Article
Oncology
Hongyao Jia, Di Wu, Zhiru Zhang, Sijie Li
Summary: The study revealed that MAFG-AS1 acts as an oncogenic lncRNA in breast cancer by regulating the miR-150-5p/MYB axis, thereby affecting the proliferation and migration of breast cancer cells.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Review
Immunology
Donna M. D'Agostino, Vittoria Raimondi, Micol Silic-Benussi, Vincenzo Ciminale
Summary: This article reviews the role of microRNA miR-150-5p in cell transformation by HTLV-1. Studies have shown that miR-150-5p levels are reduced in HTLV-1 transformed cells, but upregulated in ATLL samples, highlighting the need for further research to elucidate its mechanisms in HTLV-1 infection and pathogenesis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yazan Al Salhi, Manfredi Bruno Sequi, Fabio Maria Valenzi, Andrea Fuschi, Alessia Martoccia, Paolo Pietro Suraci, Antonio Carbone, Giorgia Tema, Riccardo Lombardo, Antonio Cicione, Antonio Luigi Pastore, Cosimo De Nunzio
Summary: Cancer stem cells (CSCs) are a small and elusive subpopulation of self-renewing cancer cells that have the remarkable ability to initiate, propagate, and spread malignant disease. Previous studies have focused on the role of CSCs in the development and progression of PCa. PCa CSCs typically originate from luminal prostate cells, and the Wnt, Sonic Hedgehog, and Notch signaling pathways are involved in their development. Epithelial mesenchymal transition and specific miRNAs also play important roles in this process. Targeting these pathways has shown promise in improving the management of PCa development and progression. CSCs in prostate cancer represent a significant and promising area of research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Zhaoping Liu, Pan Wang, Shunling Yuan, Yanyan Wang, Pengfei Cao, Feng Wen, Hui Li, Lin Zhu, Long Liang, Zi Wang, Bin Hu, Fuxiang Zheng, Jing Liu, Xiaojuan Xiao, Ji Zhang
Summary: In this study, BC200 was found to be highly expressed in MDS patients and promoted the malignant proliferation of MDS cells through the miR-150-5p/MYB positive feedback loop. This provides evidence for BC200 as a potential therapeutic target in MDS.
CELL DEATH & DISEASE
(2022)
Article
Virology
Ravi C. Dubey, Nazmir B. Alam, Ritu Gaur
Summary: The microRNA miR-150 plays a crucial role in HIV infection, increasing viral spread within cells by regulating the expression of glucose transporter-1 (GLUT1). The study reveals that HIV Tat protein enhances miR-150 expression, leading to elevated glucose uptake and promoting viral replication.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Medicine, Research & Experimental
Xingwang Zhao, Rui Dong, Zhongwei Tang, Juan Wang, Chunyou Wang, Zhiqiang Song, Bing Ni, Longlong Zhang, Xiaochong He, Yi You
Summary: The downregulation of circLOC101928570 in systemic lupus erythematosus plays a critical role in suppressing SLE progression through the miR-150-5p/c-myb/IL2RA axis. circLOC101928570 may serve as a potential biomarker for the diagnosis and therapy of SLE.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Oncology
Wen Jess Li, Xiaozhuo Liu, Emily M. Dougherty, Dean G. Tang
Summary: The article reviews the tumor suppressive role of miRNA-34a in prostate cancer and discusses therapeutic development strategies for advanced prostate cancer patients.
Article
Reproductive Biology
Eun Jung Sohn
Summary: This study reported the expression profiles of circRNAs in ovarian cancer stem cells (CSCs) and suggested that circRNAs may serve as potential diagnostic and predictive biomarkers for ovarian cancer.
JOURNAL OF OVARIAN RESEARCH
(2022)
Article
Oncology
Lan Zhang, Xiaohui Wang, Yunfei Li, Jing Han, Xianzheng Gao, Shenglei Li, Feng Wang
Summary: This study elucidated the role of c-Myb in immune escape of EAC cells by promoting the transcription of miR-145-5p and inhibiting SPOP-dependent ubiquitination and degradation of PD-L1. These findings present a new target for adjunct therapy of EAC.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Chemistry, Medicinal
Massimo Moro, Orazio Fortunato, Giulia Bertolini, Mavis Mensah, Cristina Borzi, Giovanni Centonze, Francesca Andriani, Daniela Di Paolo, Patrizia Perri, Mirco Ponzoni, Ugo Pastorino, Gabriella Sozzi, Mattia Boeri
Summary: Despite improvements in therapies and screening strategies, lung cancer prognosis remains poor, especially for patients with metastatic tumors. Cancer stem cells (CSCs) are a major cause of the low survival rate, and microRNA miR-486-5p has been identified as a potential therapeutic target for lung cancer.
Article
Medicine, Research & Experimental
Ping Li, Hongyan Xin, Lili Lu
Summary: This study demonstrates that MSC-derived EVs transfer miR-424 to down-regulate MYB and inhibit tumorigenesis and angiogenesis of ovarian cancer. The findings suggest a potential prognostic marker and therapeutic target for ovarian cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Gladys Y-P Ko, Fei Yu, Kayla J. Bayless, Michael L. Ko
Summary: Diabetic retinopathy is a diabetic eye disease that affects both neural retina and retinal vasculature, leading to vision impairment. Chronic inflammation, apoptosis, and pathological angiogenesis play crucial roles in the pathogenesis of this disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Min Qiu, Shuheng Zhai, Qin Fu, Da Liu
Summary: The research reveals that exosomal miR-150-3p promotes osteoblast proliferation and differentiation in osteoporosis, providing a new insight for treating patients with osteoporosis.
HUMAN GENE THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Maria V. Yusenko, Amke Trentmann, Debora A. Casolari, Luca Abdel Ghani, Mairin Lenz, Melanie Horn, Wolfgang Doerner, Stefan Klempnauer, Henning D. Mootz, Maria Francisca Arteaga, Jan-Henrik Mikesch, Richard J. D' Andrea, Thomas J. Gonda, Carsten Mueller-Tidow, Thomas J. Schmidt, Karl-Heinz Klempnauer
Summary: Recent studies have identified C/EBP beta as a potential target for the treatment of AML by indirectly inhibiting the transcription factor MYB. This suggests that targeting of C/EBP beta may have therapeutic potential against AML.
Review
Biochemistry & Molecular Biology
Loshini Soundararajan, Sudha Warrier, Arun Dharmarajan, Natarajan Bhaskaran
Summary: Reactive oxygen species (ROS) and its related signaling pathways and regulating molecules play a major role in the growth and development of cancer stem cells. CSCs possess robust self-renewal and tumorigenic potential, are resistant to conventional chemo- and radiotherapy, and eradicating CSCs may be the key to curing cancer. However, CSCs efficiently expel ROS by upregulating ROS scavengers, protecting them from ROS-mediated cell death and leading to chemoresistance and radioresistance.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)