Editorial Material
Environmental Sciences
Christian Rellstab
Summary: By combining highly resolved climatic and genomic data, researchers have identified high maladaptation of a North American tree species in its northern and eastern distribution range, highlighting the importance of considering migration and dispersal in assessing population responses to climate change.
NATURE CLIMATE CHANGE
(2021)
Article
Multidisciplinary Sciences
Mahboobeh Yeganeh-Hajahmadi, Mehrnaz Mehrabani, Mojdeh Esmaili, Mitra Shadkam Farokhi, Mojgan Sanjari
Summary: Insulin has been found to worsen the progression of diabetic retinopathy (DR) by promoting angiogenesis. The expression of endogenous angiogenic peptide, apelin, is triggered by insulin. However, the use of protaminated insulin as an inhibitor of the apelin receptor may help decrease the negative effects of insulin in DR progression.
SCIENTIFIC REPORTS
(2023)
Review
Endocrinology & Metabolism
Cheng Li, Hongna Cheng, Binay Kumar Adhikari, Shudong Wang, Na Yang, Wenyun Liu, Jian Sun, Yonggang Wang
Summary: This review summarizes the role of the Apelin-APJ system in diabetes and obesity, aiming to provide a better understanding of the mechanism and function of apelin and its receptor in the pathophysiology of diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Geir Bjorklund, Torsak Tippairote, Maryam Dadar, Fernando Lizcano, Jan Aaseth, Olga Borisova
Summary: Obesity and associated non-communicable diseases are on the rise globally due to modern lifestyle choices affecting metabolic energy and dietary habits. The conversion of white adipose tissue to beige adipose tissue may have beneficial effects on health outcomes.
CURRENT MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Emilie Dubois-Deruy, Yara El Masri, Annie Turkieh, Philippe Amouyel, Florence Pinet, Jean-Sebastien Annicotte
Summary: Lysine acetylation is a conserved mechanism that affects various biological processes, and its dysregulation is associated with cardiac dysfunction. This review summarizes the regulation of cardiac acetylation and its roles in both physiological and pathological conditions, highlighting its importance in cardiovascular diseases and suggesting KATs and KDACs as potential therapeutic targets for heart failure.
Article
Ecology
Gregor F. F. Fussmann, Michael Kopp
Summary: In rapidly changing environments, populations and species may face difficulties in adapting and avoiding extinction or replacement. Reciprocal transplant experiments are commonly used to assess the fitness of different populations in their respective environments. However, this study shows that the inference from reciprocal transplants can be misleading when applied to populations that are adapting to environmental change, leading to the conclusion of maladaptation even when the populations are following an evolutionary trajectory of fitness increase over time.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2023)
Review
Green & Sustainable Science & Technology
Chia-Fa Chi, Shiau-Yun Lu, Willow Hallgren, Daniel Ware, Rodger Tomlinson
Summary: Maladaptation, associated with risk transfer and risk substitution, has not received enough research attention; combining spatial land analysis with climate change analysis is crucial for identifying maladaptation; further research should integrate spatial land analysis methods to avoid maladaptive risk.
Article
Green & Sustainable Science & Technology
Rachel Bezner Kerr
Summary: Food systems, including production, processing, distribution, consumption, and waste, are under pressure to adapt to climate change. This paper reviews the literature on maladaptation in food systems, provides examples of different types of maladaptive outcomes, and discusses strategies to prevent maladaptation.
CURRENT OPINION IN ENVIRONMENTAL SUSTAINABILITY
(2023)
Article
Geriatrics & Gerontology
Di He, Yiwen Qiu, Mengsha Yan, Tianjing Zhou, Zongxue Cheng, Jun Li, Qiong Wu, Zuyun Liu, Yimin Zhu
Summary: Metabolically unhealthy overweight/obesity and normal weight individuals, but not metabolically healthy overweight/obesity, have an accelerated frailty progression compared to metabolically healthy normal weight individuals. Regardless of obesity status, transitioning from a healthy metabolic status to an unhealthy metabolic status accelerates frailty progression compared to stable metabolically healthy normal weight individuals. This emphasizes the importance of metabolic status in frailty progression and suggests the stratified management of obesity based on metabolic status.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Multidisciplinary Sciences
Beatrice Romier, Cedric Dray, Laetitia Vanalderwiert, Amandine Wahart, Thinhinane Hocine, Alizee Dortignac, Christian Garbar, Corinne Garbar, Camille Boulagnon, Nicole Bouland, Pascal Maurice, Amar Bennasroune, Herve Sartelet, Laurent Martiny, Laurent Duca, Philippe Valet, Sebastien Blaise
Summary: Recent studies have shown that apelin deficiency in mice leads to vascular stiffening and wall remodeling. The absence of apelin expression results in inflammation of adipose tissue and ECM remodeling, affecting vascular homeostasis.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Ruikai Jia, Min Huang, Lichun Qian, Xiaoye Yan, Qing Lv, Hua Ye, Li Ye, Xin Wu, Weizhi Chen, Ye Chen, Yankai Jia, Yueqing Huang, Huihui Wu
Summary: This study identified microbial compositional and gene functional alterations during the progression from central obesity to type 2 diabetes (T2D), highlighting enrichment of opportunistic pathogens in obese T2D patients and depletion of sugar and amino acid metabolism genes. The abundance of these depleted genes was negatively associated with plasma glycemia level and the percentage of individuals with impaired plasma glucose status, suggesting a potential biomarker for identifying central obese individuals at high risk of developing T2D.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Green & Sustainable Science & Technology
Pritha Datta, Bhagirath Behera
Summary: The importance of farmers' adaptation measures in addressing climate change is widely recognized. However, the effectiveness of these measures in reducing vulnerability is not always certain, and there are cases where they may lead to maladaptive outcomes. This study conducted a comprehensive assessment of farmers' adaptation measures and their subsequent maladaptive outcomes in the Eastern-Himalayan foothills of West Bengal, India. The findings highlight the need for more inclusive adaptation measures that consider multiple factors and promote sustainability.
