Article
Dentistry, Oral Surgery & Medicine
Marcelo Vitale, Monica Grazieli Correa, Edilson Ervolino, Fabiano Ribeiro Cirano, Fernanda Vieira Ribeiro, Mabelle Freitas Monteiro, Marcio Zaffalon Casati, Suzana Peres Pimentel
Summary: This study evaluated the effect of resveratrol (RES) on the prevention of medication-related osteonecrosis of the jaws (MRONJ) in ovariectomized (OVX) rats treated with zoledronate (ZOL). The results showed that RES reduced tissue impairment caused by ZOL, but it could not prevent the occurrence of MRONJ.
Review
Chemistry, Multidisciplinary
Krzysztof Wrobel, Maciej Sikora, Maciej Checinski, Maria Jas, Dariusz Chlubek
Summary: MRONJ is a condition that is becoming more common in dental and maxillofacial practice, requiring comprehensive, accessible, and up-to-date data. Besides bisphosphonates, angiogenesis inhibitors and anti-RANKL monoclonal antibodies can also increase the risk of the disease. Thorough physical examination, periodic correction of dental prostheses, and adequate preparation for oral procedures can prevent or minimize the risk of MRONJ.
APPLIED SCIENCES-BASEL
(2021)
Review
Pharmacology & Pharmacy
M. Dioguardi, M. DI Cosola, C. Copelli, S. Cantore, C. Quarta, G. Nitsch, D. Sovereto, F. Spirito, G. A. Caloro, A. P. Cazzolla, R. Aiuto, E. Cascardi, A. greco Lucchina, L. LO Muzio, A. Ballini, F. Mastrangelo
Summary: Bisphosphonates, commonly used anti-resorptive medications, inhibit osteoclast activity by disrupting the macrophage colony-stimulating factor pathway. Oral surgery in patients undergoing bisphosphonate therapy carries a high risk of developing osteonecrosis of the jaws.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Review
Oncology
Raiza Querrer, Nathalia Ferrare, Nilce Melo, Cristine Miron Stefani, Paula Elaine Diniz dos Reis, Carla Ruffeil Moreira Mesquita, Gabriel Alvares Borges, Andre Ferreira Leite, Paulo Tadeu Figueiredo
Summary: Bisphosphonate-related ONJ and denosumab-related ONJ exhibit differences in imaging characteristics, with the former showing bone sequestra increase, cortical bone lysis, and bone density increase, while the latter showing larger bone sequestra, more frequent periosteal reactions, and mandibular canal enhancement.
SUPPORTIVE CARE IN CANCER
(2021)
Review
Medicine, General & Internal
Mario Dioguardi, Francesca Spirito, Mario Alovisi, Riccardo Aiuto, Daniele Garcovich, Vito Crincoli, Andrea Ballini, Giorgia Apollonia Caloro, Lorenzo Lo Muzio
Summary: Antiresorption drugs like bisphosphonates and monoclonal antibodies are used in the treatment of osteoporosis and other bone-related diseases. These drugs have been associated with cases of osteonecrosis of the jaws (MRONJ). Risk factors include extraction procedures in oral surgery, particularly in the mandible and maxilla. A systematic review and meta-analysis was conducted to determine if there is a greater risk of MRONJ in male or female subjects and to assess the involvement of osteonecrosis in different extraction sites. After analyzing 24 studies, the results showed a trend of higher risk in males and in the posterior mandibular sector, but further studies are needed to confirm these findings.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Christian Bacci, Alessia Cerrato, Elisa Bardhi, Anna Chiara Frigo, Selma Ahcene Djaballah, Stefano Sivolella
Summary: This study assessed the efficacy of different preventive dental visits and treatments in reducing the risk of medication-related osteonecrosis of the jaws (MRONJ). The results indicated that compliance with specialist recommendations can reduce the risk of MRONJ for patients.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Medicine, General & Internal
Gianluca Colapinto, Funda Goker, Riccardo Nocini, Massimo Albanese, Pier Francesco Nocini, Salvatore Sembronio, Francesca Argenta, Massimo Robiony, Massimo Del Fabbro
Summary: The aim of this randomized study was to evaluate the effect of pentoxifylline and tocopherol in patients that had developed MRONJ after tooth extractions. The study showed that patients who received pharmacological treatment had better mucosal healing after 1 month and clinical and radiographic healing of the bone lesion after 6 months.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Vanessa Costa de Sousa, Fatima Regina Nunes Sousa, Raquel Felipe Vasconcelos, Conceicao S. Martins, Amanda Pimentel Lopes, Nicholas Militao, Delane Viana, Karuza Alves, Renata Leitao, Gerly A. C. Brito, Virginia Girao, Paula Goes
Summary: Atorvastatin has a positive effect on bisphosphonate-induced osteonecrosis of the jaw in rats. It improves mucosal healing, increases viable osteocytes, reduces cell apoptosis, and decreases bone sequestration. It also modulates inflammation and improves bone vitality, metabolism, and structure.
