Article
Engineering, Chemical
Chuangnian Zhang, Ying Dong, Jing Gao, Xiaoli Wang, Yanjun Jiang
Summary: This study introduced a cancer nanovaccine based on SiO2 nanoflowers with a unique radial pore structure, which significantly improved cross-presentation and stimulated the production of cytotoxic T lymphocyte cells. The nanovaccine demonstrated excellent storage stability, low cytotoxicity to dendritic cells, and a high antigen loading capacity. Additionally, in vitro and in vivo studies confirmed the potential of this nanovaccine as a therapeutic option for cancer treatment.
FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING
(2021)
Article
Chemistry, Physical
Shaoli Liu, Qiao Jiang, Xiao Zhao, Ruifang Zhao, Yuanning Wang, Yiming Wang, Jianbing Liu, Yingxu Shang, Shuai Zhao, Tiantian Wu, Yinlong Zhang, Guangjun Nie, Baoquan Ding
Summary: A DNA nanodevice vaccine has been developed to stimulate a tumor-specific cytotoxic T lymphocyte response, leading to inhibition of tumor growth and prevention of metastasis. The vaccine utilizes molecular adjuvants and antigen peptides within a tubular DNA nanostructure to trigger T-cell activation and cancer cytotoxicity, showing promising results in mouse cancer models. The vaccination generates long-term T-cell responses which effectively protect against tumor rechallenge.
Article
Medicine, Research & Experimental
Olivia Amanda Oest Mullertz, Peter Andersen, Dennis Christensen, Camilla Foged, Aneesh Thakur
Summary: The mucosal surfaces of the lungs are a major site for entry of airborne pathogens and pulmonary vaccination can induce protective mucosal immunity. Researchers found that altering the surface charge of liposomes can enhance specific T-cell responses, but the impact on mucosal immunity remains unclear.
MOLECULAR PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Yun Yang, Shuang Ge, Zhen Song, Anni Zhao, Liqun Zhao, Zhiming Hu, Dingyi Cai, Zelong Zhang, Liusheng Peng, Dongshui Lu, Ping Luo, Weijun Zhang, Hongwu Sun, Quanming Zou, Hao Zeng
Summary: Epitope peptides are not ideal for nasal administration immunity due to low immunogenicity and poor delivery efficiency. An intranasal self-assembled nanovaccine (I-OVA NE) loaded with IKVAV-OVA257-264 peptides showed enhanced antigen uptake and prolonged nasal residence time in vivo, leading to the induction of peptide-specific CD8+T cells and protective immunity in tumor-bearing mice.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Multidisciplinary
Kaige Chen, Zheng Zhang, Jiachen Zhang, Ziyuan Fang, Wang Dong, Yucai Wang, Min Li
Summary: This study explores a new antigen-caged adjuvant strategy, in which a controlled bio-mineralization method is used to prepare antigen-caged metal adjuvants. The results demonstrate that this strategy can enhance the adjuvanticity of aluminum adjuvants and promote the internalization of antigen and adjuvant by antigen-presenting cells, leading to robust humoral and cellular immune responses.
Article
Multidisciplinary Sciences
Kairat Tabynov, Maxim Solomadin, Nurkeldi Turebekov, Meruert Babayeva, Gleb Fomin, Ganesh Yadagiri, Renu Sankar, Toktassyn Yerubayev, Nikolai Petrovsky, Gourapura J. Renukaradhya, Kaissar Tabynov
Summary: We developed a novel intranasal SARS-CoV-2 subunit vaccine called NARUVAX-C19/Nano based on the spike protein receptor-binding domain (RBD) entrapped in mannose-conjugated chitosan nanoparticles (NP). The NP vaccine showed immunogenicity and protective efficacy in mice and Syrian hamsters, but did not prevent viral transmission to naive cage-mates. The addition of a toll-like receptor 9 agonist, CpG55.2, as an adjuvant enhanced the cellular immune response.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Zhen-Lin Gao, Wei Xu, Sui-Juan Zheng, Qi-Jia Duan, Rong Liu, Jin-Zhi Du
Summary: Cancer vaccines are important in cancer immunotherapy, but their effectiveness is limited by the insufficient delivery of antigens and adjuvants. In this study, a cancer nanovaccine G5-pBA/OVA@Mn was prepared through the interaction of manganese ions, benzoic acid-modified polyamidoamine dendrimer, and ovalbumin antigen. The nanovaccine showed prophylactic effects and inhibited tumor growth, demonstrating its potential in cancer immunotherapy.
