Article
Biochemistry & Molecular Biology
Trent D. Henderson, Jaewoo Choi, Scott W. Leonard, Brian Head, Robyn L. Tanguay, Carrie L. Barton, Maret G. Traber
Summary: Muscle wasting due to aging may be caused by oxidative stress damage and inadequate protection by lipophilic antioxidants like vitamin E. Previous studies on vitamin E-deficient adult zebrafish showed muscular abnormalities and behavioral defects. This study aimed to investigate the interaction between muscle degeneration from aging and oxidative damage from vitamin E deficiency in aging zebrafish through metabolomic analysis. Results showed that both aging and vitamin E deficiency led to changes in metabolite and pathway profiles, but each factor also had unique alterations, suggesting the need for further research with confirmatory approaches.
Article
Multidisciplinary Sciences
Clara Cooper-Mullin, Wales A. Carter, Ronald S. Amato, David Podlesak, Scott R. McWilliams
Summary: The study found that ingested lipophilic antioxidant alpha-tocopherol can quickly reach muscle mitochondria in flying birds with regular exercise, helping to offset the oxidative costs of flight muscle metabolism.
Article
Environmental Sciences
Ahmed Abdelraouf Salem, Kira Trares, Matthias Kohl, Eugene Jansen, Hermann Brenner, Ben Schottker
Summary: The study found a significant association between current smoking and increased levels of oxidative stress biomarker D-ROM, while there was no association with TTP levels. There is a dose-response relationship between smoking amount and D-ROM concentrations, indicating long-term effects of smoking on redox balance.
ENVIRONMENTAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Marta Martin-Fernandez, Victor Arroyo, Carmen Carnicero, Rebeca Siguenza, Reyes Busta, Natalia Mora, Beatriz Antolin, Eduardo Tamayo, Patricia Aspichueta, Irene Carnicero-Frutos, Hugo Gonzalo-Benito, Rocio Aller
Summary: This study found that elevated levels of lipid peroxidation (LPO) are significantly associated with a NASH score of >= 4 in NAFLD patients. LPO levels above 315.39 μM were identified as an independent risk factor. The model showed good discrimination ability in distinguishing NASH patients. Therefore, understanding the molecular mechanisms of basal inflammation may help identify biomarkers and therapeutic targets for NASH.
Review
Biochemistry & Molecular Biology
Heshu Chen, Chenyu Wang, Zemin Liu, Xinmiao He, Wenjie Tang, Liuqin He, Yanzhong Feng, Di Liu, Yulong Yin, Tiejun Li
Summary: Ferroptosis is a novel type of non-apoptotic cell death that can be triggered by specific modulators. It has potential implications in preventing inflammatory storms and cancer development. Ferroptosis may mediate biological processes such as oxidative stress and iron overload to treat cancer.
Review
Biochemistry & Molecular Biology
Ashley K. Putman, G. Andres Contreras, Lorraine M. Sordillo
Summary: Oxidative stress is associated with the generation of oxidized products such as IsoP, which are highly specific biomarkers of lipid peroxidation. Despite advancements in their detection and use, there is still limited knowledge about the biological activity and potential roles of IsoP in oxidative stress pathology, especially in veterinary medicine.
Article
Agriculture, Dairy & Animal Science
Rachel C. Turner, Charles J. Innis, Brian A. Stacy, Jorge A. Hernandez, Richard C. Hill, Karen C. Scott, Salvatore Frasca, Michael M. Garner, Rachel E. Burns, Michael D. Arendt, Jennifer Brisson, Terry M. Norton, Sea Rogers Williams, Adam Kennedy, Amy B. Alexander, Nicole I. Stacy
Summary: This study found that diagnosis of steatitis in cold-stunned KRT takes a long time, with diverse histologic findings in affected adipose tissue. Cold-stunned KRT with steatitis had significantly lower plasma vitamin E concentrations, lower TBARS concentrations, and higher T/E ratios compared to controls.
