Review
Engineering, Biomedical
Ilijana Kovrlija, Janis Locs, Dagnija Loca
Summary: Octacalcium phosphate (OCP) has significant advantages as a precursor to biologically formed apatite and is utilized as a carrier for biologically active substances in bone regeneration. However, research on drug delivery systems with OCP is still in its pioneering stage, and comprehensive data is lacking to fully understand the benefits it can bring. Further studies are needed to explore the potential of OCP in drug delivery systems for bone tissue engineering.
ACTA BIOMATERIALIA
(2021)
Article
Physiology
Hongzhou Shen, Lvyuan Li, Chenglong Zhang, Yang Chen, Hongbo Yu, Jiawen Si, Guofang Shen
Summary: A novel strategy of composite grafting with BMP2-loaded calcium phosphate cements (BMP2-CPC) and autogenous bone harvested by minimally invasive technique was developed and evaluated for alveolar bone grafting. The composite graft demonstrated satisfactory bone-repairing efficacy and improved resorption performance, making it an eligible alternative for application in alveolar bone grafting.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Mayumi Iijima, Kazuki Komatsu, Hiroyuki Kagi, Yu Maekawa, Takenori Sasaki, Susumu Hyodo, Ryota Kimura, Takeshi Futami, Michio Suzuki
Summary: The elephant shark has unique dental organs called hypermineralized tooth plates, which consist of hydroxyapatite (HAp) and whitlockite (WH). The research on the tooth plates of the elephant shark using X-ray diffraction technique revealed that HAp was formed in the early stage while WH formed subsequently and became the major phase. The presence of low crystalline HAp around WH may be related to tissue hardening.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Chemistry, Multidisciplinary
Joo-Seong Kim, Tae-Sik Jang, Suk-Young Kim, Won-Pyo Lee
Summary: This study evaluated the effect of a commercialized octacalcium phosphate (OCP)-based synthetic bone substitute material (Bontree(R)) in vitro, in vivo, and in clinical cases. Bontree(R) suppressed RANKL and increased ALP activity, showing a high new bone formation ability. Clinical application demonstrated a 100% success rate for ridge or sinus augmentation using Bontree(R).
APPLIED SCIENCES-BASEL
(2021)
Article
Materials Science, Ceramics
Antonia Ressler, Irena Ivanisevic, Andreja Zuzic, Nicolas Somers
Summary: Octacalcium phosphate shows promising properties for bone tissue regeneration, but hydroxyapatite is still considered the most promising material. Many studies confirm the superior performance of octacalcium phosphate in vivo.
CERAMICS INTERNATIONAL
(2022)
Article
Orthopedics
Cheol-Hee Jeong, Jooseong Kim, Hyun Sil Kim, Song-Yi Lim, Dawool Han, Aaron J. Huser, Sang Bae Lee, Yeonji Gim, Jeong Hyun Ji, Dohun Kim, Amaal M. Aldosari, Kyelim Yun, Yoon Hae Kwak
Summary: In this study, three types of OCPs were compared to commercially available 8-TCP for their potential to promote bone formation in rat tibias with defects. The results showed that OCP/Alg was equivalent to 8-TCP in promoting bone bridge formation and had better biodegradability. OCP/Col accelerated bone formation in defect repair.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Biochemistry & Molecular Biology
Anastasia Yu. Teterina, Igor V. Smirnov, Irina S. Fadeeva, Roman S. Fadeev, Polina V. Smirnova, Vladislav V. Minaychev, Margarita I. Kobyakova, Aleksandr Yu. Fedotov, Sergey M. Barinov, Vladimir S. Komlev
Summary: The study presented the synthesis of low-temperature calcium phosphate compounds with strontium substitution to improve bioactive properties, indicating the effectiveness of using strontium in OCP for enhancing biocompatibility in composite materials intended for bone repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Seok-Jun Kim, Joo-Seong Kim, Woong Kim, Suk-Young Kim, Won-Pyo Lee
Summary: This study evaluated the efficacy of using Bontree (R) for LSFE through radiographic and histomorphometric analysis. The results showed that Bontree (R) is effective in promoting new bone formation.