Article
Chemistry, Multidisciplinary
Monika Teslak, Hanna Sobczak, Iwona Ordyniec-Kwasnica, Barbara Kochanska, Barbara Drogoszewska
Summary: The study assessed the knowledge and awareness of MRONJ among Polish dentists and dentistry students, finding that oral and maxillofacial surgeons had the highest level of understanding, while students' knowledge was similar to dentists. Improving dentists' understanding of MRONJ could help reduce the occurrence of the disease in the future.
APPLIED SCIENCES-BASEL
(2021)
Review
Pharmacology & Pharmacy
Filip Michalak, Sylwia Hnitecka, Marzena Dominiak, Kinga Grzech-Lesniak
Summary: Medications that inhibit bone resorption are commonly prescribed by orthopedists, hematologists, or oncologists, with dental professionals often overlooking their impact on oral health. While primarily affecting older individuals due to oncological issues or postmenopausal consequences, anyone can be at risk. Careful interviews and analysis of patient history and disease should always be conducted before taking any action with these medications.
Article
Dentistry, Oral Surgery & Medicine
Diana Nogueira, Ines Morais Caldas, Ricardo Jorge Dinis-Oliveira
Summary: This manuscript provides a comprehensive review on medication-related osteonecrosis of the jaw (MRONJ), including its pathophysiology, diagnosis, prevention, and other clinical and forensic aspects. The article also introduces a possible differential diagnosis and emphasizes the need for further research and consensus in treatment and management. Rating: 9/10.
ARCHIVES OF ORAL BIOLOGY
(2023)
Review
Oncology
Emily Sunny Lee, Meng-Chen Tsai, Jing-Xuan Lee, Chuki Wong, You-Ning Cheng, An-Chi Liu, You-Fang Liang, Chih-Yuan Fang, Chia-Yu Wu, I-Ta Lee
Summary: This article explores the complex relationship between bisphosphonates, commonly used for treating osteoporosis and tumors, and bisphosphonate-related osteonecrosis of the jaws (BRONJ) after dental procedures. The impact of bisphosphonates on bone density and resorption and their effect on dental treatments are emphasized. Dental patients on bisphosphonates are at a higher risk of BRONJ, necessitating dentists' awareness of these risks. Topical applications of bisphosphonates enhance dental implant success and aid in periodontal treatment, while systemic administration significantly increases the risk of BRONJ, particularly in inflamed conditions. Preventive measures involve maintaining oral health, considering alternative treatments, and careful pre-operative and post-operative follow-ups. Future research could focus on finding bisphosphonate alternatives with fewer side effects or developing combinations that reduce BRONJ risk. This review underscores the need for further exploration of bisphosphonates and their implications in dental procedures.
Article
Multidisciplinary Sciences
Farnoosh Razmara, Mohammad Bayat, Sadegh Shirian, Ghazal Shabankare, Abdolreza Mohamadnia, Mostafa Mortazavi, Mohammad-Reza Alijani, Naghmeh Bahrami
Summary: The study found that using PRP + collagen scaffold showed better therapeutic effects compared to using scaffold alone, increasing bone mineralized density, number of osteoblasts, and new bone formation. In preventing BRONJ, PRP + collagen scaffold demonstrated better efficacy.
Article
Chemistry, Multidisciplinary
Joao Andre Correia, Jose Ricardo Ferreira, Miguel Amaral Nunes, Antonio Capelo, Miguel de Araujo Nobre, Francisco Salvado
Summary: VSP and CAD/CAM-customized materials facilitated complete resection of necrotic bone and rigid fixation in MRONJ patients, leading to simplified approach with shorter operative times, reduced morbidity, and predictable results.
APPLIED SCIENCES-BASEL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Alessandro Cuozzo, Vincenzo Iorio-Siciliano, Emanuele Vaia, Leopoldo Mauriello, Andrea Blasi, Luca Ramaglia
Summary: This study evaluated the 12-month incidence of MRONJ after tooth extractions and possible related risk factors in osteoporotic patients treated with oral bisphosphonates. The results showed a low risk of MRONJ after tooth extraction in these patients, with only 1 case of osteonecrosis observed after 12 months. Gender was found to have a significant correlation with MRONJ onset.
JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Marco Meleti, Diana Cassi, Luis Bueno, Ronell Bologna-Molina
Article
Biotechnology & Applied Microbiology
V Pereira-Prado, G. Vigil-Bastitta, C. Sanchez-Romero, M. Arocena, N. Molina-Frechero, R. Gonzalez-Gonzalez, M. Meleti, R. Bologna-Molina
Summary: The study found that the expression of Gal-3 and HIF-1α in ameloblastomas may be a response to hypoxic stress, and the co-expression of these proteins in CA may be involved in the biological behavior of this variant.
