A novel PI3K inhibitor alleviates fibrotic responses in fibroblasts derived from Peyronie’s plaques

HS-173, a novel phosphatidylinositol 3-kinase (PI3K) inhibitor, has anti-tumor activity through promoting apoptosis and inhibiting angiogenesis

(2012) Hyunseung Lee et al.   CANCER LETTERS

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(2012) George Bobustuc et al.   MOLECULAR MEDICINE

Lipopolysaccharide Induces Lung Fibroblast Proliferation through Toll-Like Receptor 4 Signaling and the Phosphoinositide3-Kinase-Akt Pathway

(2012) Zhengyu He et al.   PLoS One

Induction of cardiac fibroblast lysyl oxidase by TGF-β1 requires PI3K/Akt, Smad3, and MAPK signaling

(2011) Tetyana G. Voloshenyuk et al.   CYTOKINE

Peyronie's disease: perspectives on therapeutic targets

(2011) Ibrahim A Abdel-Hamid et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Inhibition of PI3K Prevents the Proliferation and Differentiation of Human Lung Fibroblasts into Myofibroblasts: The Role of Class I P110 Isoforms

(2011) Enrico Conte et al.   PLoS One

Pathologic Caveolin-1 Regulation of PTEN in Idiopathic Pulmonary Fibrosis

(2010) Hong Xia et al.   AMERICAN JOURNAL OF PATHOLOGY

Discovery of new azaindole-based PI3Kα inhibitors: Apoptotic and antiangiogenic effect on cancer cells

(2010) Seunghee Hong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Transforming Growth Factor (TGF)-β Type I Receptor Kinase (ALK5) Inhibitor Alleviates Profibrotic TGF-β1 Responses in Fibroblasts Derived from Peyronie's Plaque

(2010) Shuguang Piao et al.   Journal of Sexual Medicine

The Management of Peyronie's Disease: Evidence-based 2010 Guidelines

(2010) David Ralph et al.   Journal of Sexual Medicine

Activity of any class IA PI3K isoform can sustain cell proliferation and survival

(2010) L. C. Foukas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of phosphatidylinositol 3-kinase signaling in hepatic stellate cells blocks the progression of hepatic fibrosis

(2009) Gakuhei Son et al.   HEPATOLOGY

The TGF-β, PI3K/Akt and PTEN pathways: established and proposed biochemical integration in prostate cancer

(2008) Stephen J. Assinder et al.   BIOCHEMICAL JOURNAL

Expression and functional pharmacology of the bradykinin B1 receptor in the normal and inflamed human gallbladder

(2008) E. Andre et al.   GUT

The PTEN–PI3K pathway: of feedbacks and cross-talks

(2008) A Carracedo et al.   ONCOGENE

Peyronie’s disease: Past, present, future?

(2008) Alan W. Shindel et al.   Current Urology Reports