Article
Chemistry, Multidisciplinary
Rodrigo Ken Kawassaki, Mariana Romano, Mayara Klimuk Uchiyama, Roberta Mansini Cardoso, Mauriicio S. Baptista, Sandra H. P. Farsky, Khallil Taverna Chaim, Robson Raphael Guimaraes, Koiti Araki
Summary: A novel ultrasmall paramagnetic nanoparticle (UPN), decorated with iron oxide on 3 nm titanium dioxide nanoparticles, has been developed as a potential alternative blood-pool contrast agent to gadoteric acid (GA) for MR angiography. It exhibits comparable relaxometric parameters to GA and has strong and prolonged contrast enhancement before renal excretion.
Article
Nanoscience & Nanotechnology
Li-Hua Deng, Hai Jiang, Fu-Lin Lu, Han-Wei Wang, Yu Pu, Chang-Qiang Wu, Hong-Jie Tang, Ye Xu, Tian-Wu Chen, Jiang Zhu, Cheng-Yi Shen, Xiao-Ming Zhang
Summary: By using PEGylated SPIO nanoparticles as MRI contrast agents, different nanocrystal sizes and PEG coatings can be utilized to achieve T-1, T-2, or T-1-T-2 dual-mode imaging at different magnetic field intensities.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Pharmacology & Pharmacy
Jiali Li, Xue Jiang, Lihuan Shang, Zhen Li, Conglian Yang, Yan Luo, Daoyu Hu, Yaqi Shen, Zhiping Zhang
Summary: The study successfully synthesized L-epigallocatechin gallate complexed Mn2+ nanoparticles with good biocompatibility, stability, pH sensitivity, and anti-tumor properties, potentially serving as an MRI contrast agent.
Review
Nanoscience & Nanotechnology
Can Chen, Jianxian Ge, Yun Gao, Lei Chen, Jiabin Cui, Jianfeng Zeng, Mingyuan Gao
Summary: USPIO nanoparticles, with their excellent MRI performance and remarkable biosafety profile, have shown considerable applications in developing T-1 contrast agents and T-2/T-1 switchable contrast agents, and have been widely used in the diagnosis of vascular pathological changes, inflammations, and malignant tumors.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Applied
Hamed Nosrati, Marziyeh Salehiabar, Faezeh Mozafari, Jalil Charmi, Nuri Erdogan, Mohammadreza Ghaffarlou, Fatemeh Abhari, Hossein Danafar, Ali Ramazani, Yavuz Nuri Ertas
Summary: Early diagnosis and treatment of cancer is crucial, and theranostic systems play a significant role in this aspect. In this study, bi-functional nanoparticles were developed as dual MRI/CT contrast agent and carrier of natural anticancer drug. These nanoparticles showed good performance in both MRI and CT imaging contrast, while also demonstrating high biocompatibility and anticancer activity.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
K. R. Preethy, Ponesakki Ganesan, M. Chamundeeswari
Summary: In this research, superparamagnetic graphene composites were produced using leaf extracts of Melia dubia and Prosopis juliflora. Commercial graphite was replaced with low-cost raw bio source, Pennisetum glaucum panicle waste for graphene oxide production. The composites exhibited enhanced surface area, good conductivity, and high loading capacity.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2023)
Article
Chemistry, Physical
Hao Zhang, Zhijia Lv, Dongzhi Xue, Tianqi Zhang, Longhai Jin, Yue Cao, Shuai Zhang, Yinghui Wang, Hongjie Zhang
Summary: A TME-responsive theranostic nanoagent was fabricated using a layer-by-layer synthesis method, which can achieve enhanced chemotherapy within tumor cells without collateral damage to normal tissues. The nanoagent efficiently kills tumor cells in both in vitro and in vivo experiments.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Nanoscience & Nanotechnology
Jian Liu, Bobo Zheng, Ping Zhang, Liangjie Wang
Summary: This research aimed to construct PASP surface-modified USPIO NPs for monitoring cerebral perfusion. The results showed that the PASP-USPIO NPs were successfully prepared and exhibited an increase in positive staining of endothelial cells and a decrease in the rate of change in signal-to-noise ratio.
