Article
Pharmacology & Pharmacy
Cassiele T. Cesco, Artur J. M. Valente, Alexandre T. Paulino
Summary: Chitosan/DNA blend hydrogel and chitosan/pectin blend hydrogel were synthesized for releasing methylene blue, and characterized by various techniques. The study revealed that the methylene blue loading had different impacts on the hydrogels, with higher release rates observed in simulated gastric fluid. The release kinetics of methylene blue in the hydrogels followed a pseudo-second-order mechanism.
Article
Materials Science, Multidisciplinary
T. Nalini, S. Khaleel Basha, A. Mohamed Sadiq, V. Sugantha Kumari
Summary: This study explored the fabrication of pectin/chitosan nanoparticle beads as a nanocarrier for hydrophobic quercetin. The beads showed high encapsulation efficiency and loading capacity, and were capable of sustained release of the drug. The presence of pectin in the formulation improved the mechanical resistance and antibacterial properties of the beads. Encapsulation enhanced the antioxidant potency of quercetin and showed good blood compatibility. In vitro cytotoxicity studies indicated the viability of the beads on the L929 cell line. Overall, the PEC/CSNP beads can be considered as an effective drug delivery vehicle with stability in the gastrointestinal tract.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Polymer Science
Junqing Qian, Yan Chen, Qian Wang, Xiaohua Zhao, Haiyan Yang, Feng Gong, Hui Guo
Summary: The study prepared nisin microcapsules to improve the stability of nisin and enhance its application effectiveness in food. The microcapsules, prepared by complex embedding nisin with pectin and chitosan, showed good loading and encapsulation efficiency. It was observed that there is a release process in the microcapsules, but the thermal stability of nisin microcapsules significantly increased after high temperature treatment.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Polymer Science
Amer Rashid Hameed, Hatem Majdoub, Fawzi Habeeb Jabrail
Summary: Cross-linked microspheres loaded with Favipiravir SARS-CoV-2 antiviral drug were prepared using different cross-linking techniques. Analysis revealed that one of the polysaccharides was pectin extracted from pomegranate peels. The surface morphology of the microspheres differed, with Glu microspheres having a rough surface and SHMP microspheres having a smooth surface. The loading percentage of the drug was higher in SHMP microspheres, and the release time depended on the pH of the release medium.
Article
Biochemistry & Molecular Biology
Theodore Ebenezer Leonard, Alvaro Filbert Liko, Marsia Gustiananda, Agus Budiawan Naro Putra, Ario Betha Juanssilfero, Pietradewi Hartrianti
Summary: Mucoadhesive drug delivery systems (DDS) can enhance localized drug distribution and retention, promoting safer chemotherapy for colorectal cancer (CRC). Carbohydrate polymers, such as pectin (P) and chitosan (CS), are potential biomaterials for CRC-targeted DDS due to their gelling ability, mucoadhesive property, colonic digestibility, and anticancer activity. Thiolation can augment polymer mucoadhesion, while the P-CS polyelectrolyte complex improves structural stability. TP-CS composites show superior mucoadhesive properties compared to single- or dual-crosslinked counterparts, making them promising biomaterials for CRC-targeted DDS.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Regina R. Vildanova, Svetlana F. Petrova, Sergey V. Kolesov, Vitaliy V. Khutoryanskiy
Summary: Preparation of stable hydrogels using charge-complementary polyelectrolyte chains offers practical advantages over the use of organic crosslinking agents. This study utilizes natural polyelectrolytes-chitosan and pectin-with their biocompatibility and biodegradability. Different molecular weights of pectin are used to prepare hydrogels with varying rheological characteristics and swelling kinetics. These polyelectrolyte hydrogels can release the cytostatic drug cisplatin over an extended period, potentially improving the effectiveness of cancer treatment.
