Article
Endocrinology & Metabolism
Shan Cai, Jiajia Dang, Panliang Zhong, Ning Ma, Yunfei Liu, Di Shi, Zhiyong Zou, Yanhui Dong, Jun Ma, Yi Song
Summary: This study analyzed the sex differences in the prevalence of obesity phenotypes and their risk factors among children and adolescents in China. The results showed higher prevalence of obesity phenotypes in boys and identified various risk factors such as parental smoking, birth weight, and lifestyle factors. The findings highlight the importance of considering sex differences in managing obesity phenotypes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Edith E. Schermer, Peter M. Engelfriet, Anneke Blokstra, W. M. Monique Verschuren, H. Susan J. Picavet
Summary: The study found changing trends in health-related lifestyle factors over 30 years at both population and individual levels, emphasizing the importance of individual-level changes in predicting potential changes in health-related lifestyles.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Herculina Salome Kruger, Zelda De Lange-Loots, Iolanthe Marike Kruger, Marlien Pieters
Summary: Obesity is associated with increased cardiometabolic risk, but some individuals can maintain metabolically healthy obesity (MHO). A study found that about half of the black South African adults with MHO maintained this state over a 10-year period, while some became metabolically unhealthy overweight/obese. The metabolic profiles of MHO individuals were similar to those with normal weight, but had some unfavorable factors.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Clinical Neurology
Hwanjin Park, Kounseok Lee
Summary: The study found that moderate waist circumference may reduce suicidal thoughts for metabolically healthy women above 40 years old. While severe abdominal obesity was associated with increased suicide risk, this association was not significant when emotional difficulties like depression were considered.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Medicine, General & Internal
Sidar Copur, Cem Tanriover, Furkan Yavuz, Katherine R. Tuttle, Mehmet Kanbay
Summary: Metabolically healthy obesity or overweight refers to being obese or overweight without any major metabolic disorder or cardiovascular diseases. However, it is recognized as an important risk factor for the development of cardiovascular diseases. Tirzepatide, a newly developed glucose-lowering agent, has shown potential benefits in reducing the risk of adverse cardiovascular outcomes in metabolically healthy obese or overweight patients.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Review
Medicine, General & Internal
Cem Tanriover, Sidar Copur, Abduzhappar Gaipov, Batu Ozlusen, Rustu E. Akcan, Masanari Kuwabara, Mads Hornum, Daniel H. Van Raalte, Mehmet Kanbay
Summary: Obesity is a complex condition with different subtypes, one of which is metabolically healthy obesity (MHO). MHO has various definitions and its prevalence differs in different studies. Mechanisms underlying MHO include adipose tissue types and distribution, hormones, inflammation, diet, microbiota, and genetics. While MHO has relatively favorable metabolic characteristics compared to metabolically unhealthy obesity (MUO), it is still associated with important chronic diseases and has the potential to progress into an unhealthy phenotype. The major treatment options for MHO include dietary modifications, exercise, bariatric surgery, and specific medications.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Saioa Gomez-Zorita, Maite Queralt, Maria Angeles Vicente, Marcela Gonzalez, Maria P. Portillo
Summary: The relationship between obesity and metabolically healthy obese (MHO) as well as metabolically obese normal weight (MONW) individuals is complex and varied. Different classifications have been used in studies, making it difficult to define MHO and MONW. Main determinants of MHO include growth type, anatomical location, adipose tissue inflammation, while MONW is mainly influenced by genetic background and lifestyle factors.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Ruziana Mona Wan Mohd Zin, Muhammad Yazid Jalaludin, Abqariyah Yahya, Ahmad Kamil Nur Zati Iwani, Fuziah Md Zain, Janet Yeow Hua Hong, Abdul Halim Mokhtar, Wan Nazaimoon Wan Mohamud
Summary: This study aimed to compare several parameters related to obesity between metabolically healthy obese (MHO) and metabolically unhealthy obese (MUO) children, and to examine the predictors associated with the MHO phenotype.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Vanda Craveiro, Elisabete Ramos, Joana Araujo
Summary: The study suggests that healthy obesity can be explained by lower exposure to adiposity, whether in terms of shorter duration or lower quantity, and a more favorable body fat distribution.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Nutrition & Dietetics
Matina Kouvari, Nathan M. D'Cunha, Thomas Tsiampalis, Manja Zec, Domenico Sergi, Nikolaj Travica, Wolfgang Marx, Andrew J. McKune, Demosthenes B. Panagiotakos, Nenad Naumovski
Summary: The aim of this study was to evaluate the association between metabolically healthy overweight/obesity (MHO) status and longitudinal cognitive function while considering the stability of the condition. The study found that maintaining a healthy metabolic status over time has a greater impact on cognitive function than body weight alone.
