Article
Cell Biology
Hyun-Jin Kim, Byungjae Hwang, Maria Reva, Jieun Lee, Byeong Eun Lee, Youngeun Lee, Eun Jeong Cho, Minseok Jeong, Seung Eun Lee, Kyungjae Myung, Ja-Hyun Baik, Jung-Hoon Park, Jae-Ick Kim
Summary: Dopamine synapses are important for volitional movement and reward-related behaviors, with dysfunction leading to psychiatric and neurological disorders. Research reveals that dopamine transmission is strongly correlated with GABA co-transmission, and dopamine synapses have similar structure and function to GABAergic synapses with regional heterogeneity.
Article
Cell Biology
Natalie J. Guzikowski, Ege T. Kavalali
Summary: Earlier studies explored the organization of proteins that drive neurotransmitter release and postsynaptic signaling at excitatory synapses, but the spatial organization of neurotransmission at inhibitory synapses remains unclear. This study used the specific interaction between antimalarial artemisinins and the inhibitory synapse scaffold protein, gephyrin, to investigate the functional organization of GABAAR-mediated neurotransmission. The results suggest that the GABAergic postsynaptic apparatus has a concentric center-surround organization, where the peripheral gephyrin clusters selectively maintain spontaneous GABAergic neurotransmission, facilitating its autonomous function in regulating Bdnf expression.
Article
Multidisciplinary Sciences
Yue Hao, Haowen Liu, Xian-Ting Zeng, Ya Wang, Wan-Xin Zeng, Kang-Ying Qian, Lei Li, Ming-Xuan Chi, Shangbang Gao, Zhitao Hu, Xia-Jing Tong
Summary: The study reveals that CaMKII functions in GABAergic neurons to recruit GABA(A)Rs by triggering anterograde signals, providing insights into the mechanism of inhibitory synaptic transmission.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Zahra S. Thirouin, Marta Figueiredo, Mohammad Hleihil, Raminder Gill, Giovanna Bosshard, R. Anne McKinney, Shiva K. Tyagarajan
Summary: BDNF regulates the spatial and temporal distribution of SUMO proteins in neurons, influencing the post-synaptic protein SUMOylation. BDNF signaling promotes the nuclear exodus of SUMO proteins and their enrichment in dendrites, mediated by the receptor tropomyosin-related kinase B. PIAS-3, a SUMO E3 ligase, is specifically enriched in dendrites in response to BDNF signaling and modulates the ERK1/2 kinase pathway signaling.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Cell Biology
Teresa M. L. Cramer, Berangere Pinan-Lucarre, Anna Cavaccini, Angeliki Damilou, Yuan-Chen Tsai, Musadiq A. Bhat, Patrizia Panzanelli, Nicolas Rama, Patrick Mehlen, Dietmar Benke, Theofanis Karayannis, Jean-Louis Bessereau, Shiva K. Tyagarajan
Summary: The study reveals the crucial role of Adamtsl3 and DCC in synapse formation and maintenance, particularly in the adaptation of GABAergic synapses. These findings are of significant importance for schizophrenia research.
Article
Neurosciences
Kunwei Wu, Ryan David Shepard, David Castellano, Wenyan Han, Qingjun Tian, Lijin Dong, Wei Lu
Summary: A phosphorylation site on Shisa7 was found to be critical for GABA(A)R trafficking, and it contributes to the behavioral endophenotypes displayed in neurodevelopmental disorders.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hyun-Jung An, Cheol-Jung Lee, Ga-Eun Lee, Youngwon Choi, Dohyun Jeung, Weidong Chen, Hye Suk Lee, Han Chang Kang, Joo Young Lee, Dae Joon Kim, Jin-Sung Choi, Eun Suh Cho, Jong-Soon Choi, Yong-Yeon Cho
Summary: FBXW7 regulates ERK3 stability by promoting its ubiquitination and degradation, thereby suppressing lung cancer cell proliferation.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Cell Biology
Saebom Lee, Hye Guk Ryu, Sin Ho Kweon, Hyerynn Kim, Hyeonwoo Park, Kyung-Ha Lee, Sang-Min Jang, Chan Hyun Na, Sangjune Kim, Han Seok Ko
Summary: Non-receptor tyrosine kinase c-Abl is involved in the development of various neurodegenerative disorders. This study reveals that TDP-43 is a novel substrate for c-Abl and its phosphorylation by c-Abl leads to increased levels of TDP-43 in the cytoplasm and the formation of stress granules. In addition, phosphorylation of TDP-43 by c-Abl promotes its aggregation and neuronal cell death.
