-Ramirez
Summary: In this study, LuVO4:Eu3+, Bi3+ films were prepared by the sol-gel method and deposited by the dip-coating technique. The obtained films had transparent, fracture-free, and homogenous characteristics. The crystal structure of the films was tetragonal, with a high orientation along the (200) low-energy direction. The luminescence properties of the films showed enhanced light yield of Eu3+ as the Bi3+ content increased, indicating a highly efficient energy transfer mechanism between Bi3+ and Eu3+.
Article
Pharmacology & Pharmacy
Nourhan A. Abdulla, Gehan F. Balata, Hanaa A. El-ghamry, Eman Gomaa
Summary: The study developed a nanoemulsion-based intranasal gel of Clozapine to enhance its bioavailability with no toxic side effects, showing promising potential for the treatment of schizophrenia.
SAUDI PHARMACEUTICAL JOURNAL
(2021)
Article
Chemistry, Applied
S. Roy, S. P. Ghosh, D. Pradhan, P. K. Sahu, J. P. Kar
Summary: Porous TiO(2) thin films were synthesized using F127 as a structure-directing agent, with increasing F127 concentration leading to higher oxide charge density and maximum interface trap density. The addition of 3mM F127 showed better memory effect in resistive switching study.
JOURNAL OF POROUS MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Marek Kozicki, Marcin Bartosiak, Piotr Maras, Radoslaw Wach, Slawomir Kadlubowski
Summary: This work presents a new type of combined radiochromic ionizing radiation dosimeter for radiotherapy. The dosimeter, LCV-Pluronic F-127, responds to ionizing radiation by developing a blue color with an intensity related to the radiation dose. By adding sodium chloride (NaCl), the temperature stability of the dosimeter is improved. The study also proposes methods for manufacturing lung mimicking dosimeters and 3D composite dosimeters.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Chemistry, Physical
M. Jaszczak, E. Sasiadek, S. Kadlubowski, M. Dudek, M. Kozicki
Summary: A new potassium iodide based radiochromic gel dosimeter with Pluronic F-127 gel matrix was developed and showed potential for use in 3D radiotherapy dosimetry.
RADIATION PHYSICS AND CHEMISTRY
(2021)
Article
Plant Sciences
Badr Alzahrani, Abozer Y. Y. Elderdery, Nasser A. N. Alzerwi, Abdullah Alsrhani, Afnan Alsultan, Musaed Rayzah, Bandar Idrees, Fares Rayzah, Yaser Baksh, Ahmed M. M. Alzahrani, Suresh K. K. Subbiah, Pooi Ling Mok
Summary: Nanotechnology is a popular research topic with revolutionary applications. Tin oxide (SnO2) has gained considerable attention due to its intriguing features. This study successfully tailored the properties of synthesized SnO2 nanoparticles and provided insights into their synthesis process. Additionally, green Pluronic-coated SnO2 nanoparticles showed significant anticancer effects against HepG2 cells.
Article
Pharmacology & Pharmacy
Yufeng Zhang, Hua Liu, Minghui Johnson Tang, Nicolas James Ho, Tsun Lam Shek, Zhijun Yang, Zhong Zuo
Summary: This study presented a novel approach for the selection of bioequivalence (BE) extended-release (ER) formulations, using dissolution tests, principal component analysis (PCA), IVIVC model development, and in vivo pharmacokinetic data analysis. A pilot BE study in healthy volunteers confirmed the WM formulation as the most suitable for GXR.
Article
Plant Sciences
Dan Li, Yuanfeng Lyu, Jiajia Zhao, Xiaoyu Ji, Yufeng Zhang, Zhong Zuo
Summary: The study evaluated the biodistribution of Polygoni Multiflori Radix components in rats, revealing significant accumulation of TSG and EMG in the liver and kidney after multiple oral administrations of PMR. This accumulation was considered to be associated with the toxicity of PMR.