Article
Pharmacology & Pharmacy
Aline Martins dos Santos, Andreia Bagliotti Meneguin, Dewan Taslima Akhter, Nicholas Fletcher, Zachary H. Houston, Craig Bell, Kristofer J. Thurecht, Maria Palmira Daflon Gremia
Summary: Encapsulation of chitosan nanoparticles loaded with 5-fluorouracil within retrograded starch and pectin microparticles allowed for controlled release rates of the chemotherapeutic agent, providing enhanced protection along the gastrointestinal tract. In vivo studies demonstrated faster clearance of chitosan nanoparticles, highlighting the importance of specific degradability by colon microbiota in preventing unwanted absorption into the bloodstream. This research shows the potential of using retrograded starch and pectin microparticles as carriers for delivering drug-loaded nanoparticles to the colon, offering insights for the development of oral systems for colorectal cancer therapy.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Chemistry, Physical
Dorota Wojcik-Pastuszka, Kinga Barczyszyn, Witold Musial
Summary: The study evaluated the release of drugs to the colon from coated pectin beads doped with synthetic polymers and the interactions between ingredients. It was found that the release of 5-ASA mainly followed the Higuchi equation, and the mass transport in the first stage of release followed a non-Fickian model, with the formulation doped with PA (polyacrylic acid) being the most suitable.
Article
Chemistry, Applied
Danling Xu, Xiaogan Zhao, Ghahvechi Chaeipeima Mahsa, Kai Ma, Changliang Zhang, Xin Rui, Mingsheng Dong, Wei Li
Summary: The aim of this study was to prepare pectin microspheres with varying degrees of methyl esterification cross-linked with divalent cationic calcium to encapsulate two strains of Lactiplantibacillus plantarum. The microspheres demonstrated compact and smooth surfaces when the pectin had a degree of methoxy-esterification of 28%, and the bacteria showed a stochastic distribution throughout the gel reticulation. Lower methoxy-esterification pectin significantly improved the probiotics' tolerance in simulated gastrointestinal conditions, and the controlled release of microspheres was pH-dependent. The Caco-2 cell adhesion model indicated better adhesion at a degree of methoxy-esterification of 60%.
CARBOHYDRATE POLYMERS
(2023)
Article
Biotechnology & Applied Microbiology
Pezhman Mosallanezhad, Hossein Nazockdast, Zahed Ahmadi, Amir Rostami
Summary: This study investigated wound dressings composed of polycaprolactone and chitosan, with the inclusion of curcumin and zinc oxide nanoparticles as antibacterial agents. The research showed that the electrospun nanofibers had a nanofibrous structure, good physicochemical properties, and interacted well with water. The inclusion of curcumin, zinc oxide nanoparticles, and chitosan effectively inhibited bacterial growth, but high concentrations of curcumin decreased cell viability and attachment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Yazid Zaiki, Athirah Iskandar, Tin Wui Wong
Summary: Chitosan, as a biotechnological derivative of chitin, has various pharmaceutical and biomedical applications. It can encapsulate and deliver cancer therapeutics with specific drug targeting at the tumor microenvironment, enhancing cancer cytotoxic drug actions. To minimize off-target effects and drug-related adverse reactions, it is clinically necessary to achieve highly targeted drug delivery at the lowest possible drug doses.
