Review
Pharmacology & Pharmacy
Carlos Bendicho-Lavilla, Iria Seoane-Viano, Francisco J. Otero-Espinar, Asteria Luzardo-Alvarez
Summary: This article discusses the challenges of subcutaneous administration of peptide-based therapeutics in diabetes treatment and provides an overview of formulations available for different routes of administration with improved bioavailability and reduced frequency of administration.
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Biochemistry & Molecular Biology
Kelly Q. Zhou, Simerdeep K. Dhillon, Laura Bennet, Alistair J. Gunn, Joanne O. Davidson
Summary: Hypoxic-ischemic encephalopathy is a brain injury caused by a lack of oxygen and blood supply at birth, leading to a high risk of death or disability. The approved treatment is therapeutic hypothermia, but a significant number of infants still develop disability even with this treatment. Recent studies have shown that there is persistent neuroinflammation after therapeutic hypothermia, suggesting that targeting this inflammation may have additive benefits. Exendin-4, a glucagon-like peptide 1 receptor agonist, has shown promising neuroprotective effects in preclinical studies. Further research is needed to understand the safety, timing, and efficacy of using Exendin-4 as an adjunct to therapeutic hypothermia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Mariam Alatrach, Christina Agyin, Carolina Solis-Herrera, Olga Lavryneko, John Adams, Amalia Gastaldelli, Curtis Triplitt, Ralph A. DeFronzo, Eugenio Cersosimo
Summary: This study found that SGLT2 inhibitors have an effect on the increase of endogenous glucose production (EGP) in patients with type 2 diabetes after oral glucose intake. Despite elevated plasma insulin and glucagon, the stimulation of EGP was observed, suggesting that additional factors may be involved.
Article
Medicine, General & Internal
Dandan Mao, Huanyi Cao, Mai Shi, Chi Chiu Wang, Joseph Kwong, Joshua Jing Xi Li, Yong Hou, Xing Ming, Heung Man Lee, Xiao Yu Tian, Chun Kwok Wong, Elaine Chow, Alice Pik Shan Kong, Vivian Wai Yan Lui, Paul Kay Sheung Chan, Juliana Chung Ngor Chan
Summary: Our study revealed that the expression of PSMA2 and GLP-1R was increased and positively correlated in T2D-related cervical cancer specimens, suggesting hyperglycemia might promote cancer growth by increasing PSMA2 expression, which could be attenuated by Exendin-4.
Article
Radiology, Nuclear Medicine & Medical Imaging
Olof Eriksson, Irina Velikyan, Torsten Haack, Martin Bossart, Iina Laitinen, Philip J. Larsen, Jan Erik Berglund, Gunnar Antoni, Lars Johansson, Stefan Pierrou, Joachim Tillner, Michael Wagner
Summary: In this study, an optimized and simplified scanning protocol for 68Ga-exendin4 was developed to enable reproducible imaging of GLP1R in the pancreas. 68Ga-exendin4 PET may enable quantification of longitudinal changes in pancreatic GLP1R during the development of type 2 diabetes, as well as target engagement studies of novel glucagonlike peptide-1 agonists.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Editorial Material
Biochemistry & Molecular Biology
Roy W. Beck
Summary: Automated insulin delivery systems, used in type 1 diabetes, hold promise for patients with type 2 diabetes and are expected to have a significant impact on public health.
Article
Biochemistry & Molecular Biology
Thuy An Trinh, Thai Minh Duy Le, Hien Thi-Thanh Nguyen, Thanh Loc Nguyen, Jaeyun Kim, Dai Phu Huynh, Doo Sung Lee
Summary: An injectable hydrogel system has been developed that can provide sustained release of a glucagon-like peptide-1 receptor agonist at the injection site, reducing the need for daily injections in type 2 diabetes patients. The system exhibits excellent biocompatibility and holds promise for the treatment of this chronic disease.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Endocrinology & Metabolism
Lin Zhang, Yanjin Hu, Yu An, Qiu Wang, Jia Liu, Guang Wang
Summary: This study used a lipidomic approach to investigate lipid changes in response to treatment with exenatide in T2DM patients. The results showed that exenatide treatment can improve lipid metabolism, especially sphingomyelins, lysophosphatidylcholines, and lysophosphatidylethanolamines.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Emilie H. Zobel, Rasmus S. Ripa, Bernt J. von Scholten, Viktor Rotbain Curovic, Andreas Kjaer, Tine W. Hansen, Peter Rossing, Joachim Storling
Summary: Liraglutide has been found to exert anti-inflammatory effects in the peripheral blood mononuclear cells of individuals with type 2 diabetes, with no significant presence of GLP-1 receptor expression. Further research is needed to clarify the indirect effects of liraglutide on PBMC gene expression and establish the anti-inflammatory potential of GLP-1 receptor agonists.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Han Liu, Suohui Zhang, Zequan Zhou, Mengzhen Xing, Yunhua Gao
Summary: In this study, two-layer sustained-release microneedles (TS-MNs) were successfully fabricated for the sustained delivery of exenatide (EXT). The TS-MNs showed good mechanical strength and could penetrate the skin for drug release. Moreover, the TS-MNs retained high drug activity during storage and had high relative bioavailability.