Article
Chemistry, Multidisciplinary
Hui-xi Zou, Yu-feng Zhang, Da-fang Zhong, Yong Jiang, Fei Liu, Qian-yu Zhao, Zhong Zuo, Yi-fan Zhang, Xiao-yu Yan
Summary: A population pharmacokinetic model was developed to characterize the nonstationary pharmacokinetics of furmonertinib and its active metabolite AST5902. Model-based simulation showed an increase in furmonertinib clearance during treatment, while the concentration of total active compounds appeared to be stable. Food intake, serum alkaline phosphatase, and body weight were identified as significant covariates affecting pharmacokinetics.
ACTA PHARMACOLOGICA SINICA
(2022)
Review
Pharmacology & Pharmacy
Yufeng Zhang, Chung Man Ip, Yuen Sze Lai, Zhong Zuo
Summary: This article discusses the significance of HERB-Drug Interaction (HDI) databases and provides an overview of the currently available databases. It suggests using a standardized format and Concept Unique Identifier (CUI) to accelerate structured data collection.
DRUG METABOLISM AND DISPOSITION
(2022)
Article
Chemistry, Physical
Yaxiang Gong, Yuanfeng Wei, Yuan Gao, Zunting Pang, Jianjun Zhang, Shuai Qian
Summary: This study reports a novel l-phenylalanine monohydrate (l-Phe·H2O) soft crystal, which has the potential to be developed as a medical microdevice due to its flexibility and biosafety. The study investigates the bending mechanism of the l-Phe·H2O soft crystal by analyzing the variations of hydrogen bonds. In situ micro-Raman and in situ micro-infrared spectra show that the hydrogen bonds rupture and rearrange during the bending process. Energy calculations suggest that the non-directional Coulomb attraction is the major force maintaining the crystal integrity when bent.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Chemistry, Multidisciplinary
Runming Wang, Jasper Fuk-Woo Chan, Suyu Wang, Hongyan Li, Jiajia Zhao, Tiffany Ka-Yan Ip, Zhong Zuo, Kwok-Yung Yuen, Shuofeng Yuan, Hongzhe Sun
Summary: The emergence of SARS-CoV-2 variants impacts vaccine efficacy, highlighting the importance of further developing orally administered anti-SARS-CoV-2 therapies. A cocktail therapy combining colloidal bismuth subcitrate or bismuth subsalicylate with N-acetyl-l-cysteine shows potent preclinical anti-SARS-CoV-2 efficacy, offering a potential at-home treatment for combating SARS-CoV-2 and future coronavirus infections.
Review
Chemistry, Multidisciplinary
Weili Heng, Xiaoshuang He, Yutong Song, Jiawei Han, Zunting Pang, Shuai Qian, Jianjun Zhang, Yuan Gao, Yuanfeng Wei
Summary: This review highlights the potential of cocrystals and coamorphous systems in improving the pharmaceutical properties of traditional Chinese medicine (TCM). It provides an overview of the definition, preparation methods, characterization techniques, and pharmaceutical properties of these systems. The formation mechanisms and intermolecular interactions are discussed, along with recent research on drug delivery using cocrystallization and coamorphization technologies.