Review
Biochemistry & Molecular Biology
Yun Kyung Cho, Yoo La Lee, Chang Hee Jung
Summary: Metabolically healthy obesity (MHO) is a condition in which people with obesity are resistant to the detrimental effects of excess body fat. MHO is characterized by differences in fat distribution, adipokine types, and levels of chronic inflammation compared to metabolically unhealthy obesity (MUO). Although there is no established definition for MHO, it is often described as a specific type of obesity with lower levels of insulin resistance or inflammatory markers. Understanding the characteristics that differentiate MHO from MUO can provide new insights into the mechanisms behind obesity-related metabolic derangements and diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Lingling Tong, Mei Tian, Xiaoyan Ma, Ling Bai, Jinyu Zhou, Wenqing Ding
Summary: This study aimed to screen the metabolomes of individuals with unhealthy obesity phenotype and identify potential metabolic pathways that could regulate various metabolic profiles of obesity in Chinese adolescents. The results showed that several metabolites and pathways were associated with metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO).
Article
Endocrinology & Metabolism
Jing Fu, Qiu Wang, Lin Zhang, Jia Liu, Guang Wang
Summary: This study aimed to explore the relationship between serum bilirubin levels and metabolic alterations in different obesity phenotypes. The results showed that the metabolically healthy obesity (MHO) group had favorable metabolic profiles and higher bilirubin levels compared to the metabolically unhealthy obesity (MUHO) group. Bilirubin was negatively correlated with cholesterol, insulin resistance, and inflammation markers.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Ziyi Zhou, John Macpherson, Stuart R. Gray, Jason M. R. Gill, Paul Welsh, Carlos Celis-Morales, Naveed Sattar, Jill P. Pell, Frederick K. Ho
Summary: The study found that individuals with metabolically healthy obesity (MHO) had higher rates of heart failure and respiratory diseases, but not necessarily atherosclerotic cardiovascular diseases. Compared to metabolically healthy individuals without obesity, those with MHO had higher risks of diabetes, cardiovascular diseases, heart failure, respiratory diseases, and all-cause mortality.
Article
Biochemistry & Molecular Biology
Carolina Gutierrez-Repiso, Teresa Maria Linares-Pineda, Andres Gonzalez-Jimenez, Francisca Aguilar-Lineros, Sergio Valdes, Federico Soriguer, Gemma Rojo-Martinez, Francisco J. Tinahones, Sonsoles Morcillo
Summary: This study found that DNA methylation status is associated with the stability/worsening of the MHO phenotype, identifying two potential biomarkers for transitioning to an unhealthy state and highlighting immune system-related pathways as therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Peripheral Vascular Disease
Daniel A. Duprez, David R. Jacobs, Leah I. B. Andrews, Lyndia C. Brumback, Julie O. Denenberg, Robyn L. Mcclelland, Isac C. Thomas, Michael H. Criqui, Matthew A. Allison
Summary: This study investigated the difference, reproducibility, and incidence of cardiovascular disease (CVD) in inter-arm systolic blood pressure (sIAD). It found that high absolute sIAD values were not persistent over time, but were associated with increased risk for stroke and peripheral arterial disease (PAD). Measuring systolic blood pressure between arms can help identify individuals at higher risk for CVD.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Cardiac & Cardiovascular Systems
Olli Raitakari, Noora Kartiosuo, Katja Pahkala, Nina Hutri-Kahonen, Lydia A. Bazzano, Wei Chen, Elaine M. Urbina, David R. Jacobs Jr, Alan Sinaiko, Julia Steinberger, Trudy Burns, Stephen R. Daniels, Alison Venn, Jessica G. Woo, Terry Dwyer, Markus Juonala, Jorma Viikari
Summary: Elevated Lp(a) level in youth is associated with increased risk of adult atherosclerotic cardiovascular disease outcomes, but not with increased carotid intima-media thickness. This conclusion was derived from two similar studies.
