期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 454, 期 2, 页码 703-711出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2013.05.031
关键词
Gold nanoparticles; PEG; Folate; Docetaxel; Prostate cancer; LnCaP cells
资金
- Brazilian Ministry of Education (CAPES Nanobiotec Project) [04/CII-2008, 23038.019135/2009-63]
- Brazilian Ministry of Education (CAPES PDSE Program) [05560/12]
- University of Bordeaux 1
- Chinese Scholarship Council (CSC)
The aim of these studies was to synthesize, characterize and evaluate the efficacy of pegylated gold nanoparticles (AuNPs) that differed in their PEG molecular weight, using PEG 550 and PEG 2000. The synthesis of the gold nanoparticles was carried out by modified Brust method with a diameter of 4-15 nm. The targeting agent folic acid was introduced by the covalent linkage. Finally, the anti-cancer drug docetaxel was encapsulated by the AuNPs by non covalent adsorption. The nanoparticles were characterized by transmission electron microscopy and used for in vitro studies against a hormone-responsive prostate cancer cell line, LnCaP. The loaded nanoparticles reduced the cell viability in more than 50% at concentrations of 6 nM and above after 144 h of treatment. Moreover, observation of prostate cancer cells by optical microscopy showed damage to the cells after exposure to drug-loaded AuNPs while unloaded AuNPs had much less effect. (C) 2013 Elsevier B. V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据