Article
Chemistry, Multidisciplinary
Divya Chauhan, Neha Singh, Shagufta Afreen, Neetu Talreja, Mohammad Ashfaq, Nalini Sankararamakrishnan, Ganga Ram Chaudhary
Summary: The study focuses on the synthesis of thermo-responsive polymeric membranes for oil/water separation based on cellulose acetate (CA) and poly(N-isopropyl acrylamide) (PNIPAM) through electrospinning, with the hydrophilicity/hydrophobicity easily tuned by adjusting the PNIPAM content in the membrane.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Polymer Science
Tingyu He, Yanqiu Wang, Atsushi Narumi, Liang Xu, Shin-ichiro Sato, Xiande Shen, Toyoji Kakuchi
Summary: This paper presents a comprehensive study on the thermoresponsive properties of statistic copolymers and multiblock copolymers synthesized with different copolymerization methods. It was found that the disorder of copolymers plays a decisive role in phase-transition behavior, with some copolymers exhibiting a two-stage phase transition in water.
Article
Agriculture, Multidisciplinary
Feihu Bi, Deshui Yu, Zengming Wei, Hanchen Wei, Hui Ren, Yulong Wang, Dalong Ren, Zan Hua, Bo Huang, Guang Yang
Summary: Transgenic RNA interference (RNAi) is a promising approach to manage plant diseases and insect pests. Nonviral nanostructured dsRNA carriers have potential for RNAi application, but targeted and effective release into pest cells remains a challenge for practical use.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biophysics
Nikolaos Naziris, Natassa Pippa, Athanasios Skandalis, Katarzyna Milowska, L. Lucja Balcerzak, Stergios Pispas, Maria Bryszewska, Costas Demetzos
Summary: The study introduces a novel thermoresponsive chimeric nanocarrier, combining phospholipids and block copolymers, with multifunctionality and stability. By constructing model lipid bilayers and developing nanoparticles, the functionality of the system under elevated temperature conditions was demonstrated. In vitro experiments suggest the biocompatibility of these nanosystems, promising for future research and application.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biochemical Research Methods
Zhe Zhang, Huaiqing Chen, Liang Fang, Huawei He, Chengde Mao, Hua Zuo
Summary: This study reports a simple and efficient solution-phase synthesis method to conjugate hydrophobic molecules to DNAs. The resulting amphiphilic DNAs can spontaneously assemble into nanomicelles, which may serve as nanocarriers for cellular delivery of nucleic acids and water-insoluble drugs.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Polymer Science
Naoki Ozawa, Ji Ha Lee, Isamu Akiba, Tomoki Nishimura
Summary: Polymer architecture has a significant influence on the morphology of polymer self-assemblies. However, there is limited understanding of how changes in macromolecular architecture affect the structures of self-assemblies and the conformation of polymer chains within them. In this study, we examined the self-assembly behavior of four different amphiphilic copolymers with varying chain configurations. We found that changes in macromolecular architecture can result in the formation of different nanostructures, and the conformation of polymer chains within the self-assemblies also varies.
Article
Polymer Science
Yeseong Seo, So Yeong Park, Jaeyong Lee, Jin Kon Kim, Chao Duan, Weihua Li
Summary: The morphology formed in a binary blend of two different copolymers can vary depending on the molecular weights and volume fractions, with cylindrical microdomains forming when there is a significant difference in molecular weights and a lamellar morphology observed when the molecular weights are closer. This study also found interesting inverted cylinders formed in certain conditions, with the stability of these structures attributed to factors such as domain swelling and radial distribution of polymer blocks. Self-consistent field theory (SCFT) was used to verify experimental results.
Article
Polymer Science
Yeseong Seo, Dokyung Woo, Luyang Li, Weihua Li, Jin Kon Kim
Summary: The phase behavior of polystyrene-(polystyrene-b-poly(2-vinylpyridine))(3) miktoarm star copolymer was investigated, with the volume fraction of the PS block (f(PS)) and the chain asymmetry of the PS chain (t) found to significantly influence the phase behavior. Different f(PS) and t values resulted in the formation of distinct structures, consistent with theoretical predictions.
