Article
Engineering, Biomedical
Yichuan Pang, Li Su, Yao Fu, Fan Jia, Chenxi Zhang, Xiankun Cao, Wenxin He, Xueqian Kong, Jiake Xu, Jie Zhao, An Qin
Summary: This study targeted the proprotein convertase furin in breast cancer bone metastasis using bone-targeting superparamagnetic iron oxide (SPIO) nanoparticles, effectively inhibiting both osteoclastic bone resorption and breast cancer invasion. The system shows promise as a therapeutic and diagnostic strategy for breast cancer bone metastasis.
BIOACTIVE MATERIALS
(2021)
Article
Biophysics
Iryna Antal, Martina Koneracka, Martina Kubovcikova, Vlasta Zavisova, Alena Jurikova, Iryna Khmara, Maria Omastova, Matej Micusik, Monika Barathova, Lenka Jelenska, Ivana Kajanova, Miriam Zatovicova, Silvia Pastorekova
Summary: Antibody-modified magnetic nanoparticles were successfully prepared and demonstrated the ability to target cancer cells specifically by conjugating specific monoclonal antibodies on their surface. The internalization of these nanoparticles into tumor cells expressing hypoxic marker was confirmed, showing their potential for targeted cancer therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Kyle M. Kirkpatrick, Benjamin H. Zhou, Philip C. Bunting, Jeffrey D. Rinehart
Summary: Magnetization is a measurable property of materials that provides information about their electronic structure, phase purity, and impurities. Superparamagnetism, a size-dependent property of magnetic materials, has been underexplored in the field of quantum materials. In this study, a statistical model is used to analyze a dataset of variable-size superparamagnetic Fe3O4 particles. The results show that parameters of the intrinsic probability distribution, such as the maximum susceptibility, are more suitable for describing the superparamagnetic behavior compared to standard measures like saturation magnetization. This analysis has potential applications in synthesis diagnostics and prediction of new properties and functionality.
Article
Chemistry, Multidisciplinary
Fernando Espinola-Portilla, Oracio Serrano-Torres, Gilberto F. Hurtado-Lopez, Uriel Sierra, Anne Varenne, Fanny d'Orlye, Laura Trapiella-Alfonso, Silvia Gutierrez-Granados, Gonzalo Ramirez-Garcia
Summary: Chemotherapeutic drugs often cause harmful side effects due to their low specificity, prompting the development of more effective drug dosage and administration strategies. In this study, a smart drug nanocarrier was synthesized by covalently functionalizing superparamagnetic iron oxide nanoparticles with a triblock copolymer, enabling precise drug release in acidic environments.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Zuzanna Z. Janczuk, Agnieszka Jedrych, Sylwia Parzyszek, Anita Gardias, Jacek Szczytko, Michal Wojcik, Paola Tiberto
Summary: This study reports the preparation of MNPs composites using excess liquid crystal-like ligands, which allows for precise and reversible control of magnetic nanoparticles in thin films, showing great potential for various applications.
Article
Chemistry, Multidisciplinary
Lorenzo Cursi, Silvia Vercellino, Mura M. McCafferty, Emily Sheridan, Vanya Petseva, Laurent Adumeau, Kenneth A. Dawson
Summary: Magnetic nanoparticles are valuable tools for studying complex intracellular bio-nano interactions. By synthesizing biocompatible multifunctional nanoparticles with fluorescent properties, intracellular tracking of nanoparticles can be achieved, providing a promising approach for studying bio-nano interactions.
Article
Chemistry, Multidisciplinary
Mona Kappes, Bernhard Friedrich, Felix Pfister, Christian Huber, Ralf Phillipp Friedrich, Rene Stein, Christian Braun, Julia Band, Eveline Schreiber, Christoph Alexiou, Christina Janko
Summary: Noncontact manipulation of cells in regenerative medicine using superparamagnetic iron oxide nanoparticles (SPIONs) allows for new possibilities in tissue engineering. SPIONs can be used as drug transporters, contrast agents, or to make cells maneuverable by magnetic forces. Different SPION coatings, such as PAM and citrate, show good cellular loading and magnetic controllability of cells. This research demonstrates the potential for using SPIONs in 3D cell cultures and highlights their ability to accelerate spheroid formation and micropatterning.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Korobi Konwar, Niyorjyoti Sharma, Pranjali Pranjali, Anupam Guleria, Som Datta Kaushik, Anupam Dutta, Rupak Mukhopadhyay, Debasis Sen, Weibo Gao, Pritam Deb
Summary: The study aims to explore the relationship between structure and relaxivity by observing transverse relaxivity enhancement in MRI of differently organized superparamagnetic complex ensembles. The spatial arrangement of nanoparticles, magnetic easy axes, and anisotropy energy landscape were found to affect transverse relaxation. The research simplifies the limitation of the quantum mechanical outer-sphere diffusion model of MR relaxivity.
