Article
Pharmacology & Pharmacy
Kristyna Dvorakova, Petr Stepanek, Jirina Kroupova, Jarmila Zbytovska
Summary: Transdermal drug delivery is a non-invasive method with advantages over conventional routes of administration. However, the skin barrier needs to be modulated with enhancers, and currently there is a lack of enhancers with low toxicity and reversible effects. A study found that a series of new N-alkylmorpholines showed enhanced transdermal and dermal delivery, with the most effective derivatives having 10-14 carbons. The enhancers interacted predominantly with stratum corneum lipids.
Article
Pharmacology & Pharmacy
Ines Nikolic, Mitar Simic, Ivana Pantelic, Goran Stojanovic, Jelena Antic Stankovic, Bojan Markovic, Snezana Savic
Summary: Various approaches have been proposed for improving dermal drug delivery, such as chemical penetration enhancers and electrical current methods like iontophoresis. In this study, curcumin-loaded nanoemulsions with and without monoterpenes as penetration enhancers, as well as an adhesive dermal delivery system based on iontophoresis, were designed and evaluated. The results showed that iontophoresis was equally efficient as other methods in terms of curcumin penetration through superficial skin layers. Further improvement of iontophoresis as a mobile adhesive system would be a practical contribution in the field of dermal drug application.
Article
Multidisciplinary Sciences
Nicholas G. Lamson, Katherine C. Fein, John P. Gleeson, Alexandra N. Newby, Sijie Xian, Kyle Cochran, Namit Chaudhary, Jilian R. Melamed, Rebecca L. Ball, Kanika Suri, Vishal Ahuja, Anna Zhang, Adrian Berger, Dmytro Kolodieznyi, Brigitte F. Schmidt, Gloria L. Silva, Kathryn A. Whitehead
Summary: The study found that strawberry and its red pigment pelargonidin can serve as effective enhancers for oral absorption of macromolecules, with minimal adverse effects and significant bioactivity in mouse models.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Pharmacology & Pharmacy
Jiuheng Ruan, Chao Liu, Haoyuan Song, Ting Zhong, Peng Quan, Liang Fang
Summary: Skin pharmacokinetics (SPK) can explain the different effects of permeation enhancers on drug permeation at the kinetic level. SPK of permeation enhancers can be classified into lateral elimination and longitudinal elimination, and evaluated using the diffusion ratio (DRSC-EP). The linear relationship between parameters such as ke-enhancer and Delta Cmax-drug, MRTenhancer and Delta Tmax-drug, and AUCt-enhancer and Delta AUCt-drug suggests that SPK precisely controls drug permeation in vivo.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Tanmay Padhye, Kavya Sree Maravajjala, Karnam Laxmi Swetha, Swati Sharma, Aniruddha Roy
Summary: Oral drug delivery is convenient and cost-effective, but the complex physiology of the gastrointestinal tract and drug absorption mechanisms can greatly impact oral absorption of drugs.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Biophysics
Eva Abramov, Nissim Garti
Summary: This study aims to develop a dermal delivery system based on embedding liquid nanovehicles into polymeric films to achieve controlled release of nanodroplets. The technology results in the formation of homogeneous, transparent, and elastic films with high loading capacity of nanodomains, which spontaneously reform during dermal application. Ex-vivo release studies demonstrate significant permeation of curcumin through pig skin, highlighting the potential of this novel film technology as a solid platform reservoir for liquid nanovehicles.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Pharmacology & Pharmacy
Deepanjan Datta, Dhruvisha Sureshbhai Panchal, Venkata Vamsi Krishna Venuganti
Summary: The study demonstrates that a combination of chemical enhancers and tape-stripping techniques significantly increases the permeation of vancomycin hydrochloride (VH) across the skin, leading to enhanced local and systemic treatment of bacterial infections. Results from experiments and pharmacokinetic analysis suggest that this approach could be a promising method for delivering antibiotics through topical route.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Pharmacology & Pharmacy
Kanokwan Singpanna, Chaiyakarn Pornpitchanarong, Prasopchai Patrojanasophon, Theerasak Rojanarata, Tanasait Ngawhirunpat, S. Kevin Li, Praneet Opanasopit
Summary: Transdermal drug delivery via the skin is a promising method, and gold nanoparticles (AuNPs) have emerged as a useful tool in this area. This review provides a comprehensive summary of the properties, synthesis, and applications of AuNPs in transdermal drug delivery.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ekaterina P. Vasyuchenko, Philipp S. Orekhov, Grigoriy A. Armeev, Marine E. Bozdaganyan
Summary: The cutaneous delivery route is increasingly common for drug administration, with the use of chemical penetration enhancers (CPEs) to facilitate drug transport through skin layers. The creation of a CPE-DB database allows for the classification and identification of new enhancers, as well as the prediction of biological activity using machine-learning applications.
