Article
Oncology
Katherine Tucker, Yajie Yin, Stuart-Allison Staley, Ziyi Zhao, Ziwei Fang, Yali Fan, Xin Zhang, Hongyan Suo, Wenchuan Sun, Varun Vijay Prabhu, Joshua E. Allen, Chunxiao Zhou, Victoria L. Bae-Jump
Summary: ONC206, a chemically modified derivative of ONC201, is a potent inhibitor of cell proliferation and shows anti-tumorigenic effects in ovarian cancer. It has the potential to be an important therapeutic option for ovarian cancer treatment.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Guangxu Xu, Weimin Kong, Ziwei Fang, Yali Fan, Yajie Yin, Stephanie A. Sullivan, Arthur-Quan Tran, Leslie H. Clark, Wenchuan Sun, Tianran Hao, Luyu Zhao, Chunxiao Zhou, Victoria L. Bae-Jump
Summary: The natural product asparagus officinalis exhibits anti-tumorigenic and anti-metastatic effects on serous ovarian cancer cells by decreasing cell viability, inducing apoptosis, and reducing adhesion and invasion abilities. Additionally, it shows synergistic anti-proliferative activity when combined with paclitaxel, and inhibits tumor growth and reduces serum levels of VEGF in a mouse model of ovarian cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Daniel J. Garcia-Dominguez, Nabil Hajji, Roser Lopez-Alemany, Sara Sanchez-Molina, Elisabet Figuerola-Bou, Francisco J. Moron Civanto, Santiago Rello-Varona, Eduardo Andres-Leon, Adrian Benito, Hector C. Keun, Jaume Mora, Oscar M. Tirado, Enrique de Alava, Lourdes Hontecillas-Prieto
Summary: The study evaluated the effects of a selective G9a histone methyltransferase inhibitor (BIX01294) on the metastatic process of Ewing sarcoma (EWS). The results showed that overexpression of G9a in EWS tumors is associated with poor prognosis. Furthermore, the inhibition of G9a with BIX01294 disrupted several steps of metastasis in vitro and reduced tumor growth and metastases in mouse models. The study also identified the sialidase NEU1 as a direct target and effector of G9a in the metastatic process of EWS.
Article
Reproductive Biology
Xin Zhang, Wenjie Gu, Aiqin Lin, Renjie Duan, Likai Lian, Yuanyuan Huang, Tiechen Li, Qing Sun
Summary: Through bioinformatics analysis, it was found that OIP5 is highly expressed in ovarian cancer and may be an important biomarker for this cancer. Further experiments confirmed that silencing the OIP5 gene can inhibit the proliferation, migration, and invasion of ovarian cancer cells, induce cell cycle arrest, and promote cell apoptosis.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Oncology
Yali Fan, Jiandong Wang, Ziwei Fang, Stuart R. Pierce, Lindsay West, Allison Staley, Katherine Tucker, Yajie Yin, Wenchuan Sun, Weimin Kong, Varun Prabhu, Joshua E. Allen, Chunxiao Zhou, Victoria L. Bae-Jump
Summary: ONC201 shows promising anti-tumor potential in ovarian cancer by suppressing cell proliferation and inducing apoptosis through multiple pathways. It also inhibits adhesion and invasion in cancer cells. Additionally, it can suppress tumor growth and decrease serum VEGF production, which is accelerated by obesity.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yu Huang, Yali Fan, Ziyi Zhao, Xin Zhang, Katherine Tucker, Allison Staley, Hongyan Suo, Wenchuan Sun, Xiaochang Shen, Boer Deng, Stuart R. Pierce, Lindsay West, Yajie Yin, Michael J. Emanuele, Chunxiao Zhou, Victoria Bae-Jump
Summary: This study investigated the effect of CDK1 expression on the prognosis of ovarian cancer patients and the anti-tumorigenic effect of the CDK1 inhibitor, RO-3306. The results showed that the overexpression of CDK1 was associated with poor prognosis, and RO-3306 effectively reduced cell proliferation and tumor growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Xuehan Bi, Xiao Lv, Dajiang Liu, Hongtao Guo, Guang Yao, Lijuan Wang, Xiaolei Liang, Yongxiu Yang
Summary: METTL3 promotes the maturation of miR-126-5p through m6A modification, which in turn targets PTEN to activate the PI3K/Akt/mTOR pathway in ovarian cancer progression. This study provides potential targets for future ovarian cancer treatment and reveals tumorigenic mechanisms regulated by m6A modification.
