Article
Oncology
Long He, Xiang Pan, Xialu Wang, Yuhua Cao, Peng Chen, Cheng Du, Daifa Huang
Summary: There is a mutual regulation between Rab6c and miR-218 in bladder cancer cells, where Rab6c promotes the proliferation and invasion of bladder cancer cells while miR-218 has the opposite effect.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Yongzhi Li, Benkang Shi, Fengming Dong, Xingwang Zhu, Bing Liu, Yili Liu
Summary: The study demonstrates that high expression of KCNQ1OT1 in bladder cancer promotes tumor progression by regulating the miR-218-5p/HS3ST3B1 signaling pathway.
CANCER GENE THERAPY
(2021)
Article
Neurosciences
Zhirong Wan, Madiha Rasheed, Yumeng Li, Qin Li, Peifu Wang, Jilai Li, Zixuan Chen, Jichen Du, Yulin Deng
Summary: Depression is a common but often neglected symptom of Parkinson's disease (PD), and there is a need for suitable diagnostic biomarkers. This study aimed to assess the potential of brain-enriched miR-218-5p and miR-320-5p as biomarkers for depression in Chinese PD patients. The results showed downregulation of miR-218-5p and miR-320-5p and upregulation of IL-6 and S100B in depressed PD patients. These miRNAs were negatively correlated with depression scores and IL-6 levels, and positively correlated with PD duration and medication. ROC analysis demonstrated their potential as diagnostic biomarkers. Furthermore, in silico analysis identified key neurological pathways regulated by the targets of these miRNAs. In conclusion, miR-218-5p and miR-320-5p may serve as future biomarkers for depression in PD, aiding in early diagnosis and treatment.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zhi Chen, Xiang Cao, Qinyue Lu, Jingpeng Zhou, Yuhao Wang, Yanni Wu, Yongjiang Mao, Huifen Xu, Zhangping Yang
Summary: The study found that circ01592 promotes milk fat synthesis and increases the content of unsaturated fatty acids by binding to miR-218, while the function of miR-218 is opposite to that of circ01592. These findings provide a new research pathway for improving milk quality.
Article
Biochemistry & Molecular Biology
Liangliang Ren, Minxiao Jiang, Dingwei Xue, Huan Wang, Zeyi Lu, Lifeng Ding, Haiyun Xie, Ruyue Wang, Wenqin Luo, Li Xu, Mingchao Wang, Shicheng Yu, Sheng Cheng, Liqun Xia, Haifeng Yu, Peng Huang, Naijin Xu, Gonghui Li
Summary: The study reveals that nitroxoline suppresses metastasis in bladder cancer via the EGR1/circNDRG1/miR-520h/smad7/EMT signaling pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Oncology
Hao Lin, Xiaojun Shi, Haoran Li, Jialiang Hui, Ruiyu Liu, Zihao Chen, Yuwen Lu, Wanlong Tan
Summary: The study identified miR-93-5p and miR-516a-5p in urinary exosomes as potential biomarkers for bladder cancer detection, showing promising diagnostic value in BC patients. Further validation demonstrated that the expression level of miR-93-5p was associated with the progression of bladder cancer.
Article
Neurosciences
Angelica Torres-Berrio, Alice Morgunova, Michel Giroux, Santiago Cuesta, Eric J. Nestler, Cecilia Flores
Summary: miR-218 expression in adolescence may serve as both a marker of risk and a target for early interventions in stress vulnerabilities, as it regulates Dcc expression and correlates with social defeat stress vulnerability in adulthood in male mice.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Neurosciences
Neal D. Amin, Gokhan Senturk, Giancarlo Costaguta, Shawn Driscoll, Brendan O'Leary, Dario Bonanomi, Samuel L. Pfaff
Summary: This study found that microRNA (miRNA) can govern different gene network outputs at different expression levels, and miRNA-dependent phenotypes emerge at specific dose ranges due to hidden regulatory inflection points in their gene networks.
