期刊
INTERNATIONAL JOURNAL OF OPTOMECHATRONICS
卷 5, 期 3, 页码 191-216出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15599612.2011.604246
关键词
electrophysiology; fluorescence; holography; laser dissection; optical tweezers
资金
- Compagnia di San Paolo [3881 SD/sd 2008.1267]
- Telethon-Italy [GGP09134]
- Italian Institute of Technology foundation
We present an optical system that combines IR (1064 nm) holographic optical tweezers with a sub-nanosecond-pulsed UV (355 nm) laser microdissector for the optical manipulation of single neurons and entire networks both on transparent and non-transparent substrates in vitro. The phase-modulated laser beam can illuminate the sample concurrently or independently from above or below assuring compatibility with different types of microelectrode array and patch-clamp electrophysiology. By combining electrophysiological and optical tools, neural activity in response to localized stimuli or injury can be studied and quantified at sub-cellular, cellular, and network level.
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