Article
Materials Science, Multidisciplinary
Jeong-Min Park, Min-Ho Choi, Eunseo Lee, Sang-Min Lee
Summary: This study presents Cu-chelated hybrid polyionic complex (HPIC) core/shell-type nanostructures with thermoresponsive catalytic activity for Cu-catalyzed Fenton-like reactions. The incorporation of NiPAAm allows for temperature-sensitive control of catalytic activity, while pPEGMA enables reversible flocculation of nanocatalysts for facile recycling without significant loss of catalytic activity. These results demonstrate the potential of metal-chelated HPIC nanostructures as smart materials for catalytic nanoplatforms.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Polymer Science
Arman Moini Jazani, Chaitra Shetty, Hourieh Movasat, Kamaljeet Kaur Bawa, Jung Kwon Oh
Summary: The acid-degradable polymeric nanoassemblies labeled with acetaldehyde acetal groups in both hydrophobic cores and at core/corona interfaces exhibit synergistic response to acidic pH at dual locations, which induces rapid drug release.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Jessica Bassi da Silva, Peter Haddow, Marcos Luciano Bruschi, Michael Thomas Cook
Summary: This article investigates graft copolymers with brush-like architectures containing thermoresponsive monomers. The study explores the chemical structure of the thermoresponsive polymer and its impact on phase behavior and rheological properties. The materials show potential for temperature-responsive applications in the field of medical materials.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Polymer Science
Lauren E. E. Ball, Gabriela Garbonova, Rueben Pfukwa, Bert Klumperman
Summary: Responsive triblock copolymers were synthesized and studied for their potential use in drug delivery systems in biomedical research.
Article
Polymer Science
Albert Prause, Michelle Hechenbichler, Robert F. Schmidt, Miriam Simon, Sylvain Prevost, Leide P. Cavalcanti, Yeshayahu Talmon, Andre Laschewsky, Michael Gradzielski
Summary: Temperature control of rheological properties of aqueous solutions can be achieved by the addition of temperature-responsive amphiphilic polymers. In this study, three sets of acrylamide-based block copolymers with different architectures were explored, and their viscosities showed a substantial increase with increasing temperature. The changes in rheological properties were correlated with the mesoscopic organization of the systems.
Article
Biochemical Research Methods
Nicole I. Halaszynski, Jeffery G. Saven, Darrin J. Pochan, Christopher J. Kloxin
Summary: Alkyl halide side groups are selectively incorporated into monodispersed, computationally designed coiled-coil-forming peptide nanoparticles. Well-defined, thermoresponsive star copolymer architectures are synthesized by polymerizing Poly-[2-(dimethylamino)-ethyl methacrylate] (PDMAEMA) from the coiled-coil periphery using photoinitiated atom transfer radical polymerization (photoATRP). This facile synthetic route can be readily extended to other monomers for a range of new complex star-polymer macromolecules.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Koji Okuno, Takuya Arisawa, Yuri Kamon, Akihito Hashidzume, Francoise M. Winnik
Summary: Thermoresponsive water-soluble polymers with different amide side chains were synthesized and found to have varying solubility, with secondary amide side chains leading to insoluble polymers and tertiary amide side chains resulting in soluble polymers.
Review
Hematology
Hanieh Kolahi Azar, Aylar Imanpour, Hanieh Rezaee, Fatemeh Ezzatifar, Zeinab Zarei-Behjani, Mohammadreza Rostami, Mahmoud Azami, Nima Behestizadeh, Nima Rezaei
Summary: This article discusses the importance of two core elements, mesenchymal stromal cells (MSCs) and chimeric antigen receptor (CAR)-T cells, in cell therapy procedures. It analyzes multiple parameters that affect cell homing and the impact of several chemokines in the tumor microenvironment on the homing process. Emerging comprehensive mechanistic strategies and their significant role in cell therapy remodeling are reviewed, and the development of combination therapies incorporating MSCs and CAR-T cells for cancer treatment is discussed.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2023)
Article
Immunology
Niloufar Yazdanpanah, Arezou Rezaei, Vahid Ziaee, Nima Rezaei
Summary: Juvenile systemic lupus erythematosus (JSLE) is a complex disorder with unclear causes. Environmental factors, genetic factors, and immune system dysregulation are believed to play a role in JSLE etiology. The NLRP3 inflammasome, an important mediator of inflammation, is thought to be involved in JSLE etiology. This study found that the CT genotype of the NLRP3 rs3806265 gene was more common in patients with JSLE compared to healthy controls.
