Article
Neurosciences
Syed M. Adil, Evan Calabrese, Lefko T. Charalambous, James J. Cook, Shervin Rahimpour, Ahmet F. Atik, Gary P. Cofer, Beth A. Parente, G. Allan Johnson, Shivanand P. Lad, Leonard E. White
Summary: This study successfully constructed an atlas of the human brainstem using high-resolution MRI technology, which is available online for interactive use, providing a new tool for neuroanatomical education and research.
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexander Rau, Pia M. Jungmann, Thierno D. Diallo, Marco Reisert, Elias Kellner, Michel Eisenblaetter, Fabian Bamberg, Matthias Jung
Summary: Quantitative MRI techniques, such as diffusion microstructure imaging (DMI), can provide additional information about muscular function and microstructure, potentially serving as a potential biomarker for young athletes.
EUROPEAN RADIOLOGY
(2023)
Article
Clinical Neurology
Anna Zdunczyk, Fabia Roth, Thomas Picht, Peter Vajkoczy
Summary: In this study, navigated transcranial magnetic stimulation (nTMS)-based diffusion tensor imaging (DTI) fiber tracking was used to successfully visualize somatotopic descending motor pathways in patients with brainstem cavernomas. Higher preoperative resting motor threshold (RMT) values were associated with postoperative motor deficits. In patients with new deficits, the distance between the lesion and corticospinal tract (CST) was less than 1 mm.
JOURNAL OF NEUROSURGERY
(2021)
Article
Medicine, Research & Experimental
Yu Zhang, Andrei A. Vakhtin, Jessica Dietch, Jennifer S. Jennings, Jerome A. Yesavage, J. David Clark, Peter J. Bayley, J. Wesson Ashford, Ansgar J. Furst
Summary: The study identified the role of the brainstem in chronic sleep problems and pain in GWI veterans, with atrophy and abnormal diffusion tensor metrics of the brainstem correlated with symptom severity, highlighting the importance of the brainstem in GWI symptoms.
Article
Chemistry, Applied
Kathryn E. Anderssen, Mathias Kranz, Shaheen Syed, Svein Kristian Stormo
Summary: This study investigates the use of diffusion tensor imaging (DTI) magnetic resonance imaging (MRI) as a quantitative method to describe the structure of muscle tissue in meat and seafood. The results show that DTI can effectively distinguish between different sample qualities and detect changes caused by freezing and thawing damage.
Article
Oncology
Urs Wuertemberger, Martin Diebold, Daniel Erny, Jonas A. Hosp, Oliver Schnell, Peter C. Reinacher, Alexander Rau, Elias Kellner, Marco Reisert, Horst Urbach, Theo Demerath
Summary: Diffusion microstructure imaging (DMI) can be used to differentiate brain metastases from glioblastomas. Perilesional T2 hyperintensity in brain metastases is mainly due to edema, while in glioblastomas, there is tumor infiltration.
Article
Neurosciences
Haining Li, Qiuli Zhang, Qianqian Duan, Jiaoting Jin, Fangfang Hu, Jingxia Dang, Ming Zhang
Summary: The study found local abnormal surface contraction in certain regions of the brainstem in ALS patients, as well as differences in white matter integrity. Disease severity was positively associated with white matter integrity in specific regions of the brainstem.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vito Chianca, Domenico Albano, Stefania Rizzo, Mario Maas, Luca Maria Sconfienza, Filippo Del Grande
Summary: This study evaluated the inter-observer and inter-vendor reliability of diffusion tensor imaging parameters in the musculoskeletal system. The results showed high levels of agreement between observers and no significant inter-vendor differences were observed. This indicates that diffusion tensor imaging is highly reproducible and reliable in the musculoskeletal system.
INSIGHTS INTO IMAGING
(2023)
Article
Clinical Neurology
Jan Valosek, Rene Labounek, Tomas Horak, Magda Horakova, Petr Bednarik, Milos Kerkovsky, Jan Kocica, Tomas Rohan, Christophe Lenglet, Julien Cohen-Adad, Petr Hlustik, Eva Vlckova, Zdenek Kadanka, Josef Bednarik, Alena Svatkova
Summary: The study found diffusion abnormalities in the gray matter, dorsal and lateral tracts in chronic degenerative spinal cord compression, with more profound alterations in DCM than NMDC patients. Diffusion metrics were affected in the C3-6 area and above the compression level at C3, with more profound rostral deficits in DCM. Alterations in lateral motor and dorsal sensory tracts correlated with motor and sensory evoked potentials, while electromyography outcomes corresponded with gray matter microstructure. DCM disability corresponded with microstructure alteration in lateral columns.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Fengzhao Zhu, Yulong Wang, Xiangchuang Kong, Yuan Liu, Lian Zeng, Xirui Jing, Sheng Yao, Kaifang Chen, Lian Yang, Xiaodong Guo
Summary: The combination of conventional MRI with DTI-DTT is a valid diagnostic approach for acute traumatic cervical SCI. Lower intramedullary lesion length and intramedullary hemorrhage length, and higher fractional anisotropy value and connection rates of fiber tractography are linked to better neurological outcomes.
