Article
Neurosciences
Madeleine Kyrke-Smith, Lenora J. Volk, Samuel F. Cooke, Mark F. Bear, Richard L. Huganir, Jason D. Shepherd
Summary: Research shows that mice lacking the Arc gene do not exhibit deficits in hippocampal long-term potentiation (LTP), indicating that Arc is not necessary for LTP in the hippocampus.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Carolina A. Oliva, Daniela S. Rivera, Angie K. Torres, Carolina B. Lindsay, Cheril Tapia-Rojas, Francisco Bozinovic, Nibaldo C. Inestrosa
Summary: In Octodon degus, females experience more severe aging than males. Andrographolide treatment improves complex behaviors related to age-detrimental effects in females.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Adrian Gonzalez-Martin, Tomas Moyano, Daniela A. Gutierrez, Franciso J. Carvajal, Waldo Cerpa, Jonathan G. Hanley, Rodrigo A. Gutierrez, Alejandra R. Alvarez
Summary: Studies have shown that c-Abl kinase deficiency in the brain of mice can improve learning acquisition and memory consolidation, and also affect gene expression patterns in the mouse hippocampus. Trained c-Abl KO mice exhibit upregulation of genes involved in synaptic plasticity and actin cytoskeleton dynamics, and have larger and more densely distributed dendritic spines.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Andrew C. Toader, Josue M. Regalado, Yan Ran Li, Andrea Terceros, Nakul Yadav, Suraj Kumar, Sloane Satow, Florian Hollunder, Alessandra Bonito-Oliva, Priya Rajasethupathy
Summary: Memories formed initially in the hippocampus are gradually stabilized to the cortex for long-term storage. The mechanisms of this brain re-organization are poorly understood. By recording neural activity in the circuits connecting the hippocampus and cortex in mice performing a memory-guided virtual reality task over weeks, researchers identified a strong correlation between memory and activity in the anterior thalamus, with inhibition of this activity disrupting memory consolidation. Additionally, gain amplification enhanced consolidation of memories that were otherwise not consolidated. The researchers also found that the anteromedial thalamus preferentially encodes salient memories and gradually increases correlations with the cortex to facilitate tuning and synchronization of cortical ensembles, suggesting a mechanism for the selection and stabilization of hippocampal memories into longer-term cortical storage.
Article
Neurosciences
Megane Missaire, Nicolas Fraize, Jean-Christophe Comte, Bruno Truchet, Regis Parmentier, Paul-Antoine Salin, Gael Malleret
Summary: Long-term storage of information in memory relies on long-term synaptic plasticity processes. Studies have shown synaptic changes after training in long-term/reference memory and working memory tasks. Consolidation of long-term information leads to delayed synaptic potentiation, while optimal information processing into working memory triggers synaptic depression.
Article
Neurosciences
Lorenzo More, Lucia Privitera, Philippa Perrett, Daniel D. Cooper, Manuel Van Gijsel Bonnello, J. Simon C. Arthur, Bruno G. Frenguelli
Summary: The transcription factor CREB plays a crucial role in regulating physiological functions in the central nervous system. Recent research has focused on the phosphorylation of the S133 residue in CREB, which is required for its transcriptional activation. Previous studies using molecular genetic techniques have resulted in conflicting results, possibly due to the manipulation of endogenous CREB. In this study, the researchers generated a postnatal and forebrain-specific mutant of CREB S133A to avoid potential complications. The findings show that CREB S133 is necessary for spatial cognitive flexibility, basal synaptic transmission, and long-term potentiation in the hippocampus, highlighting its importance in neuronal function, synaptic plasticity, and cognition.
Article
Medicine, Research & Experimental
Jee Hyun Yi, Se Jin Jeon, Huiyoung Kwon, Eunbi Cho, Jieun Jeon, Somin Moon, A. Young Park, Hyun-Ji Kwon, Ye Hee Lee, Kyoung Ja Kwon, Chan Young Shin, Dong Hyun Kim
Summary: Stress is a common part of life and can cause various neurological and psychiatric disorders. Proper stress management is important for maintaining a healthy life. This study investigated the impact of ethyl pyruvate (EP) on stress-induced cognitive decline and found that EP can block the inhibitory effect of the stress hormone corticosterone on synaptic plasticity. Administration of EP improved cognitive decline caused by stress by regulating Akt/GSK-3β signaling and improving neurogenesis and synaptic function deficits.