Article
Chemistry, Multidisciplinary
Gagandeep Singh, Gaya S. Dasanayake, Claylee M. Chism, Priyavrat Vashisth, Amandeep Kaur, Sandeep Kumar Misra, Joshua S. Sharp, Eden E. L. Tanner
Summary: Achieving safe and efficacious drug delivery remains a challenge, and this study presents a promising approach using biocompatible GBILs to modify the surface of PLGA nanoparticles. The modified nanoparticles showed enhanced uptake by breast cancer cells and could potentially serve as a versatile platform for targeted drug delivery and gene therapy applications.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Article
Polymer Science
Asif Nawaz, Arshad Farid, Muhammad Safdar, Muhammad Shahid Latif, Shakira Ghazanfar, Nosheen Akhtar, Soad K. Al Jaouni, Samy Selim, Muhammad Waseem Khan
Summary: This research developed a curcumin hydrogel containing natural essential oils as permeation enhancers and demonstrated that suitable natural permeation enhancers can improve the in vitro release and ex vivo permeation and retention of curcumin. Among various natural essential oils, 3% aloe vera oil had the greatest effect on the permeability rate and skin retention of curcumin.
Review
Pharmacology & Pharmacy
Victor Hmingthansanga, Nidhi Singh, Superna Banerjee, Sivakumar Manickam, Ravichandiran Velayutham, Subramanian Natesan
Summary: Delivery of drugs via transdermal routes offers advantages, but overcoming the skin's barrier properties remains challenging. Chemical permeation enhancers (CPEs) can improve transdermal drug delivery, but may have side effects. With advancements in analytical techniques, synthetic chemistry, and combinatorial studies, CPEs-aided transdermal drug delivery is expected to reach its full potential.
Article
Cell Biology
Peter Gennemark, Katrin Walter, Niclas Clemmensen, Dinko Rekic, Catarina A. M. Nilsson, Jane Knochel, Mikko Holtta, Linda Wernevik, Birgitta Rosengren, Dorota Kakol-Palm, Yanfeng Wang, Rosie Z. Yu, Richard S. Geary, Stan J. Riney, Brett P. Monia, Rikard Isaksson, Rasmus Jansson-Lofmark, Cristina S. J. Rocha, Daniel Linden, Eva Hurt-Camejo, Rosanne Crooke, Lloyd Tillman, Tina Ryden-Bergsten, Bjorn Carlsson, Ulf Andersson, Marie Elebring, Anna Tivesten, Nigel Davies
Summary: In this study, a chemically modified PCSK9 antisense oligonucleotide (ASO) with potential for oral delivery was developed and shown to effectively reduce LDL cholesterol levels. Animal experiments demonstrated liver targeting and significant reductions in PCSK9 and LDL cholesterol levels after oral administration.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Giulia Di Prima, Mariano Licciardi, Flavia Bongiovi, Giovanna Pitarresi, Gaetano Giammona
Summary: The study successfully demonstrated the potential of conjugating ocular permeation enhancers to polymers to prepare self-assembling biopolymers with enhancer properties. The self-assembling biopolymers showed the ability to load dexamethasone and self-assemble at various concentrations.
Article
Polymer Science
Randa Mohammed Zaki, Mohamed A. Ibrahim, Doaa H. Alshora, Amal El Sayeh Abou El Ela
Summary: This study aimed to prepare Span 60-based elastic nanovesicles using the adapted ethanol injection method, and evaluate their ability to improve transdermal permeation of tacrolimus. Different concentrations and types of penetration enhancers were assessed for their impact on the physicochemical properties of the nanovesicles. The results showed significant enhancement in in vitro release compared to pure drug suspension.