ENVIRONMENT DEVELOPMENT AND SUSTAINABILITY
(2023)
Review
Biochemistry & Molecular Biology
Amanda A. de Oliveira, Ander Vergara, Xiaopu Wang, John C. Vederas, Gavin Y. Oudit
Summary: The Apelin/ApelinR pathway plays important roles in the cardiovascular system and is linked to various diseases, making it a critical therapeutic strategy. However, Apelin peptides are susceptible to degradation, limiting their therapeutic potential, leading researchers to develop more stable analogs and synthetic agonists.
Article
Endocrinology & Metabolism
Jose E. Galgani, Rodrigo Fernandez-Verdejo
Summary: Glucose, fatty acids, and amino acids are oxidized to produce ATP for energy, and the complex adaptive systems in the body adjust fuel oxidation rates based on fuel availability. Metabolic flexibility refers to the ability of cells, tissues, or organisms to adapt fuel oxidation to fuel availability, which can be impaired in conditions like insulin resistance, diabetes, and obesity. Mitochondrial dysfunction in these conditions has been linked to metabolic inflexibility and overall metabolic health.
Editorial Material
Biochemistry & Molecular Biology
Jacqueline A. Seiglie, Devaki Nambiar, David Beran, J. Jaime Miranda
Summary: The increasing recognition of the impact of social determinants of health on diabetes risk and outcomes should influence health provision and diabetes research.
Article
Clinical Neurology
Juan Luis Sanchez-Sanchez, Kelly V. Giudici, Sophie Guyonnet, Julien Delrieu, Yan Li, Randall J. Bateman, Angelo Parini, Bruno Vellas, Philipe de Souto Barreto
Summary: Baseline plasma MCP-1 levels were associated with longitudinal declines in overall cognitive and episodic memory performance in older adults over a 4-year follow-up. Interaction between plasma MCP-1 and A beta(42/40) may determine cognitive decline, especially in individuals with amyloid plaques. Further research should clarify the precise mechanism of this association.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Medicine, Research & Experimental
Antoine Deney, Vanessa Nader, Anthony Matta, Romain Itier, Pauline Fournier, Olivier Lairez, Nathalie Pizzinat, Didier Carrie, Frederic Boal, Michel Galinier, Oksana Kunduzova, Rania Azar, Jerome Roncalli
Summary: This study found that more than half of patients with heart failure had coronary artery disease, and older age and male sex were common risk factors for both HFpEF and HFrEF.
MEDICAL SCIENCE MONITOR
(2022)
Article
Cardiac & Cardiovascular Systems
Pascal Lim, Clement Delmas, Olivier Sanchez, Nicolas Meneveau, Roger Rosario, Helene Bouvaist, Anne Bernard, Jacques Mansourati, Francis Couturaud, Mustapha Sebbane, Pierre Coste, Gwenole Rohel, Bernard Tardy, Caroline Biendel, Olivier Lairez, Fabrice Ivanes, Romain Gallet, Jean-Luc Dubois-Rande, Damien Fard, Gilles Chatelier, Tabassome Simon, Muriel Paul, Pierre-Andre Natella, Richard Layese, Sylvie Bastuji-Garin
Summary: In normotensive patients with intermediate-risk PE, a single bolus of furosemide improved the primary efficacy outcome at 24 hours and maintained stable renal function. In the furosemide group, urine output increased, without demonstrable improvement in heart rate, systolic blood pressure, or arterial oxygenation.
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2022)
Review
Cardiac & Cardiovascular Systems
Nobuhiro Tahara, Olivier Lairez, Jin Endo, Atsushi Okada, Mitsuharu Ueda, Tomonori Ishii, Yoshinobu Kitano, Hahn-Ey Lee, Eleonora Russo, Toru Kubo
Summary: The Tc-99m-labelled bone radiotracer scintigraphy is an effective diagnostic method for early detection of ATTR-CM, with high sensitivity and specificity. However, the adoption of this technique for early diagnosis in daily clinical practice by general cardiologists is still limited, highlighting the need for guidance and education in this area.