Article
Medicine, Research & Experimental
Wanqiu Niu, Yanhong Duan, Yu Kang, Xiaohua Cao, Qingsheng Xue
Summary: This study investigated the effect of propofol on fear memory extinction and synaptic plasticity in a PTSD mice model. The results showed that propofol can accelerate fear memory extinction and restore impaired synaptic plasticity in the hippocampus of PTSD mice.
Editorial Material
Cell Biology
Yue Pan, Guangjun Zhou, Wenwen Li, Xingzhi He, Cuicui Li, Yanjun Li, Tao Li, Hailan Hu, Huan Ma
Summary: This study revealed a novel mechanism in which synaptic activities recruit long-lasting autophagy through excitation-transcription coupling for synaptic remodeling.
Article
Biotechnology & Applied Microbiology
Yingying Zha, Yan Jin, Xinxing Wang, Lin Chen, Xulai Zhang, Ming Wang
Summary: In this study, the distribution of fullerenol in the brain was confirmed using MALDI-TOF-MS, and it was found that a low dose of fullerenol could improve lead-induced impairment in learning and memory through long-term changes in hippocampal synaptic plasticity. Structural alterations in synaptic connection were observed, suggesting the therapeutic potential of fullerenol in the development of new drugs.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Environmental Sciences
Rundong Liu, Lin Bai, Mengchen Liu, Ruike Wang, Yingying Wu, Qiong Li, Yue Ba, Huizhen Zhang, Guoyu Zhou, Fangfang Yu, Hui Huang
Summary: Lead and high-fat diets are co-occurring risk factors for cognitive impairment. This study found that combined exposure to lead and high-fat diets exacerbates cognitive deficits and affects synaptic plasticity through multiple signaling pathways. The study highlights the importance of evaluating the effects of mixed exposures on brain function in realistic environments and the need to modulate central pathways to prevent neurological disorders.
ENVIRONMENTAL POLLUTION
(2022)
Article
Biochemistry & Molecular Biology
Grzegorz Wiera, Katarzyna Lebida, Anna Maria Lech, Patrycja Brzdak, Inge Van Hove, Lies De Groef, Lieve Moons, Enrica Maria Petrini, Andrea Barberis, Jerzy W. Mozrzymas
Summary: This study demonstrates that MMP3 plays a key role in iLTP mechanisms, affecting behaviors that in part depend on GABAergic plasticity.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Soomaayeh Heysieattalab, Jafar Doostmohammadi, Mahgol Darvishmolla, Negin Saeedi, Narges Hosseinmardi, Masoumeh Gholami, Mahyar Janahmadi, Samira Choopani
Summary: Long-term administration of ASA and SS may have detrimental effects on spatial learning and memory, as well as hippocampal synaptic plasticity, leading to impairments in memory acquisition and retrieval.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Neurosciences
Dan C. Li, Elizabeth G. Pitts, Niharika M. Dighe, Shannon L. Gourley
Summary: Cocaine self-administration can disrupt flexible modification of behavioral routines. This study explores the mechanistic factors behind the long-term behavioral changes caused by cocaine use. The researchers found that the reduction of PSD-95 protein in the orbitofrontal cortex (OFC) and lower GluN2B subunit content in the OFC are associated with deficits in decision-making behavior and resilience to escalating oral cocaine seeking. The inhibition of GluN2B-NMDARs prevents the dysregulation of neuronal structure and function in the OFC, preserving mature dendritic spine densities and functional connections necessary for action flexibility.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Zhengchang Lei, Kristin Henderson, Krystyna Keleman
Summary: Learning enhances sleep, and a neural circuit in Drosophila mediates the learning-induced sleep, ensuring that only long or intense learning experiences are consolidated into long-term memory.