Article
Biochemistry & Molecular Biology
Linas Cerniauskas, Asta Mazeikiene, Egle Mazgelyte, Egle Petrylaite, Ausra Linkeviciute-Dumce, Neringa Burokiene, Dovile Karciauskaite
Summary: Cardiovascular diseases are the leading cause of mortality worldwide. This study aimed to evaluate oxidative lipid degradation biomarkers and antioxidant defense system components in healthy women and their relationships with age, anthropometric measures, and lipid metabolism biomarkers. The findings suggest that these indices could be useful biomarkers in the research of aging, obesity, and atherosclerosis pathogenesis.
Article
Biochemistry & Molecular Biology
Marlena Rademacher, Hartmut Kuhn, Astrid Borchert
Summary: GPX4, as the only enzyme capable of reducing complex lipid peroxides to the corresponding alcohols, plays a role in erythroid differentiation of mouse erythroleukemia cells, but heterozygous expression of a catalytically inactive Gpx4 is not sufficient to compromise erythropoiesis in vivo and ex vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Vesna Sredoja Tisma, Stela Bulimbasic, Danica Galesic Ljubanovic, Kresimir Galesic, Jadranka Morovic-Vergles, Josko Mitrovic, Koji Uchida, Franz Tatzber, Neven Zarkovic, Morana Jaganjac
Summary: This study investigated the implication of oxidative stress in small-vessel vasculitis, focusing on acrolein immunohistochemistry in affected skin vessels and systemic stress response. It was found that systemic redox homeostasis and iron metabolism are altered in SVV patients, with possible biomarkers identified for evaluating oxidative status, disease activity, and prevalence. Furthermore, a strong correlation between the accumulation of acrolein-protein adducts in the skin and disease progression was revealed.
Article
Biochemistry & Molecular Biology
Po-Keng Cheng, Hsin-Chang Chen, Pao-Lin Kuo, Jung-Wei Chang, Wan-Ting Chang, Po-Chin Huang
Summary: This study investigated the association between oxidative and nitrosative stress and thyroid hormones, finding that an imbalance of oxidative and nitrosative stress may alter thyroid hormone homeostasis during pregnancy, which could affect embryonic and fetal development.
Article
Biology
Mate Mackei, Gabor Matis, Andor Molnar, Csilla Sebok, Julia Voroshazi, Laszlo Pal, Karoly Dublecz, Ferenc Husveth, Zsuzsanna Neogrady
Summary: The liver was found to be the most susceptible to heat-provoked oxidative stress, with rapid activation of protective pathways and the involvement of sHSP-s leading to an over-compensation mechanism.
JOURNAL OF THERMAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yingya Zhao, Marina S. Nogueira, Ginger L. Milne, Xingyi Guo, Hui Cai, Qing Lan, Nathaniel Rothman, Qiuyin Cai, Yu-Tang Gao, Qingxia Chen, Xiao-Ou Shu, Gong Yang
Summary: The study found that miRNAs associated with F2-IsoP-M are enriched for various lipid peroxidation-related processes, and some miRNAs exhibited functional interactions with mRNAs involved in the regulation of beta-oxidation.
Article
Biochemistry & Molecular Biology
Marta Martin-Fernandez, Rocio Aller, Maria Heredia-Rodriguez, Esther Gomez-Sanchez, Pedro Martinez-Paz, Hugo Gonzalo-Benito, Laura Sanchez-de Prada, Oscar Gorgojo, Irene Carnicero-Frutos, Eduardo Tamayo, Alvaro Tamayo-Velasco
Summary: This study revealed the presence of oxidative stress in COVID-19 patients, with high levels of antioxidant enzymes and oxidative cell damage, while total antioxidant capacity was lower. Elevated lipid peroxidation (LPO) levels above 1948.17 mu M were independently associated with a higher risk of intubation or death at 28 days in COVID-19 patients.
Review
Medicine, General & Internal
Fanwen Jiang, Lin Zhou, Chun Zhang, Hui Jiang, Zhuping Xu
Summary: This systematic review compared circulating malondialdehyde (MDA) levels in people with and without diabetic retinopathy (DR). The results showed that circulating MDA levels were higher in people with DR compared to those without.
CHINESE MEDICAL JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)