Review
Pharmacology & Pharmacy
Jatin Machhi, Farah Shahjin, Srijanee Das, Milankumar Patel, Mai Mohamed Abdelmoaty, Jacob D. Cohen, Preet Amol Singh, Ashish Baldi, Neha Bajwa, Raj Kumar, Lalit K. Vora, Tapan A. Patel, Maxim D. Oleynikov, Dhruvkumar Soni, Pravin Yeapuri, Insiya Mukadam, Rajashree Chakraborty, Caroline G. Saksena, Jonathan Herskovitz, Mahmudul Hasan, David Oupicky, Suvarthi Das, Ryan F. Donnelly, Kenneth S. Hettie, Linda Chang, Howard E. Gendelman, Bhavesh D. Kevadiya
Summary: This article summarizes the treatment and vaccine development during the COVID-19 pandemic, focusing on the role played by nanocarrier delivery.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Materials Science, Multidisciplinary
Faizan Zarreen Simnani, Dibyangshee Singh, Paritosh Patel, Anmol Choudhury, Adrija Sinha, Aditya Nandi, Shailesh Kumar Samal, Suresh K. Verma, Pritam Kumar Panda
Summary: Immunization is a potential weapon against pandemics and can save lives by reducing mortality rates of infectious and chronic illnesses. Nanomaterials are being developed as nanocarriers for vaccines against global diseases, such as HIV, malaria, TB, and influenza. This study evaluates current and next-generation vaccination platforms and discusses the importance of dose-dependent vaccines in inducing neutralizing antibodies.
Article
Pharmacology & Pharmacy
Douglas Borges de Figueiredo, Kan Kaneko, Tasson da Costa Rodrigues, Ronan MacLoughlin, Eliane Namie Miyaji, Imran Saleem, Viviane Maimoni Goncalves
Summary: Pneumococcal disease is a global burden, and the current vaccines are becoming less effective due to serotype replacement. This study investigated the use of polymeric nanoparticles to deliver PspA, a candidate for new pneumococcal vaccines, and found that PGA-co-PDL/HCl-CS or PLGA/HCl-CS nanoparticles with encapsulated or adsorbed PspA provided serotype-independent protection.
Article
Chemistry, Multidisciplinary
Hayoon Jeong, Chung-Sung Lee, Jangsu Lee, Jonghwan Lee, Hee Sook Hwang, Min Lee, Kun Na
Summary: This study presents a novel nanoparticulate vaccine system, NanoVac, which utilizes photochemical immunomodulation to enhance antigen residence in the nasal cavity, stimulate immune responses, and effectively prevent influenza virus infection post-immunization.
