Article
Biochemistry & Molecular Biology
Killian Flegeau, Jing Jing, Romain Brusini, Melanie Gallet, Capucine Moreno, Lee Walker, Francois Bourdon, Jimmy Faivre
Summary: In this study, a novel rheological procedure was used to evaluate the degradation kinetics of TEOSYAL RHA((R)) filler in contact with HAase. Mathematical analyses were developed to determine the optimal time between injections and number of enzymatic units for maximizing degradation kinetics.
Article
Polymer Science
Eva Daminato, Giulio Bianchini, Valerio Causin
Summary: This study aims to develop a novel technology for manufacturing high-performance HA-based fillers with minimal amounts of crosslinking agents. The newly developed fillers, functionalized with different amounts of BDDE and formulated with CTL, showed comparable resistance against hyaluronidase, swelling, and cohesivity to commercial products. However, they demonstrated excellent elasticity and higher compression resistance, making them very promising for their lifting effect.
Article
Surgery
Shirin Hamed-Azzam, Cat Burkat, Abed Mukari, Daniel Briscoe, Narish Joshi, Richard Scawn, Eran Alon, Morris Hartstein
Summary: This study reports a series of cases where dermal filler injected into the face migrated to the orbit, leading to orbital complications. Treatment methods and possible mechanisms of this complication are discussed. Patients may present with orbital symptoms, but the distance between the injection site and the complication site could lead to delays in diagnosis.
AESTHETIC SURGERY JOURNAL
(2021)
Article
Polymer Science
Daniel Cassuto, Clara Cigni, Gilberto Bellia, Chiara Schiraldi, Mohsen Akbari
Summary: The efficacy of a new medical device for adipose tissue restoration in the face was evaluated through a case series study. The device utilized patented NAHYCO((R)) Hybrid Technology to deliver a specific combination of high-molecular-weight and low-molecular-weight hyaluronan. Results showed immediate increase in soft tissue thickness, with continued improvement over a 6-month follow-up period.
Article
Biochemistry & Molecular Biology
Bo Min Hong, Geum Lan Hong, Min A. Gwak, Kyung Hyun Kim, Jae Eun Jeong, Ju Young Jung, Su A. Park, Won Ho Park
Summary: The new HA-DA hydrogel filler has excellent mechanical properties, biocompatibility, injectability, and can stably adhere to the injection site, potentially overcoming the limitations of commercial fillers.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Alexandre Porcello, Paula Gonzalez-Fernandez, Olivier Jordan, Eric Allemann
Summary: This study proposes the use of thermoresponsive nanoforming hyaluronic acid derivatives for the treatment of osteoarthritis pain through injection in the joints. By adding specific chemicals, the residence time of the hydrogel in the body can be prolonged and it exhibits improved resistance to degradation and optimal viscoelastic properties. The results demonstrate the significant potential of these engineered hyaluronic acid derivatives as next-generation long-acting viscosupplementation products for osteoarthritic patients.
Review
Biochemistry & Molecular Biology
Salvatore Piero Fundaro, Giovanni Salti, Dennis Malvin Hernandez Malgapo, Silvia Innocenti
Summary: This review describes the rheological properties of hyaluronic acid (HA) fillers, aiming to help clinicians understand their characteristics and their likely correlation with clinical outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Surgery
Hyung Min Hahn, Woo Beom Lee, Il Jae Lee
Summary: The new biphasic filler G-filler has improved rheologic properties that effectively stimulate extracellular matrix production and angiogenesis without safety concerns.
AESTHETIC PLASTIC SURGERY
(2021)
Review
Multidisciplinary Sciences
Siew-Li Goh, Zulkarnain Jaafar, Yan-Nee Gan, Alston Choong, Jaspreet Kaur, Burak Kundakci, Samihah Abdul Karim, Muhammad Rahmani Jaffar, Mohamad Shariff A. Hamid
Summary: This network meta-analysis compared prolotherapy with other injection therapies for chronic soft tissue injuries, finding that prolotherapy did not show statistically significant pain benefits over other therapies, but consistently had better effects on function compared to non-injections and corticosteroid injections.
Article
Dermatology
Uwe Wollina, Alberto Goldman
Summary: This retrospective study evaluated the use of monophasic hyaluronic acid in treating tear trough deformities in 45 Caucasian female patients, with significant improvements observed in the majority of patients lasting for a considerable duration without severe adverse events.