SCIENCE OF ADVANCED MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Gilbert Aaron Lee, Wan-Li Lin, Duen-Pang Kuo, Yi-Tien Li, Yu-Wei Chang, Yung-Chie Chen, Shiu-Wen Huang, Justin Bo-Kai Hsu, Cheng-Yu Chen
Summary: Lipid-coated SPIO nanoparticles conjugated with PD-L1 antibodies can specifically target PD-L1 expression in glioblastoma, including temozolomide-resistant cases, as demonstrated in this study through characterizations such as dynamic light scattering and in vivo T2* map MRI analysis. This approach shows promise for early diagnosis and predicting responses to targeted PD-L1 immunotherapy in glioblastoma patients.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Jianxian Ge, Cang Li, Ning Wang, Ruru Zhang, Mohammad Javad Afshari, Can Chen, Dandan Kou, Dandan Zhou, Ling Wen, Jianfeng Zeng, Mingyuan Gao
Summary: Polyethylene glycol (PEG) is commonly used to enhance the biocompatibility and blood circulation time of iron oxide nanoparticles (IONPs) as MRI contrast agents. However, the surface effect induced by PEGylation can impact the relaxometric properties of IONPs and subsequently affect imaging results. In this study, three diphosphonate PEGs with different molecular weights were used to replace the hydrophobic oleate ligands of IONPs, and the relationship between PEG chain length and relaxometric properties of IONPs was investigated.
Article
Nanoscience & Nanotechnology
Ji-wook Kim, Jiyong Cheong, Hayeon Cheong, Jun Geol Yoon, Joon-Yong Jung, Jae-Hyun Lee, Tae-Hyun Shin
Summary: Inverted iron oxide nanoparticles (i-IONPs) show great potential for musculoskeletal imaging with stronger and longer-lasting contrast effects compared to clinical gadolinium-based contrast agents, providing clear visualization of anatomical details of the joint. Additionally, i-IONPs are completely eliminated from the joint cavity without accumulation or harmful effects and are excreted from the body through renal clearance.
ACS APPLIED NANO MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Ji Hye Jin, Hyeji Um, Ji Hyeon Oh, Youngbuhm Huh, Yuna Jung, Dokyoung Kim
Summary: A new nano-formulation based on gadolinium silicate-coated porous silicon nanoparticles (pSiNPs) is introduced as an MRI contrast agent and drug delivery carrier. The newly developed surface coating method using gadolinium ions (Gd3+) resulted in nanoparticles (named pSiNPs-Gd) that exhibited T-1-type MR responses and high drug encapsulation efficacy. The nanoparticle characterization, MR signal, cytotoxicity, and drug release profile were systematically analyzed. These findings contribute to the development of multi-functional pSiNPs-based nanotherapeutics and their applications in various fields.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Chemistry, Multidisciplinary
Yen-Lan Chang, Pei-Bang Liao, Ping-Han Wu, Wei-Jen Chang, Sheng-Yang Lee, Haw-Ming Huang
Summary: The low-molecular-weight hyaluronic acid-conjugated superparamagnetic iron oxide nanoparticles synthesized in this study exhibited selective cytotoxicity toward cancer cells and had no cytotoxic effects on normal fibroblast cells. These nanoparticles have the potential to be used as both a candidate for magnetic resonance imaging applications and an injectable anticancer agent.
Article
Chemistry, Medicinal
Marzena Wyskocka-Gajda, Lukasz Przypis, Monika Olesiejuk, Tomasz Krawczyk, Anna Kuznik, Krzysztof Nawara, Masafumi Minoshima, Fuminori Sugihara, Kazuya Kikuchi, Nikodem Kuznik
Summary: Investigation into iron(III) chelates with N,O-aminophenol showed high versatility and tuning potential, with functionalization with galactose providing a bioresponsive character sensitive to enzyme activity. The resulting complexes exhibited extremely high relaxivity and could change relaxivity by over 80% through enzymatic hydrolysis. MRI and cytotoxicity studies confirmed the bioresponsive character and good biocompatibility of these iron-based chelates.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chi-Feng Chiang, Yuan-Hung Hsu, Wen-Yuan Hsieh, Tzu-Hsin Liao, Chih-Lung Chen, Yung-Chu Chen, Po-Chin Liang, Shian-Jy Wang
Summary: This study evaluated the safety and clinical validity of IOP Injection as an MRI contrast agent in diagnosing hepatocellular carcinoma (HCC). It was found that IOP-enhanced MRI had a sensitivity of 100% for detecting HCC, and it could also visualize subtle vascular invasion.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Materials Science, Multidisciplinary
F. Antao, M. Dias, J. B. Correia, A. Galatanu, M. Galatanu, U. V. Mardolcar, A. Myakush, M. M. Cruz, A. Casaca, R. C. da Silva, E. Alves
Summary: The CuCrFeTiV high entropy alloy was synthesized through mechanical alloying and spark plasma sintering, and its properties were analyzed using various techniques. The alloy exhibited favorable magnetic properties, thermal performance, and potential for thermal barrier applications.