Review
Chemistry, Inorganic & Nuclear
Dandan Wang, Wenxing Gu, Weiliang Chen, Jin Zhou, Le Yu, Byung Kook Kim, Xuenong Zhang, Jong Seung Kim
Summary: Nanovaccines based on nanomaterials have emerged as an advanced technology for enhancing anti-tumor immunotherapy. They stimulate antigen presenting cells to release signals and activate immune-killing T cells, improving the efficacy of immunotherapy. The positive regulation of nanovaccines enhances antigen presentation and recruits more immune-killing T cells.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Jia Liu, Gaoyang Liu, Ye Cao, Hui Du, Tianqiang Liu, Mingzhu Liu, Pengfei Li, Yang He, Gaoxue Wang, Qing Yu, Erlong Wang
Summary: A multi-epitope subunit vaccine based on Streptococcus and a nanovaccine system combining bacterial nanocellulose were developed and evaluated for immune protection against S. agalactiae and S. iniae infection in tilapia.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Jia Liu, Gaoyang Liu, Ye Cao, Hui Du, Tianqiang Liu, Mingzhu Liu, Pengfei Li, Yang He, Gaoxue Wang, Qing Yu, Erlong Wang
Summary: The BNC-rSS nanovaccine significantly enhanced immune protection against Streptococcus agalactiae and Streptococcus iniae infection in tilapia, indicating its potential for cross-protection.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Maria Tsakiri, Nikolaos Naziris, Costas Demetzos
Summary: Traditional vaccines have been effective in eliminating infectious diseases, while innovative vaccine platforms provide a new pathway to overcome dangerous pandemics by developing safe and effective formulations. These platforms play a crucial role in vaccinology, inducing immune responses.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Obstetrics & Gynecology
Ana N. Goncalves, Jorge Correia-Pinto, Cristina Nogueira-Silva
Summary: The study compares different imagiological methods for predicting fetal pulmonary hypoplasia in general diseases, PROM, and CDH. Results show discrepancies in predictive values due to group heterogeneity, with 2D measurements being more affected than 3D. Ultrasonographic methods, especially 2D-US, demonstrate useful predictive value in outcome estimation for PROM and CDH.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Ophthalmology
Pedro S. Brito, Jorge Costa, Catarina Barbosa-Matos, Sandra M. Costa, Jorge Correia-Pinto, Rufino M. Silva
Summary: This study investigated the impact of serum biomarkers on the response to anti-vascular endothelial growth factor treatment in diabetic macular edema (DME) patients. The results indicated that high sensitivity C-reactive protein was associated with limited anatomic response and persistent DME, while lower levels of serum vascular endothelial growth factor-A were linked to a higher risk of persistent DME.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Paulo Mota, Joao Barbosa-Martins, Rute S. Moura, Estevao Lima, Alice Miranda, Jorge Correia-Pinto, Emanuel Carvalho-Dias
SCIENTIFIC REPORTS
(2020)
Review
Chemistry, Multidisciplinary
Tamara G. Dacoba, Shubaash Anthiya, German Berrecoso, Iago Fernandez-Marino, Carmen Fernandez-Varela, Jose Crecente-Campo, Desiree Teijeiro-Osorio, Fernando Torres Andon, Maria J. Alonso
Summary: Research in cancer therapeutics has led to the development of various pharmacological molecules, with nanotechnology playing a crucial role in overcoming biopharmaceutical challenges. Advances in drug discovery, molecular biology, and biomaterials have contributed significantly to the design of nanodelivery strategies, highlighting the potential for improved therapeutic outcomes.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Instruments & Instrumentation
Federico Quattrini, German Berrecoso, Jose Crecente-Campo, Maria Jose Alonso
Summary: Polymeric nanocarriers play a crucial role in drug delivery, and AF4 is a technique that can accurately characterize their properties. AF4 can help understand the multifunctionality of nanomaterials and optimize drug formulations.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Instruments & Instrumentation
Ana Sara Cordeiro, Yagmur Farsakoglu, Jose Crecente-Campo, Maria de la Fuente, Santiago F. Gonzalez, Maria Jose Alonso
Summary: Nanotechnology has been utilized as a valuable tool to enhance immune responses against modern antigens. Specifically designed nanocarriers have shown to provide protection, stability, and controlled release properties to various types of antigens. A focus on using beta-glucan derivatives, such as carboxymethyl-beta-glucan, in conjunction with chitosan has resulted in the development of novel nanocarriers with desirable physicochemical properties and high protein association efficiency. These nanocarriers have demonstrated potential in achieving efficient vaccine responses, as seen in biodistribution studies and immunization experiments in mice.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Hugo Fernandes-Silva, Marco G. Alves, Henrique Araujo-Silva, Ana M. Silva, Jorge Correia-Pinto, Pedro F. Oliveira, Rute S. Moura
Summary: The study found that as lung branching morphogenesis progresses, glucose consumption decreases while lactate, acetate, and alanine production increases. Changes in LDH protein expression levels suggest that LDHB may contribute to the rise in lactate. Oxygen consumption rate remains stable throughout branching morphogenesis.
