Article
Pharmacology & Pharmacy
Leonor Vasconcelos Garcia, Diana Silva, Maria Madalena Costa, Henrique Armes, Madalena Salema-Oom, Benilde Saramago, Ana Paula Serro
Summary: Chronic wound treatment is a major contributor to global medical expenses. The development of novel wound care systems, such as wound dressings loaded with antiseptics, can offer a solution. This study investigated the potential of casein hydrogel dressings loaded with Octiset(R) or polyhexanide for treating chronic wounds. The hydrogels showed desirable physical properties and sustained controlled drug-release, while also exhibiting good antimicrobial properties and compatibility with biological systems.
Article
Dermatology
Anne-Marie Salisbury, Marc Mullin, Lauren Foulkes, Rui Chen, Steven L. Percival
Summary: In this in vitro study, multiple models were used to evaluate the biofilm management capabilities of seven commercially-available wound dressings. The results showed that the effectiveness varied among the dressings, with controlled-release iodine foam dressing and silver nanocrystalline dressing showing the most potent biofilm reduction in all models tested.
INTERNATIONAL WOUND JOURNAL
(2022)
Review
Polymer Science
Erfan Rezvani Ghomi, Mina Niazi, Seeram Ramakrishna
Summary: Wound healing has always been a challenge throughout human history. Modern dressings offer advantages over traditional bandages, but they lack responsiveness to wound conditions. Smart dressings can interact with the environment, monitor healing stages, and provide valuable information for treatment.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2022)
Review
Chemistry, Multidisciplinary
Ruonan Dong, Baolin Guo
Summary: Wound management is a major challenge globally, and smart wound dressings offer potential solutions for promoting wound healing. By employing built-in sensors and smart materials, smart wound dressings can interact with wounds, sense and respond to changes in wound conditions or environment.
Article
Biochemistry & Molecular Biology
Song Tang, Zhoujie Gong, Zefan Wang, Xia Gao, Xiaonan Zhang
Summary: Developing advanced dressings that integrate multiple functions is crucial in wound treatment. In this study, a hydrogel dressing composed of Xanthan gum and polyacrylamide was successfully prepared. The PAAm-XG hydrogels showed excellent mechanical properties, high water uptake efficiency, and demonstrated compatibility with bioactive molecules. Furthermore, the hydrogels significantly accelerated wound healing in vivo. These findings suggest that the multifunctional PAAm-XG hydrogels are promising for wound treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Pengpeng Deng, Wenyi Jin, Zilin Liu, Mingyong Gao, Jinping Zhou
Summary: Novel water-soluble adenine-modified chitosan derivatives have shown excellent antibacterial properties, biocompatibility, and effectiveness in promoting wound healing. They have potential applications in wound dressings and offer new ideas for the design of multifunctional biomaterials.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Physical
Janice Caroline Hardt, Michelly Cristina Galdioli Pella, Ana Caroline Reis Meira, Andressa Giombelli Rosenberger, Josiane Caetano, Douglas Cardoso Dragunski
Summary: This study evaluated the potential application of silver sulfadiazine loaded PBAT/PCL microfibers as wound dressings, which exhibited antimicrobial activity and controlled release. The results showed that the fiber diameter and crystallinity were concentration-dependent on the silver sulfadiazine, and the release profile was biphasic with both fast and sustained release.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Dermatology
Qi Qin, Daijiro Haba, Chihiro Takizawa, Sanai Tomida, Mao Kunimitsu, Takeo Minematsu, Hiromi Sanada, Gojiro Nakagami
Summary: The study aims to establish a method for collecting viable cells from discarded wound dressings. A protocol was designed to wash out nonadherent cells and detach adherent cells from silicone-faced foam wound dressings using trypsin-EDTA. The optimal concentration and incubation time of trypsin-EDTA for collecting equivalent proportions of different cell types to the original cell population were determined through in vitro and ex vivo studies.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Pharmacology & Pharmacy
E. Massarelli, D. Silva, A. F. R. Pimenta, A. Fernandes, J. L. G. Mata, H. Armes, M. Salema-Oom, B. Saramago, A. P. Serro