BIOTECHNIC & HISTOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Marco Meleti, Eleonora Quartieri, Rita Antonelli, Margherita E. Pezzi, Benedetta Ghezzi, Maria Vittoria Viani, Giacomo Setti, Emanuela Casali, Elena Ferrari, Tecla Ciociola, Alberto Spisni, Thelma A. Pertinhez
Article
Environmental Sciences
Giuseppina Campisi, Rodolfo Mauceri, Francesco Bertoldo, Giordana Bettini, Matteo Biasotto, Giuseppe Colella, Ugo Consolo, Olga Di Fede, Gianfranco Favia, Vittorio Fusco, Mario Gabriele, Antonio Lo Casto, Lorenzo Lo Muzio, Antonia Marciano, Marco Mascitti, Marco Meleti, Michele D. Mignogna, Giacomo Oteri, Vera Panzarella, Umberto Romeo, Andrea Santarelli, Paolo Vescovi, Claudio Marchetti, Alberto Bedogni
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Otorhinolaryngology
Davide B. Gissi, Luca Morandi, Giuseppe Colella, Roberto De Luca, Giuseppina Campisi, Rodolfo Mauceri, Umberto Romeo, Gianluca Tenore, Michele D. Mignogna, Daniela Adamo, Giacomo Oteri, Antonia Marciano, Paolo Vescovi, Marco Meleti, Rosario Serpico, Dario Di Stasio, Monica Pentenero, Andrea Santarelli, Alberto Bianchi, Salvatore Crimi, Claudio Marchetti, Achille Tarsitano, Maria Pia Foschini, Lucio Montebugnoli
Summary: The aim of this Italian multicenter study was to evaluate the diagnostic performance of a minimally invasive method for the detection of oral squamous cell carcinoma (OSCC) based on 13-gene DNA methylation analysis in oral brushing samples. The study confirmed the diagnostic performance of the novel procedure in a large cohort of brushing specimens collected from 11 different centers and analyzed in blindness.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Letter
Dentistry, Oral Surgery & Medicine
Maddalena Manfredi, Giulia Ghidini, Erminia Ridolo, Silvia Pizzi
Review
Dentistry, Oral Surgery & Medicine
Monica Pentenero, Lorenzo Azzi, Giovanni Lodi, Maddalena Manfredi, Elena Varoni
Summary: This systematic review aimed to assess whether chronic mechanical trauma can be considered a risk factor for oral squamous cell carcinoma (OSCC). The study found that there is currently not enough evidence to support the role of trauma in oral carcinogenesis and more prospective cohort studies are needed to better assess the relationship between trauma and OSCC.
Letter
Dentistry, Oral Surgery & Medicine
Monica Pentenero, Lorenzo Azzi, Giovanni Lodi, Maddalena Manfredi, Elena Maria Varoni
Editorial Material
Dentistry, Oral Surgery & Medicine
Maddalena Manfredi, Maura Mureddu, Cristina Mancini, Paolo Vescovi
Article
Dentistry, Oral Surgery & Medicine
Marco Meleti, Rita Antonelli, Maria Vittoria Viani, Margherita Pezzi, Thelma Pertinhez, Paolo Vescovi
Summary: This study focuses on reporting the recent research on the potential use of saliva as biomarkers for the diagnosis of oral and systemic diseases, highlighting the procedures for saliva collection. The study found that DNA, RNA, proteins, and metabolites in saliva can serve as biomarkers for oral cancer and other diseases.
Article
Surgery
Ilaria Giovannacci, Cristina Magnoni, Giuseppe Pedrazzi, Paolo Vescovi, Marco Meleti
Summary: This study investigated the association between autofluorescence (AF) alterations and clinicopathological features in patients with oral squamous cell carcinoma and potentially malignant disorders. The results showed that AF patterns were significantly influenced by clinical appearance and histological diagnosis. AF was found to be a promising adjunctive tool to conventional oral examinations, although it demonstrated high sensitivity with low specificity.
PHOTOBIOMODULATION PHOTOMEDICINE AND LASER SURGERY
(2021)
Article
Health Care Sciences & Services
Maria Vittoria Viani, Luigi Corcione, Chiara Di Blasio, Ronell Bologna-Molina, Paolo Vescovi, Marco Meleti
Article
Dentistry, Oral Surgery & Medicine
Alessandro Del Vecchio, Paolo Vescovi, Francesco Spadari, Giovanni Maria Gaeta, Gaspare Palaia, Gianluca Tenore, Luciano Pacifici, Aldo Oppici, Marco Meleti, Sergio Salina, Umberto Romeo
Review
Dentistry, Oral Surgery & Medicine
Marco Meleti, Diana Cassi, Paolo Vescovi, Giacomo Setti, Thelma A. Pertinhez, Margherita Eleonora Pezzi
MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL
(2020)
Article
Dentistry, Oral Surgery & Medicine
Celeste Sanchez-Romero, Vanesa Pereira-Prado, Estefania Sicco, Mariana Suarez, Gabriel Tapia-Repetto, Ramon Carreon-Burciaga, Rogelio Gonzalez-Gonzalez, Mariana Villarroel-Dorrego, Marco Meleti, Nelly Molina-Frechero, Ronell Bologna-Molina
Summary: The study found that the expression patterns of caveolin-1 in oral epithelium, embryonic, and odontogenic tumor tissues are diverse, and caveolin-1 may play a role in protumoral events but not necessarily in the malignant transformation process. Further research is needed to clarify and confirm these hypotheses.
MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL
(2021)
