Review
Environmental Sciences
Luis Daniel Martinez-Razo, Alejandra Martinez-Ibarra, Edgar Ricardo Vazquez-Martinez, Marco Cerbon
Summary: DEHP, considered an endocrine disruptor chemical (EDC), is widely used in the plastic industry and can have negative effects on placental development and function, potentially impacting fetal growth. Research indicates that DEHP and MEHP can impair key processes in placental development and affect various placental functions. Clinical evidence also supports the connection between DEHP exposure and adverse pregnancy outcomes and pathologies.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Engineering, Environmental
Charlotte Henkel, Jonas Lamprecht, Thorsten Hueffer, Thilo Hofmann
Summary: Phthalic acid esters are important additives for PVC, but they are harmful to aquatic organisms. This study investigated the leaching of phthalates from PVC microplastics into water and found that environmental factors such as salinity and flow conditions can affect the leaching process.
Article
Chemistry, Multidisciplinary
Kuo-Cheng Lan, Te- Weng, Wei-Che Chiang, Chen-Yuan Chiu, Ding-Cheng Chan, Rong-Sen Yang, Shing-Hwa Liu
Summary: DEHP and its metabolite MEHP have been found to inhibit myogenesis in vitro, suggesting their potential role as environmental risk factors affecting muscle differentiation.
APPLIED SCIENCES-BASEL
(2022)
Article
Engineering, Environmental
Hongdan Wang, Yunqing Wang, Qiaoning Wang, Min Lv, Xizhen Zhao, Yunxia Ji, Xiaoyue Han, Xiaoyan Wang, Lingxin Chen
Summary: Microplastics have toxic effects on aquatic organisms due to their characteristics of large specific surface area, high hydrophobicity, and surface charge. This study investigated the effects of polyvinyl chloride-microplastics (PVC-MPs) and di(2-ethylhexyl) phthalate (DEHP) on zebrafish embryos and larvae. It was found that PVC-MPs reduced the hatching rate of zebrafish embryos and caused zebrafish mortality, while DEHP slowed down the death rate. The compound pollution of PVC-MPs and DEHP induced reactive oxygen species production and activated antioxidant defense signaling pathway. Moreover, PVC-MPs inhibited the expression of genes related to cardiac development, while the combined pollution showed an antagonistic effect.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Engineering, Environmental
Xia Li, Jianpeng Li, Sijia Hao, Ailing Han, Yayu Yang, Guozhen Fang, Jifeng Liu, Shuo Wang
Summary: A enzyme mimic material inspired by serine proteases was developed to degrade DEHP, which was then immobilized onto RC membranes for continuous recycling degradation. This biocatalytic membrane showed effective DEHP degradation and good stability, offering a promising biomaterial for water decontamination and liquid food depollution.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Metallurgy & Metallurgical Engineering
Luyan Chen, Bicheng Deng, Shengting Kuang, Wuping Liao
Summary: In this study, a novel extractant HA was synthesized and used for the extraction and separation of HREs. The results showed that HA has higher separation factors and follows cation exchange mechanism for the extraction of REs. HA exhibits high loading capacities and good solvent extraction performance.
Article
Engineering, Chemical
Carlo Boaretti, Riccardo Donadini, Martina Roso, Alessandra Lorenzetti, Michele Modesti
Summary: This study investigated a transesterification process to convert DEHP to less toxic phthalates in the context of PVC mechanical recycling, achieving high conversion rates for pure DEHP but facing limitations in the presence of PVC phthalate mixture.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2021)
Article
Chemistry, Applied
Yuting Liang, Zhi Jiang, Wenfeng Shangguan
Summary: This study investigated the photocatalytic reaction behavior of DEHP over surface platinized TiO2, with the oxidation state of platinum found to be crucial in determining the photocatalytic activity. Platinized titania with oxidized Pt species showed higher photocatalytic activity compared to metallic Pt. Photocatalysis coupled with thermal catalysis can enhance the degradation of DEHP, and Pt oxide, particularly PtO, can improve the photocatalytic oxidation efficiency by promoting the separation efficiency of photo generated carriers.
Article
Biology
Yukiko Tando, Hitoshi Hiura, Asuka Takehara, Yumi Ito-Matsuoka, Takahiro Arima, Yasuhisa Matsui
Summary: Maternal exposure to DEHP induces DNA hypermethylation of spermatogenesis-related gene promoters in fetal testicular germ cells in F1 mice, leading to downregulation of gene expression in spermatogonia and subsequent defects in spermatogenesis.