Article
Engineering, Biomedical
Itsuki Oizumi, Ryo Hamai, Yukari Shiwaku, Yu Mori, Takahisa Anada, Kazuyoshi Baba, Naohisa Miyatake, Soshi Hamada, Kaori Tsuchiya, Shin-Nosuke Nishimura, Eiji Itoi, Osamu Suzuki
Summary: This study investigated the effect of the simultaneous hydrolysis of octacalcium phosphate (OCP) and poly (lactic-co-glycolic acid) (PLGA) on osteoconductivity. Increasing OCP dose was found to lead to higher weight loss of PLGA and lower glass transition temperature of PLGAs. OCP/PLGA composites demonstrated enhanced bone formation and regenerative capacity in femoral defects.
ACTA BIOMATERIALIA
(2021)
Article
Cell & Tissue Engineering
Keiko Matsui, Tadashi Kawai, Yushi Ezoe, Toshiki Yanagisawa, Tetsu Takahashi, Shinji Kamakura
Summary: The study investigated the use of OCPcol with TPTD for repairing intractable bone defects, showing superior bone regeneration over other treatments.
TISSUE ENGINEERING PART A
(2021)
Article
Cell & Tissue Engineering
Kei-ichiro Miura, Miho Sasaki, Seigo Ohba, Sawako Noda, Misa Sumi, Shinji Kamakura, Tetsu Takahashi, Izumi Asahina
Summary: This study evaluated the stability of dental implants 5 years after maxillary sinus floor augmentation with an octacalcium phosphate-collagen composite through clinical and radiological assessments. The success of the implants was confirmed by both types of evaluations, with no adverse events observed during the follow-up period.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2022)
Article
Engineering, Biomedical
Xiaoyan Ren, Qi Zhou, Meiwand Bedar, David Foulad, Kelly X. X. Huang, Dillon Dejam, Natalie J. J. Dahan, Vasiliki Kolliopoulos, Brendan A. C. Harley, Justine C. C. Lee
Summary: The study investigates the effects of phosphate content in nanoparticulate mineralized collagen glycosaminoglycan (MC-GAG) on the microenvironment and osteoprogenitor differentiation. It is found that MC-GAG exhibits a temporal relationship with soluble phosphate, eluting early in culture and then absorbing, regardless of the differentiation of primary human mesenchymal stem cells (hMSCs). The intrinsic phosphate content of MC-GAG is sufficient to stimulate osteogenic differentiation of hMSCs without the addition of exogenous phosphate, and this process can be reduced but not eliminated by knocking down the sodium phosphate transporters PiT-1 or PiT-2. The contributions of PiT-1 and PiT-2 to MC-GAG-mediated osteogenesis are nonredundant but nonadditive.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Xue Yang, Die Yang, Xianyu Lin, Derong Li, Wenqi Shi, Zhiqiang Xiang, Changdao Mu, Liming Ge, Defu Li, Zhilang Xu
Summary: The use of collagen-based heterogeneous bilayer membrane in guided bone regeneration has shown great potential in oral surgery. The membrane, prepared using dialdehyde carboxymethyl cellulose cross-linked collagen and dehydrothermal treatment, demonstrated improved mechanical properties, reduced biodegradation rate, and enhanced osteoblast response. The compact lower layer of the membrane acted as a strong barrier to fibroblasts, while the loose upper layer enhanced the adhesion, proliferation, and osteogenic differentiation of osteoblasts.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Medicine, Research & Experimental
S. A. Alkaabi, D. S. Natsir Kalla, G. A. Alsabri, A. Fauzi, A. Tajrin, W. E. G. Mueller, H. C. Schroeder, X. G. Wang, T. Forouzanfar, M. N. Helder, M. Ruslin
Summary: This study aims to evaluate the feasibility, safety, and osteoinductivity of Ca-polyP MPs as a bone-inducing graft material in humans. A prospective non-blinded first-in-man clinical pilot study of 8 alveolar cleft patients aged 13 years or older will be conducted to assess the safety and feasibility of Ca-PolyP MPs as a bone-inducing graft material, with clinical evaluation after 6 months.
