☆ 4.7 Article

Chitosan oligosaccharide-arachidic acid-based nanoparticles for anti-cancer drug delivery

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2013)

期刊

INTERNATIONAL JOURNAL OF PHARMACEUTICS

卷 441, 期 1-2, 页码 373-380

出版社

ELSEVIER SCIENCE BV

DOI: 10.1016/j.ijpharm.2012.11.018

关键词

Arachidic acid; Chitosan oligosaccharide; Doxorubicin; Head and neck cancer; Self-assembly

类别

Pharmacology & Pharmacy

资金

National Research Foundation of Korea (NRF)
Korean government (MEST) [2011-0030635]
MarineBio Research Program [NRF-C1ABA001-2011-0018561]
National Research Foundation of Korea [2009-0083533] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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摘要

Chitosan oligosaccharide-arachidic acid (CSOAA) conjugate was successfully synthesized and used for the development of self-assembled nanoparticles for doxorubicin (DOX) delivery. The molar substitution of AA on CSO and critical micelle concentration (CMC) of CSOAA were measured. Physicochemical properties of DOX-loaded CSOAA-based nanoparticles, such as particle size, zeta potential and morphology, were also characterized. The DOX-loaded CSOAA-based nanoparticles showed spherical shape with a mean diameter of 130 nm and positive charge. According to the result of in vitro release test, DOX-loaded CSOAA-based nanoparticles exhibited sustained and pH-dependent drug release profiles. The CSOAA showed negligible cytotoxicity in FaDu, human head and neck cancer, cells. Cellular uptake of DOX in FaDu cells was higher in the nanoparticle-treated group compared to the free DOX group. The anti-tumor efficacy of DOX-loaded nanoparticles was also verified in FaDu tumor xenografted mouse model. These results suggested that synthesized amphiphilic CSOAA might be used for the preparation of self-assembled nanoparticles for anti-cancer drug delivery. (C) 2012 Elsevier B. V. All rights reserved.

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