Article
Endocrinology & Metabolism
Jonatan Bagger, Magnus F. G. Grondahl, Asger Lund, Jens J. Holst, Tina Vilsboll, Filip K. Knop
Summary: The study showed that GLP-1 potentiated the glucagon-suppressive effect of glucose in a dose-dependent manner in healthy individuals and patients with type 2 diabetes. However, patients with type 1 diabetes were insensitive to the glucagonostatic effects of both glucose and GLP-1.
Article
Plant Sciences
Shammi Akter, Shajia Afrin, Jaeyoon Kim, Joohyun Kang, Md Abdur Razzak, Per-Olof Berggren, Inhwan Hwang
Summary: GLP-1 is a peptide that stimulates insulin secretion and is widely used to treat diabetes. This study demonstrates the production of recombinant Exendin-4 using plants and confirms the effectiveness of plant-produced Exendin-4 in comparison to chemically synthesized Exendin-4.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Chemistry, Medicinal
Yaqin Zhang, Ruofei Chen, Yangyang Jia, Mingwei Chen, Zongwen Shuai
Summary: The study revealed that the GLP-1R agonist exenatide has an effect on coagulation function and platelet aggregation in patients with type 2 diabetes mellitus, which is beneficial for reducing the risk of cardiovascular events.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Endocrinology & Metabolism
Linong Ji, Ying Du, Min Xu, Xiangjun Zhou, Zhaohui Mo, Jianhua Ma, Jiarui Li, Yufeng Li, Jingna Lin, Yanjun Wang, Jing Yang, Weihong Song, Hui Jin, Shuguang Pang, Hui Liu, Ping Li, Jie Liu, Minxiu Yao, Wenhui Li, Xiaohong Jiang, Feixia Shen, Houfa Geng, Haifeng Zhou, Jianmin Ran, Minxiang Lei, Yinghong Du, Shandong Ye, Qingbo Guan, Wenshan Lv, Huiwen Tan, Tao Chen, Jinkui Yang, Guijun Qin, Shiyun Li, Lei Chen
Summary: This study demonstrated that PB-119 doses were more effective in controlling blood sugar and well-tolerated compared to placebo over a 12-week period in treatment-naive Chinese patients with type 2 diabetes.
Article
Endocrinology & Metabolism
Annemarie B. van der Aart-van Der Beek, Ellen Apperloo, Niels Jongs, Dennis B. Rouw, C. David Sjostrom, Iris Friedli, Lars Johansson, Daniel H. van Raalte, Klaas Hoogenberg, Hiddo J. L. Heerspink
Summary: This study evaluated the effects of dapagliflozin, exenatide, and the combination of dapagliflozin and exenatide on reducing albuminuria in patients with type 2 diabetes and microalbuminuria or macroalbuminuria. The study found that all three treatments could reduce albuminuria, with the combination therapy showing the most significant reduction.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
C. Ellero, J. Han, S. Bhavsar, B. B. Cirincione, M. B. DeYoung, A. L. Gray, I. Yushmanova, P. W. Anderson
Article
Endocrinology & Metabolism
Sunil Bhavsar, Sunder Mudaliar, Alan Cherrington
CURRENT DIABETES REVIEWS
(2013)
Article
Endocrinology & Metabolism
C. M. Mack, C. X. Moore, C. M. Jodka, S. Bhavsar, J. K. Wilson, J. A. Hoyt, J. L. Roan, C. Vu, K. D. Laugero, D. G. Parkes, A. A. Young
INTERNATIONAL JOURNAL OF OBESITY
(2006)
Article
Endocrinology & Metabolism
RA Pittner, CX Moore, SP Bhavsar, BR Gedulin, PA Smith, CM Jodka, DG Parkes, JR Paterniti, VP Srivastava, AA Young
INTERNATIONAL JOURNAL OF OBESITY
(2004)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)