Article
Environmental Sciences
Hyunki Cho, Yohan Seol, Seungyun Baik, Baeckkyoung Sung, Chang Seon Ryu, Young Jun Kim
Summary: The effects of MEHP exposure on Daphnia magna were investigated, revealing that MEHP exposure increased lipid droplet numbers and the reproduction rate of adult female daphnids. Furthermore, MEHP exposure enhanced lipid metabolism and altered the expression levels of ecdysone receptor and vitellogenin.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Shivani Popli Goyal, Tripti Agarwal, Vijendra Mishra, Ankur Kumar, Chakkaravarthi Saravanan
Summary: This study identified two strains of Lactobacillus (Lactobacillus rhamnosus GG and Lactobacillus plantarum MTCC 25,433) that can rapidly adsorb over 85% of DEHP. The adsorption of DEHP was affected by cell wall polysaccharides, proteins, lipids, and peptidoglycan. These findings suggest that these Lactobacillus strains could be potential strategies for detoxification of DEHP-contaminated foods.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Review
Environmental Sciences
Wing Sum Kwan, Vellaisamy A. L. Roy, Kwan Ngok Yu
Summary: DEHP, widely used as a plasticizer in consumer products, has been linked to adverse health effects, prompting the need for toxicological assessment. Zebrafish embryos have become a popular in vivo model for studying DEHP toxicity, aiming to assess both acute and chronic effects on different developmental stages.
Article
Biodiversity Conservation
Xianxu Li, Qian Wang, Can Wang, Zhongkang Yang, Jinhua Wang, Lusheng Zhu, Dexin Zhang, Jun Wang
Summary: This study investigated the acute and chronic toxicity of DEHP on zebrafish, focusing on oxidative damage, neurotoxicity, and DNA damage in the liver. The results showed that DEHP enhanced oxidative stress, lipid peroxidation, and cytotoxicity in zebrafish liver, leading to DNA damage. The severity of the effects was positively correlated with the concentration of DEHP.
ECOLOGICAL INDICATORS
(2022)
Article
Environmental Sciences
Ling Yang, Jiao Zou, Zhenle Zang, Liuyongwei Wang, Zhulin Du, Dandan Zhang, Yun Cai, Minghui Li, Qiyou Li, Junwei Gao, Haiwei Xu, Xiaotang Fan
Summary: Using a human cerebral organoid model, researchers found that DEHP exposure inhibited cell proliferation and increased apoptosis, impairing the morphogenesis of the human cerebral cortex. DEHP exposure disrupted neurogenesis and neural progenitor migration, possibly due to dysplasia of radial glia cells. RNA sequencing analysis showed that DEHP-induced disorder in cell-extracellular matrix interactions might play a crucial role in the neurodevelopment of human cerebral organoids.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Pengfei Hou, Wenting Dai, Yanshan Jin, Fengqi Zhao, Jianxin Liu, Hongyun Liu
Summary: This study demonstrates that DEHP exposure has adverse effects on lactation, including energy insufficiency, inflammation activation, oxidative stress aggravation, and disturbance of milk production. These findings are important for understanding the health risks of the plastic additive DEHP on female lactation dysfunction.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biotechnology & Applied Microbiology
