Review
Pharmacology & Pharmacy
Sujeet Kumar Raj, M. Ravindra Babu, Sukriti Vishwas, M. V. N. L. Chaitanya, Vancha Harish, Gaurav Gupta, Dinesh Kumar Chellappan, Kamal Dua, Sachin Kumar Singh
Summary: Diabetes is a common disease that requires insulin for treatment. Advances in technology have led to improvements in diabetes management, giving patients more options for insulin delivery. This review focuses on traditional insulin therapy, the development of insulin analogues, different routes of insulin administration, and novel drug delivery systems and continuous glucose monitoring systems for diabetes management.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kamran Tari, Soroush Khamoushian, Tayyebeh Madrakian, Abbas Afkhami, Marek Jan Los, Arash Ghoorchian, Mohammad Reza Samarghandi, Saeid Ghavami
Summary: This study investigates the potential of water-soluble polypyrrole nanoparticles (WS-PPyNPs) as a drug donor matrix for controlled transdermal iontophoresis of insulin (INS), showing significantly increased drug delivery compared to passive delivery. The separation of WS-PPyNPs and INS under cathodal stimulation led to higher drug permeation, highlighting the potential applicability of WS-PPyNPs in the development of controlled transdermal iontophoresis of INS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Instruments & Instrumentation
Qida Zong, Ranran Guo, Naijun Dong, Guixia Ling, Peng Zhang
Summary: Microneedle technology, as a promising alternative to subcutaneous insulin injection, has developed rapidly but still faces technical challenges, researchers are making efforts to overcome these limitations.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Phimchanok Sakunpongpitiporn, Witthawat Naeowong, Anuvat Sirivat
Summary: This study investigates the release and permeation mechanism of insulin using silk fibroin hydrogels as a matrix. Results show that the diffusion coefficient and release rate of insulin are affected by the concentration of silk fibroin and electric field. The time required to generate aqueous pathways through the skin is longer, leading to relatively lower release and permeation rates of insulin.
Article
Instruments & Instrumentation
Rawita Morarad, Witthawat Naeowong, Anuvat Sirivat
Summary: Transdermal insulin delivery is achieved by utilizing PANI:PSS as a drug carrier to improve drug delivery capability. The in vitro drug release of insulin loaded PANI:PSS showed improved efficiency compared to pristine insulin alone, while the ex vivo release-skin permeation was hindered by the pig skin acting as a barrier. Modified insulin transdermal delivery with PANI:PSS influences the rate, amount, and duration of insulin release.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Review
Environmental Sciences
Ishrat Zahoor, Sukhbir Singh, Tapan Behl, Neelam Sharma, Tanveer Naved, Vetriselvan Subramaniyan, Shivkanya Fuloria, Neeraj Kumar Fuloria, Saurabh Bhatia, Ahmed Al-Harrasi, Lotfi Aleya, Shahid Nazir Wani, Celia Vargas-De-La-Cruz, Simona Bungau
Summary: Research has shown that microneedles are a non-invasive, painless method for transdermal insulin delivery, reducing discomfort for patients compared to traditional subcutaneous injections; different types of microneedles, including solid, dissolving, hydrogel, coated, and hollow microneedles, have been developed and several microneedle products are now available in the market.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Materials Science, Multidisciplinary
Goeen Jeong, Hyung-Seop Han, Hojeong Jeon, Yu-Chan Kim, Ho Won Jang, Myoung-Ryul Ok
Summary: Although metallic microneedles (MNs) and iontophoresis have been extensively studied, the use of biodegradable metals for transdermal drug delivery has not received much attention. In this study, Mg was employed as a promising candidate for an MN electrode due to its metallic properties and the hydrogen gas generated during Mg corrosion. The Mg MN electrode was fabricated using a nanosecond laser, and the hydrogen gas produced during iontophoresis was measured at various applied potentials. The results demonstrate an optimal potential range for iontophoresis based on the combined effect of enhanced drug diffusion and impediment from hydrogen generation.