NATURE COMMUNICATIONS
(2022)
Article
Veterinary Sciences
F. Wielaender, F. M. K. James, M. A. Cortez, G. Kluger, J. N. Nessler, A. Tipold, H. Lohi, A. Fischer
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2018)
Article
Multidisciplinary Sciences
Franziska Wielaender, Riika Sarviaho, Fiona James, Marjo Hytoenen, Miguel Cortez, Gerhard Kluger, Lotta Koskinen, Meharji Arumilli, Marion Kornberg, Andrea Bathen-Noethen, Andrea Tipold, Kai Rentmeister, Sofie Bhatti, Velia Huelsmeyer, Irene C. Boettcher, Carina Taestensen, Thomas Flegel, Elisabeth Dietschi, Tosso Leeb, Kaspar Matiasek, Andrea Fischer, Hannes Lohi
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Clinical Neurology
Krutika Joshi, Lily Shen, Feng Cao, Susan Dong, Zhengping Jia, Miguel A. Cortez, O. Carter Snead
Editorial Material
Clinical Neurology
Puneet Jain, Robyn Whitney, Miguel A. Cortez
JOURNAL OF CLINICAL NEUROSCIENCE
(2018)
Article
Clinical Neurology
Vera Nenadovic, Robyn Whitney, Jason Boulet, Miguel A. Cortez
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2018)
Article
Cell Biology
Celeste Leung, Feng Cao, Robin Nguyen, Krutika Joshi, Afif J. Aqrabawi, Shuting Xia, Miguel A. Cortez, O. Carter Snead, Jun Chul Kim, Zhengping Jia
Review
Genetics & Heredity
Jason L. Jia, Shiyi Chen, Vishalini Sivarajah, Derek Stephens, Miguel A. Cortez
ORPHANET JOURNAL OF RARE DISEASES
(2018)
Article
Clinical Neurology
Puneet Jain, Pratima Gulati, Daad Alsowat, Miguel A. Cortez, O. Carter Snead, Robyn Whitney
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2018)
Article
Clinical Neurology
Shiro Baba, Vasily A. Vakorin, Sam M. Doesburg, Chizuko Nagamori, Miguel A. Cortez, Ryoko Honda, Tomonori Ono, Keisuke Toda, Hanako Nishimoto, Toshihiro Ebihara, Kana Sakai, Ayako Ochi, O. Carter Snead, Hiroshi Baba, Hiroshi Otsubo
Article
Veterinary Sciences
Thomas Parmentier, Gabrielle Monteith, Miguel A. Cortez, Franziska Wielaender, Andrea Fischer, Tarja S. Jokinen, Hannes Lohi, Sean Sanders, Veronique Sammut, Tricia Tai, Fiona M. K. James
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2020)
Article
Multidisciplinary Sciences
Feng Cao, Jackie J. Liu, Susan Zhou, Miguel A. Cortez, O. Carter Snead, Jing Han, Zhengping Jia
NATURE COMMUNICATIONS
(2020)
Article
Veterinary Sciences
Masayasu Ukai, Thomas Parmentier, Miguel A. Cortez, Andrea Fischer, Luis Gaitero, Hannes Lohi, Stephanie Nykamp, Tarja S. Jokinen, Danielle Powers, Veronique Sammut, Sean Sanders, Tricia Tai, Franziska Wielaender, Fiona James
Summary: Many veterinary studies on epilepsy rely on subjective caregiver-derived histories to determine seizure frequency, while in human medicine objective EEG data are used. This study found a weak correlation between reported seizures and EEG-confirmed ictal paroxysmal discharges in dogs, suggesting potential underreporting of seizures. Confirmation of this phenomenon in dogs through prospective studies is recommended.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Clinical Neurology
Ipsita Goswami, Bryan Maguire, Vann Chau, Emily W. Tam, Elana Pinchefsky, Robyn Whitney, Diane Wilson, Steven P. Miller, Miguel A. Cortez
Summary: This study investigates the association between heart rate variability (HRV) in infants at risk of Infantile Epileptic Spasm Syndrome (IESS) and the clinical onset of IESS. The study found that early HRV patterns may be potential predictors for the development of IESS, providing valuable prognostic information.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, General & Internal
Nihan Carcak, Melike Sahiner, Ozlem Akman, Medine Gulcebi Idrizoglu, Miguel A. Cortez, O. Carter Snead, Esat Eskazan, Filiz Onat
NORTHERN CLINICS OF ISTANBUL
(2020)
Meeting Abstract
Clinical Neurology
O. Snead, Susan Dong, Krutika Joshi, Miguel Cortez