Article
Biochemistry & Molecular Biology
Xavier Llorente, Gerard Esteruelas, Lorena Bonilla, Mariana Garnica Agudelo, Ingrid Filgaira, Daniel Lopez-Ramajo, Ruoyi C. Gong, Concepcio Soler, Marta Espina, Maria Luisa Garcia, Joan Manils, Montserrat Pujol, Elena Sanchez-Lopez
Summary: Nanocarriers, including nanostructured lipid carriers (NLC), are highly effective for topical drug administration. Optimized NLCs loaded with the drug Riluzole (RLZ-NLCs) were developed as a potential treatment, featuring biodegradability, biocompatibility, and sustained drug release. RLZ-NLCs showed successful delivery of RLZ in a sustained manner, inhibition of keratinocyte cell proliferation, and non-angiogenic properties, making them a promising strategy for treating keratinocyte hyperproliferative conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biophysics
Maxius Gunawan, Veerakiet Boonkanokwong
Summary: Lipid nanoparticles have been used to enhance the delivery of antioxidants in the gastrointestinal tract, overcoming challenges such as low solubility and stability. These nanoparticles can improve the bioavailability and effectiveness of antioxidant compounds, making them valuable in nutraceutical formulations.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Pharmacology & Pharmacy
S. Moraes, A. Marinho, S. Lima, A. Granja, J. P. Araujo, S. Reis, C. T. Sousa, C. Nunes
Summary: This study developed folic acid conjugated nanostructured lipid carriers (NLCs) as an effective doxorubicin delivery method targeted to breast cancer cells, with enhanced cellular uptake and targeting potential. In vitro studies showed good release performance and storage stability of the NLCs, indicating the potential for oral administration and targeted doxorubicin delivery to breast cancer cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biophysics
Luisa Ribeiro Nicoleti, Leonardo Delello Di Filippo, Jonatas Lobato Duarte, Marcela Tavares Luiz, Rafael Miguel Sabio, Marlus Chorilli
Summary: Glioblastoma multiforme is a common and aggressive brain cancer, and current treatments face challenges. Kaempferol, a flavonoid, shows anti-tumor activity but has limited bioavailability. The use of nanostructured lipid carriers (NLC) can improve the delivery of lipophilic drugs, enhancing their therapeutic efficacy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Pharmacology & Pharmacy
Claudia Pina Costa, Joao Nuno Moreira, Jose Manuel Sousa Lobo, Ana Catarina Silva
Summary: The management of CNS disorders is challenging due to the need for drugs to cross the BBB and reach the brain. Using the intranasal route combined with lipid-based nanocarriers has shown promising results in targeting drugs to the brain. Although the exact mechanism remains unclear, these systems are more effective than other routes and are expected to be approved by regulatory authorities in the future.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Chemistry, Applied
Xin Shu, Liang Zhang, Wenyan Liao, Jinfang Liu, Like Mao, Fang Yuan, Yanxiang Gao
Summary: This study investigated the impacts of individual emulsifiers on the properties, stability, and digestion behavior of lutein-loaded nanostructured lipid carriers. The results showed that different emulsifiers have regulatory effects on the crystallization behavior of the carriers, and can improve the encapsulation efficiency and stability of lutein. Additionally, the individual emulsifiers and lutein endowed the carriers with excellent antioxidant capacity and optimal sustained release properties.
Article
Biochemical Research Methods
Eman Gomaa, Heba A. Fathi, Noura G. Eissa, Mahmoud Elsabahy
Summary: Construction of nanocarriers, such as NLCs, has great potential in drug delivery systems. NLCs, as a new generation of solid lipid nanoparticles, have higher drug loading efficiency compared to SLNs and offer advantages in terms of preparation and scalability.
Review
Biochemistry & Molecular Biology
Gustavo Henrique Rodrigues da Silva, Ludmilla David de Moura, Fabiola Vieira de Carvalho, Gabriela Geronimo, Talita Cesarim Mendonca, Fernando Freitas de Lima, Eneida de Paula
Summary: This study focused on NLC formulations for encapsulation of antineoplastic agents, with special emphasis on in vivo studies. NLC has emerged as a powerful DDS to improve the bioavailability, targeting, and efficacy of antineoplastics, while decreasing their toxic effects.