METALS AND MATERIALS INTERNATIONAL
(2023)
Article
Pharmacology & Pharmacy
Kamchai Saepang, S. Kevin Li, Doungdaw Chantasart
Summary: The study explored the potential of skin microchannels created by polymer microneedle patches for enhancing transdermal drug delivery of pramipexole dihydrochloride. Results showed that drug-loaded dissolving microneedle (DMN) patches greatly improved PXCl transdermal delivery compared to conventional methods, while hydrogel-forming microneedle (HGMN) patches provided more sustained drug delivery. Electromigration was identified as the main mechanism for iontophoresis of PXCl through microchannels, with HGMN patches showing greater flux enhancement than DMN patches. The study indicates the potential application of microneedle patches, either alone or in combination with iontophoresis, as an alternative method for PXCl administration.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Polymer Science
Qida Zong, Rong Zhou, Zhining Zhao, Yan Wang, Cheng Liu, Peng Zhang
Summary: In this study, a simplified method for the preparation of insulin microneedle patch with rapid and controlled drug release was developed using phenylboronic acid modified methacrylate hyaluronic acid as the drug carrier. This approach offers a direction for simplifying the concept of controlled-release insulin microneedle patch and facilitating production.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Rawita Morarad, Witthawat Naeowong, Sumonman Niamlang, Anuvat Sirivat
Summary: A porous thermoplastic polyurethane (TPU) matrix was successfully fabricated and used for insulin delivery through a transdermal patch. The experiment showed that the insulin released amount and diffusion coefficient were influenced by the matrix pore size and electric field strength.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Instruments & Instrumentation
Yu Wang, Lijuan Zeng, Wenting Song, Jianping Liu
Summary: The stratum corneum of skin poses a strong barrier to most molecules, limiting transdermal drug delivery. Iontophoresis technology has emerged as an effective method to enhance drug permeation through the skin, providing a more efficient, noninvasive, and patient-friendly approach while widening the scope of drugs for transdermal delivery.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Tatsuro Amano, Naoto Fujii, Ying-Shu Quan, Glen P. Kenny, Narihiko Kondo, Hirofumi Yamashita, Yoshimitsu Inoue
Summary: Emotional stress-induced sweating in glabrous skin of the palm and sole has a negative impact on quality of life. This study investigated the effectiveness of using microneedles to enhance iontophoretic delivery of pilocarpine to modulate sweat production. The microneedle array enhanced skin permeability and sweat production on the palm without increasing pilocarpine delivery, suggesting its potential use in understanding and treating conditions such as hyperhidrosis.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biotechnology & Applied Microbiology
Yuanyuan Jin, Da Liu, Zhen Lu, Lubing Yang, Jiangli Chen, Xuyan Zhou, Zhidong Qiu, Ye Jin
Summary: Ginsenosides, the bioactive compounds of ginseng, were formulated into GSLs and GSNs to enhance transdermal absorption efficiency. Results showed that GSL-7 exhibited higher anti-photoaging effects compared to GSN-4 and GS, indicating its potential for skin tissue repair and reduction of UV-induced skin aging.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Amruta A. Dandekar, Harsha T. Garimella, Carrie L. German, Ajay K. Banga
Summary: This study demonstrates the feasibility of using microneedles and iontophoresis to deliver tofacitinib citrate transdermally. Microneedles significantly enhance the delivery, and a synergistic effect is observed when combined with iontophoresis.
PHARMACEUTICAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Tais Gratieri, Rhita Zarhloule, Sachin Dubey, Yogeshvar N. Kalia
Summary: The study found that skin barrier impairment affects the iontophoretic transport of both low and high molecular weight permeants, with removal of the stratum corneum not always leading to increased iontophoretic delivery. The decrease of electroosmotic flow and facilitated transport of ions impacted cation delivery by anodal iontophoresis, but the effects were partly offset by enhanced passive diffusion. Decreased electroosmosis favored cathodal electrotransport.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Parasitology
Muneaki Hashimoto, Masahiko Numata, Shouki Yatsushiro, Yusuke Ido, Masato Tanaka, Kazuaki Kajimoto, Masatoshi Kataoka
JOURNAL OF PARASITOLOGY
(2018)
Article
Chemistry, Applied
Kazuaki Kajimoto, Tatsuhito Katsumi, Takashi Nakamura, Masatoshi Kataoka, Hideyoshi Harashima
JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY
(2018)
Article
Infectious Diseases
Muneaki Hashimoto, Hirokazu Sakamoto, Yusuke Ido, Masato Tanaka, Shouki Yatsushiro, Kazuaki Kajimoto, Masatoshi Kataoka
Article
Parasitology
Yusuke Ido, Muneaki Hashimoto, Shouki Yatsushiro, Masato Tanaka, Kazumichi Yokota, Kazuaki Kajimoto, Masatoshi Kataoka
JOURNAL OF PARASITOLOGY
(2019)
Article
Biophysics
Takeki Yamamoto, Shouki Yatsushiro, Muneaki Hashimoto, Kazuaki Kajimoto, Yusuke Ido, Kaori Abe, Yasuyuki Sofue, Takahiro Nogami, Takuya Hayashi, Kenji Nagatomi, Noboru Minakawa, Hiroaki Oka, Toshihiro Mita, Masatoshi Kataoka
BIOSENSORS & BIOELECTRONICS
(2019)
Article
Parasitology
Muneaki Hashimoto, Yusuke Ido, Masato Tanaka, Kazumichi Yokota, Kazuaki Kajimoto, Masatoshi Kataoka
PARASITOLOGY INTERNATIONAL
(2019)
Article
Parasitology
Muneaki Hashimoto, Mika Bando, Jun-ichi Kido, Kazumichi Yokota, Toshihiro Mita, Kazuaki Kajimoto, Masatoshi Kataoka
PARASITOLOGY INTERNATIONAL
(2019)
Article
Multidisciplinary Sciences
Takeki Yamamoto, Muneaki Hashimoto, Kenji Nagatomi, Takahiro Nogami, Yasuyuki Sofue, Takuya Hayashi, Yusuke Ido, Shouki Yatsushiro, Kaori Abe, Kazuaki Kajimoto, Noriko Tamari, Beatrice Awuor, George Sonye, James Kongere, Stephen Munga, Jun Ohashi, Hiroaki Oka, Noboru Minakawa, Masatoshi Kataoka, Toshihiro Mita
SCIENTIFIC REPORTS
(2020)
Article
Medicine, Research & Experimental
Saed Abbasi, Yusuke Sato, Kazuaki Kajimoto, Hideyoshi Harashima
MOLECULAR PHARMACEUTICS
(2020)
Article
Microbiology
Muneaki Hashimoto, Kazumichi Yokota, Kazuaki Kajimoto, Musashi Matsumoto, Atsuro Tatsumi, Kenichi Yamamoto, Tomonori Hyodo, Kiichiro Matsushita, Noboru Minakawa, Toshihiro Mita, Hiroaki Oka, Masatoshi Kataoka
Article
Pharmacology & Pharmacy
Dai Majima, Ryosuke Mitsuhashi, Misaki Yamasaki, Kazuaki Kajimoto, Tatsuya Fukuta, Kentaro Kogure
Summary: The study demonstrated that α-tocopheryl succinate (TS) can suppress lipid accumulation in adipocytes by regulating lipid metabolic cell signaling, promoting lipolysis, and inhibiting lipid synthesis.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Chemistry, Analytical
Kazumichi Yokota, Muneaki Hashimoto, Kazuaki Kajimoto, Masato Tanaka, Sanae Murayama, Makusu Tsutsui, Yoshihiro Nakajima, Masateru Taniguchi, Masatoshi Kataoka
Summary: In this study, the resistive pulse method (RPM) was used to accurately discriminate cancer cells from leukocytes by measuring individual cell size, deformability, and surface charge in a solution with a low electrolyte concentration.
Article
Chemistry, Analytical
Kazumichi Yokota, Asae Takeo, Hiroko Abe, Yuji Kurokawa, Muneaki Hashimoto, Kazuaki Kajimoto, Masato Tanaka, Sanae Murayama, Yoshihiro Nakajima, Masateru Taniguchi, Masatoshi Kataoka
Summary: This study demonstrates the successful discrimination of different yeasts using the resistive pulse method, ensuring efficient production and safety. By measuring the ionic current response of cells and evaluating the shape of the current blockage waveform, accurate discrimination between Saccharomyces pastorianus and Dekkera spp. was achieved, along with quantitative detection of budding cells in Saccharomyces pastorianus.
Article
Microbiology
Muneaki Hashimoto, Kazumichi Yokota, Kazuaki Kajimoto, Musashi Matsumoto, Atsuro Tatsumi, Yoshihiro Nakajima, Toshihiro Mita, Noboru Minakawa, Hiroaki Oka, Masatoshi Kataoka
Meeting Abstract
Oncology
Kazuaki Kajimoto
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)