Yoshikazu Arai, Koji Hayakawa, Daisuke Arai, Rie Ito, Yusuke Iwasaki, Koichi Saito, Kazuhiko Akutsu, Satoshi Takatori, Rie Ishii, Rumiko Hayashi, Shun-Ichiro Izumi, Norihiro Sugino, Fumio Kondo, Masakazu Horie, Hiroyuki Nakazawa, Tsunehisa Makino, Mitsuko Hirosawa, Kunio Shiota, Jun Ohgane
BIOMED RESEARCH INTERNATIONAL
(2015)
Article
Genetics & Heredity
Junko Yotsumoto, Akihiko Sekizawa, Nobuhiro Suzumori, Takahiro Yamada, Osamu Samura, Miyuki Nishiyama, Kiyonori Miura, Hideaki Sawai, Jun Murotsuki, Michihiro Kitagawa, Yoshimasa Kamei, Hideaki Masuzaki, Fumiki Hirahara, Toshiaki Endo, Akimune Fukushima, Akira Namba, Hisao Osada, Yasuyo Kasai, Atsushi Watanabe, Yukiko Katagiri, Naoki Takeshita, Masaki Ogawa, Takashi Okai, Shunichiro Izumi, Haruka Hamanoue, Mayuko Inuzuka, Kazufumi Haino, Naoki Hamajima, Haruki Nishizawa, Yoko Okamoto, Hiroaki Nakamura, Takeshi Kanegawa, Jun Yoshimatsu, Shinya Tairaku, Katsuhiko Naruse, Hisashi Masuyama, Maki Hyodo, Takashi Kaji, Kazuhisa Maeda, Keiichi Matsubara, Masanobu Ogawa, Toshiyuki Yoshizato, Takashi Ohba, Yukie Kawano, Haruhiko Sago
JOURNAL OF HUMAN GENETICS
(2016)
Editorial Material
Clinical Neurology
Yuko Ohnuki, Shigeaki Suzuki, Takashi Shiina, Akinori Uruha, Yurika Watanabe, Shingo Suzuki, Shunichiro Izumi, Jin Nakahara, Kohei Hamanaka, Kazuko Takayama, Norihiro Suzuki, Ichizo Nishino
Article
Genetics & Heredity
Miyuki Nishiyama, Akihiko Sekizawa, Kohei Ogawa, Hideaki Sawai, Hiroaki Nakamura, Osamu Samura, Nobuhiro Suzumori, Setsuko Nakayama, Takahiro Yamada, Masaki Ogawa, Yukiko Katagiri, Jun Murotsuki, Yoko Okamoto, Akira Namba, Haruka Hamanoue, Masanobu Ogawa, Kiyonori Miura, Shunichiro Izumi, Yoshimasa Kamei, Haruhiko Sago
PRENATAL DIAGNOSIS
(2016)
Article
Obstetrics & Gynecology
Makio Shozu, Hiroshi Ishikawa, Reiko Horikawa, Hideya Sakakibara, Shun-ichiro Izumi, Takashi Ohba, Yasushi Hirota, Tsutomu Ogata, Yutaka Osuga, Koji Kugu
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2017)
Article
Obstetrics & Gynecology
Osamu Samura, Akihiko Sekizawa, Nobuhiro Suzumori, Aiko Sasaki, Seiji Wada, Haruka Hamanoue, Fumiki Hirahara, Hideaki Sawai, Hiroaki Nakamura, Takahiro Yamada, Kiyonori Miura, Hideaki Masuzaki, Setsuko Nakayama, Takashi Okai, Yoshimasa Kamei, Akira Namba, Jun Murotsuki, Tomohiro Tanemoto, Akimune Fukushima, Kazufumi Haino, Shinya Tairaku, Keiichi Matsubara, Kazuhisa Maeda, Takashi Kaji, Masanobu Ogawa, Hisao Osada, Haruki Nishizawa, Yoko Okamoto, Takeshi Kanagawa, Aiko Kakigano, Michihiro Kitagawa, Masaki Ogawa, Shunichiro Izumi, Yukiko Katagiri, Naoki Takeshita, Yasuyo Kasai, Katsuhiko Naruse, Reiko Neki, Hisashi Masuyama, Maki Hyodo, Yukie Kawano, Takashi Ohba, Kiyotake Ichizuka, Yasuhiro Kido, Toshiyuki Fukao, Norio Miharu, Takeshi Nagamatsu, Atsushi Watanabe, Naoki Hamajima, Masaya Hirose, Ayako Sanui, Nahoko Shirato, Junko Yotsumoto, Miyuki Nishiyama, Tatsuko Hirose, Haruhiko Sago
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2017)
Article
Obstetrics & Gynecology