IMMUNOLOGICAL INVESTIGATIONS
(2023)
Review
Immunology
Maryam Noori, Farimah Fayyaz, Nima Rezaei
Summary: In this systematic review and meta-analysis, the authors found that Helicobacter pylori infection reduces the efficacy of immune checkpoint inhibitors in patients with cancer. The infection is associated with reduced overall survival, progression-free survival, and increased rate of disease progression. These findings suggest that H. pylori infection status could serve as a potential biomarker for predicting the effectiveness of immune checkpoint inhibitors.
Review
Immunology
Gita Manzari Tavakoli, Mohammad Hossein Mirzapour, Sepideh Razi, Nima Rezaei
Summary: Melanoma, the most aggressive form of skin cancer, has been extensively studied for the development of efficient treatments. Surgical resection, targeted therapies, and immune checkpoint inhibitors are the best approaches for treating early and advanced/metastatic melanoma. Ferroptosis, an iron-dependent cell death pathway, and its inducers have shown potential in overcoming resistance to conventional therapies in advanced/metastatic melanoma. This review discusses the mechanisms of ferroptosis, its environmental triggers, and its implications for the treatment of melanoma.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Immunology
Mahsa Bagherzadeh-Fard, Mohammad Amin Yazdanifar, Mona Sadeghalvad, Nima Rezaei
Summary: Objective: The objective of this systematic review is to demonstrate the effectiveness of Erenumab in preventing episodic and chronic migraines, which is still being researched. Background: Migraine is a chronic neurovascular disorder that causes disability and societal burden. Existing medications for migraine prevention often have undesirable side effects and limited efficacy. Erenumab, a monoclonal antibody targeting calcitonin gene-related peptide receptors, has recently been approved by the FDA for migraine prevention. Methods: A systematic review was conducted using Scopus and PubMed databases, searching for articles from 2016 to March 18, 2022, with keywords Erenumab or AMG 334 and migraine. Results: Out of 605 papers, 53 were eligible for investigation. Erenumab at dosages of 70 mg and 140 mg showed a reduction in monthly migraine days and acute migraine-specific medication days. It also demonstrated high rates of reduction in monthly migraine days from the baseline in different regions. Erenumab was effective from the first week of administration and throughout the treatment period. It also showed efficacy in treating migraines with allodynia, aura, prior preventive therapy failure, medication overuse headache, and menstrual migraine. Combination therapy with other preventive drugs, such as Onabotulinumtoxin-A, yielded favorable outcomes. Conclusion: Erenumab exhibited remarkable efficacy in both short-term and long-term treatment of episodic and chronic migraines, especially in patients with difficult-to-treat migraine headaches.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Immunology
Soren Nooraei, Alireza Sarkar Lotfabadi, Milad Akbarzadehmoallemkolaei, Nima Rezaei
Summary: Vaccination is the most effective method for preventing and reducing the impact of infectious diseases in animals and humans. Adjuvants are substances that enhance the immune response and can improve the body's immune reactions. Nanoparticles have shown promise as more effective adjuvants due to their ability to target antigen-presenting cells and easily cross biological barriers.
Article
Allergy
Negar Moradian, Samaneh Zoghi, Elham Rayzan, Simin Seyedpour, Raul Jimenez Heredia, Kaan Boztug, Nima Rezaei
Summary: This article reports a male patient with SCN4 caused by G6PC3 gene deficiency, manifested as recurrent bacterial infections and multi-systemic complications, and showed rare large platelets on peripheral blood smear. The authors recommend considering G6PC3 gene mutation in cases of congenital, unexplained neutropenia.
ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY
(2023)
Article
Allergy
Soodeh Ghadimi, Mahnaz Jamee, Hassan Abolhassani, Nima Parvaneh, Nima Rezaei, Samaneh Delavari, Mahnaz Sadeghi-Shabestari, Sedigheh Rafiei Tabatabaei, Alireza Fahimzad, Shahnaz Armin, Zahra Chavoshzadeh, Samin Sharafian
Summary: DCLRE1C gene mutation leads to severe combined immunodeficiency (SCID) with recurrent infections, impaired immune system development, and radiosensitivity. This study identified 9 Iranian patients with confirmed DCLRE1C mutation, most of whom were born in consanguineous families. The patients presented with early-onset respiratory tract infections, chronic diarrhea, and autoimmune disorders, along with reduced B cell and CD4+ cell counts and IgA deficiency.
ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY
(2023)
Review
Rheumatology
Parnian Shobeiri, Saba Maleki, Mobina Amanollahi, Amirhossein Habibzadeh, Antonio L. Teixeira, Nima Rezaei
Summary: This study aimed to investigate the blood BDNF levels in patients with SLE. The meta-analysis of 8 studies showed no significant differences in blood BDNF concentrations between SLE patients and healthy controls. Further high-quality studies are needed to explore the potential role and relevance of BDNF in SLE.
ADVANCES IN RHEUMATOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Mohammad Varzandeh, Leila Sabouri, Vahid Mansouri, Maliheh Gharibshahian, Nima Beheshtizadeh, Michael R. Hamblin, Nima Rezaei
Summary: Radiosensitizers are compounds or nanostructures that enhance the effectiveness of ionizing radiation in killing cells. They increase the susceptibility of cancer cells to radiation-induced killing while minimizing damage to healthy tissues. This review discusses various nano-radiosensitizers and their combinations with other cancer therapies, highlighting the benefits, drawbacks, challenges, and future prospects.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Review
Immunology
Fatemeh Mohammadi, Amirhossein Yadegar, Mahta Mardani, Aryan Ayati, Hassan Abolhassani, Nima Rezaei
Summary: Inborn errors of immunity (IEI) are a group of about 490 genetic disorders that result in abnormal functioning or development of immune system components. The literature has identified a wide range of manifestations related to IEI. Physicians face challenges in diagnosing and managing affected individuals due to overlapping signs and symptoms. The past decade has seen advancements in molecular diagnosis of IEI patients, which can be crucial for diagnostic algorithms, prognosis, and possible therapeutic interventions. However, there is a lack of appropriate guidelines for IEI diagnosis in different organs, leading to an increase in undiagnosed patients.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Review
Virology
Hanie Karimi, Vahid Mansouri, Nima Rezaei
Summary: This paper discusses the hypothesis of antibody transmission through the placenta and breast milk following SARS-CoV-2 infection or vaccination, while considering the potential harm and benefits to the fetus/infant.
Article
Allergy
Soroush Khojasteh-Kaffash, Peyvand Parhizkar Roudsari, Amir Ghaffari Jolfayi, Noosha Samieefar, Nima Rezaei
Summary: This study aims to investigate asthma exacerbation in children during the COVID-19 pandemic. According to the results, mild to moderate asthma is not associated with increased severity of COVID-19 or adverse outcomes. There has been a decrease in emergency visits, non-emergent visits, and asthmatic attacks during the pandemic, which can be attributed to reduced exposure to allergens, improved treatment compliance, and decreased risk of other respiratory viral infections. Based on available studies, COVID-19 vaccination is safe for children with asthma, and there is no conclusive evidence of asthma exacerbation after vaccination.
Review
Oncology
Ali Faegh, Aysan Moeinafshar, Nima Rezaei
Summary: Renal cell carcinoma is a rare type of cancer that can cause inferior vena cava (IVC) thrombosis and decrease the survival rate of patients. The standard treatment is radical nephrectomy and IVC thrombectomy, but it is a challenging surgery with many complications. This paper reviews new surgical methods and compares open, laparoscopic, and robotic approaches for IVC thrombectomy to determine the optimal surgical technique for different cases.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Review
Neurosciences
Ghazaleh Ghaffaripour Jahromi, Sepideh Razi, Nima Rezaei
Summary: This comprehensive review explores the pathophysiological models of depression and the relationship between NLRP3 inflammasome activation and depression. By adopting the inflammatory theory, the central role of NLRP3 inflammasome activation in depression is explained and supported by evidence from human studies and animal models. The activation of the inflammasome is not limited to the central nervous system, but extends to the gut and peripheral immune systems, affecting the balance of the microbiota-gut-brain axis.
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
