Article
Infectious Diseases
Flavia Pedrini, Virginia S. Nazato, Moema A. Hausen, Daniel Komatsu, Stela S. Pena, Ana Lidia M. Almeida, Fernanda J. C. Pirola, Marina P. Francoso, Eliana A. R. Duek
Summary: State-of-the-art sustained drug delivery systems aim to improve pharmacological transport by controlling the ratio between drug release and therapeutic effect. Biodegradable polymer microspheres like PLGA play a crucial role in directing drug release to specific regions of interest.
Article
Chemistry, Multidisciplinary
Shuying Wang, Griffin Downing, Karl F. Olsen, Tomi K. Sawyer, Roger D. Cone, Steven P. Schwendeman
Summary: This study developed a long-acting release formulation for setmelanotide using remote loading into PLGA microspheres. The loaded microspheres demonstrated slow and continuous peptide release, leading to long-term inhibition of food intake and body weight control in a diet induced obese murine model. This provides a promising treatment option for obesity.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Polymer Science
Maria Herrero-Herrero, Jose Antonio Gomez-Tejedor, Ana Valles-Lluch
Summary: Tailored membranes with a fiber diameter of 1.8 μm were electrospun from PLGA and PCLGA solutions by adjusting electrospinning and polymer solution parameters. PCLGA, with its amorphous morphology, required the addition of a salt to increase conductivity for successful electrospinning, presenting notable difficulties due to its structure. Interestingly, PCLGA, with a higher glycolic acid molar fraction, could be successfully electrospun, a feat not previously reported.
Article
Engineering, Biomedical
Shengtang Li, Xuewen Shi, Bo Xu, Jian Wang, Peng Li, Xin Wang, Jinpeng Lou, Ziyao Li, Chengwei Yang, Songkai Li, Ping Zhen
Summary: This study prepared vancomycin-loaded PLGA microspheres with silk fibroin (SF) coating and investigated their in vitro drug release behavior. The results showed that SF coating could alleviate the initial burst release and reduce the cumulative drug release of the microspheres, potentially prolonging the drug action time and improving the anti-infection effect.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2022)
Article
Biotechnology & Applied Microbiology
Heejun Park, Eun-Sol Ha, Jeong-Soo Kim, Min-Soo Kim
Summary: The study aimed to develop an improved sustained-release PLGA microsphere of exenatide using supercritical fluid extraction of emulsions (SFEE). The effect of various process parameters on the fabrication of exenatide-loaded PLGA microspheres was investigated using the Box-Behnken design. The results showed that the SFEE process improved the properties of PLGA microspheres, including smaller particle size, higher encapsulation efficiency, and lower burst release.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Materials Science, Multidisciplinary
Akhand Pratap Singh, Om Prakash, Sunil Kumar, Aparna Shukla, Pralay Maiti
Summary: The study demonstrates the suitability of poly(lactic acid-co-glycolic acid) (PLGA) as a sustained drug delivery vehicle for melanoma treatment. PLGA nanoparticles (NPs) and PLGA film encapsulated with paclitaxel (PTX) show greater efficacy in inhibiting melanoma cell proliferation and reducing tumor volume, compared to pure drug and control group. The sustained drug delivery systems also result in minimal damage to vital organs and fewer side effects.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Chisong Lee, Jinkyung Kim, Daniel Junmin Um, Youseong Kim, Hye Su Min, Jiwoo Shin, Jee Hye Nam, Geonwoo Kang, Mingyu Jang, Huisuk Yang, Hyungil Jung
Summary: The study introduced a novel heat-melting method to fabricate hydrophobic PLGA DMNs for transdermal drug delivery, avoiding potentially harmful organic solvents. The implanted HMP-DMNs successfully separated from the patch within 10 minutes and released encapsulated molecules for nearly 4 weeks, demonstrating safe and effective sustained drug delivery without the use of organic solvents. This research offers an innovative approach to utilizing PLGA as a material for transdermal drug delivery systems.
Article
Polymer Science
Jie Yan, Paula Facal Marina, Anton Blencowe
Summary: Poly(ethylene glycol)-b-poly(lactic-co-glycolic acid) (PEG-PLGA) block copolymers and their thermoresponsive hydrogels have been widely studied for sustained drug delivery. The microstructure of these copolymers is highly sensitive to the reaction conditions, such as temperature and catalyst loading, which influence the occurrence and extent of side reactions during ring-opening polymerization. Our detailed study revealed that increasing the catalyst loading had negligible effects on side reactions but surprisingly increased the polymerization rate of lactide relative to glycolide. These findings provide valuable insights for the improved synthesis of PLGA-PEG-PLGA copolymers and their hydrogels.