Article
Biochemistry & Molecular Biology
Lara A. Gruijs da Silva, Francesca Simonetti, Saskia Hutten, Henrick Riemenschneider, Erin L. Sternburg, Lisa M. Pietrek, Jakob Gebel, Volker Doetsch, Dieter Edbauer, Gerhard Hummer, Lukas S. Stelzl, Dorothee Dormann
Summary: This translated article investigates the regulatory role of post-translational modifications (PTMs) on protein phase separation and aggregation. The study finds that hyperphosphorylation of TDP-43 protein has a protective effect, reducing aggregation and making the condensates more liquid-like and dynamic.
Article
Multidisciplinary Sciences
Seungjoon Kim, Mooseok Kang, Dongseok Park, Ae-Ree Lee, Heinrich Betz, Jaewon Ko, Iksoo Chang, Ji Won Um
Summary: The study used molecular dynamics simulations and in silico analyses to investigate the effects of mutations on Gephyrin, finding that A91T and G375D mutations reduced the binding free energy of gephyrin oligomer formation and altered clustering patterns in cells and neurons. The G375D mutation also disrupted interactions with GABA(A) receptors and neuroligin-2 in mouse brain, leading to deficits in GABAergic synapse maintenance and neuronal hyperactivity in specific mice models.
Article
Cell Biology
Yan Yan, Karl N. Krecke, Aditi S. Bapat, Tingyuan Yang, Michael W. Lopresti, Douglas G. Mashek, Ameeta Kelekar
Summary: The study revealed a novel role for PHLPP2 in targeting AMP-activated protein kinase (AMPK) to suppress the survival response of leukemia cells under glucose limitation. Silencing PHLPP2 prolonged the survival of leukemia cells by promoting AMPK-mediated fatty acid oxidation. This discovery could lead to better therapeutic strategies for both cancer and metabolic diseases.
CELL DEATH & DISEASE
(2021)
Article
Biology
Campbell D. Lawson, Samantha Peel, Asier Jayo, Adam Corrigan, Preeti Iyer, Mabel Baxter Dalrymple, Richard J. Marsh, Susan Cox, Isabel Van Audenhove, Jan Gettemans, Maddy Parsons
Summary: Fascin is an important regulator of F-actin bundling in tumor cells. It has been found that Fascin bundles F-actin within the nucleus, supporting chromatin organization and efficient DNA damage response. Increased nuclear accumulation of Fascin leads to sustained nuclear F-actin bundling, resulting in reduced invasion, viability, and apoptosis of cancer cells.
Article
Biology
Komal Ramani, Nirmala Mavila, Aushinie Abeynayake, Maria Lauda Tomasi, Jiaohong Wang, Michitaka Matsuda, Eki Seki, Arya Mani
Summary: This study reveals a potential therapeutic target for liver fibrosis by investigating the role of AKAP12 phosphorylation in HSC activation. The researchers found that AKAP12's scaffolding activity toward HSP47 is inhibited by phosphorylation in activated HSCs. Using CRISPR gene editing, they restored AKAP12's scaffolding function, inhibiting HSP47's collagen maturation and HSC activation. AKAP12 phospho-editing significantly reduced fibrosis, ER stress response, HSC inflammatory signaling, and liver injury in mice.