EUROPEAN SPINE JOURNAL
(2022)
Article
Medicine, General & Internal
Jacob S. Ecanow, David B. Ecanow, Bradley Hack, Nondas Leloudas, Pottumarthi V. Prasad
Summary: DTI parametric maps can safely be used to avoid biopsy of breast lesions; in appropriate patients, DTI has the potential to reduce unnecessary breast biopsies.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiali Shao, Xuewei Zhang, Wenrui Xu, Zhe Zhang, Jieying Zhang, Hua Guo, Tao Jiang, Weihong Zhang
Summary: The study found that NODDI has good reliability in evaluating epileptogenic tubers in TSC patients. ICVF showed advantages in detecting subtle epileptogenic tubers, and NODDI parameters have the potential to identify epileptogenicity.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daneshwari Kalage, Pankaj Gupta, Ajay Gulati, Thakur Deen Yadav, Vikas Gupta, Lileswar Kaman, Ritambhra Nada, Harjeet Singh, Santosh Irrinki, Parikshaa Gupta, Chandan Das, Usha Dutta, Manavjit Sandhu
Summary: Objective: To investigate the diagnostic performance of a multiparametric MRI protocol in the characterization of gallbladder wall thickening. Methods: Consecutive adults with gallbladder wall thickening were evaluated using multiparametric MRI, and the association of MRI parameters with malignant gallbladder wall thickening was analyzed. Results: The quantitative MRI parameters were significantly associated with malignant gallbladder wall thickening, and the multiparametric MRI showed higher sensitivity than conventional MRI for diagnosing malignant gallbladder wall thickening. Conclusion: Multiparametric MRI improved the diagnostic performance for differentiating benign and malignant gallbladder wall thickening.
EUROPEAN RADIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ruiqing Ni
Summary: Amyloid-beta (A beta) is crucial in the pathogenesis of Alzheimer's disease, with aberrant accumulation leading to neuroinflammation, cerebrovascular alterations, and cognitive impairments. High-field MRI technology has enabled non-invasive visualization of A beta-related alterations in animal models, offering translational value for clinical MRI applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Arka Das, Amrit Chowdhary, Chris Kelly, Irvin Teh, Christian T. Stoeck, Sebastian Kozerke, Nicholas Maxwell, Thomas P. Craven, Nicholas J. Jex, Christopher E. D. Saunderson, Louise A. E. Brown, Hadar Ben-Arzi, Anshuman Sengupta, Stephen P. Page, Peter P. Swoboda, John P. Greenwood, Jurgen E. Schneider, Sven Plein, Erica Dall'Armellina
Summary: The study showed that DTI MRI can reveal microstructural differences in myocardium between HCM patients, athletes, and healthy volunteers. HCM patients had significantly higher diffusion and isotropy compared to athletes and volunteers, while the difference between athletes and volunteers was minimal.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Quin E. Denfeld, Beth A. Habecker, S. Albert Camacho, Mary Roberts Davis, Nandita Gupta, Shirin O. Hiatt, Mary E. Medysky, Jonathan Q. Purnell, Kerri Winters-Stone, Christopher S. Lee
Summary: In heart failure (HF), women are significantly more likely to be physically frail compared with men, with both genders exhibiting more comorbidities and worse symptoms; in men, physical frailty is characterized by worse physiological characteristics.
CIRCULATION-HEART FAILURE
(2021)
Meeting Abstract
Endocrinology & Metabolism
Chandni H. Anadkat, Jonathan Q. Purnell, Nicole E. Marshall, Amy M. Valent, Janne Boone-Heinonen, Kimberly Vesco
Review
Obstetrics & Gynecology
Nicole E. Marshall, Barbara Abrams, Linda A. Barbour, Patrick Catalano, Parul Christian, Jacob E. Friedman, William W. Hay, Teri L. Hernandez, Nancy F. Krebs, Emily Oken, Jonathan Q. Purnell, James M. Roberts, Hora Soltani, Jacqueline Wallace, Kent L. Thornburg
Summary: Healthy nutrition and diet play a crucial role in preconception and pregnancy, emphasizing nutrient-dense whole foods while avoiding excessive processed foods and saturated fats. Extreme restriction of any macronutrient class should be avoided, and early interventions are necessary to prevent adverse outcomes. Breastfeeding provides personalized nutrition for infants and is associated with short- and long-term health benefits for both mother and child.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Endocrinology & Metabolism
Nichole E. Carlson, Ken W. Horton, John E. Hokanson, Patricia A. Cleary, David R. Jacobs, John D. Brunzell, Jonathan Q. Purnell
Summary: Obesity is a significant health issue for participants with type 1 diabetes undergoing intensive diabetes management. The study compared weight gain in those receiving intensive and conventional type 1 diabetes treatment, as well as a population without diabetes. It was found that weight gain with intensive therapy occurred in two stages and resulted in similar or higher obesity rates compared to the population without diabetes after 2 years. Glucose control and family history were identified as influential factors.