Article
Chemistry, Multidisciplinary
Yiye Lu, Geoffrey W. Coates
Summary: Poly(lactic-co-glycolic acid) (PLGA) is widely used in various biomedical applications due to its biodegradability and biocompatibility. This study successfully developed a method to synthesize syndioenriched, alternating PLGA from racemic methyl-glycolide (rac-MeG), and confirmed the high degree of alternation of the comonomer sequence and moderate syndiotacticity within the polymer backbone stereoconfiguration through NMR investigations.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Yiye Lu, Geoffrey W. Coates
Summary: Poly(lactic-co-glycolic acid) (PLGA) is a biodegradable and biocompatible polymer used in biomedical applications. This study presents a method for synthesizing syndioenriched, alternating PLGA from racemic methyl-glycolide with the use of an optimized racemic aluminum catalyst. The resulting material has a high degree of alternation in copolymer sequence and moderate syndiotacticity, and is amorphous, making it suitable for drug complexation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Biochemistry & Molecular Biology
Eswaramoorthy Thirumalaikumar, S. Vimal, Ramamoorthy Sathishkumar, M. Ravi, V. Karthick, S. Ramya, John Thomas, Vinay Kumar, Chinnaperumal Kamaraj, Thavasimuthu Citarasu
Summary: Encapsulation of DNA vaccines onto carriers enhances antigen immunogenicity. In this study, DNA vaccines were loaded onto biodegradable polymer microspheres and delivered to goldfish, resulting in improved innate immune response and survival rate.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Guangliang Liu, Roberto Martinez, Anika Bhatnagar, Kathleen McEnnis
Summary: PLGA is a commonly used drug carrier in nanomedicines due to its biodegradability, biocompatibility, and low toxicity. The glass transition temperature (T-g), which is an indicator of drug release behavior, is often overlooked in the physico-chemical characterization and study of drug release. This study investigated the influence of polymeric (PVA) and ionic (DMAB) surfactants on the T-g of PLGA nanoparticles and found that the choice and residual amount of surfactant are crucial parameters in designing the physico-chemical properties of PLGA particles.
Article
Materials Science, Multidisciplinary
Akhtar Jahan Siddiqa, Nilesh Kumar Shrivastava, M. E. Ali Mohsin, Mustufa Haider Abidi, Mohamed Abdel Fattah Sharaf, Tauqeer Ahmed Shaikh
Summary: This study investigated the stability and in vitro release of letrozole-loaded PLGA microparticles with different ratios of biopolymer. The release kinetics were evaluated using three theoretical models, with Higuchi and Korsmeyer-Peppas showing the highest correlation coefficients. Scanning electron microscopy and Fourier-transform infrared spectroscopy analysis confirmed the stability of PLGA and the drug bioavailability over an 80-day period.