MATERIALS SCIENCE AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Veronica Vighetto, Luisa Racca, Marta Canta, Joana C. Matos, Bianca Dumontel, Maria Clara Goncalves, Valentina Cauda
Summary: Nanomedicine is an emerging treatment approach for cancer, utilizing smart nanoparticles with high sensitivity and selectivity to reduce toxic effects of conventional chemotherapy, where amorphous-titania propyl-amine functionalized nanoparticles coated with bovine serum albumin are stimulated by high energy shock waves to induce cytotoxic effects in cancer cells.
Article
Materials Science, Ceramics
H. Jalili, B. Aslibeiki, A. Hajalilou, O. Musalu, L. P. Ferreira, M. M. Cruz
Summary: Recent studies have demonstrated the importance of the chemical composition and shape of magnetic nanoparticles in determining their properties. In this study, we synthesized cube-like nanoparticles and bimagnetic nanocomposites using an eco-friendly co-precipitation method. The nanocomposites exhibited good exchange-coupling interaction between the hard and soft magnetic phases, resulting in enhanced saturation magnetization. These materials showed promise for use in magnetic hyperthermia.
CERAMICS INTERNATIONAL
(2022)
Article
Materials Science, Multidisciplinary
A. Hajalilou, L. P. Ferreira, M. E. Melo Jorge, C. P. Reis, M. M. Cruz
Summary: The study explored the potential of Ag-Fe3O4 composite nanoparticles and their ferrofluids for hyperthermia applications, revealing their high potential for destroying malignant tumor cells through synthesis, characterization, and evaluation of heating performance.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2021)
Article
Food Science & Technology
Aline C. Giardini, Bianca G. Evangelista, Morena B. Sant'Anna, Barbara B. Martins, Carmen L. P. Lancellotti, Adriano P. Ciena, Marucia Chacur, Rosana L. Pagano, Orlando G. Ribeiro, Vanessa O. Zambelli, Gisele Picolo
Summary: The study indicates that Crotalphine (CRO) may have beneficial effects on multiple sclerosis (MS) by inhibiting neuroinflammation and improving symptoms to control disease progression.
Article
Chemistry, Multidisciplinary
Joana Goncalves, Claudia Nunes, Liliana Ferreira, Maria Margarida Cruz, Helena Oliveira, Veronica Bastos, Alvaro Mayoral, Qing Zhang, Paula Ferreira
Summary: Fucoidan-coated magnetite nanoparticles exhibit great potential for magnetic hyperthermia therapy, showing high specific loss power and intrinsic loss power values while maintaining biocompatibility, meeting the required criteria for MHT application.
Article
Biochemistry & Molecular Biology
Barbara B. Martins, Natalia G. Hosch, Queren A. Alcantara, Grant R. Budas, Che-Hong Chen, Daria Mochly-Rosen, Julio C. B. Ferreira, Vanessa O. Zambelli
Summary: The activation of the PKC epsilon-ALDH2 axis plays a crucial role in mitigating aldehyde-mediated pain in rodents, with potential implications for pain management in patients. Selective activation of this axis could provide a novel treatment approach for pain relief.
Article
Biochemistry & Molecular Biology
Adriana Janeca, Flavia S. C. Rodrigues, Maria Clara Goncalves, Monica Faria
Summary: A novel cellulose acetate-based monophasic hybrid skinned amine-functionalized membrane was synthesized, characterized, and evaluated for its permeation properties, showing excellent permeability and rejection selectivity towards various solutes such as urea, creatinine, and uric acid while retaining albumin.