CRYSTAL GROWTH & DESIGN
(2022)
Review
Pharmacology & Pharmacy
Meiling Su, Jingwen Zhang, Zudi Li, Yuanfeng Wei, Jianjun Zhang, Zunting Pang, Yuan Gao, Shuai Qian, Weili Heng
Summary: Small molecular gels based on non-covalent interactions are attracting research interest for their potential advantages in terms of high structural functionality, lower biological toxicity, and reversible stimulus-response. This review provides an overview of recent advances in small molecular gels, including their gelation mechanism, gel properties, and physicochemical characterizations. It also discusses the effects of drug-based small molecular gels on drug development and their potential applications in the pharmaceutical fields.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Article
Chemistry, Medicinal
Fei Ding, Wei Cao, Runze Wang, Ningning Wang, Anran Li, Yuanfeng Wei, Shuai Qian, Jianjun Zhang, Yuan Gao, Zunting Pang
Summary: Coamorphization and cocrystal technologies have gained significant attention in the pharmaceutical industry for their ability to improve solubility, dissolution, and bioavailability of poorly water-soluble drugs. This study prepared a single homogeneous coamorphous system of BCS II drug bai-calein (BAI) and nicotinamide (NIC) with a single transition temperature. Interestingly, the coamorphous BAI-NIC transformed into its cocrystal form under the influence of temperature and humidity stress, instead of forming a physical mixture of crystalline BAI and NIC. The transformation rate was temperature-dependent and the crystallinity of the cocrystal increased with increasing temperature. Water vapor sorption tests indicated that the transformation was faster under higher humidity conditions, attributed to the accelerated nucleation process of cocrystal BAI-NIC.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Medicine, Research & Experimental
Peiya Shen, Chunfeng Zhang, Enshi Hu, Yuan Gao, Yuanfeng Wei, Jianjun Zhang, Shuai Qian, Weili Heng
Summary: Cocrystal (CC) and coamorphous (CM) formulations of indomethacin (IMC) and nicotinamide (NIC) were produced using hot-melt extrusion (HME) technique. Different formulations were selectively obtained by adjusting the barrel temperature of HME. The CC and CM formulations showed enhanced dissolution and stability compared to crystalline/amorphous IMC. This study provides an environmentally friendly strategy for the flexible regulation of CC and CM formulations.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Meiling Su, Maoli Huang, Yuanfeng Wei, Yuan Gao, Jianjun Zhang, Shuai Qian, Weili Heng
Summary: A highly unusual diamond-shaped habit of honokiol was obtained from volatile DESs due to the formation of the hole and molecular cluster environments and the preferential adsorption of DESs on the (010) face.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Pharmacology & Pharmacy
Meiling Su, Maoli Huang, Zunting Pang, Yuanfeng Wei, Yuan Gao, Jianjun Zhang, Shuai Qian, Weili Heng
Summary: This study firstly utilized deep eutectic solvent (DES) to improve the powder mechanical properties and tabletability of drugs, and explored the interfacial interaction mechanism. The results showed that DES could form solid-liquid interfaces in the drug powders and enhance the interparticulate interactions, leading to improved tabletability.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Physical
Zezhi Lin, Wei Cao, Jianjun Zhang, Yuanfeng Wei, Shuai Qian, Yuan Gao, Weili Heng
Summary: For the first time, a simple and efficient approach to separate active monomers with larger diameters from structurally similar natural compounds has been proposed. The defective MOF, with hierarchical microporous/mesoporous structures and Cu1+/Cu2+ mixed-valence sites, demonstrated specific loading of silibinin A&B with high separation capacity. This separation technique offers advantages of high specificity, efficiency, and ease of operation.
APPLIED SURFACE SCIENCE
(2023)
Review
Materials Science, Biomaterials
Wei Cao, Zezhi Lin, Daoyi Zheng, Jianjun Zhang, Weili Heng, Yuanfeng Wei, Yuan Gao, Shuai Qian
Summary: Metal-organic gels (MOGs) are functional soft substances with a 3D network structure and solid-like behavior. They have potential advantages of high porosity, flexible structure, and adjustable mechanical properties. In the pharmaceutical field, MOGs are extensively researched for intelligent drug delivery, programmable drug release, tissue repair, drug detection, etc.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Jiawei Han, Luyuan Li, Qian Yu, Daoyi Zheng, Yutong Song, Jianjun Zhang, Yuan Gao, Weili Heng, Shuai Qian, Zunting Pang
Summary: The study focused on improving drug solubility and investigating the potential transformation between co-amorphous and co-crystal systems. The co-crystal system showed enhanced dissolution and maintained supersaturation, while the co-amorphous system exhibited reduced dissolution due to gel formation. The stronger intermolecular interactions between the components led to directional rearrangement and transformation from co-amorphous to co-crystal.
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