Article
Oncology
Yuxiao Chang, Ziran Huang, Fengyi Hou, Yuejiao Liu, Likun Wang, Zhen Wang, Yifan Sun, Zhiyuan Pan, Yafang Tan, Lei Ding, Hong Gao, Ruifu Yang, Yujing Bi
Summary: This study revealed an important relationship between Parvimonas micra (P. micra) and colorectal cancer (CRC) through cell experiments and mouse models. Transcriptomics and microRNA sequencing showed that P. micra promoted CRC development through the activation of the miR-218-5p/Ras/ERK/c-Fos pathway.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Immunology
Alissa K. Rutman, Sarita Negi, Nasim Saberi, Kashif Khan, Jean Tchervenkov, Steven Paraskevas
Summary: Delayed graft function (DGF) in kidney transplantation is associated with ischemic injury and carries long term functional and immunological risks. Kidney perfusate-derived extracellular vesicles (KP-EV) express donor-specific human leukocyte antigen and can modulate immune responses in transplant recipients. This discovery could lead to novel intervention strategies to improve graft function and survival.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Danielle Rodrigues Cortez, Fabio Mitsuo Lima, Joao Luis Reis-Cunha, Daniella Castanheira Bartholomeu, Rolando Andre Rios Villacis, Silvia Regina Rogatto, Andre Guilherme Costa-Martins, Fernanda Sycko Marchiano, Rafaela Andrade do Carmo, Jose Franco da Silveira, Marjorie Mendes Marini
Summary: In this study, the genetic differences between two lineages of Chagas disease-causing parasite T. cruzi were analyzed using intraspecific array-based comparative genomic hybridization (aCGH). The results showed that clone D11 had more chromosomal gains and losses compared to the parental G strain. These genomic changes suggest a dynamic genome in clone D11 that responds to environmental stress by altering gene copy numbers and generating segmental aneuploidy.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Rodolfo Ocadiz-Delgado, Solangy Lizcano-Meneses, Jessica-Angelina Trejo-Vazquez, Juan-Cristobal Conde-Perezprina, Frida Garrido-Palmas, Elizabeth Alvarez-Rios, Enrique Garcia-Villa, Graciela Ruiz, Berenice Illades-Aguiar, Marco Antonio Leyva-Vazquez, Alejandro Garcia-Carranca, Patricio Gariglio
Summary: The study evaluated the relative abundance of three circulating miRNAs in serum from HPV16-positive patients with LSILs. miR-15b expression remained unchanged, while miRNAs 34a and 218 were higher in LSIL patients compared to healthy women. The study also determined mRNA expression levels of selected gene targets, finding correlations between serum and tissue samples from the same patients.
Article
Oncology
Hossein Sendi, Mostafa Yazdimamaghani, Mengying Hu, Nikhila Sultanpuram, Jie Wang, Amber S. Moody, Ellie McCabe, Jiajie Zhang, Amanda Graboski, Liantao Li, Juan D. Rojas, Paul A. Dayton, Leaf Huang, Andrew Z. Wang
Summary: Efficient delivery of miR-122 to hepatocytes using a nanomedicine-based formulation has the potential to prevent and treat colorectal cancer liver metastasis. Mechanistically, it downregulates key genes involved in metastatic and cancer inflammation pathways, increases CD8(+)/CD4(+) T-cell ratio, and decreases immunosuppressive cell infiltration, making the liver more conducive to antitumor immune response.