DERMATOLOGIC THERAPY
(2021)
Article
Chemistry, Applied
Pu Qiao, Kaiyuan Shi, Yanlong Wang, Bo Li, Lei Su, Ke Zhang, Katsuyoshi Nishinari, Guoqiang Yang
Summary: For the first time, a rapid and effective method for gel formation from hyaluronic acid (HA) using dynamic pressure has been demonstrated. The hydrogels prepared through the alternate compression-decompression procedure exhibit a layered structure and high yield. Compared to conventional freeze-thawed hydrogels, these gels have enhanced intermolecular interaction and improved mechanical properties. This method is fast, simple, and safe, providing new ideas for obtaining physical gels and contributing to the development of HA-based materials in biomedical and agricultural applications.
FOOD HYDROCOLLOIDS
(2023)
Article
Polymer Science
Xue-Bin Ma, Rong Yang, Kanaparedu P. C. Sekhar, Bo Chi
Summary: Injectable hydrogels with step-by-step tunable crosslinking degree were prepared using a dual crosslinking strategy in this study, showing good biocompatibility and mechanical properties. These hydrogels have great potential in soft tissue engineering.
CHINESE JOURNAL OF POLYMER SCIENCE
(2021)
Article
Surgery
Jasmine Seror, Miriam Stern, Revital Zarka, Nadav Orr
Summary: Recombinant human type I collagen, which is structurally and functionally identical to human type I collagen, has been successfully expressed and extracted from genetically modified tobacco plants. Unlike tissue-extracted protein, rhCollagen is non-immunogenic and non-allergenic, with an intact triple helix structure displaying superior biological functionality. A photocurable rhCollagen has been developed through chemical modification, allowing cross-linking under illumination at various wavelengths while maintaining its structural and biological functions. The potential applications of this photocurable rhCollagen in aesthetic medicine, particularly as a dermal filler and a bioink for 3D-printed breast implants, are discussed.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Article
Surgery
Leonie W. Schelke, Peter J. Velthuis, Tom Decates, Jonathan Kadouch, Michael Alfertshofer, Konstantin Frank, Sebastian Cotofana
Summary: This study compared the ultrasound-guided targeted and flooding protocols for managing adverse vascular events following hyaluronic acid-based aesthetic injections. The results showed that the ultrasound-guided targeted protocol utilized less hyaluronidase and restored clinical symptoms faster.
AESTHETIC SURGERY JOURNAL
(2023)
Review
Dermatology
Ploymanee Wongprasert, Cecile A. Dreiss, Gillian Murray
Summary: Soft-tissue augmentation using hyaluronic acid-based dermal fillers is a popular non-surgical treatment for restoring volume loss and filling fine lines. This article reviews the methods and parameters used to characterize dermal fillers, providing a useful guide for clinicians and injectors in selecting the optimal product for each patient.
DERMATOLOGIC THERAPY
(2022)
Article
Instruments & Instrumentation
Tommaso Iannitti, Michael F. McDermott, Carmen Laurino, Andrea Malagoli, Beniamino Palmieri
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2017)
Article
Instruments & Instrumentation
Tommaso Iannitti, Julio Cesar Morales-Medina, Alberto Merighi, Valentina Boarino, Carmen Laurino, Maria Vadala, Beniamino Palmieri
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2018)
Article
Oncology
Luca Imperatori, Damiano Giardini, Gino Latini, Giuseppe Migliori, Claudio Blasi, Feisal Bunkheila, Cesare Breschi, Rodolfo Mattioli, Silvia Pelliccioni, Carmen Laurino, Maria Vadala, Beniamino Palmieri, Tommaso Iannitti
CANCER MANAGEMENT AND RESEARCH
(2018)
Article
Chemistry, Medicinal
Julio C. Morales-Medina, Gonzalo Flores, Annamaria Vallelunga, Natalie H. Griffiths, Tommaso Iannitti
DRUG DEVELOPMENT RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Annamaria Vallelunga, Tommaso Iannitti, Giovanna Dati, Sabrina Capece, Marco Maugeri, Ersilia Tocci, Marina Picillo, Giampiero Volpe, Autilia Cozzolino, Massimo Squillante, Giulio Cicarelli, Paolo Barone, Maria Teresa Pellecchia
MOLECULAR BIOLOGY REPORTS
(2019)
Article
Food Science & Technology
Tommaso Iannitti, Alessandro Di Cerbo, Anna Rita Loschi, Stefano Rea, Michiko Suzawa, Julio Cesar Morales-Medina
FOOD SCIENCE & NUTRITION
(2020)
Article
Medicine, General & Internal
Beniamino Palmieri, Tommaso Iannitti, Julio Cesar Morales-Medina, Maria Vadala
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2020)
Article
Neurosciences
Gonzalo Flores, Gabriel Daniel Flores-Gomez, Alfonso Diaz, Julio Cesar Penagos-Corzo, Tommaso Iannitti, Julio Cesar Morales-Medina
Summary: Aging is a complex process that can lead to neurodegenerative diseases and cognitive deficits. Understanding neural changes is critical for designing new therapies targeting aging and associated pathologies.