Review
Biochemistry & Molecular Biology
Lassi Koski, Cecilia Ronnevi, Elina Berntsson, Sebastian K. T. S. Warmlander, Per M. Roos
Summary: ALS, Alzheimer's disease, Parkinson's disease and other neurodegenerative disorders have a significant impact on patients, caregivers, and society due to the aggregation of proteins in nerve cells. TDP-43 seems to play a specific role in ALS pathogenesis, and further research is needed on the role of metals in TDP-43 aggregation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Yuan Tian, Yi Wang, Angela M. Jablonski, Yinghui Hu, Jonathan A. Sugam, Markus Koglin, Shawn J. Stachel, Heather Zhou, Jason M. Uslaner, Sophie Parmentier-Batteur
Summary: Elevated levels of TTBK1 were observed in the motor cortex of ALS patients, and TTBK1 was found to phosphorylate TDP-43 directly, leading to the formation of high molecular species and subsequent neuronal loss. Inhibiting TTBK1 significantly alleviated TDP-43 phosphorylation and aggregation, suggesting a potential therapeutic strategy for ALS and FTLD.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Medicine, Research & Experimental
Hong-Ru Chen, Ching-Wen Chen, Yi-Min Kuo, Brandon Chen, Irena S. Kuan, Henry Huang, Jolly Lee, Neil Anthony, Chia-Yi Kuan, Yu-Yo Sun
Summary: Monocytes play a significant role in neonatal brain injury, promoting acute inflammatory responses and transforming into pathological microglia. Blocking the influx of monocytes may be a potential therapy for neonatal brain injury.
Article
Nutrition & Dietetics
Chung Y. Hsu, Jung-Nien Lai, Woon-Man Kung, Chao-Hsien Hung, Hei-Tung Yip, Yu-Chen Chang, Cheng-Yu Wei
Summary: Tube feeding, specifically nasogastric tube (NGT) placement, is commonly used for patients with severe swallowing issues. This study in Taiwan aimed to determine the prevalence and outcomes of long-term NGT placement. The results showed that long-term NGT use was associated with a higher risk of comorbidities and mortality.
Article
Multidisciplinary Sciences
Yi-Min Kuo, Hsien-Yung Lai, Elise Chia-Hui Tan, Yi-Shiuan Li, Ting-Yun Chiang, Shiang-Suo Huang, Wen-Cheng Huang, Ya-Chun Chu
Summary: GlideScope achieved equivalent performance in nasotracheal intubation (NTI) with or without cervical immobilization. The upper lip bite test class was predictive of intubation time, the necessity of auxiliary manipulations, and a nasoIDS >= 4.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Jun-Jun Yeh, Shih-Hueh Syue, Yi-Fun Sun, Yi-Ting Yeh, Ya-Chi Zheng, Cheng-Li Lin, Chung Y. Hsu, Chia-Hung Kao
Summary: This study investigated the effects of hydroxychloroquine on the risk of pulmonary vascular disease in interstitial lung disease patients. The results showed that patients receiving hydroxychloroquine treatment, especially those using it for a medium to long-term period or young women, had a higher risk of pulmonary vascular disease.
Article
Environmental Sciences
Shih-Wei Chen, Han-Jie Lin, Stella Chin-Shaw Tsai, Cheng-Li Lin, Chung Y. Hsu, Tsai-Ling Hsieh, Chuan-Mu Chen, Kuang-Hsi Chang
Summary: This study aims to investigate the association between air pollution and chronic rhinosinusitis (CRS). Using databases from Taiwan's National Health Insurance and Air Quality Monitoring, the study found that higher levels of air pollutants, such as PM2.5, NO2, and PM10, were significantly associated with increased CRS risk.
Article
Environmental Sciences
Kuang-Hsi Chang, Chieh-Lin Jerry Teng, Yi-Chao Hsu, Stella Chin-Shaw Tsai, Han-Jie Lin, Tsai-Ling Hsieh, Chih-Hsin Muo, Chung Y. Hsu, Ruey-Hwang Chou
Summary: This study assessed the environmental risk factors of benign brain tumors (BBT) by integrating patients' clinical data and daily air quality data. The results indicated that long-term exposure to air pollutants such as CO, NO2, and PM2.5 may be associated with an increased risk of BBT.
