Article
Biology
Malgorzata Klosek, Dagmara Jaworska, Grazyna Pietsz, Ewelina Szliszka
Summary: This study examined the apoptotic effect of santin in combination with TRAIL on colon cancer cells. Flow cytometry and fluorescence microscopy were used to observe apoptosis and death receptor expression. It was found that santin synergized with TRAIL to induce apoptosis in colon cancer cells. This synergistic effect was achieved by increasing the expression of death receptors TRAIL-R1 and TRAIL-R2 and altering the mitochondrial membrane potential.
Article
Biochemistry & Molecular Biology
Erina Shiraishi, Keishi Ishida, Daisuke Matsumaru, Akiko Ido, Youhei Hiromori, Hisamitsu Nagase, Tsuyoshi Nakanishi
Summary: Research indicates that Brazilian green propolis may act as a skin sensitizer with moderate sensitivity. The effective concentration is 1-2% and can be safely used.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Nagi B. Kumar, Stephanie Hogue, Julio Pow-Sang, Michael Poch, Brandon J. Manley, Roger Li, Jasreman Dhillon, Alice Yu, Doratha A. Byrd
Summary: Green tea catechins (GTCs) have been shown to prevent the progression of prostate cancer (PCa), especially in men with low-risk PCa on active surveillance. The gut microbiome metabolizes GTCs, making them more accessible to the body. The gut microbiome also influences other processes related to PCa progression. Considering the independent roles of GTCs and the gut microbiome, as well as their relationship to individual responses, can enhance clinical decision-making.
Article
Chemistry, Medicinal
Karina Basso Santiago, Joao Carlos Zamae Rodrigues, Eliza de Oliveira Cardoso, Fernanda Lopes Conte, Karen Ingrid Tasca, Graziela Gorete Romagnoli, Jennyfer Andrea Aldana-Mejia, Jairo Kenupp Bastos, Jose Mauricio Sforcin
Summary: Brazilian red propolis (BRP) exhibits selective cytotoxicity against prostate cancer cells, enhances immune modulation activity and fungicidal activity.
PHYTOTHERAPY RESEARCH
(2023)
Article
Agriculture, Multidisciplinary
Jiangli Ding, Tomoh Matsumiya, Ryo Hayakari, Yuko Shiba, Shogo Kawaguchi, Kazuhiko Seya, Kayo Ueno, Tadaatsu Imaizumi
Summary: The study found that propolis intake led to the presence of the bioactive component artepillin C in the serum, with higher levels observed in females. Menstrual status did not impact serum artepillin C levels in the female group.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Food Science & Technology
Norihisa Mikami, Hiroko Tani, Ryoji Kawakami, Atsushi Sugimoto, Shimon Sakaguchi, Tomoki Ikuta
Summary: Research shows that Brazilian green propolis increases TNFR2 expression in Tregs via the IRF4/cMyc axis, with artepillin C being a major effective component. These findings suggest that propolis and artepillin C have the potential to activate Tregs through TNFR2 expression, and may be beneficial for the prevention and treatment of autoimmune or inflammatory diseases.
FOOD SCIENCE & NUTRITION
(2021)
Article
Geriatrics & Gerontology
Takuro Okamura, Masahide Hamaguchi, Ryo Bamba, Hanako Nakajima, Yuta Yoshimura, Tomonori Kimura, Yoshitaka Hashimoto, Saori Majima, Takafumi Senmaru, Emi Ushigome, Naoko Nakanishi, Mai Asano, Masahiro Yamazaki, Yuichiro Nishimoto, Takuji Yamada, Chizuru Fujikura, Takashi Asama, Nobuaki Okumura, Hiroshi Takakuwa, Ryoichi Sasano, Michiaki Fukui
Summary: This study demonstrates for the first time that propolis can improve sarcopenic obesity by improving dysbiosis due to overeating and provides new insights into diet-microbiota interactions during sarcopenic obesity.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Environmental Sciences
Stephane Zingue, Julia Cisilotto, Robinson Charly Mbe Fogang, Edwige Nana Tchoupang, Derek Tantoh Ndinteh, Nestor-Fernand Tchuenguem Fohouo, Dieudonne Njamen, Tania Beatriz Creczynski-Pasa
Summary: Ethanol-extracted Cameroonian propolis demonstrated anti-mammary tumor effects by inducing apoptosis through the mitochondrial pathway, inhibiting MMP-2 activity, and down-regulating certain key proteins. It also prevented tumor migration and invasion, highlighting its potential as a natural treatment for breast cancer.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Toxicology
Venera Cardile, Adriana C. E. Graziano, Rosanna Avola, Alejandro Madrid, Alessandra Russo
Summary: Physodic acid, a lichen secondary metabolite, exhibits antigrowth and pro-apoptotic activity on prostate cancer cells. It also sensitizes LNCaP cells to TRAIL-induced apoptosis.