Article
Chemistry, Multidisciplinary
Liliana P. Ferreira, Cesar P. Reis, Tiago T. Robalo, M. E. Melo Jorge, Paula Ferreira, Joana Goncalves, Abdollah Hajalilou, Maria Margarida Cruz
Summary: Magnetite nanoparticles were synthesized using gelatin, agar-agar, or pectin as additives, achieving a higher reproducibility of the particle morphology and magnetic characteristics.
Article
Materials Science, Multidisciplinary
Roya Kavkhani, Abdollah Hajalilou, Ebrahim Abouzari-Lotf, Liliana P. Ferreira, Maria Margarida Cruz, Mostafa Yusefi, Elahe Parvini, Alireza Bali Ogholbeyg, Umi Nabilah Ismail
Summary: Magnetic fluid hyperthermia (MFH) is a promising cancer therapeutic approach that can be used in conjunction with other treatment methods. It is important to find innovative materials with a higher specific absorption rate (SAR) to further reduce the dose of magnetic nanoparticles in tumor treatment through MFH, while being suitable for MRI as well.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Fahimeh Zare, Adriana Janeca, Seyyed M. Jokar, Monica Faria, Maria Clara Goncalves
Summary: Chronic kidney disease (CKD) is a serious threat to public health, especially in the US where the number of end-stage kidney disease (ESKD) patients has increased significantly. Protein-bound uremic toxins (PBUTs) are not effectively removed by traditional haemodialysis (HD), leading to their accumulation and worsening of patients' conditions. Various techniques have been proposed to improve the removal of PBUTs, with binding competition showing promising potential.
Article
Materials Science, Ceramics
B. Aslibeiki, N. Eskandarzadeh, H. Jalili, A. Ghotbi Varzaneh, P. Kameli, I. Orue, V. Chernenko, A. Hajalilou, L. P. Ferreira, M. M. Cruz
Summary: In this study, CoFe(2)O(4) magnetic nanoparticles (MNPs) were successfully synthesized by an eco-friendly method, and the effect of Triethylene glycol (TEG) coating on their structural, magnetic, and magnetothermal properties was investigated. The results showed that TEG coating can increase the saturation magnetization and heating efficiency of the nanoparticles.
CERAMICS INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Goncalo A. Marcelo, Joana Galhano, Tiago T. Robalo, Maria Margarida Cruz, Maria D. Marcos, Ramon Martinez-Manez, Maria Paula Duarte, Jose Luis Capelo-Martinez, Carlos Lodeiro, Elisabete Oliveira
Summary: In this study, a biocompatible, antimicrobial magneto-fluorescent nanosystem (NANO3) was developed for the delivery of a dual doxorubicin-ofloxacin formulation against cancer-related bacterial infections. The mesoporous silica matrix of NANO3 allows for high drug loading capacity and stimuli-driven release, with preference for tumor-like acidic media. Hyperthermia induces heat generation and doubles drug release, resulting in significant antimicrobial activity. NANO3 shows potential as a future dual anticancer and antimicrobial therapeutic vector due to its drug loading capacity and surface availability for further modification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
J. Wells, D. Ortega, U. Steinhoff, S. Dutz, E. Garaio, O. Sandre, E. Natividad, M. M. Cruz, F. Brero, P. Southern, Q. A. Pankhurst, S. Spassov
Summary: The study highlights the current lack of harmonization in the characterization of MNPs in MFH, indicating a need for standardized and quantitative characterization techniques to address uncertainties and improve measurement accuracy.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2021)
Article
Chemistry, Multidisciplinary
Nur Hanisah AbuTalib, Alec P. LaGrow, Maximilian O. Besenhard, Oleksandr Bondarchuk, Andreas Sergides, Simone Famiani, Liliana P. Ferreira, M. Margarida Cruz, Asterios Gavriilidis, Nguyen Thi Kim Thanh
Summary: This study focuses on the synthesis of iron oxide nanoparticles based on iron(m) acetylacetonate decomposition in organic solvents, leading to anisotropic IONPs. The effects of varying amounts of oleylamine and a nitrogen purge on particle morphology were fully explored. The study revealed the crucial role of oleylamine in tuning particle size and the importance of nitrogen gas purge in forming branched and multiply branched NPs.
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