Article
Environmental Sciences
Fu-Shun Yen, Chih-Cheng Hsu, Kai-Chieh Hu, Yu-Tung Hung, Chung Y. Hsu, James Cheng-Chung Wei, Chii-Min Hwu
Summary: This study aimed to investigate the impact of metformin use on the risk of chronic urticaria in patients with type 2 diabetes. The results showed a significantly higher risk of chronic urticaria development among metformin users compared to nonusers. The risk was even higher for patients with longer duration of metformin use. Further prospective studies are needed to confirm these findings.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Immunology
Fu-Shun Yen, James Cheng-Chung Wei, Ying-Hsiu Shih, Chung Y. Hsu, Chih-Cheng Hsu, Chii-Min Hwu
Summary: This study shows that older adults with type 2 diabetes mellitus who use metformin as a pre-influenza vaccination have lower risks of hospitalization for influenza, pneumonia, cardiovascular disease, mechanical ventilation, and mortality compared to nonusers of metformin.
Article
Biochemistry & Molecular Biology
Jui-Ting Mao, Jung-Nien Lai, Yi-Hsiu Fu, Hei-Tung Yip, Yen-Chun Lai, Chung-Y Hsu, Sung-Hsiung Chen, Shu-Jui Kuo
Summary: This study aimed to investigate the effects of aspirin and clopidogrel on the risk of hip fracture among type 2 diabetes patients. The study found that higher dosage and longer duration of antiplatelet drugs could be associated with lower fracture risk, while lower dosage and shorter duration could be associated with higher fracture risk. The best regimen to prevent hip fracture was the use of aspirin and clopidogrel for at least 3 years.
Article
Neurosciences
Yu-Jie Huang, Chia-Chi Hung, Pei-Chien Hsu, Po-Yi Lee, Yen-An Tsai, Yu-Chiao Hsin, Xie-Ting Lee, Chia-Cheng Chou, Mei-Lien Chen, Der-Cherng Tarng, Yi-Hsuan Lee
Summary: Chronic kidney disease (CKD) is associated with mental disorders caused by the accumulation of indoxyl-3-sulfate (I3S) in the brain. I3S induces oxidative stress and activates the aryl hydrocarbon receptor (AhR). This study showed that AhR plays a crucial role in CKD-induced brain disorders and disturbance of neuron-astrocyte interaction.
Article
Biochemistry & Molecular Biology
Mei-Han Kao, Chien-Yu Huang, Wai-Mui Cheung, Yu-Ting Yan, Jin-Jer Chen, Yuan-Soon Ho, Chung Y. Hsu, Teng-Nan Lin
Summary: This study confirms the existence of a neuroprotective ATF3 -> CTMP signal cascade in the ischemic brain and suggests the therapeutic potential of both ATF3 overexpression and CTMP knockdown for stroke treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
Chung-Hsin Yeh, Fung-Chang Sung, Chih-Hsin Muo, Pao-Sheng Yen, Chung Y. Y. Hsu
Summary: A retrospective cohort study found that women with primary dysmenorrhea (PD) have a higher risk of stroke compared to those without dysmenorrhea. The study suggests that women with PD are at increased risk for ischemic stroke.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Environmental Sciences
Hueng-Chuen Fan, Chuan-Mu Chen, Jeng-Dau Tsai, Kuo-Liang Chiang, Stella Chin-Shaw Tsai, Ching-Ying Huang, Cheng-Li Lin, Chung Y. Hsu, Kuang-Hsi Chang
Summary: This study found a significant correlation between early-life exposure to particulate matter PM2.5 and PM10 and attention-deficit/hyperactivity disorder (ADHD).
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Physiology
Yi-Min Kuo, Yi-Hsuan Lee
Summary: This article reviews the action mechanisms and potential applications of epoxyeicosatrienoic acids (EETs) and their metabolic enzyme soluble epoxide hydrolase (sEH) in the central nervous system. EETs exhibit beneficial effects such as anti-inflammation, anti-apoptosis, and anti-oxidation through multiple signaling pathways, while inhibition of sEH holds potential therapeutic value in cardiovascular disease and cancer treatment.
CHINESE JOURNAL OF PHYSIOLOGY
(2022)