Article
Neurosciences
Jose Tiago Costa-Pereira, Rita Oliveira, Irene Guadilla, Maria Jose Guillen, Isaura Tavares, Pilar Lopez-Larrubia
Summary: Chemotherapy-induced neuropathy is a common complication of cancer treatment. This study found that neuronal function and metabolic profiles in specific brain regions are altered during chemotherapy-induced neuropathy, suggesting their involvement in pain processing and modulation.
BRAIN RESEARCH BULLETIN
(2023)
Correction
Chemistry, Medicinal
Ana Teresa Silva, Isabel S. Oliveira, Joana Gomes, Luisa Aguiar, Diana Fontinha, Denise Duarte, Fatima Nogueira, Miguel Prudencio, Eduardo F. Marques, Catia Teixeira, Ricardo Ferraz, Paula Gomes
Article
Neurosciences
Milou T. Brand, Rita F. de Oliveira
Summary: This study investigated the age-related temporal effects in perceptual-motor recalibration after motor disruptions. The results showed that older adults recalibrated faster than young adults, despite having reduced muscle strength and flexibility, especially when the task was more challenging.
HUMAN MOVEMENT SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Aline Jeane Costa Sousa, Benedito Pereira de Sousa Neto, Douglas Soares da Costa, Maisa Campelo de Sousa, Camila Ernanda Sousa de Carvalho, Lucindo Jose Quintans-Junior, Jullyana Souza Siqueira Quintans, Josyanne Araujo Neves, Francilene Vieira da Silva, Ana Flavia Seraine Custodio Viana, Paulo Humberto Moreira Nunes, Rita de Cassia Meneses Oliveira
Summary: This study aimed to evaluate the antiulcerogenic and healing activity of the acetate of hecogenin in models of gastric lesions induced by ethanol and ischemia-reperfusion, as well as in a model of gastric ulcers induced by acetic acid. The results showed that the acetate of hecogenin exhibited significant antiulcerogenic and healing effects in these models.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Juliana Lima Nascimento, Angelica Gomes Coelho, Ytallo Samuel Oliveira Barros, Irisdalva Sousa Oliveira, Francilene Vieira da Silva, Ana Flavia Seraine Custodio Viana, Bruno Quirino Araujo, Marcio dos Santos Rocha, Francisco das Chagas Pereira de Andrade, Celma de Oliveira Barbosa, Helio de Barros Fernandes, Anderson Nogueira Mendes, Joaquim Soares da Costa-Junior, Rita de Cassia Meneses Oliveira, Massimo Lucarini, Alessandra Durazzo, Daniel Dias Rufino Arcanjo, Antonia Maria das Gracas Lopes Cito
Summary: Bacuri, a native plant of Brazil, has antioxidant activity against free radicals. In this study, an inclusion complex of beta-cyclodextrin (beta-CD) with the hexanic extract of bacuri seeds (BSHE) was produced, characterized and evaluated for its gastroprotective effect. The inclusion complex showed enhanced gastroprotective activity, indicating the potential use of this formulation in the treatment of peptic ulcers.
APPLIED SCIENCES-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Isabel S. Oliveira, Sandra G. Silva, Maria Luisa do Vale, Eduardo F. Marques
Summary: This study investigated the aggregation properties of two catanionic mixtures containing biomimetic surfactants derived from serine. One of the mixtures formed vesicles that only existed within a very narrow compositional range, with average diameters of 80 and 300 nm and a bimodal population. These vesicles are promising for application as drug/gene nanocarriers.
Review
Biochemistry & Molecular Biology
Rita Oliveira, Joana Ferreira, Luis Filipe Azevedo, Isabel F. Almeida
Summary: Skin type classification is important for recommending and selecting appropriate cosmetic products and skin care protocols, as well as in clinical research. Various methods, including non-invasive bioengineering tools, visual and tactile methods, and artificial intelligence-based tools, have been proposed for classifying skin typologies.
Review
Microbiology
Rita A. Oliveira, Vitor Cabral, Ines Torcato, Karina B. Xavier
Summary: The coexistence of gut microbiota and the host is a symbiotic relationship that benefits both parties. Bacteria can communicate through chemical signaling, such as quorum sensing, to regulate group behaviors for host colonization. However, most studies on microbial-host interactions regulated by quorum sensing have focused on pathogens. This article focuses on the emerging studies of quorum sensing in gut microbiota symbionts and their group behaviors for mammalian gut colonization, as well as the challenges and approaches to uncover the molecule-mediated communication mechanisms.