Article
Chemistry, Applied
Yayuan Xu, Xintian Li, Zhuqing Dai, Zhongyuan Zhang, Lei Feng, Meimei Nie, Chunquan Liu, Dajing Li, Min Zhang
Summary: In this study, lutein nanostructured lipid carriers (Lutein-NLCs) with different interface structures were constructed by combining whey protein isolate with surfactant Tween 80. The kinetics of lipid hydrolysis, mixed micelles formation, and lutein bioaccessibility were analyzed. The results indicated that S-Lutein-NLCs and C-Lutein-NLCs showed better resistance to bile salt displacement compared to D-Lutein-NLCs. S-Lutein-NLCs also had higher lutein bioaccessibility compared to D-Lutein-NLCs and C-Lutein-NLCs. The release of MAGs and FFAs significantly influenced the micellization of lutein and its bioaccessibility. D-LuteinNLCs and C-Lutein-NLCs exhibited a better sustained-release effect. Additionally, C-Lutein-NLCs exhibited a stronger inhibitory effect on lutein degradation with a higher lutein retention rate.
FOOD HYDROCOLLOIDS
(2023)
Article
Pharmacology & Pharmacy
Boontida Morakul, Varaporn Buraphacheep Junyaprasert, Krisada Sakchaisri, Veerawat Teeranachaideekul
Summary: The aim of this study was to improve the stability and anti-inflammatory activity of cannabidiol (CBD) for dermal delivery by encapsulating it in nanostructured lipid carriers (NLCs). CBD-NLCs were prepared using different oils and surfactants, and showed successful encapsulation with small particle sizes. The CBD-NLCs exhibited enhanced chemical stability and slower release of CBD, as well as reduced cytotoxicity and increased anti-inflammatory activity compared to the CBD extract alone.
Review
Microbiology
Victor Hugo Sousa Araujo, Leonardo Delello Di Filippo, Jonatas Lobado Duarte, Larissa Sposito, Bruna Almeida Furquim de Camargo, Patricia Bento da Silva, Marlus Chorilli
Summary: This study aimed to explore the potential of using solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for the treatment of cutaneous fungal infections. Research demonstrated that these nanosystems optimize the effectiveness of biomolecules and provide occlusion and hydration in the applied region.
CRITICAL REVIEWS IN MICROBIOLOGY
(2021)
Review
Chemistry, Medicinal
Viliana Gugleva, Velichka Andonova
Summary: The challenge faced by researchers in achieving sufficient ocular bioavailability is due to the complex structure of the eye and its protective physiological mechanisms. Low viscosity eye drops and short ocular residence time contribute to low drug concentration at the target site. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are being developed as drug delivery platforms to overcome these challenges and enhance ocular bioavailability. They are biocompatible, biodegradable, and can be sterilized and scaled-up. Surface modifications can prolong ocular residence time, enhance penetration, and improve performance.
Article
Pharmacology & Pharmacy
Lital Cohen, Yehuda G. Assaraf, Yoav D. Livney
Summary: Prostate cancer is a common cancer in older men and current treatments have limited efficacy. Researchers have developed targeted nanoparticles that can deliver drugs effectively and reduce toxic side effects.
Review
Pharmacology & Pharmacy
Julia German-Cortes, Mireia Vilar-Hernandez, Diana Rafael, Ibane Abasolo, Fernanda Andrade
Summary: Nanotechnology has made significant contributions to cancer treatment by improving the effectiveness and specificity of chemotherapy through the use of nanoparticles, particularly solid lipid nanoparticles (SLNs). SLNs offer higher stability, active targeting, sustained and controlled release, and multifunctional therapy, making them an ideal drug delivery system.
Article
Nanoscience & Nanotechnology
Lorena Bonilla-Vidal, Marta Switalska, Marta Espina, Joanna Wietrzyk, Maria Luisa Garcia, Eliana B. Souto, Anna Gliszczynska, Elena Sanchez Lopez
Summary: APG-NLC containing rosehip oil was developed, which exhibited favorable physicochemical characteristics, long-term stability, sustained release of APG, and cytotoxicity in cancer cells without affecting healthy cells.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)