CANCER GENE THERAPY
(2021)
Article
Medicine, Research & Experimental
Jiangtao Yu, Xiaoli Hu, Xiuxiu Chen, Qiangyong Zhou, Qi Jiang, Zhengzheng Shi, Haiyan Zhu
Summary: CNOT7 plays an important role in biological processes and has potential for treating malignant tumors. This study aimed to investigate the functions and mechanism of CNOT7 in ovarian cancer. Results showed that CNOT7 overexpression in A2780 and SKOV3 cells could be partially or completely eliminated by treatment with the AKT inhibitor LY294002.
Article
Medicine, Research & Experimental
Tianshui Sun, Fangfang Bi, Zhuonan Liu, Qing Yang
Summary: In ovarian cancer patients, TMEM119 is overexpressed and associated with poor survival. Experimental results indicate TMEM119 promotes proliferation, invasion, and migration of ovarian cancer cells. Additionally, TMEM119 may exert oncogenic effects by regulating PDGFRB expression and activating the PI3K/AKT signaling pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, General & Internal
Chuanfeng Zhang, Ruirui Pan, Shuangshuang Ma, Shoucai Xu, Baosheng Wang
Summary: This study found that dezocine has significant inhibitory effects on the growth and metastasis of ovarian cancer cells,suppressing cell viability in a dose-dependent manner and reducing migration and invasion abilities. Additionally, dezocine inhibited the Akt/mTOR signaling pathway and inhibited the expression of CRABP2, with CRABP2 functioning as a downstream effector of dezocine.
Article
Oncology
Lili Zhang, Huixiao Chen, Fengxi He, Shiqian Zhang, Aihua Li, Aifeng Zhang, Anqi Zhang
Summary: miR-320a plays an important role in ovarian cancer progression and infiltration, promoting the proliferation, migration, and invasion of EOC cells by targeting RASSF8.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yang Bai, Chenchen Ren, Baojin Wang, Jingge Xue, Feiyan Li, Jiaxi Liu, Li Yang
Summary: Recent studies have shown that MAFG-AS1 stimulates the malignant progression of OC by upregulating NFKB1-mediated IGF1 via miR-339-5p, highlighting a potential novel therapeutic target against OC.
CANCER GENE THERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Xu Zhang, Hao Xiong, Yong Zhao, Shengqiang Lin, Xiang Huang, Cheng Lin, Shihui Mao, Demin Chen
Summary: This research identifies the circLONP2/miR-584-5p/YAP1 axis as a novel regulatory module in the progression of bladder cancer. The study shows that circLONP2 plays an oncogenic role by regulating the miR-584-5p/YAP1 axis, and targeting this interaction could be a potential strategy for treating bladder cancer.
Editorial Material
Oncology
Jiong Lin
Summary: The paper focused on the anti-tumor activity of echinacoside in liver cancer through the miR-503-3p/TGF-beta 1/Smad axis, suggesting it as a safe and effective treatment. However, the presence of some confusing issues in the paper raised concerns.
CANCER CELL INTERNATIONAL
(2021)
Review
Cell Biology
Krishan K. Thakur, Aviral Kumar, Kishore Banik, Elika Verma, Elina Khatoon, Choudhary Harsha, Gautam Sethi, Subash C. Gupta, Ajaikumar B. Kunnumakkara
Summary: Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, primarily affecting younger women. Long noncoding RNAs (lncRNAs) play a crucial role in TNBC treatment, serving as novel diagnostic and prognostic biomarkers. Extensive research is ongoing to uncover the mechanisms through which lncRNAs modulate TNBC progression and treatment.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)