期刊
INTERNATIONAL JOURNAL OF ONCOLOGY
卷 43, 期 5, 页码 1523-1530出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ijo.2013.2097
关键词
esophageal squamous cell carcinoma; integrin alpha 6; tumorigenesis; biodistribution; xenograft model
类别
资金
- National R&D Program for Cancer Control [1120260]
- Ministry of Health and Welfare, Republic of Korea
- Radiological Translational Research Program (RTR), Korea Institute of Radiological & Medical Sciences [50455-2012]
- Korea Health Promotion Institute [1120260] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Esophageal squamous cell carcinoma (ESCC), the most common subtype of esophageal cancer in East Asian countries, is a devastating disease characterized by distinctly high incidence and mortality rates. Our previous expression profile analysis showed that integrin alpha 6 (ITGA6) is highly expressed in ESCC tissues. To validate cell surface expression of ITGA6 as a novel target in ESCC, we investigated ITGA6 expression in tumor tissue samples and cell lines of ESCC and found that ITGA6 was upregulated in these cells. In vitro knockdown of ITGA6 in ESCC cells resulted in inhibition of cell proliferation, invasion and colony formation. In addition, we demonstrated that ITGA6 associates with integrin beta 4 (ITGB4), and that this heterodimer complex is upregulated in both ESCC tissues and cell lines. Moreover, our biodistribution results in an ESCC xenograft model indicated that ITGA6 is a possible target for antibody-related diagnostic and therapeutic modalities in ESCC. Thus, our findings suggest that ITGA6 plays an important role in tumorigenesis in ESCC and represents a potential therapeutic target in the treatment of ESCC.
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