期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 471, 期 1-2, 页码 166-172出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2014.05.028
关键词
Multimeric micelles; Grain-marked micelles; Chlorin e6 (Ce6); Magnetic resonance imaging; Photodynamic therapy
资金
- Korean Health Technology R&D Project, Ministry of Health Welfare [A111291]
- Korea Health Promotion Institute [A111291] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Multimeric grain-marked micelles consisting of an inner core micelle (for Fe3O4 encapsulation) and outer multi-grain micelles (for chlorin e6 (Ce6, a model drug) encapsulation) were fabricated using a micelle-to-micelle conjugation method. Grain micelles (mono-thiol functionalized micelles) were chemically linked to the surface of the core micelle (multi-maleimide functionalized micelle). These micelles enable discrete compartments for Ce6 and iron oxide (Fe3O4) that enable a significantly increased in vivo photodynamic tumor inhibition while preserving high contrast magnetic resonance (MR) imaging of the tumor in vivo. (C) 2014 Elsevier B.V. All rights reserved.
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