Article
Chemistry, Applied
J. Alarcon-Moyano, D. Acuna, S. Matiacevich, L. Caballero, F. Melo, F. Quero, P. Diaz-Calderon
Summary: This study evaluated the physical-chemical properties and structure of cellulose nanocrystals (CNC) dried by two different methods: Spray-Drying (SD) or Freeze-Drying (FD). The results showed that the drying method influenced the size, aspect ratio, and sorption of CNC. However, it did not affect zeta potential, crystallinity, or degradation temperature. The study suggests that the drying method plays a role in modifying the physico-chemical properties of CNC.
FOOD HYDROCOLLOIDS
(2023)
Article
Polymer Science
Alen Oseli, Alenka Vesel, Ema Zagar, Lidija Slemenik Perse
Summary: This study investigates the mechanisms of network formation using single-walled carbon nanotubes in polyethylene matrices, and finds that the network is constructed from SWCNT bundles at a specific critical volume fraction. The behavior of the bundles at different Phi(v,crit) values influences the configuration of the network.
Article
Engineering, Chemical
Merve B. Adali, Antonello Barresi, Gianluca Boccardo, Giorgia Montalbano, Roberto Pisano
Summary: Spray freeze-drying is a promising manufacturing technology with many advantages, but there are still technical challenges for its industrial scale implementation. This study aims to investigate the relationship between atomization conditions and the characteristics of lyophilized powder, and finds that particle morphology is determined by solid content, while average particle size increases with feed flow rate and viscosity. Additionally, the specific surface area of the lyophilized powder depends on the initial solid content and excipient type.
Article
Pharmacology & Pharmacy
Emilia Jakubowska, Michal Bielejewski, Bartlomiej Milanowski, Janina Lulek
Summary: The aim of this study was to investigate the effect of freeze-drying on the particle size of bottom-up processed cilostazol nanosuspension after redispersion. Optimal freeze-drying conditions were identified, and the freeze-dried nanocrystals retained their original size, polymorphic form, and improved dissolution rate.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Thermodynamics
Klara Szentmihalyi, Zoltan May, Eszter Bodis, Judit Toth, Laszlo Trif, Szilvia Klebert, Tivadar Feczko, Zoltan Karoly
Summary: Spray freeze-drying is an effective method for reducing the particle size of thermosensitive organic substances. This study found that when water or dimethyl sulphoxide solutions were used, the particle size of metronidazole was reduced by two and one order of magnitude, respectively. The particle size was mainly affected by experimental parameters, while the solvent had a smaller effect.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2022)
Article
Pharmacology & Pharmacy
Christoph Marschall, Gesche Graf, Madlen Witt, Bernhard Hauptmeier, Wolfgang Friess
Summary: Protein powder suspensions were prepared using swing-mill and compared to cryogenic dry milling. Wet media milling resulted in increased protein aggregation, while cryogenic dry milling could reduce aggregation, but caused damage to mAb if not cooled with liquid nitrogen.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Eetu Valkama, Ondrej Haluska, Vesa-Pekka Lehto, Ossi Korhonen, Katja Pajula
Summary: The study demonstrates the feasibility of producing stable amorphous solid dispersions from practically water insoluble drug compounds using freeze-drying method with DMSO solutions. The developed method results in amorphous binary solid dispersions that remain stable at room temperature, suitable for further research purposes.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Thermodynamics
Chun Luo, Sha Mi, Naijun Zhou, Zhiqiang Liu, Wenjun Shi
Summary: This paper experimentally investigates the freezing stage of the mannitol solution, focusing on the effects of cooling rate and solute mass fraction. The results show that the morphology of the freezing front is more affected by the cooling rate than the solute mass fraction, and the ice crystal morphology also varies under different freezing conditions.
INTERNATIONAL JOURNAL OF THERMAL SCIENCES
(2023)
Article
Acoustics
Melanie Girard, Francois Bertrand, Jason R. Tavares, Marie-Claude Heuzey
Summary: This study investigates the ultrasonication process of CNCs using rheology, comparing the dispersion states of suspensions with different concentrations. The findings provide insights on how to control the dispersion of CNCs effectively.
ULTRASONICS SONOCHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Ghania Degobert, Dunya Aydin
Summary: Polymeric nanocapsules have core-shell structure that provide advantages in drug delivery systems. However, instability issues reduce shelf-life and hinder clinical use and commercialization. Lyophilization is a common method to overcome these issues in the pharmaceutical industry, especially for labile compounds.
Article
Mechanics
Li Sun, Tianqi Liang, Chunwei Zhang, Jianyun Chen
Summary: This study investigates the compounded shear-thickening fluids (STFs) consisting of needlelike carbon fiber powder (CFP), silicon dioxide (SiO2), and polyethylene glycol (PEG). The compounded STFs exhibit significant rheological behavior and shear-thickening effects, and show excellent energy dissipation capacity and dynamic stability. The key performance index of the compounded STFs is demonstrated to be improved by ten times or even higher, making it a novel type of STFs for engineering practice.
Article
Chemistry, Physical
Zhongxiang Wang, Youyi Tai, Jin Nam, Yadong Yin
Summary: This study investigates the evolution of size, morphology, phase, and surface properties of Mn2+-doped ZnS nanorods during calcination. It reveals a complex dependence of phase and ML performance on various factors. The phase composition has a significant impact on ML intensity, while photoluminescence is affected by optical absorption from carbon species generated by surface ligands.
CHEMISTRY OF MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Klara Szentmihalyi, Krisztina Morica, Gabor Gigler, Zoltan May, Eszter Bodis, Judit Toth, Monika Bakonyi, Szilvia Klebert, Tivadar Feczko, Zoltan Karoly
Summary: Micronized metronidazole was successfully prepared using the spray freeze-drying method and demonstrated its effectiveness in reducing symptoms of rosacea in an animal model.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Christoph Marschall, Madlen Witt, Bernhard Hauptmeier, Wolfgang Friess
Summary: This study focuses on formulating protein drug preparations as protein powder suspensions in non-aqueous vehicles for subcutaneous injections. By utilizing protein powder suspensions, high protein stability can be achieved without the need for drying or reconstitution, offering a more convenient way of medication for patients.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Yingyuan Zhao, Zhaoxuan Wang, Shuxian Liu, Shiying Xie, Yinchun Xie, Ruifang Li, Hiroaki Oda
Summary: This research screens the best ratio of compound lyophilization protectants through single-factor experiments and response surface optimization experiments, and prepares excellent astaxanthin/BSA/chitosan nanosuspension (ABC-NPs) lyophilized powder, solving the problem of inconvenient storage and transportation of aqueous drugs.
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)