Article
Dentistry, Oral Surgery & Medicine
Styliani Anoixiadou, Andreas Parashis, Ioannis Vouros
Summary: This study compared the efficacy of MINST and MINST+EMD in treating intrabony defects ≤ 7 mm. Both groups showed significant improvements at 12 months, with the application of EMD leading to higher pocket closure rates and more successful composite outcomes. The additional application of EMD did not further improve mean clinical or radiographic outcomes.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Renata Cimoes, Leogenes M. Santiago, Arnaldo de Franca Caldas Junior, Bruna de Carvalho Farias Vajgel, Jeniffer Perussolo, Nikolaos Donos
Summary: The use of EMD in conjunction with SPPF in the surgical treatment of intrabony defects in controlled T2DM patients showed improved clinical outcomes in terms of CAL gain and PPD reduction after 6 months.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Boroka Klara Csifo-Nagy, Eleonora Solyom, Vera Lili Bognar, Annamaria Nevelits, Ferenc Dori
Summary: This study compared the clinical efficacy of a new generation of platelet-rich fibrin (A-PRF+) with enamel matrix derivative (EMD) in the healing of intrabony defects. Results showed that both treatments resulted in similar clinical outcomes, with statistically significant reductions in pocket depth and gains in clinical attachment level six months post-operatively.
Article
Dentistry, Oral Surgery & Medicine
Kentaro Imamura, Eiichi Suzuki, Takahiro Takeuchi, Atsushi Saito
Summary: The Modified Minimally Invasive Surgical Technique (M-MIST) combined with recombinant human fibroblast growth factor (rhFGF)-2 therapy showed favorable clinical outcomes in the treatment of intrabony defects, leading to improvements in oral health-related quality of life.
INTERNATIONAL JOURNAL OF PERIODONTICS & RESTORATIVE DENTISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jiahong Shi, Jinmeng Wang, Zhiyu Yang, Jingwen Li, Lang Lei, Houxuan Li
Summary: This study investigated a novel periodontal endoscopy-aided non-incisional regeneration technique (NIT) for the treatment of intra-bony defects. The results showed significant clinical and radiographic improvements in the NIT group compared with the periodontal endoscopy-aided scaling and root planing (PSRP) group at a 1-year follow-up. NIT may be considered as an alternative surgical treatment for periodontal intra-bony defects.
Article
Chemistry, Physical
Darko Bozic, Ivan Catovic, Ana Badovinac, Larisa Music, Matej Par, Anton Sculean
Summary: The study showed that the combination of HA and deproteinized porcine bone mineral in treating deep intrabony defects led to significant improvements in CAL and PPD, indicating it as a valid new approach.
Article
Dentistry, Oral Surgery & Medicine
Malgorzata Pietruska, Ewa Dolinska, Robert Milewski, Anton Sculean
Summary: This study found that there were no substantial added clinical benefits from postoperative administration of amoxicillin in conjunction with regenerative periodontal surgery using DBBM and GTR.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Andrea Pilloni, Mariana A. Rojas, Lorenzo Marini, Paola Russo, Yoshinori Shirakata, Anton Sculean, Roberta Iacono
Summary: The study compared the clinical outcomes of regenerative periodontal surgery using hyaluronic acid and enamel matrix derivative. Both treatments showed significant improvements in clinical outcomes, with EMD resulting in greater reduction in probing depth compared to HA.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Biochemistry & Molecular Biology
Giovanna Pitarresi, Fabio Salvatore Palumbo, Calogero Fiorica, Flavia Bongiovi, Annalisa Martorana, Salvatore Federico, Cinzia Maria Chinnici, Gaetano Giammona
Summary: An alkyl functionalized gellan gum derivative was used to create hydrogels containing hydroxyapatite and tricalcium phosphate nanoparticles for injectable nanostructured scaffolds in bone regeneration. The presence of inorganic nanoparticles reinforced the 3D hydrated polymeric networks without affecting injectability, and improved the physicochemical properties of ionotropic crosslinked hydrogels. Loading and release experiments demonstrated the drug delivery features of the injectable systems.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Vasiliki P. Koidou, Eleni Hagi-Pavli, Luigi Nibali, Nikolaos Donos
Summary: This study aims to understand the molecular healing process of intrabony defects following non-surgical periodontal therapy (NSPT) using gingival crevicular fluid (GCF). Limited information is currently available about the GCF of intrabony defects and the changes in biomarker levels in the GCF after treatment. The results show significant changes in GCF markers as early as 1 day after NSPT, along with signs of cellular senescence activation.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Mohamed Abdelrasoul, Ahmed Abd El-Fattah, Gehan Kotry, Omneya Ramadan, Marwa Essawy, Jahangir Kamaldin, Sherif Kandil
Summary: This study evaluated the effectiveness of a novel biodegradable bioactive hydrogel template loaded with melatonin in periodontal regenerative therapy. The results showed that the melatonin-loaded template accelerated bone formation and improved its quality, leading to complete periodontal regeneration.
Article
Dentistry, Oral Surgery & Medicine
Vincenzo Iorio-Siciliano, Andrea Blasi, Stefan-Ioan Stratul, Luca Ramaglia, Vela Octavia, Giovanni E. Salvi, Anton Sculean
Summary: In the treatment of suprabony periodontal defects, the use of EMD in conjunction with OFD may lead to better clinical outcomes compared to OFD alone.
CLINICAL ORAL INVESTIGATIONS
(2021)
Review
Pharmacology & Pharmacy
G. Cecoro, L. Guida, A. Iuorio, L. Nucci, P. Pesce, M. Annunziata
Summary: Cell-based therapies have shown promising results in the surgical treatment of intrabony periodontal defects, with significant improvement in clinical attachment level and reduction in intrabony defect depth. However, caution should be taken in interpreting the results due to the limited number of available RCTs, study design heterogeneity, and short follow-up duration.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Sharmistha Das, Saurav Panda, Rashmita Nayak, Rinkee Mohanty, Anurag Satpathy, Abhaya Chandra Das, Manoj Kumar, Barbara Lapinska
Summary: This systematic review compares the treatment efficacy of resorbable and non-resorbable barrier membranes in guided tissue regeneration for intrabony defects in patients with chronic periodontitis. The results show that the resorbable membrane group had significant improvements in gingival recession coverage and intrabony defect fill, avoiding the need for a second surgical intervention.
APPLIED SCIENCES-BASEL
(2022)
Review
Dentistry, Oral Surgery & Medicine
Chen-Yi Lee, Ting Sung, Po-Chun Chang
Summary: This article assesses the efficacy of periodontal regenerative therapy (PRT) in treating periodontal intrabony defects in East Asians. A systematic review was conducted, evaluating studies that used regenerative procedures such as barrier membrane (BM) and enamel matrix derivative (EMD) applications. The findings indicate that PRT showed improved regenerative outcomes compared to open flap debridement (OFD) in East Asians, with BM application appearing less efficient than in non-East Asians. BM with bone replacement graft (BRG) showed inferior clinical attachment level (CAL) gain compared to BM alone, while EMD with BRG showed superior CAL gain compared to EMD alone.
JOURNAL OF DENTAL SCIENCES
(2023)