Article
Medicine, Research & Experimental
Wenxian Tian, Xiangfei Yuan, Yongna Song, Jianxia Zhai, Haixia Wei, Linna Wang, Dan Li, Qiusheng Chen
Summary: The study showed that miR-218 downregulated glucose metabolism in NSCLC cells by directly targeting GLUT1 and through the NF-kappa B signaling pathway.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Asmaa M. Elfiky, Rania Hassan Mohamed, Fatma El-Zahraa Abd EL-Hakam, Mohamed A. Yassin, Mahmoud ElHefnawi
Summary: This study demonstrated the potential of LA-PAMAM carrier for targeted delivery of tumor suppressor miR-218 as a therapeutic candidate for HCC. The combination of hyperbranched polyamidoamine and lactobionic acid efficiently suppressed HepG2 cell proliferation and down-regulated the oncogenic HOXA1 target.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Oncology
Kazuki Kuroshima, Hirofumi Yoshino, Shunsuke Okamura, Masafumi Tsuruda, Yoichi Osako, Takashi Sakaguchi, Satoshi Sugita, Shuichi Tatarano, Masayuki Nakagawa, Hideki Enokida
Article
Oncology
Hirofumi Yoshino, Hideki Enokida, Yoichi Osako, Nijiro Nohata, Masaya Yonemori, Satoshi Sugita, Kazuki Kuroshima, Masafumi Tsuruda, Shuichi Tatarano, Masayuki Nakagawa
MOLECULAR ONCOLOGY
(2020)
Article
Multidisciplinary Sciences
Masafumi Tsuruda, Hirofumi Yoshino, Shunsuke Okamura, Kazuki Kuroshima, Yoichi Osako, Takashi Sakaguchi, Satoshi Sugita, Shuichi Tatarano, Masayuki Nakagawa, Hideki Enokida
Article
Immunology
Yasutoshi Yamada, Hideki Enokida, Hiroki Harada, Saiki Saito, Taichi Miyauchi, Shuji Nagatomi, Masato Minami, Akihiko Mitsuke, Tomoaki Ishihara, Hiroaki Nishimura, Shuichi Tatarano, Norihiko Goto, Yuichi Akasaki, Masayuki Nakagawa
TRANSPLANTATION PROCEEDINGS
(2020)
Article
Multidisciplinary Sciences
Hirofumi Yoshino, Yasutoshi Yamada, Hideki Enokida, Yoichi Osako, Masafumi Tsuruda, Kazuki Kuroshima, Takashi Sakaguchi, Satoshi Sugita, Shuichi Tatarano, Masayuki Nakagawa
Article
Oncology
Shunsuke Okamura, Hirofumi Yoshino, Kazuki Kuroshima, Masafumi Tsuruda, Yoichi Osako, Takashi Sakaguchi, Masaya Yonemori, Yasutoshi Yamada, Shuichi Tatarano, Masayuki Nakagawa, Hideki Enokida
Summary: The study established cisplatin-resistant BC cell lines and identified miR-486-5p as a tumor suppressor microRNA that targets EHHADH gene, affecting cancer cell proliferation, migration, invasion, and cisplatin sensitivity.
Article
Oncology
Katsuhiro Ito, Takashi Kobayashi, Takahiro Kojima, Kensuke Hikami, Takeshi Yamada, Kosuke Ogawa, Kenji Nakamura, Naoto Sassa, Akira Yokomizo, Takashige Abe, Kazunari Tsuchihashi, Shuichi Tatarano, Junichi Inokuchi, Ryotaro Tomida, Maki Fujiwara, Atsushi Takahashi, Kazumasa Matsumoto, Kosuke Shimizu, Hiromasa Araki, Ryoma Kurahashi, Yu Osaki, Yu Tashiro, Masayuki Uegaki, Osamu Ogawa, Hiroshi Kitamura, Hiroyuki Nishiyama
Summary: The study found that despite comparable safety profiles, patients with PS >= 2 showed worse overall response rates and overall survival compared to those with PS <= 1. Among patients with impaired performance status, those with NLR <3.5 and no liver metastasis may benefit the most from pembrolizumab therapy.
Article
Urology & Nephrology
Minoru Kato, Takashi Kobayashi, Yoshiyuki Matsui, Katsuhiro Ito, Kensuke Hikami, Takeshi Yamada, Kosuke Ogawa, Kenji Nakamura, Naoto Sassa, Akira Yokomizo, Takashige Abe, Kazunari Tsuchihashi, Shuichi Tatarano, Junichi Inokuchi, Ryotaro Tomida, Maki Fujiwara, Atsushi Takahashi, Kazumasa Matsumoto, Kosuke Shimizu, Hiromasa Araki, Ryoma Kurahashi, Yu Ozaki, Yu Tashiro, Masayuki Uegaki, Takahiro Kojima, Junji Uchida, Osamu Ogawa, Hiroyuki Nishiyama, Hiroshi Kitamura
Summary: This study investigated the impact of chemotherapy cycles and response on overall survival in metastatic urothelial carcinoma patients treated with pembrolizumab. The results showed that the therapeutic benefit of pembrolizumab can be expected regardless of the response to or number of cycles of platinum-based first-line chemotherapy.