Article
Biochemistry & Molecular Biology
Qianyu Sun, Tianzhong Yuan, Gang Yang, Daliang Guo, Lizheng Sha, Rendang Yang
Summary: In this study, sustained-release composite microspheres containing curcumin-loaded cyclodextrin metal-organic frameworks (CD-MOFs-Cur) were successfully prepared using a solid-in-oil-in-oil (s/o/o) emulsifying solvent evaporation method. These composite microspheres exhibited different degradation rates and curcumin release rates, and showed favorable cytocompatibility.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Jiaen Wu, Shanshan Xu, Charles C. Han, Guangcui Yuan
Summary: Neutron techniques were used to investigate the drug loading and releasing properties of PLGA. The hydration of PLGA, reversible with humidity and temperature changes, was found to originate from molecular compatibility with water. The evolution of drug domains inside electrospun PLGA fibers was tracked using SANS, with domain size and relaxation speed related to temperature and PLGA's glassy property. The release kinetics from fibers with different drug loading were discussed based on SANS and USANS findings.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Pharmacology & Pharmacy
Minh-Quan Le, Fabien Violet, Cedric Paniagua, Xavier Garric, Marie-Claire Venier-Julienne
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2018)
Article
Pharmacology & Pharmacy
Juan Aparicio-Blanco, Victor Sebastian, Jean P. Benoit, Ana I. Torres-Suarez
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2019)
Article
Pharmacology & Pharmacy
Giovanna Lollo, Kevin Matha, Martina Bocchiardo, Jerome Bejaud, Ilaria Marigo, Angelique Virgone-Carlotta, Thomas Dehoux, Charlotte Riviere, Jean-Paul Rieu, Stephanie Briancon, Thomas Perrier, Olivier Meyer, Jean-Pierre Benoit
JOURNAL OF DRUG TARGETING
(2019)
Article
Parasitology
Gabriela V. Ullio Gamboa, Patricia E. Pensel, Maria C. Elissondo, Sergio F. Sanchez Bruni, Jean-Pierre Benoit, Santiago D. Palma, Daniel A. Allemandi
EXPERIMENTAL PARASITOLOGY
(2019)
Article
Oncology
Laura Pinton, Elena Masetto, Marina Vettore, Samantha Solito, Sara Magri, Marta D'Andolfi, Paola Del Bianco, Giovanna Lollo, Jean-Pierre Benoit, Hideho Okada, Aaron Diaz, Alessandro Della Puppa, Susanna Mandruzzato
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2019)
Article
Biotechnology & Applied Microbiology
Gabriela Ullio-Gamboa, Kenea C. Udobi, Sophie Dezard, Marla K. Perna, Keila N. Miles, Narciso Costa, Frederic Taran, Alain Pruvost, Jean-Pierre Benoit, Matthew R. Skelton, Pascale de Lonlay, Aloise Mabondzo
Article
Pharmacology & Pharmacy
M. L. Formica, G. V. Ullio Gamboa, L. Tartara, J. D. Luna, J. P. Benoit, S. D. Palma
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Article
Multidisciplinary Sciences
Ana Cadete, Ana Olivera, Magnus Besev, Pradeep K. Dhal, Lidia Goncalves, Antonio J. Almeida, Guillaume Bastiat, Jean-Pierre Benoit, Maria de la Fuente, Marcos Garcia-Fuentes, Maria Jose Alonso, Dolores Torres
SCIENTIFIC REPORTS
(2019)
Article
Parasitology
Julia Fabbri, Juan Pablo Espinosa, Patricia Eugenia Pensel, Sandra Karina Medici, Gabriela Ullio Gamboa, Jean Pierre Benoit, Maria Celina Elissondo
Article
Chemistry, Physical
Thao-Quyen Nguyen-Pham, Lazhar Benyahia, Guillaume Bastiat, Jeremie Riou, Marie-Claire Venier-Julienne
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2020)
Article
Biotechnology & Applied Microbiology
Laura Pinton, Sara Magri, Elena Masetto, Marina Vettore, Ilaria Schibuola, Vincenzo Ingangi, Ilaria Marigo, Kevin Matha, Jean-Pierre Benoit, Alessandro Della Puppa, Vincenzo Bronte, Giovanna Lollo, Susanna Mandruzzato
JOURNAL OF NANOBIOTECHNOLOGY
(2020)
Article
Pharmacology & Pharmacy
Kevin Matha, Giovanna Lollo, Giuseppe Taurino, Renaud Respaud, Ilaria Marigo, Molood Shariati, Ovidio Bussolati, An Vermeulen, Katrien Remaut, Jean-Pierre Benoit
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2020)
Article
Nanoscience & Nanotechnology
Molood Shariati, Giovanna Lollo, Kevin Matha, Benedicte Descamps, Christian Vanhove, Leen Van de Sande, Wouter Willaert, Lieve Balcaen, Frank Vanhaecke, Jean-Pierre Benoit, Wim Ceelen, Stefaan C. De Smedt, Katrien Remaut
ACS APPLIED MATERIALS & INTERFACES
(2020)
Review
Pharmacology & Pharmacy
Kevin Matha, Brice Calvignac, Jean-Pierre Gangneux, Jean-Pierre Benoit
Summary: Visceral leishmaniasis is a neglected disease in many countries, but nanomedicine has shown success in treating it, particularly with liposomal amphotericin B's remarkable cure rates. However, developing more efficient strategies like targeting functionalization, oral formulations, or combined therapies face numerous obstacles and raise many questions.
EXPERT OPINION ON DRUG DELIVERY
(2021)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)