Article
Cardiac & Cardiovascular Systems
Yuni Choi, David R. R. Jacobs Jr, Michael Patrick Bancks, Cora E. E. Lewis, EunSeok Cha, Fengxia Yan, Mercedes R. R. Carnethon, Pamela J. J. Schreiner, Daniel A. A. Duprez
Summary: The study found that the American Heart Association's cardiovascular health (CVH) score is closely associated with early-onset diabetes, later-onset diabetes, and subsequent complications of diabetes. Higher CVH score is associated with lower risk of both early- and later-onset diabetes, as well as diabetic complications. This study highlights the importance of maintaining good cardiovascular health in preventing diabetes and its complications.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Letter
Respiratory System
Motahareh Vameghestahbanati, Coralynn Sack, Artur Wysoczanski, Eric A. Hoffman, Elsa Angelini, Norrina B. Allen, Alain G. Bertoni, Junfeng Guo, David R. Jacobs Jr, Joel D. Kaufman, Andrew Laine, Ching-Long Lin, Daniel Malinsky, Erin D. Michos, Elizabeth C. Oelsner, Steven J. Shea, Karol E. Watson, Andrea Benedetti, R. Graham Barr, Benjamin M. Smith
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Sport Sciences
Tyler D. Quinn, Abbi Lane, Kelley Pettee Gabriel, Barbara Sternfeld, David R. Jacobs, Peter Smith, Bethany Barone Gibbs
Summary: This study examined the associations between fitness and leisure-time physical activity (LTPA) and occupational physical activity (OPA). The results showed a positive correlation between LTPA and fitness, while OPA was negatively correlated with fitness. These findings are important for physical activity research and public health promotion.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Biochemistry & Molecular Biology
Drew R. R. Nannini, Yinan Zheng, Brian T. Joyce, Kyeezu Kim, Tao Gao, Jun Wang, David R. R. Jacobs, Pamela J. J. Schreiner, Kristine Yaffe, Philip Greenland, Donald M. M. Lloyd-Jones, Lifang Hou
Summary: The study reveals the association between marijuana use and DNA methylation levels, with a stronger correlation in recent and cumulative users. The research also identifies pathways and diseases related to cellular proliferation, hormone signaling, infections, schizophrenia, bipolar disorder, and substance-related disorders.
MOLECULAR PSYCHIATRY
(2023)
Article
Cardiac & Cardiovascular Systems
Alessandro Menotti, Paolo Emilio Puddu, Anthony G. Kafatos, Hanna Tolonen, Hisashi Adachi, David R. Jacobs
Summary: This study aimed to investigate mortality rates from three major cardiovascular diseases (coronary heart disease, cerebrovascular diseases, and other heart diseases of uncertain etiology) in a pooled cohort over a 60-year follow-up period. The results showed that countries with high serum cholesterol levels had higher death rates from coronary heart disease, while countries with low cholesterol levels had higher death rates from stroke and other heart diseases. Differences in lifelong cardiovascular disease mortalities across different countries were smaller than expected.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Respiratory System
Gabrielle Y. Liu, Laura A. Colangelo, Samuel Y. Ash, Raul San Jose Estepar, David R. Jacobs, Bharat Thyagarajan, J. Michael Wells, Rachel K. Putman, Bina Choi, Christopher S. Stevenson, Mercedes Carnethon, George R. Washko, Ravi Kalhan
Summary: This epidemiological study found that CT lung injury is associated with future interstitial features and restrictive spirometry abnormality. Among 2213 participants, a 10% higher amount of CT lung injury at mean age 40 years was associated with a 4.37% higher amount of lung tissue characterised as interstitial features at mean age 50 years. Compared to those with the lowest quartile of CT lung injury at mean age 40 years, there were higher odds of incident restrictive spirometry at mean age 55 years in quartile 2, quartile 3, and quartile 4.