INTERNATIONAL JOURNAL OF UROLOGY
(2021)
Meeting Abstract
Oncology
Akira Yokomizo, Futoshi Morokuma, Masatoshi Eto, Masaki Shiota, Hideyasu Matsuyama, Hiroaki Matsumoto, Toshiyuki Kamoto, Naoki Terada, Kazuya Kawahara, Hideki Enokida, Shuichi Tatarano, Naohiro Fujimoto, Katsuyoshi Higasijima, Hideki Sakai, Tomoaki Hakariya, Tsukasa Igawa, Shigetaka Suekane, Tomomi Kamba, Yutaka Sugiyama, Seiji Naito
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Motoki Tamai, Shuichi Tatarano, Shunsuke Okamura, Wataru Fukumoto, Issei Kawakami, Yoichi Osako, Takashi Sakaguchi, Satoshi Sugita, Masaya Yonemori, Yasutoshi Yamada, Masayuki Nakagawa, Hideki Enokida, Hirofumi Yoshino
Summary: MiR-99a-5p induces cellular senescence in gemcitabine-resistant bladder cancer cells by targeting SMARCD1, thereby inhibiting cell growth and restoring sensitivity to gemcitabine.
MOLECULAR ONCOLOGY
(2022)
Article
Urology & Nephrology
Shuichi Tatarano, Akihiko Mitsuke, Takashi Sakaguchi, Ryosuke Matsushita, Satoru Inoguchi, Hirofumi Yoshino, Hiroaki Nishimura, Yasutoshi Yamada, Hideki Enokida
Summary: This study analyzed the clinical outcomes of laparoscopic adrenalectomy for pheochromocytomas in hemodialysis compared with nonhemodialysis patients. The results showed that increasing intravascular volume before surgery in hemodialysis patients made perioperative hemodynamic management safer. The study also found that an increase in systolic blood pressure at CO2 insufflation was an independent predictor of a hypertensive spike during the surgery.
INTERNATIONAL JOURNAL OF NEPHROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hirofumi Yoshino, Shuichi Tatarano, Motoki Tamai, Masafumi Tsuruda, Sayaka Iizasa, Junya Arima, Issei Kawakami, Wataru Fukumoto, Ichiro Kawahara, Gang Li, Takashi Sakaguchi, Satoru Inoguchi, Yasutoshi Yamada, Hideki Enokida
Summary: Exosomes containing miR-1 were found to inhibit tumor growth in renal cell carcinoma (RCC), and the study explored the functional role of exosomal miR-1 and its potential as a tumor marker in RCC.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Masaki Shiota, Shuichi Tatarano, Toshiyuki Kamoto, Hideyasu Matsuyama, Hideki Sakai, Tsukasa Igawa, Tomomi Kamba, Naohiro Fujimoto, Yuya Sekine, Hiroko Kimura, Shintaro Narita, Naoki Terada, Yukihide Momozawa, Shusuke Akamatsu, Tomonori Habuchi, Akira Yokomizo, Seiji Naito, Masatoshi Eto
Summary: This study aimed to identify genetic markers that could predict the outcome of androgen-deprivation therapy (ADT) for advanced prostate cancer. Through a genome-wide association study (GWAS), single-nucleotide polymorphisms (SNPs) associated with radiographic progression-free survival (rPFS) and adverse events (AEs) were identified. Validation studies confirmed the association of these SNPs with ADT outcomes, and a genetic prognostic model using these SNPs showed excellent predictive efficacy for progression-free survival and overall survival. The study also revealed SNPs associated with AEs in ADT, such as de novo diabetes mellitus, arthralgia, and de novo dyslipidemia.
ENDOCRINE-RELATED CANCER
(2023)
Article
Urology & Nephrology
Shuichi Tatarano, Hideki Enokida, Masaya Yonemori, Rumiko Eura, Hirofumi Yoshino, Hiroaki Nishimura, Yasutoshi Yamada, Masayuki Nakagawa
Summary: The study found that the incidence of pre-DVT was 6.3% in patients undergoing urological surgery. Elderly patients and/or a cutoff D-dimer level of 1.8 μg/mL might be good indicators for pre-DVT screening by CUS. No patient developed symptomatic VTE during the 90-day postoperative follow-up period.
INVESTIGATIVE AND CLINICAL UROLOGY
(2021)
Correction
Oncology
Hideki Enokida, Yasutoshi Yamada, Shuichi Tatarano, Hirofumi Yoshino, Masaya Yonemori, Takashi Sakaguchi, Hiroaki Nishimura, Rumiko Eura, Masayuki Nakagawa
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2020)