Review
Environmental Sciences
Beniamino Palmieri, Veronica Corazzari, Maria Vadala, Annamaria Vallelunga, Julio Cesar Morales-Medina, Tommaso Iannitti
Summary: Multiple chemical sensitivity (MCS) is characterized by non-specific and recurring symptoms affecting multiple organs, with chemical intolerance being a key distinguishing feature. Current diagnosis relies on clinical symptoms as there are no specific diagnostic markers available, and more definite treatment strategies are required. Research on the pathophysiology of MCS, particularly focusing on brain networks, environmental pollution, and correlation with other pathologies, is ongoing to better understand and develop treatment strategies.
REVIEWS ON ENVIRONMENTAL HEALTH
(2021)
Article
Medicine, General & Internal
Alfredo Di Cerbo, Nazario Quagliano, Antonella Napolitano, Federica Pezzuto, Tommaso Iannitti, Alessandro Di Cerbo
Summary: The study compared two methods for measuring serum TSH levels, finding a strong correlation and meeting clinical standards. It was found that using the FastPack (R) IP method allows for quick, accurate, and reproducible measurement of TSH levels.
Article
Biochemistry & Molecular Biology
Julio Cesar Morales-Medina, Nicola Pugliese, Alessandro Di Cerbo, Claudia Zizzadoro, Tommaso Iannitti
Summary: Studies in mice have shown that constitutive activation of endogenous opioid signaling leads to both endogenous analgesia and opioid dependence. This study aimed to determine if a similar pattern exists in rats. Rats with chronic inflammatory pain were treated with different doses of the opioid receptor inverse agonist naltrexone (NTX) and monitored for withdrawal behaviors. The response to NTX in the rat model was different from the mouse model, suggesting species-related differences in pharmacological response and highlighting the importance of species selection in preclinical pain research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Beniamino Palmieri, Maria Vadala, Simone Ugo Urso, Laura Ornella Baldini, Caterina Fanelli, Julio Cesar Morales-Medina, Tommaso Iannitti
Summary: This study evaluated the efficacy of sclerofoam-assisted laser treatment combined with nutraceutical administration for the treatment of chronic venous insufficiency. The results showed promising outcomes in improving symptoms and patient conditions.
LASERS IN MEDICAL SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Laurino Carmen, Vadala' Maria, Julio Cesar Morales-Medina, Annamaria Vallelunga, Beniamino Palmieri, Tommaso Iannitti
Article
Medicine, General & Internal
Annamaria Vallelunga, Carmine Berlingieri, Marco Ragusa, Michele Purrello, Maria Rosaria Stabile, Maria Consiglia Calabrese, Julio Cesar Morales-Medina, Beniamino Palmieri, Tommaso Iannitti
CLINICAL CASE REPORTS
(2017)
Article
Cell Biology
Saul Herranz-Martin, Jayanth Chandran, Katherine Lewis, Padraig Mulcahy, Adrian Higginbottom, Callum Walker, Isabel Martinez-Pena y Valenzuela, Ross A. Jones, Ian Coldicott, Tommaso Iannitti, Mohammed Akaaboune, Sherif F. El-Khamisy, Thomas H. Gillingwater, Pamela J. Shaw, Mimoun Azzouz
DISEASE MODELS & MECHANISMS
(2017)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