Letter
Critical Care Medicine
Gabrielle Y. Liu, Laura A. Colangelo, Raul San Jose Estepar, Anthony J. Esposito, Samuel Y. Ash, Bina Choi, David R. Jacobs, Mercedes R. Carnethon, George R. Washko, Ravi Kalhan
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Endocrinology & Metabolism
Brian T. Steffen, David R. Jacobs, So-Yun Yi, Simon J. Lees, James M. Shikany, James G. Terry, Cora E. Lewis, John J. Carr, Xia Zhou, Lyn M. Steffen
Summary: This study aimed to determine whether long-term intake of artificial sweeteners and diet beverages is associated with higher fat deposition and risk of obesity. The results showed that long-term intake of sweeteners and diet beverages was associated with increased fat deposition, weight gain, and higher risk of obesity.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Daniel A. Duprez, David R. Jacobs Jr
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Genetics & Heredity
Maryam Kavousi, Maxime M. Bos, Hanna J. Barnes, Christian L. Lino Cardenas, Doris Wong, Haojie Lu, Chani J. Hodonsky, Lennart P. L. Landsmeer, Adam W. Turner, Minjung Kho, Natalie R. Hasbani, Paul S. de Vries, Donald W. Bowden, Sandesh Chopade, Joris Deelen, Ernest Diez Benavente, Xiuqing Guo, Edith Hofer, Shih-Jen Hwang, Sharon M. Lutz, Leo-Pekka Lyytikaeinen, Lotte Slenders, Albert V. Smith, Maggie A. Stanislawski, Jessica van Setten, Quenna Wong, Lisa R. Yanek, Diane M. Becker, Marian Beekman, Matthew J. Budoff, Mary F. Feitosa, Chris Finan, Austin T. Hilliard, Sharon L. R. Kardia, Jason C. Kovacic, Brian G. Kral, Carl D. Langefeld, Lenore J. Launer, Shaista Malik, Firdaus A. A. Mohamed Hoesein, Michal Mokry, Reinhold Schmidt, Jennifer A. Smith, Kent D. Taylor, James G. Terry, Jeroen van der Grond, Joyce van Meurs, Rozemarijn Vliegenthart, Jianzhao Xu, Kendra A. Young, Nuno R. Zilhao, Robert Zweiker, Themistocles L. Assimes, Lewis C. Becker, Daniel Bos, J. Jeffrey Carr, L. Adrienne Cupples, Dominique P. v. de Kleijn, Menno de Winther, Hester M. den Ruijter, Myriam Fornage, Barry I. Freedman, Vilmundur Gudnason, Aroon D. Hingorani, John E. Hokanson, M. Arfan Ikram, Ivana Isgum, David R. Jacobs, Mika Kaehoenen, Leslie A. Lange, Terho Lehtimaeki, Gerard Pasterkamp, Olli T. Raitakari, Helena Schmidt, P. Eline Slagboom, Andre G. Uitterlinden, Meike W. Vernooij, Joshua C. Bis, Nora Franceschini, Bruce M. Psaty, Wendy S. Post, Jerome I. Rotter, Johan L. M. Bjoerkegren, Christopher J. O'Donnell, Lawrence F. Bielak, Patricia A. Peyser, Rajeev Malhotra, Sander W. van der Laan, Clint L. Miller
Summary: This study conducted a large-scale analysis and identified eleven new risk loci for coronary artery calcification (CAC), a measure of subclinical atherosclerosis. These new loci are related to bone mineralization, phosphate catabolism, and hormone metabolic pathways. The findings contribute to a better understanding of the genetic architecture of CAC and provide potential targets for therapeutic interventions.
Article
Medicine, General & Internal
Junia N. de Brito, Daniel J. McDonough, Mahesh Mathew, Lisa B. VanWagner, Pamela J. Schreiner, Kelley Pettee Gabriel, David R. Jacobs Jr, James G. Terry, John Jeffrey Carr, Mark A. Pereira
Summary: This study found that higher levels of vigorous-intensity physical activity (VPA) throughout young to middle adulthood were associated with a reduced risk of nonalcoholic fatty liver disease (NAFLD) in middle age.
Article
Peripheral Vascular Disease
Gabor Szalo, Margareta I. Hellgren, Matthew Allison, Ying Li, Lennart Rastam, Karin Radholm, Entela Bollano, Daniel A. Duprez, David R. Jacobs, Ulf Lindblad, Bledar Daka
Summary: The association between arterial elasticity obtained by radial artery pulse wave analysis and risk for cardiovascular diseases (CVD) was investigated. The study found a significant increase in the risk for incident CVD with each quartile decrease in arterial elasticity.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Geriatrics & Gerontology
Paolo Emilio Puddu, Alessandro Menotti, David R. Jacobs, Hisashi Adachi, Antony Kafatos, Hanna Tolonen
Summary: This study examined the age at death and its determinants in cohorts of middle-aged men. The results showed that cardiovascular disease risk factors were strongly associated with age at death. Other factors such as age, physical activity, and smoking status were also related to age at death.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)