期刊
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
卷 16, 期 3, 页码 125-132出版社
SPRINGER
DOI: 10.1007/s10989-010-9201-4
关键词
Neoglycopeptides; Neoglycoproteins; Glycosylation; Conjugation; Azide-alkyne cycloadditon; Click chemistry
Novel chemical methods to access homogeneous samples of glycopeptides and glycoproteins and their mimetics, so-called neoglycopeptides and neoglycoproteins, have developed rapidly in recent years owing to an increased need to investigate both their roles in molecular biology and their potential as therapeutic agents. This article summarizes the application of the copper-catalyzed azide-alkyne cycloaddition for the chemical synthesis of neoglycopeptides and neoglycoproteins.
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