Summary: A new PVA/Ch based wound dressing was developed, which showed protection, hydration, and controlled release of antiseptics. The dressings exhibited antibacterial activity against S. aureus and S. epidermidis, with the ones loaded with PHMB showing better cytotoxicity and irritability properties. The application of this dressing in wound treatment in a dog led to faster recovery compared to conventional treatment, suggesting its potential as an alternative in wound care.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Ningning Yuan, Kan Shao, Shan Huang, Cheng Chen
Summary: This paper discusses the combination of natural polymers such as chitosan, alginate, and hyaluronic acid with other polymer materials, loading them in traditional hydrogels, and the development of novel multifunctional hydrogel dressings with antibacterial, self-healing, injectable, and multi-stimulation responsive properties using advanced technologies such as 3D printing, electrospinning, and stem cell therapy. The focus of this paper is on the functional properties of novel multifunctional hydrogel dressings such as chitosan, alginate, and hyaluronic acid, laying the foundation for the research of novel hydrogel dressings with better performance.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Dermatology
Fergus Watson, Rui Chen, Steven L. Percival
Summary: This study aimed to evaluate the antibacterial properties of commercially available wound dressings, with different material composition and antibacterial agents, against various in vitro microbial and biofilm models. The results showed that controlled-release iodine foam and silver-impregnated carboxymethylcellulose (CMC) wound dressings had better biofilm management properties compared to methylene blue and gentian violet-containing foam dressings. The controlled-release iodine foam and silver-impregnated CMC materials effectively prevented the dissemination of Pseudomonas aeruginosa.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Engineering, Environmental
Faheem Ahmad, Bushra Mushtaq, Sheraz Ahmad, Abher Rasheed, Yasir Nawab
Summary: An alginate hydrogel hemp nonwoven composite was developed for wound dressings. The composite was produced using the sol-gel technique, combining the anti-inflammation properties of hemp with the wound healing properties of alginate hydrogel. The concentration of alginate was found to have a greater impact on the performance of the composite compared to the nonwoven GSM.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2023)
Article
Medicine, General & Internal
Yu-Chi Wang, Hsiao-Chen Lee, Chien-Lin Chen, Ming-Chun Kuo, Savitha Ramachandran, Rong-Fu Chen, Yur-Ren Kuo
Summary: The study found that silver-releasing foam dressings were more effective in promoting wound healing of diabetic foot ulcers compared to silver-containing cream, particularly in the initial three weeks of treatment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Infectious Diseases
Gabriela Dorcioman, Ariana Hudita, Bianca Galateanu, Doina Craciun, Ionel Mercioniu, Ovidiu Cristian Oprea, Irina Negut, Valentina Grumezescu, Alexandru Mihai Grumezescu, Lia Mara Ditu, Alina Maria Holban
Summary: In this study, wound dressings were improved by applying magnetite-based nanostructured coatings, which were functionalized with Nigella sativa and dicloxacillin. The combination of materials aimed to reduce microbial contamination and promote rapid wound healing. The stability, thermal degradation, morphology, and chemical composition of the coatings were characterized using various analytical techniques. The antimicrobial effect, biocompatibility, and regenerative properties of the nanostructured coatings were evaluated through in vitro experiments, showing enhanced antimicrobial effects against opportunistic bacteria.
Article
Engineering, Biomedical
Fateme Fayyazbakhsh, Michael J. Khayat, Candy Sadler, Delbert Day, Yue-Wern Huang, Ming C. Leu
Summary: Recent advances in additive manufacturing have led to innovative solutions for tissue regeneration. This study demonstrates that 3D-printed hydrogel dressings incorporated with bioactive borate glass (BBG) can provide better outcomes for the treatment of second-degree burn wounds, including faster healing, continuous hydration, and prevention of burst water release.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