Article
Pharmacology & Pharmacy
Bruce A. Warden, Jonathan Q. Purnell, P. Barton Duell, Sergio Fazio
Summary: This study evaluated the real-world use of bempedoic acid for lipid management in patients with cardiovascular disease. The results showed that bempedoic acid was effective in reducing LDL-C levels in patients at high risk for atherosclerotic events and statin intolerance. However, high rates of treatment-emergent adverse events and drug discontinuations were observed.
JOURNAL OF CLINICAL LIPIDOLOGY
(2022)
Article
Nutrition & Dietetics
Kimberly K. Vesco, Nicole E. Marshall, Eric Baetscher, Michael C. Leo, William Rooney, Melanie Francisco, Eric Baker, Janet C. King, Patrick Catalano, Antonio E. Frias, Jonathan Q. Purnell
Summary: Excessive gestational weight gain is associated with increased total body fat, especially visceral fat accumulation. However, there is no significant correlation between weight change and lipid accumulation in the liver and muscles.
JOURNAL OF NUTRITION
(2022)
Article
Nutrition & Dietetics
Bert B. Boyer, Scarlett E. Hopkins, Howard W. Wiener, Jonathan Q. Purnell, Diane M. O'Brien, Cindy X. Zhang, Joseph E. Aslan, Theresa Aliwarga, Jeremy J. Pomeroy, Kenneth E. Thummel, Hemant K. Tiwari
Summary: This study found that habitual intake of marine mammals and fish rich in n-3 PUFAs is associated with reduced systemic inflammation in Yup'ik Alaska Native adults.
JOURNAL OF NUTRITION
(2022)
Letter
Obstetrics & Gynecology
Kent L. Thornburg, Jonathan Purnell, Nicole Marshall
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Quin E. Denfeld, Jonathan Q. Purnell, Christopher S. Lee, Eric S. Orwoll, S. Albert Camacho, Shirin O. Hiatt, Mary Roberts Davis, Kerri Winters-Stone, William R. Woodward, Beth A. Habecker
Summary: This study aimed to identify candidate biomarkers associated with physical frailty in heart failure (HF) using a multimarker strategy. The results showed that adiponectin, IGF-1, and myostatin were significantly associated with physical frailty in HF.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2023)
Article
Clinical Neurology
David Lahna, Daniel L. Schwartz, Randy Woltjer, Sandra E. Black, Natalie Roese, Hiroko Dodge, Erin L. Boespflug, Julia Keith, Fuqiang Gao, Joel Ramirez, Lisa C. Silbert
Summary: The study indicates that venous collagenosis is associated with periventricular white matter hyperintensities (pvWMHs), while arterial collagenosis is not. This suggests the importance of changes in the venous system in the commonly observed MRI white matter lesions in older individuals.
ANNALS OF NEUROLOGY
(2022)
Article
Nutrition & Dietetics
Angela M. Horgan, Gundula R. Palmbach, Julia M. Jordan, Holly S. Callahan, Kaatje E. Meeuws, David S. Weigle, Mario Kratz, Jonathan Q. Purnell
Summary: This study investigated the effect of an off-protocol meal on total caloric consumption, hunger, and satiety in a long-term ad libitum feeding study. The results showed that the off-protocol meal increased daily caloric intake without affecting appetite ratings. There was a slight reduction in intake the following day, but no change in appetite scores. Protein intake was inversely associated with daily caloric intake.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Clinical Neurology
David Lahna, Natalie Roese, Randy Woltjer, Erin L. Boespflug, Daniel Schwartz, John Grinstead, Hiroko H. Dodge, Rachel Wall, Jeffrey A. Kaye, William D. Rooney, Lisa C. Silbert
Summary: Postmortem MRI can connect macrostructural findings observed by MRI with histological changes, allowing for comprehensive characterization and study of cerebrovascular disease.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2022)
Meeting Abstract
Endocrinology & Metabolism
Nga Nguyen, Cynthia Bethea, Eric Baetscher, Paul Kievit, Jonathan Purnell
Meeting Abstract
Endocrinology & Metabolism
Chandni Anadkat, Amy Valent, Nicole Marshall, Jonathan Purnell, Kimberly Vesco
Meeting Abstract
Oncology
Alexandra Quackenbush, Erica Goddard, Claire Dorfman, Kimberly Vesco, Jonathan Purnell, Pepper Schedin