Review
Developmental Biology
Naoya Yamaguchi, Holger Knaut
Summary: Cell-extracellular matrix interactions are essential for cell anchoring and migration, with focal adhesions (FAs) playing a key role. However, the role of FAs in vivo is still not well understood.
Review
Immunology
Michael J. Shannon, Emily M. Mace
Summary: Integrins are transmembrane receptors that play a crucial role in determining tissue residency and function of natural killer cell subsets by their differential expression. Understanding the expression of integrin subtypes on NK cells provides insight into how integrin selection influences cell properties and functions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Lijun Zhong, Lin Tang, Xiaoxia He
Summary: It has been discovered that ANGPTL3 plays an oncogenic role in several types of human malignancies. This study found that ANGPTL3 is highly expressed in cervical cancer cells and silencing ANGPTL3 can inhibit cell proliferation, migration, invasion, and angiogenesis. The inhibitory effect of ANGPTL3 can be offset by upregulating the expression of alpha v beta 3, which also promotes blood vessel formation and the secretion of VEGF and VEGFR2 in cervical cancer cells.
Article
Peripheral Vascular Disease
Camilla Ariano, Chiara Riganti, Davide Cora, Donatella Valdembri, Giulia Mana, Elena Astanina, Guido Serini, Federico Bussolino, Gabriella Doronzo
Summary: This article investigates the impact of oncogenic transcription factor EB (TFEB) on the adhesion of endothelial cells to the surrounding extracellular matrix (ECM). The study reveals that TFEB promotes turnover of ECM adhesion by regulating cholesterol metabolism, suggesting it may serve as a novel target for therapeutic control of pathological angiogenesis.
Article
Pharmacology & Pharmacy
Ellen Emi Kato, Luciana Araujo Pimenta, Maira Estanislau Soares de Almeida, Vanessa Olzon Zambelli, Marinilce Fagundes dos Santos, Sandra Coccuzzo Sampaio
Summary: The study demonstrated that CTX inhibits major events involved in angiogenesis, such as tube formation and cell adhesion, proliferation, and migration. These actions were particularly effective against tumor stimuli, highlighting the importance of CTX's anti-angiogenic action in inhibiting tumor progression.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Mathilde Kerherve, Sara Rosinska, Kilian Trillet, Alya Zeinaty, Magalie Feyeux, Steven Nedellec, Julie Gavard
Summary: Glioblastoma multiforme (GBM) is a rare but devastating brain tumor in adults, with current treatments being generally ineffective. This study focused on a population of self-sustaining transformed cells with stem-like properties (GSCs) within GBM, which play a crucial role in tumor initiation, growth, invasion, and recurrence. An ex vivo model was established to explore the invasive behavior of GSCs, and it was found that the glycoprotein Neuropilin-1 (NRP1) contributes to their spreading and invasion. This study proposes a reliable approach to studying invasive properties of patient glioma cells and identifies NRP1 as a mediator in this malignant process.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Kangkang Zha, Xu Li, Guangzhao Tian, Zhen Yang, Zhiqiang Sun, Yu Yang, Fu Wei, Bo Huang, Shuangpeng Jiang, Hao Li, Xiang Sui, Shuyun Liu, Quanyi Guo
Summary: This study identified the expression of CD49f on ADSCs for the first time, and found that the expression of CD49f on ADSCs was influenced by in vitro culture passage number and inflammatory factor treatment. CD49f(+) ADSCs exhibited superior cellular functions compared with unsorted ADSCs.
CELL PROLIFERATION
(2021)
Article
Multidisciplinary Sciences
Uiyoung Han, Wijin Kim, Hyeonjin Cha, Ju Hyun Park, Jinkee Hong
Summary: The method of engineering the iPSC membrane to stimulate the inner cells of EBs while preserving cellular activities is reported in this study. The nano-coating on iPSCs allows them to retain their properties such as adhesion capability, proliferation, and pluripotency during aggregation, without inducing lineage-specific differentiation but increasing E-cadherin expression to promote EB development. This provides a foundation for future production of sophisticated patient-specific multicellular aggregates through modification of living cell membranes.
