PPAR-α agonist regulates amyloid-β generation via inhibiting BACE-1 activity in human neuroblastoma SH-SY5Y cells transfected with APPswe gene

Pharmacological chaperones stabilize retromer to limit APP processing

(2014) Vincent J Mecozzi et al.   Nature Chemical Biology

Experimental research Effects of berberine on β-secretase activity in a rabbit model of Alzheimer’s disease

(2013) Negar Panahi et al.   Archives of Medical Science

Pharmacologic Inhibition of ROCK2 Suppresses Amyloid-  Production in an Alzheimer's Disease Mouse Model

(2013) J. H. Herskowitz et al.   JOURNAL OF NEUROSCIENCE

FLZ Alleviates the Memory Deficits in Transgenic Mouse Model of Alzheimer’s Disease via Decreasing Beta-Amyloid Production and Tau Hyperphosphorylation

(2013) Xiu-Qi Bao et al.   PLoS One

Design and synthesis of 1,4-dihydropyridine derivatives as BACE-1 inhibitors

(2010) Soo-Jeong Choi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Protein aggregation diseases: pathogenicity and therapeutic perspectives

(2010) Adriano Aguzzi et al.   NATURE REVIEWS DRUG DISCOVERY

PPARα: an emerging therapeutic target in diabetic microvascular damage

(2010) Anne Hiukka et al.   Nature Reviews Endocrinology

17β-Estradiol regulates insulin-degrading enzyme expression via an ERβ/PI3-K pathway in hippocampus: Relevance to Alzheimer's prevention

(2010) Liqin Zhao et al.   NEUROBIOLOGY OF AGING

Role of Amyloid-  Glycine 33 in Oligomerization, Toxicity, and Neuronal Plasticity

(2009) A. Harmeier et al.   JOURNAL OF NEUROSCIENCE

Amyloid   Protein Dimer-Containing Human CSF Disrupts Synaptic Plasticity: Prevention by Systemic Passive Immunization

(2008) I. Klyubin et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors

(2008) Raj N Kalaria et al.   LANCET NEUROLOGY

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

PPARs in Alzheimer's Disease

(2008) Markus P. Kummer et al.   PPAR Research

PPAR Regulation of Inflammatory Signaling in CNS Diseases

(2008) John J. Bright et al.   PPAR Research

Interleukin-1β impairs brain derived neurotrophic factor-induced signal transduction

(2007) Liqi Tong et al.   NEUROBIOLOGY OF AGING