期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 441, 期 1-2, 页码 555-561出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2012.10.045
关键词
Chitosan; Sodium alginate; Silica network; Eukaryotic cell; Prokaryotic cell; Biocomposite
资金
- National University Research Council in Romania [154/2011]
- [PN-II-PT-PCCA-2011-3.2-0284]
This work is focused on the fabrication of a new drug delivery system based on polyanionic matrix (e. g. sodium alginate), polycationic matrix (e. g. chitosan) and silica network. The FT-IR, SEM, DTA-TG, eukaryotic cell cycle and viability, and in vitro assay of the influence of the biocomposite on the efficacy of antibiotic drugs were investigated. The obtained results demonstrated the biocompatibility and the ability of the fabricated biocomposite to maintain or improve the efficacy of the following antibiotics: piperacillin-tazobactam, cefepime, piperacillin, imipenem, gentamicin, ceftazidime against Pseudomonas aeruginosa ATCC 27853 and cefazolin, cefaclor, cefuroxime, ceftriaxone, cefoxitin, trimethoprim/sulfamethoxazole against Escherichia coli ATCC 25922 reference strains. (C) 2012 Elsevier B. V. All rights reserved.
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