期刊
INTERNATIONAL JOURNAL OF ONCOLOGY
卷 46, 期 2, 页码 548-554出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ijo.2014.2783
关键词
prostaglandin I-2; metastasis; maturation; pericytes; hypoxia
类别
资金
- JSPS [20590910]
- Grants-in-Aid for Scientific Research [24591147, 20590910, 24591031] Funding Source: KAKEN
Prostaglandin I-2 (PGI(2)) agonist has been reported to reduce tumor metastasis by modifying tumor angiogenesis; however, the mechanisms of how PGI(2), affects the endothelial cells or pericytes in tumor vessel maturation are still unclear. The purpose of this study was to clarify the effects of PGI(2), on tumor metastasis in a mouse lung metastasis model using Lewis lung carcinoma (LLC) cells. The mice were treated continuously with beraprost sodium (BPS), a PGI(2), analog, for 3 weeks and then examined for lung metastases. The number and size of lung metastases were decreased significantly by BPS treatment. In addition, scanning electron microscopy and immunohistochemistry revealed that BPS increased the number of tumor-associated pericytes and improved intratumor hypoxia. Collectively, this study suggests that BPS attenuated vascular functional maturation in metastatic tumors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据