Article
Dentistry, Oral Surgery & Medicine
T. Singkhorn, P. Pripatnanont, T. Nuntanaranont, D. Supakanjanakanti, W. Ritthagol
Summary: This study compared the clinical outcomes, graft quality, and graft quantity after alveolar bone grafting with and without a resorbable collagen membrane. The results showed that the use of a collagen membrane resulted in significantly lower postoperative pain and swelling. Additionally, the reduction in bone density and volume was less in the group using the collagen membrane. Therefore, the collagen membrane facilitates predictable clinical outcomes in bone maturation, bone volume preservation, and bone bridging in alveolar bone grafting.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2023)
Article
Dentistry, Oral Surgery & Medicine
N. Tsunoda, T. Kawai, M. Obara, S. Suzuki, I. Miyamoto, Y. Takeda, H. Yamada
Summary: This study demonstrates that cryosurgery is an effective and safe treatment for mucoceles in the lip or buccal mucosa. Patient age, lesion size, and duration of the lesion did not affect healing progress after cryosurgery. Cryosurgery is particularly advantageous for use in preschool children.
JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY
(2021)
Article
Cell & Tissue Engineering
Keiko Matsui, Tadashi Kawai, Yushi Ezoe, Toshiki Yanagisawa, Tetsu Takahashi, Shinji Kamakura
Summary: The study investigated the use of OCPcol with TPTD for repairing intractable bone defects, showing superior bone regeneration over other treatments.
TISSUE ENGINEERING PART A
(2021)
Article
Cell & Tissue Engineering
Atsumu Kouketsu, Keiko Matsui, Tadashi Kawai, Yushi Ezoe, Tetsu Takahashi, Shinji Kamakura
Summary: Our study revealed that the composite of OCPcolTPTD enhances bone regeneration more evenly and homogenously than OCPcol, suggesting its potential as a novel clinical technique for bone regeneration or repair.
TISSUE ENGINEERING PART A
(2022)
Article
Chemistry, Physical
Isao Hoshi, Tadashi Kawai, Shingo Kurosu, Tadaharu Minamino, Kei Onodera, Ikuya Miyamoto, Hiroyuki Yamada
Summary: This study explored the optimal conditions for titanium mesh trays in mandibular reconstruction using electron beam additive manufacturing. It was found that excellent mechanical strength could be achieved when the specimen was stretched vertically in the stacking direction with surface treatment, and adding a honeycomb structure could withstand a bite force of 2000 N. The study suggests that the EBM system is a useful technique for preparing custom-made titanium mesh trays of sufficient strength for mandibular reconstruction.
Article
Surgery
Yuko Komatsu, Tadashi Kawai, Toshimi Chiba, Yasunori Takeda, Hiroyuki Yamada
Summary: An 81-year-old woman presented with bleeding from a soft elastic bulge on the right buccal mucosa. Investigations confirmed the presence of a canalicular adenoma, and the tumor was surgically removed.
JOURNAL OF SURGICAL CASE REPORTS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Koichi Tsunoda, Akiko Kumagai, Naoko Tsunoda, Mizuki Obara, Tadashi Kawai, Yu Ohashi, Ikuya Miyamoto, Hiroyuki Yamada
Summary: This study investigated the levels of serum antioxidants and urinary oxidative stress markers in patients with oral lichen planus (OLP). The results showed that serum vitamin C levels were lower in OLP patients, but oxidative stress levels were not significantly higher. Therefore, the relationship between OLP and systemic oxidative stress was not fully elucidated in this study.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY
(2022)
Review
Surgery
Kei Takeda, Ikuya Miyamoto, Ryosuke Abe, Tadashi Kawai, Yu Ohashi, Hiroyuki Yamada
Summary: This is a rare case of tophaceous pseudogout involving the temporomandibular joint with cranial extension. The patient was diagnosed with pseudogout based on a biopsy. Considering the patient's advanced age and relatively good quality of life, the treatment plan only involved observation.