CELL AND BIOSCIENCE
(2021)
Article
Computer Science, Information Systems
Bruno Silva, Ines Pessanha, Jorge Correia-Pinto, Jaime C. Fonseca, Sandro Queiros
Summary: This paper proposes a fully automatic framework for quantifying PE severity from CT images by identifying anatomical keypoints and regularizing and extracting measurements, showing good agreement with the manual approach and improved reproducibility between indices extracted from different CTs of the same patient.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2022)
Article
Engineering, Biomedical
Fernando Veloso, Daniel Miranda, Pedro Morais, Helena R. Torres, Bruno Oliveira, Jorge Correia-Pinto, Antonio C. M. Pinho, J. L. Vilaca
Summary: This study investigates the compressive behavior of a functionally graded lattice and its potential application in cranial remodeling orthoses (CRO). The results show that the graded lattice can adapt to head growth and has a good performance in compression deformations.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Review
Materials Science, Multidisciplinary
Fernando Veloso, Joao Gomes-Fonseca, Pedro Morais, Jorge Correia-Pinto, Antonio C. M. Pinho, Joao L. Vilaca
Summary: Lattice structures are crucial for innovative solutions when materials need to be adaptive, multifunctional, and with tunable properties. This article presents an overview of methods and software for the design of functionally graded lattice structures, comparing different design approaches.
ADVANCED ENGINEERING MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Sandra Robla, Ruben Varela Calvino, Rita Ambrus, Noemi Csaba
Summary: To address the side effects and resistance issues of oral antibiotic therapy for respiratory diseases, inhalable formulations using biomaterials like protamine were developed to enhance therapeutic effect. Rifabutin-loaded protamine nanocapsules were prepared and evaluated for their physico-chemical characteristics, dissolution, permeability, stability, cytotoxicity, hemocompatibility, internalization, and aerodynamic properties. The nanocapsules showed good stability as suspension, both in storage and in biological media, as well as in the form of dry powder after lyophilization with mannitol. They exhibited excellent safety profile, cellular uptake, and compatibility with red blood cells. Furthermore, the aerodynamic evaluation demonstrated suitable particle size for pulmonary delivery of therapeutics, with a fine particle fraction deposition of up to 30% and a mass median aerodynamic diameter of about 5 µm.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Biochemical Research Methods
Maruthi Prasanna, Ruben Varela Calvino, Annie Lambert, Maria Arista Romero, Sylvia Pujals, Francois Trottein, Emilie Camberlein, Cyrille Grandjean, Noemi Csaba
Summary: This study demonstrates the potential of chitosan-based nanovaccines for efficient delivery of glycoconjugate antigens. Encapsulated glycoconjugates showed enhanced uptake by cells and better immunostimulatory properties compared to naked antigens. The study also showed a 100-fold increase in IgG response with the encapsulated glycoconjugate compared to the nonencapsulated group in mice.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Lorena Valverde-Fraga, Razan Haddad, Nasr Alrabadi, Sandra Sanchez, Carmen Remunan-Lopez, Noemi Csaba
Summary: This study aims to develop a nanosystem for improved delivery of antibiotics for pulmonary delivery. The nanocarrier, consisting of a chitosan shell and a lipid core, showed efficient antimicrobial effects against Mycobacterium tuberculosis and safe internalization in different cell models. This research provides a promising approach for the treatment of tuberculosis.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Biochemical Research Methods
Maruthi Prasanna, Ruben Varela Calvino, Annie Lambert, Maria Arista Romero, Sylvia Pujals, Francois Trottein, Emilie Camberlein, Cyrille Grandjean, Noemi Csaba
Summary: This study demonstrates the potential of chitosan-based nanovaccine for efficient delivery of glycoconjugate antigens. The encapsulation of the glycoconjugate using chitosan nanoparticles (CNPs) enhanced its immunogenicity and resulted in a significantly higher immune response compared to the nonencapsulated glycoconjugate. These findings suggest that CNPs could be a promising delivery system for pneumococcal conjugate vaccines.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Sergio del Rio-Sancho, Diego Pan Delgado, German F. de la Fuente, Tomas Garcia-Caballero, Antonio Taboada-Suarez, Noemi Csaba, Carmen Bao-Varela, Maria Jose Alonso
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2020)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