TOXICOLOGY IN VITRO
(2022)
Article
Oncology
Korie A. Grayson, Jacob M. Hope, Wenjun Wang, Cynthia A. Reinhart-King, Michael R. King
Summary: Docetaxel and cabazitaxel alone do not significantly reduce cell viability in prostate cancer cells, indicating resistance to TRAIL and taxanes individually. However, the combination of taxanes and TRAIL synergistically enhances apoptosis, with taxanes sensitizing prostate cancer cells to TRAIL-induced apoptosis. Activation of JNK by ER stress upregulates death receptor expression and plays a role in sensitizing prostate cancer cells to TRAIL-induced apoptosis.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Pharmacology & Pharmacy
Dominika Ewa Habrowska-Gorczynska, Karolina Kowalska, Kinga Anna Urbanek, Kamila Dominska, Marta Justyna Koziel, Agnieszka Wanda Piastowska-Ciesielska
Summary: This study found that prostate cancer cells are partially resistant to TRAIL-induced apoptosis, but the naturally produced compound DON may sensitize these cells to TRAIL treatment and improve therapy efficiency.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Cell Biology
Emir Bozkurt, Heiko Dussmann, Manuela Salvucci, Brenton L. Cavanagh, Sandra Van Schaeybroeck, Daniel B. Longley, Seamus J. Martin, Jochen H. M. Prehn
Summary: The study reveals that TRAIL signaling not only activates apoptosis in colon cancer cells but also induces entosis through TRAIL receptors and the structural presence of caspase-8. The association of TRAIL signaling with cell-in-cell structures is significant in colorectal cancer, especially in the context of patient prognosis. Factors controlling entosis in tumors remain to be elucidated despite the evidence of entosis in cancers.
JOURNAL OF CELL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Nada Orsolic, Maja Jazvinscak Jembrek
Summary: Interest in natural products as alternative sources of pharmaceuticals for chronic diseases, including tumors, has been renewed in recent years. Propolis and its compounds have been found to modulate various processes involved in cancer progression, such as cell proliferation, apoptosis, and oncogene signaling pathways. They also exhibit antimetastatic, anti-angiogenic, anti-inflammatory, and antiviral/bactericidal activities, as well as modulation of gut microbiota and attenuation of chemotherapy side effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Plant Sciences
Srimanta Patra, Biswajita Pradhan, Rabindra Nayak, Chhandashree Behera, Surajit Das, Samir Kumar Patra, Thomas Efferth, Mrutyunjay Jena, Sujit Kumar Bhutia
Summary: Dietary polyphenols demonstrate chemopreventive activity by modulating key molecular targets and pathways to limit cancer initiation and progression. Combining polyphenols with existing anticancer drugs enhances anticancer activity and offers promising perspectives for clinical applications.
Review
Biochemistry & Molecular Biology
Anderson Luiz-Ferreira, Teresa Pacifico, Alefe Cardoso Cruz, Federica Laudisi, Giovanni Monteleone, Carmine Stolfi
Summary: TRAIL is a promising anticancer agent that selectively induces apoptosis in transformed cells, while flavonoids, natural compounds found in plants, have shown competence in enhancing TRAIL-induced apoptosis. However, bioavailability issues are the main limitations for the clinical use of flavonoids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Integrative & Complementary Medicine
Dariusz Skaba, Tadeusz Morawiec, Marta Tanasiewicz, Anna Mertas, Elzbieta Bobela, Ewelina Szliszka, Malgorzata Skucha-Nowak, Monika Dawiec, Rindai Yamamoto, Shinobu Ishiai, Yuki Makita, Malgorzata Redzynia, Beata Janoszka, Iwona Niedzielska, Wojciech Krol
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2013)
Article
Chemistry, Applied
Urszula Blaszczyk, Beata Janoszka
Article
Chemistry, Applied
B. Janoszka, U. Blaszczyk, A. Damasiewicz-Bodzek, M. Sajewicz
Article
Chemistry, Applied
Beata Janoszka
Article
Chemistry, Applied
Beata Janoszka
Article
Food Science & Technology
Beata Janoszka
Article
Chemistry, Applied
Ewa Sniezek, Magdalena Szumska, Agnieszka Nowak, Beata Janoszka
Summary: The study found that adding onions and garlic during cooking can reduce the content of certain potentially carcinogenic compounds, but increase the presence of another substance.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2022)
Review
Environmental Sciences
Sylwia Bulanda, Beata Janoszka
Summary: Thermal treatment of high-protein food can generate mutagenic and carcinogenic compounds. Consuming processed meat is directly linked to the risk of cancer. Using spices and vegetables as additives in meat can reduce the content of carcinogenic compounds.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Food Science & Technology
Ewa Sniezek, Magdalena Szumska, Agnieszka Nowak, Roksana Muzyka, Beata Janoszka
Summary: The influence of dried fruits on the formation of carcinogenic organic compounds during meat heat treatment was studied. The content of carbolines and azaarenes in roasted pork loin was measured with and without the addition of fruits.
Article
Food Science & Technology
Agnieszka Nowak, Beata Janoszka, Magdalena Szumska, Krystyna Tyrpien-Golder
Summary: The Maillard reaction occurs between amino acids and reducing sugars to form various products known as MRPs. Factors such as pH, sugar content, and processing conditions influence the type of MRPs formed, which exhibit different biological properties. Studies focus on evaluating the impact of Maillard reaction on the quality of food products like jams.
JOURNAL OF MICROBIOLOGY BIOTECHNOLOGY AND FOOD SCIENCES
(2021)
Article
Chemistry, Analytical
Beata Janoszka
JPC-JOURNAL OF PLANAR CHROMATOGRAPHY-MODERN TLC
(2007)
Article
Biochemical Research Methods
L Warzecha, B Janoszka, U Blaszczyk, M Strozyk, D Bodzek, C Dobosz
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2004)
Article
Chemistry, Analytical
B Janoszka, L Warzecha, C Dobosz, D Bodzek
JPC-JOURNAL OF PLANAR CHROMATOGRAPHY-MODERN TLC
(2003)
Article
Chemistry, Analytical
B Janoszka, U Blaszczyk, L Warzecha, K Luks-Betlej, M Strozyk
CHEMIA ANALITYCZNA
(2003)