JOURNAL OF SURGICAL CASE REPORTS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Isao Hoshi, Ryosuke Abe, Kei Onodera, Yu Ohashi, Tadashi Kawai, Ikuya Miyamoto, Toshimi Chiba, Yasunori Takeda, Hiroyuki Yamada
Summary: This article discusses the successful treatment of osteosarcoma in a 90-year-old male patient. The patient resolved his difficulties in speech and swallowing through partial mandibular resection and reconstruction surgery, and there was no evidence of tumor recurrence or metastasis 4 years after surgery.
CASE REPORTS IN DENTISTRY
(2022)
Article
Surgery
Yuko Komatsu, Yasunori Takeda, Tadashi Kawai, Shunichi Sasou, Kazuaki Takahashi, Hiroyuki Yamada, Shu Ishibashi
Summary: This report presents a case of solitary neurofibroma in the maxillary gingiva, describing the patient's history, diagnosis, and treatment.
JOURNAL OF SURGICAL CASE REPORTS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yuki Saito, Tadashi Kawai, Shintaro Kogi, Kei Onodera, Mizuki Obara, Kei Takeda, Yuko Komatsu, Toshimi Chiba, Hiroyuki Yamada
Summary: This study retrospectively investigated cases of subcutaneous emphysema caused by dental treatment. It found that subcutaneous emphysema was more common in females and was not related to age. Patients undergoing surgical procedures requiring an air turbine or electric handpiece were at a higher risk of developing subcutaneous emphysema. Additionally, the presence or absence of systemic medical history affected the healing period.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY
(2022)
Article
Medicine, General & Internal
Tadashi Kawai, Toshimi Chiba, Kei Onodera, Naoko Tsunoda, Yuko Komatsu, Shuu Suzuki, Yuki Saito, Shintaro Kogi, Yasunori Takeda, Hiroyuki Yamada
Summary: This report describes two cases of hypo-proteinemia associated with gigantic odontogenic tumors. These two cases suggest that hypo-proteinemia might be related to plasma leakage from fistulas associated with gigantic odontogenic tumors.
AMERICAN JOURNAL OF CASE REPORTS
(2022)
Review
Dentistry, Oral Surgery & Medicine
Naoko Tsunoda, Kei Onodera, Yu Ohashi, Tadashi Kawai, Ikuya Miyamoto, Yasunori Takeda, Hiroyuki Yamada
Summary: This report describes the clinical features, diagnosis, and treatment of an intramuscular myxoma of the tongue, as well as the postoperative follow-up results.
CASE REPORTS IN DENTISTRY
(2022)
Article
Medicine, General & Internal
Tadashi Kawai, Shinsuke Kawamata, Shuu Suzuki, Yuudai Ishikawa, Yuunosuke Ikeda, Erika Yasuge, Shintaro Kogi, Atsushi Ogawa, Mitsuru Izumisawa, Hiroyuki Yamada
Summary: This report presents a case of condyle fracture at the upper neck region treated with a custom-made titanium mesh and a titanium miniplate, which makes it easy to reposition the fragment and keep it in place. Nine months after the operation, the patient had good mouth opening, no deviation of the mandible, and no breakage on the titanium mesh or plate.
AMERICAN JOURNAL OF CASE REPORTS
(2023)
Meeting Abstract
Cell & Tissue Engineering
Shinji Kamakura, Keiko Matsui, Tadashi Kawai, Yushi Ezoe, Toshiki Yanagisawa, Tetsu Takahashi
TISSUE ENGINEERING PART A
(2022)
Article
Surgery
Yuko Komatsu, Tadashi Kawai, Shoko Miura, Yasunori Takeda, Hiroyuki Yamada
Summary: This case report describes a rare case of primary rhabdomyosarcoma of the maxillary gingiva in a 12-year-old girl, presenting with trismus as the chief complaint. The histopathological diagnosis confirmed the presence of RMS in the left maxillary gingiva.
JOURNAL OF SURGICAL CASE REPORTS
(2021)