Article
Biophysics
E. V. Dukhopelnykov, Yu. N. Blyzniuk, A. A. Skuratovska, E. G. Bereznyak, N. A. Gladkovskaya
Summary: This study investigated the interaction between superparamagnetic iron oxide nanoparticles (SPIONs) and doxorubicin (DOX) and DNA. The results showed that the nanoparticles do not interact with DNA, but can load a large number of DOX molecules. At high DNA concentrations, almost all DOX molecules bind to DNA.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Neza Repar, Eva Jarc Jovicic, Ana Kump, Giovanni Birarda, Lisa Vaccari, Andreja Erman, Slavko Kralj, Sebastjan Nemec, Toni Petan, Damjana Drobne
Summary: Silica-coated superparamagnetic iron oxide nanoparticles (SPIONs) can be internalized by endothelial cells, leading to increased oxidative stress and cell death. Exogenous oleic acid (OA) can protect the cells from the harmful effects of SPIONs. OA promotes lipid droplet (LD) formation and reduces SPION-induced oxidative stress and cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Wenke Xi, Ge Zhang, Jingquan Xue, Juan Li, Yu Liu, Jianjun Wang, Wenjiang Yang
Summary: Multimodal imaging is a growing trend in molecular imaging. In this study, a SPECT/MRI dual-modality probe was developed using superparamagnetic iron oxide nanoparticles. The nanoparticles were functionalized using RGDyk peptide and DTPA chelator. In vivo SPECT imaging and T2-weighted MR imaging on tumor-bearing mice demonstrated the targeting of the probe, indicating the potential of the SPECT/MRI dual-modality probe for tumor evaluation and diagnosis.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2023)
Review
Nanoscience & Nanotechnology
Hao Wei, Yangnan Hu, Junguo Wang, Xia Gao, Xiaoyun Qian, Mingliang Tang
Summary: Superparamagnetic iron oxide nanoparticles (SPIONs) are extensively studied and utilized in biomedicine due to their superb superparamagnetic properties and reliable traceability. However, different SPIONs exhibit variations in cytotoxicity, metabolism, and cellular behaviors. A comprehensive review of the construction and application of SPIONs is necessary to address these differences.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Environmental Sciences
Jenet George, Abdullah K. Alanazi, P. Senthil Kumar, Swethaa Venkataraman, Devi Sri Rajendran, Jothyswarupha Krishnakumar Athilakshmi, Isita Singh, Ishani Singh, Pramit Sen, Maheswari Purushothaman, Palanisamy Athiyaman Balakumaran, Vinoth Kumar Vaidyanathan, Hala M. Abo-Dief
Summary: A biocatalytic membrane incorporating superparamagnetic iron oxide nanoparticles showed better performance in the removal of toxic pentachlorophenol compared to free enzymes. The immobilized laccase on the membrane exhibited higher stability and activity recovery. The use of mediators, particularly veratryl alcohol, further enhanced the removal efficacy of the immobilized laccase. The study highlights the potential of the PEES/PMVEAMA/lac membrane system for pollutant removal in a membrane bioreactor.
Article
Chemistry, Physical
Lichuang Zhang, Hao Xu, Ziyi Cheng, Yan Wei, Ruize Sun, Ziwei Liang, Yinchun Hu, Liqin Zhao, Xiaojie Lian, Xia Li, Di Huang
Summary: The surface modification of nanoparticles with cellular protein components improved the targeting performance of nanoparticles, showing potential for clinical targeted diagnosis and treatment of cancer.
JOURNAL OF PHYSICAL CHEMISTRY B
(2021)
Article
Engineering, Chemical
Somayeh Asadi Haris, Shadab Dabagh, Hamidreza Mollasalehi, Yavuz Nuri Ertas
Summary: Superparamagnetic iron oxide nanoparticles (SPIONs) were synthesized and used for efficient removal of arsenite (As(III)). The optimum removal percentages for SPIONs and SPIONs-Alg were 99% and 90%, respectively, at pH 7, 30 degrees C, and 6.5 mg/L As (III) concentration. The Langmuir isotherm model fitted the equilibrium data better than Freundlich. The adsorption kinetic data showed a better fit to the pseudo-second-order kinetic model. SPIONs-Alg could be easily collected, recovered, and reused for multiple cycles with high sorption efficiency.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)