BIOTECHNOLOGY ADVANCES
(2023)
Article
Biochemistry & Molecular Biology
Pegah Sanjarnia, Jhamak Nourmohammadi, Saeed Hesaraki
Summary: This research introduces a new wound dressing made from chitosan and copper-containing Janus nanoparticles (JNPs) that have antibacterial and anti-inflammatory properties. The JNPs were synthesized by attaching copper to PDA nanospheres and were embedded in chitosan at different concentrations. The resulting JNPs showed successful adhesion of Cu2+ ions and increased pore size and porosity with higher JNPs concentration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Pharmacology & Pharmacy
Surajit Das
Summary: Utilization of pectin in colon-specific delivery systems shows promise, especially in combination with other materials/polymers. Smartly designed pectin-based multi-particulate carriers have potential for successful colon-specific release of payload, but more clinical trials are needed to validate this idea.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Food Science & Technology
Xiaomin Zhang, Zihao Wei, Yuanjing Sun, Tian Luo, Changhu Xue
Summary: This study designed hordein/pectin nanoparticles as a colon-specific delivery system for quercetin. The results showed that the quercetin-loaded hordein/pectin nanoparticles exhibited better colloidal stability and pectin coating restrained the premature release of quercetin. In vitro and in vivo release studies demonstrated that quercetin was greatly released from the hordein/pectin nanoparticles in simulated colonic fluid and the concentration of quercetin in colon tissue was higher compared to hordein nanoparticles. These findings suggest that hordein/pectin nanoparticles have promising applications in specific delivery and release of quercetin to the colon.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Chemistry, Applied
Shyi-Tien Chen, Hsiu-Wen Chien, Chih-Yu Cheng, Hui-Min Huang, Tzu-Yu Song, Yi-Cheng Chen, Chien-Hui Wu, Yi-Huang Hsueh, Yan-Hsiung Wang, Shih-Fu Ou
Summary: Chitosan/drug coatings synthesized via electrophoretic deposition on alkali-treated Ti surfaces exhibited improved antibacterial activities and corrosion resistances. With desirable adhesion, high drug loading capacity, and prolonged drug release, these proposed coatings can effectively limit bacterial adhesion and proliferation on Ti surfaces.
PROGRESS IN ORGANIC COATINGS
(2021)
Review
Pharmacology & Pharmacy
Anumita Chaudhury, Surajit Das
Review
Pharmacology & Pharmacy
Surajit Das, Anumita Chaudhury
Article
Biophysics
Surajit Das, Wai Kiong Ng, Parijat Kanaujia, Sanggu Kim, Reginald B. H. Tan
COLLOIDS AND SURFACES B-BIOINTERFACES
(2011)
Article
Pharmacology & Pharmacy
Surajit Das, Wai Kiong Ng, Reginald B. H. Tan
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2012)
Article
Nanoscience & Nanotechnology
Anumita Chaudhury, Surajit Das, Ralph M. Bunte, Gigi N. C. Chiu
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2012)
Article
Oncology
Anumita Chaudhury, Bee Jee Tan, Surajit Das, Gigi N. C. Chiu
INTERNATIONAL JOURNAL OF ONCOLOGY
(2012)
Article
Pharmacology & Pharmacy
Anumita Chaudhury, Surajit Das, Ronald F. S. Lee, Kuan-Boone Tan, Wai-Kiong Ng, Reginald B. H. Tan, Gigi N. C. Chiu
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2012)
Article
Pharmacology & Pharmacy
Surajit Das, Ka-Yun Ng, Paul C. Ho
JOURNAL OF DRUG TARGETING
(2011)
Article
Chemistry, Multidisciplinary
Wenji Li, Surajit Das, Ka-yun Ng, Paul W. S. Heng
PHARMACEUTICAL RESEARCH
(2011)
Article
Biophysics
Surajit Das, Sie Huey Lee, Pui Shan Chow, Calum Macbeath
COLLOIDS AND SURFACES B-BIOINTERFACES
(2020)
Article
Chemistry, Multidisciplinary
Krishna M. Gupta, Surajit Das, Annie B. H. Wong, Pui Shan Chow
Summary: A simulation platform is developed to screen, evaluate, formulate, and interpret NP-based formulations for delivering actives to the skin. The study provides insights into the active permeation mechanism from NPs to the skin and can facilitate the development of lipid-based NP formulations.
Article
Chemistry, Multidisciplinary
Krishna M. Gupta, Surajit Das, Pui Shan Chow
Summary: The study investigates the mechanism of active translocation and permeation through the stratum corneum via molecular dynamics simulations and experimental studies. It shows that the active ingredient first adsorbs onto the skin surface, then penetrates slowly into the deeper layers of the skin.
Article
Nanoscience & Nanotechnology
Krishna M. Gupta, Surajit Das, Pui Shan Chow, Calum Macbeath
ACS APPLIED NANO MATERIALS
(2020)
Article
Pharmacology & Pharmacy
Surajit Das, Ka-Yun Ng
LATIN AMERICAN JOURNAL OF PHARMACY
(2011)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