Nobuhiro Suzumori, Akihiko Sekizawa, Takeshi Ebara, Osamu Samura, Aiko Sasaki, Rina Akaishi, Seiji Wada, Haruka Hamanoue, Fumiki Hirahara, Haruna Izumi, Hideaki Sawai, Hiroaki Nakamura, Takahiro Yamada, Kiyonori Miura, Hideaki Masuzaki, Takahiro Yamashita, Takashi Okai, Yoshimasa Kamei, Akira Namba, Jun Murotsuki, Tomohiro Tanemoto, Akimune Fukushima, Kazufumi Hain, Shinya Tairaku, Keiichi Matsubara, Kazutoshi Maeda, Takashi Kaji, Masanobu Ogawa, Hisao Osada, Haruki Nishizawa, Yoko Okamoto, Takeshi Kanagawa, Aiko Kakigano, Michihiro Kitagawa, Masaki Ogawa, Shunichiro Izumi, Yukiko Katagiri, Naoki Takeshita, Yasuyo Kasai, Katsuhiko Naruse, Reiko Neki, Hisashi Masuyama, Maki Hyodo, Yukie Kawano, Takashi Ohba, Kiyotake Ichizuka, Takeshi Nagamatsu, Atsushi Watanabe, Nahoko Shirato, Junko Yotsumoto, Miyuki Nishiyama, Tatsuko Hirose, Haruhiko Sago
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2018)
Article
Integrative & Complementary Medicine
Makoto Arai, Shuichi Katai, Shin-ichi Muramatsu, Takao Namiki, Toshihiko Hanawa, Shun-ichiro Izumi
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2012)
Article
Medicine, General & Internal
Yuko Ohnuki, Kazumi Takahashi, Eri Iijima, Wakoh Takahashi, Shingo Suzuki, Yuki Ozaki, Ruriko Kitao, Masatoshi Mihara, Tadayuki Ishihara, Michiyo Nakamura, Yoshie Sawano, Yu-ichi Goto, Shunichiro Izumi, Jerzy K. Kulski, Takashi Shiina, Shunya Takizawa
Article
Agriculture, Dairy & Animal Science
Li-Yi Cai, Takako Kato, Mo Chen, HongHua Wang, Ei-ichiro Sekine, Shun-ichiro Izumi, Yukio Kato
JOURNAL OF REPRODUCTION AND DEVELOPMENT
(2012)
Article
Reproductive Biology
Mo Chen, Li-Yi Cai, Saishu Yoshida, Susumu Takekoshi, Hiroshi Kajiwara, Naoto Nishimura, HongHua Wang, Takako Kato, Shun-ichiro Izumi, Yukio Kato
REPRODUCTIVE TOXICOLOGY
(2018)
Article
Genetics & Heredity
Nobuhiro Suzumori, Akihiko Sekizawa, Eri Takeda, Osamu Samura, Aiko Sasaki, Rina Akaishi, Seiji Wada, Haruka Hamanoue, Fumiki Hirahara, Hiroko Kuriki, Hideaki Sawai, Hiroaki Nakamura, Takahiro Yamada, Kiyonori Miura, Hideaki Masuzaki, Takahiro Yamashita, Yoshimasa Kamei, Akira Namba, Jun Murotsuki, Tomohiro Tanemoto, Akimune Fukushima, Kazufumi Haino, Shinya Tairaku, Keiichi Matsubara, Kazutoshi Maeda, Takashi Kaji, Masanobu Ogawa, Hisao Osada, Haruki Nishizawa, Yoko Okamoto, Takeshi Kanagawa, Aiko Kakigano, Masayuki Endo, Michihiro Kitagawa, Masaki Ogawa, Shunichiro Izumi, Yukiko Katagiri, Naoki Takeshita, Yasuyo Kasai, Katsuhiko Naruse, Reiko Neki, Hisashi Masuyama, Maki Hyodo, Yukie Kawano, Takashi Ohba, Kiyotake Ichizuka, Takeshi Nagamatsu, Atsushi Watanabe, Naomi Nishikawa, Naoki Hamajima, Nahoko Shirato, Junko Yotsumoto, Miyuki Nishiyama, Keiko Koide, Tatsuko Hirose, Haruhiko Sago
PRENATAL DIAGNOSIS
(2019)
Article
Integrative & Complementary Medicine
Makoto Arai, Yoshinobu Nakada, Shun-ichiro Izumi
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2017)
Article
Agriculture, Dairy & Animal Science
Mo Chen, Li-Yi Cai, Naoko Kanno, Takako Kato, Jinxing Lu, Fan Jin, Honghua Wang, Masayo Sekita, Masashi Higuchi, Saishu Yoshida, Hideji Yako, Hiroki Ueharu, Shun-Ichiro Izumi, Yukio Kato
JOURNAL OF REPRODUCTION AND DEVELOPMENT
(2013)
Article
Genetics & Heredity
Kazumi Takahashi, Takahide Hayano, Ryota Sugimoto, Hirofumi Kashiwagi, Mari Shinoda, Yoshihiro Nishijima, Takahiro Suzuki, Shingo Suzuki, Yuko Ohnuki, Akane Kondo, Takashi Shiina, Hirofumi Nakaoka, Ituro Inoue, Shun-ichiro Izumi
HUMAN GENOME VARIATION
(2018)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)