Article
Cardiac & Cardiovascular Systems
Clement Delmas, Jean Porterie, Geraldine Jourdan, Frank Lezoualc'h, Romain Arnaud, Stephanie Brun, Hugo Cavalerie, Gregoire Blanc, Bertrand Marcheix, Olivier Lairez, Patrick Verwaerde, Jeanne Mialet-Perez
Summary: The study investigates the feasibility, safety, and effectiveness of long-term support by a new device (IVAC2L) in pigs with ischemic CS. The results show that IVAC2L support led to significant hemodynamic improvement in pigs with CS, with some complications observed during the study.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Health Care Sciences & Services
Olivier Lairez, Virginie Blanchard, Laurent Balardy, Fanny Vardon-Bounes, Stephanie Cazalbou, Stephanie Ruiz, Samia Collot, Valerie Houard, Yves Rolland, Jean-Marie Conil, Vincent Minville
Summary: This study aims to describe the myocardial function and its evolution over time in patients infected with COVID-19, and investigate the link between inflammation and cardiac injury. The results show that COVID-19 has a low functional impact on left ventricular systolic function.
JMIR RESEARCH PROTOCOLS
(2022)
Article
Cardiac & Cardiovascular Systems
Laetitia Pourtau, Maxime Beneyto, Jean Porterie, Jerome Roncalli, Montse Massot, Caroline Biendel, Pauline Fournier, Romain Itier, Michel Galinier, Olivier Lairez, Clement Delmas
Summary: This study aimed to investigate the prevalence, management, and outcomes of haemorrhagic adverse events in patients receiving left ventricular assist devices (LVADs). The study found that bleeding events were frequent and associated with increased mortality, with gastrointestinal bleeding being the most common and intracranial haemorrhage being the most associated with mortality.
Article
Cardiac & Cardiovascular Systems
Courtney M. Campbell, Samantha LoRusso, Angela Dispenzieri, Arnt V. Kristen, Mathew S. Maurer, Claudio Rapezzi, Olivier Lairez, Brian Drachman, Pablo Garcia-Pavia, Martha Grogan, Doug Chapman, Leslie Amass
Summary: This analysis examined sex differences in patients with ATTRwt amyloidosis, and found that female patients tended to be older, have less severe cardiac impairment, and more severe walking impairment.
CARDIOLOGY AND THERAPY
(2022)
Meeting Abstract
Rheumatology
M. Lemeu, O. Lairez, S. Faguer, G. Pugnet, G. Moulis, L. Alric, A. Huart, D. Ribes, M. L. Piel-Julian, A. Constantin, D. Chauveau, L. Sailler
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Meeting Abstract
Rheumatology
E. Bories, S. De Almeida Chaves, T. Porel, L. Alric, L. Astudillo, F. Gaches, M. Michaud, F. Catros, G. Prevot, L. Sailler, D. Adoue, O. Lairez, G. Pugnet
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Medicine, General & Internal
Pablo Garcia-Pavia, Fabian Aus Dem Siepen, Erwan Donal, Olivier Lairez, Peter van der Meer, Arnt V. Kristen, Michele F. Mercuri, Aubin Michalon, Robert J. A. Frost, Jan Grimm, Roger M. Nitsch, Christoph Hock, Peter C. Kahr, Thibaud Damy
Summary: NI006, a recombinant human anti-ATTR antibody, was found to be safe and effective in reducing the cardiac amyloid load in patients with ATTR cardiomyopathy and heart failure, according to a phase 1 trial.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
Rishika Banydeen, Reid Eggleston, Antoine Deney, Astrid Monfort, Jay H. Ryu, Giuseppe Vergaro, Vincenzo Castiglione, Olivier Lairez, Michele Emdin, Jocelyn Inamo, Misbah Baqir, Remi Neviere
Summary: Transthyretin cardiac amyloidosis (ATTR-CA) is a recognized disease with high risk of heart failure and death. The combination of spirometry, cardiopulmonary exercise testing (CPET), and biomarker staging can improve risk stratification in ATTR-CA patients and may help in better management and treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
P. Garcia-Pavia, N. Piriou, R. Barriales-Villa, F. Cappelli, O. Lairez, C. Munteanu, D. Keohane, P. Mallaina
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Correction
Cardiac & Cardiovascular Systems
N. Tahara, O. Lairez, J. Endo, A. Okada, M. Ueda, T. Ishii, Y. Kitano, H-E Lee, E. Russo, T. Kubo
Meeting Abstract
Cardiac & Cardiovascular Systems
Courtney Campbell, Samantha Lorusso, Angela Dispenzieri, Arnt Kristen, Mathew S. Maurer, Claudio Rapezzi, Olivier Lairez, Brian Drachman, Pablo Garcia-Pavia, Martha Grogan, Doug Chapman, Leslie Amass
JOURNAL OF CARDIAC FAILURE
(2022)