Article
Cell Biology
Kristiane Soreng, Serhiy Pankiv, Camilla Bergsmark, Ellen M. Haugsten, Anette K. Dahl, Laura R. de la Ballina, Ai Yamamoto, Alf H. Lystad, Anne Simonsen
Summary: ALFY, an autophagy adaptor protein, has been found to play an important role in cell migration by aiding in the formation of a proper leading edge and providing guidance in directional cell movement.
JOURNAL OF CELL SCIENCE
(2022)
Article
Oncology
Elena Ricci, Mariarosa Fava, Pietro Rizza, Michele Pellegrino, Daniela Bonofiglio, Ivan Casaburi, Marilena Lanzino, Cinzia Giordano, Rosalinda Bruno, Rosa Sirianni, Ines Barone, Diego Sisci, Catia Morelli
Summary: The transcription factor FoxO3a can overcome tamoxifen resistance by up-regulating the expression of integrin alpha 5, which is a membrane protein controlling cell adhesion. The FoxO3a and integrin alpha 5 expression is significantly correlated in estrogen receptor alpha-positive tumors, and the protective effects of FoxO3a are lost in cells with reduced levels of integrin alpha 5.
Article
Multidisciplinary Sciences
Anu Autio, Huan Wang, Francisco Velazquez, Gail Newton, Charles A. Parkos, Pablo Engel, Daniel Engelbertsen, Andrew H. Lichtman, Francis W. Luscinskas
Summary: The SIRP alpha-CD47 axis plays an important role in T cell antigen priming. The reduced numbers and impaired migration of CD4(+) conventional dendritic cells (cDCs) in Cd47KO and SKI mice lead to reduced proximity between T cells and DCs in the splenic T cell zone, as well as decreased TCR activation, cell division, proliferation, and increased apoptosis in T cells.
Review
Cell Biology
Weili Xu, Tessa Bergsbaken, Karen L. Edelblum
Summary: Intestinal tissue-resident lymphocytes play a critical role in maintaining the mucosal barrier and preventing enteric infections. CD103, an integrin expressed on these lymphocytes, is involved in their activation and function, but the molecular signals it triggers are still not well understood. Research in this field can provide insights into the functional contribution of CD103 and its potential as a therapeutic target for tissue-resident lymphocyte-related diseases.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Immunology
Vyoma K. Patel, Helen Williams, Stephen C. H. Li, John P. Fletcher, Heather J. Medbury
Summary: The study found that dyslipidemia is associated with an increased potential of all monocyte subsets to extravasate, using a wider repertoire of recruitment markers. While monocyte subsets differed significantly in their expression of recruitment markers, considerable inter-participant differences played a larger role in influencing this difference.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Materials Science, Biomaterials
Hilaria Mollica, Yi Juan Teo, Alrina Shin Min Tan, Damien Zhi Ming Tan, Paolo Decuzzi, Andrea Pavesi, Giulia Adriani
Summary: The study presents an in vitro 3D PDAC-TME model to observe and quantify T cell infiltration, demonstrating that the presence of EC-lining reduces T cell infiltration significantly, and activated T cells migrate more efficiently towards cancer cells compared to not-activated cells.
BIOMATERIALS SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Hua Chai, Hua Qu, Shan He, Lei Song, Yu Yang, Hongbo Huang, Dazhuo Shi
Summary: Studies have found that zedoarondiol improves atherosclerosis plaques by inhibiting monocyte migration and adhesion to endothelial cells, and regulating the CXCL12/CXCR4 pathway. This suggests that zedoarondiol may be a promising new drug for atherosclerosis.
PHARMACOLOGICAL RESEARCH
(2022)