CELL HOST & MICROBE
(2023)
Review
Microbiology
Rita A. Oliveira, Eric G. Pamer
Summary: Increasing evidence suggests that administering live commensal bacterial species can optimize microbiome composition and enhance health. This understanding has been achieved through deep sequence analysis, metabolomic and proteomic assays, and extensive studies on the metabolism and interactions of commensal bacteria in the gut. In this review, the authors discuss important findings and considerations for re-establishing and optimizing microbiome functions through the administration of commensal bacterial consortia.
CELL HOST & MICROBE
(2023)
Article
Materials Science, Paper & Wood
Catarina Costa, Carla Silva, Eduardo F. Marques, Nuno G. Azoia
Summary: Long-chain cellulose esters (LCCEs) are cellulose derivatives with properties relevant to diverse applications. In this study, LCCEs were evaluated as eco-friendly hydrophobic additives in textiles with different compositions. The LCCE-based formulations were applied using a conventional textile dry-cleaning process. Water-repellent textiles were obtained through sustainable flourine-free compounds, without the need for crosslinkers or pre-treatments.
Article
Biochemistry & Molecular Biology
Catarina Costa, Andre Viana, Isabel S. S. Oliveira, Eduardo F. F. Marques
Summary: Interactions between polymers and surfactants in aqueous solution have significant implications in physical chemistry and industrial applications. By synthesizing two ionic derivatives from recycled cellulose, we explored the interactions of these polymers with different types of surfactants commonly used in the textile industry. The results showed that oppositely charged polymer/surfactant mixtures exhibited strong associations, while similarly charged mixtures showed minimal interactions except for the QC/CTAB system. Furthermore, the P/S mixtures significantly enhanced the hydrophilicity of a hydrophobic textile substrate at lower surfactant concentrations compared to surfactant alone.
Review
Chemistry, Medicinal
Rita Oliveira, Isabel F. Almeida
Summary: Topical treatments are important for skin diseases, but adherence is often poor. The choice of topical vehicles for drug delivery influences treatment outcomes and patient satisfaction. Patient-centric drug-product design, taking into account the patient's needs and preferences, can improve adherence to topical treatments.
Article
Chemistry, Multidisciplinary
Sara M. A. Pinto, Ana R. R. Ferreira, Daniela S. S. Teixeira, Sandra C. C. Nunes, Ana L. M. Batista de Carvalho, Joseany M. S. Almeida, Zoltan Garda, Agnes Pallier, Alberto A. C. C. Pais, Christopher M. A. Brett, Eva Toth, Maria P. M. Marques, Mariette M. M. Pereira, Carlos F. G. C. Geraldes
Summary: A new fluorinated manganese porphyrin, (Mn-TPP-p-CF3), is capable of providing dual H-1 relaxivity and F-19 NMR response to redox changes based on the Mn(III)/Mn(II) equilibrium. The properties of H-1 relaxometry and F-19 NMR make it suitable for the detection of differential redox MRI. The physical-chemical characterization shows that the Mn(III)-F distance is well tailored to allow for adequate paramagnetic effect on F-19 T-1 and T-2 relaxation times.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Physical
Dmitriy Moreira, Oren Regev, Nuno Basilio, Eduardo F. Marques
Summary: This study develops a delivery system based on dual light and pH responsive vesicles, which can achieve precise drug release. By adjusting the acid and base conditions and UV irradiation, the release of the drug is successfully controlled, demonstrating the potential application of vesicles as nano-carriers in acidic environments such as tumors.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Anesthesiology
A. V. Pereira, R. R. Oliveira, C. Esteves, M. A. Coutinho
Summary: A 68-year-old man developed severe bradycardia, hypotension, and subsequent cardiac arrest after receiving rocuronium and sugammadex during abdominal wall hernia repair surgery. Despite successful resuscitation, the exact mechanism of sugammadex-induced cardiac arrest remains unknown. This case report aims to raise awareness about this potential complication associated with the use of sugammadex.
ANAESTHESIA REPORTS
(2023)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
